在威斯达汉诺威大鼠中进行了对农药Асеtаmіprіd的研究

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-10-01 DOI:10.1016/j.etap.2025.104833

Inna Rashkivska , Mykola Produnchuk , Nadiia Nedopytanska , Petro Zhminko , Mojmir Mach , Yana Kolianchuk

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引用次数: 0

摘要

现有的农药醋氨虫（ACE）数据不足以阐明已确定的神经毒性的不确定性。目前对ACE的DNT研究是根据OECD TG 426和GLP要求进行的，以澄清不确定性。ACE以0、2.5、10和45 mg/kg/bw/d灌胃Wistar Hannover大鼠。母体毒性表现为45 mg/kg/bw/day剂量水平。在45 mg/kg/bw/day的剂量水平下显示发育毒性。在ACE发育神经毒性方面，10和45 mg/kg体重/天给药影响了声惊吓反应和运动活动，未观察到脑结构变化。根据研究结果，确定母体毒性的未观察到不良反应水平（NOAEL）为10 mg/kg bw/day。发育性神经毒性NOAEL为2.5 mg/kg bw/day。一项ACE的发育性神经毒性研究表明，神经毒性是该化合物整体毒性的关键限制因素。

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Dеvеlоpmеntаl nеurоtоxісіty study оf pesticide Асеtаmіprіd in Wistar Hannover rats

Available data on pesticide Acetamiprid (ACE) are insufficient to clarify the uncertainties identified neurotoxicity. The current DNT study of ACE was conducted according to the OECD TG 426 and GLP requirements to clarify uncertainties. ACE was administered orally by gavage Wistar Hannover rats at dose levels of 0, 2.5, 10 and 45 mg/kg/bw/day. Maternal toxicity was expressed at a dose level of 45 mg/kg/bw/day. Developmental toxicity was indicated at a dose level of 45 mg/kg/bw/day. Regarding ACE developmental neurotoxicity, administration at 10 and 45 mg/kg body weight/day affected the acoustic startle response and locomotor activity, with no observed structural brain changes. Based on the study findings, the No-Observed-Adverse-Effect Level (NOAEL) for maternal toxicity was determined to be 10 mg/kg bw/day. The NOAEL was identified as 2.5 mg/kg bw/day for developmental neurotoxicity. A developmental neurotoxicity study of ACE demonstrated that neurotoxicity is a critical limiting factor for the compound's overall toxicity.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.