早期效应生物标志物和危害指数方法评估法国电池回收者多次接触金属的风险。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-09-13 DOI:10.1016/j.etap.2025.104819

Ogier Hanser, Aurélie Martin Remy, Mathieu Melczer, Nathalie Grova, Sophie Ndaw

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引用次数: 0

摘要

电池回收会使工人接触到几种金属。本研究旨在通过探索生物标志物改善工人风险评估的潜力，并通过计算危害指数（HI）来评估累积暴露的风险，来调查这种多重暴露。对法国三家回收厂86名工人的尿液样本进行了金属生物标志物（Cd、Co、Cr、Li、Mn、Ni）、肾损伤生物标志物（α1-微球蛋白、视黄醇结合蛋白、肾损伤分子-1、n -乙酰-β- d -葡萄糖氨基苷酶、白蛋白、总蛋白）和氧化应激生物标志物（8-羟基脱氧鸟苷、丙二醛）的分析。肾损伤生物标志物水平成功区分了暴露的回收者和行政工作者，而氧化应激生物标志物水平不允许这种区分。事实证明，计算HI在检测与多种金属接触相关的风险方面是有效的，提供了比单独考虑金属时更好的风险评估。这种将HI计算和分析肾损伤生物标志物相结合的双重方法，应该在多种金属暴露工人的风险评估中得到强烈考虑。

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Early-effect biomarkers and hazard index approaches to assessing risks from multiple exposure to metals among battery recyclers in France

Battery-recycling can expose workers to several metals. This study aims to investigate this multiple exposure, by exploring the potential of effect biomarkers to improve risk assessment for workers, and by calculating a hazard index (HI) to assess the risk of cumulative exposure. Urine samples from 86 workers in three French recycling plants were analysed for metal biomarkers (Cd, Co, Cr, Li, Mn, Ni), kidney-injury biomarkers (α1-microglubulin, retinol binding protein, kidney injury molecule-1, N-acetyl-β-D-gluocosaminidase, albumin, total proteins), and oxidative-stress biomarkers (8-hydroxydeoxyguanosine, malondialdehyde). Kidney-injury biomarker levels successfully differentiated exposed recyclers from administrative workers, while oxidative-stress biomarker levels did not allow this differentiation. The calculation of a HI proved effective in detecting the risk associated with multiple metal exposure, offering a better risk assessment than when considering metals individually. This dual approach, combining HI calculation and analyzing kidney-injury biomarkers, should be strongly considered in the risk assessment of workers exposed to multiple metals.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.