二苯甲酮-3 （BP3）、双酚A （BPA）及其组合影响卵巢对促性腺激素刺激的反应。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-09-15 DOI:10.1016/j.etap.2025.104821

Valentina Galliani , Joana Fessia , Clarisa Guillermina Santamaría , Julián Elías Abud , Horacio Adolfo Rodríguez

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引用次数: 0

摘要

尽管普遍的证据表明内分泌干扰化学物质（EDCs）可能对多胎妊娠产生影响，但大多数研究都集中在第一次妊娠。利用多胎小鼠模型，我们评估了二苯甲酮-3 （BP3）、双酚a （BPA）或两者组合（BP3+BPA）暴露在两个妊娠期（P1和P2）对妊娠结局和每次妊娠的雌性后代性腺功能的影响。BPA和BP3+BPA组在P1和P2期均改变了妊娠期长度，而母鼠体重、产仔数和性别比未受影响。所有EDC暴露组P2子代排卵均受影响。值得注意的是，在所有暴露组中，窦卵泡数量减少，而BPA和BP3+BPA暴露减少了P2后代的原始卵泡储备。在hCG刺激下，BP3+BPA组P2子代雌二醇水平升高。这些发现强调了在评估EDCs的长期生殖影响时考虑累积暴露和BPA和BPA组合暴露的重要性。

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Benzophenone-3 (BP3), bisphenol A (BPA), and their combination impair ovarian response to gonadotropin stimulation in a multi-exposure multiparity model.

Despite prevailing evidence that endocrine-disrupting chemicals (EDCs) may exert effects across multiple pregnancies, most studies focus on the first pregnancy Using a multiparity murine model, we evaluated the effects of benzophenone-3 (BP3), bisphenol-A (BPA) or the combination (BP3 +BPA) exposure over two gestational periods (P1 and P2) on pregnancy outcomes and the gonadal function in female offspring from each pregnancy. While maternal weight, litter size, and sex ratio were unaffected, gestation length was altered in BPA and BP3 +BPA groups both in P1 and P2. Ovulation was affected in P2 offspring in all EDC exposed groups. Notably, antral follicle numbers were reduced in all exposed groups, while BPA and BP3 +BPA exposure diminished the primordial follicle reserve in P2 offspring. Estradiol levels were elevated in P2 offspring in the BP3 +BPA group with hCG stimulation. These findings highlight the importance of considering cumulative exposure and exposure to combinations of BP3 and BPA when assessing the long-term reproductive effects of EDCs.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.