草甘膦和农达对支持细胞增殖影响的分析。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-07-24 DOI:10.1016/j.etap.2025.104775

Cecilia Lucia Centola, Marina Ercilia Dasso, Agostina Gorga, Gustavo Marcelo Rindone, Maria Noel Galardo, Maria Fernanda Riera, Silvina Beatriz Meroni

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引用次数: 0

摘要

农达(R)是一种含有草甘膦(G)作为活性成分的制剂，已被提议作为一种影响男性生育能力的除草剂。在增殖期获得足够的支持细胞（SC）数量对成人的生殖功能和精子产生至关重要。本研究分析了G和R是否影响SC增殖和精子产生。8日龄大鼠SC培养物的体外实验表明，R降低了fsh刺激的BrdU掺入，但G没有影响。从PND 3到PND 7 （SC增殖最大的时期），每天给予R （50mg/kg）的大鼠体内研究表明，R没有改变BrdU的掺入。从PND 3到PND 14，接受R治疗的成年雄性大鼠每日精子产量（DSP）没有改变。综上所述，早期R治疗不会改变未成熟动物的支持细胞增殖，也不会改变成年动物的DSP。

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Analysis of the effects of Glyphosate and Roundup on Sertoli cell proliferation

Roundup (R), a formulation containing glyphosate (G) as active ingredient, has been proposed as an herbicide affecting male fertility. Acquiring an adequate Sertoli cell (SC) number during the proliferative periods is essential to the reproductive function and sperm production in adults. This study analyzed whether G and R affect SC proliferation and sperm production. In vitro experiments with SC cultures from 8-day-old rats show that R decreased FSH-stimulated BrdU incorporation, but G had no effect. In vivo studies in rats daily treated with R (50 mg/kg) from PND 3 to PND 7, period of maximal SC proliferation, show that R did not alter BrdU incorporation. In adult male rats that had received R treatment from PND 3 to PND 14 daily sperm production (DSP) was not altered. In summary, R treatment in early stages of life does not alter Sertoli cell proliferation in immature animals or DSP in adult animals.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.