Environmental toxicology and pharmacology最新文献_第6页

Joint action of six-component mixtures based on concentration response curves morphological parameter in acute and long-term toxicity assay 基于浓度响应曲线形态学参数的六组分混合物的联合作用在急性和长期毒性试验中的应用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-28 DOI: 10.1016/j.etap.2024.104595

Yujiao Zhang , Yajiao Li , Na Wang , Xiaoyan Ma , Jiajing Sun , Xiaochang Wang , Jiaxuan Wang

{"title":"Joint action of six-component mixtures based on concentration response curves morphological parameter in acute and long-term toxicity assay","authors":"Yujiao Zhang , Yajiao Li , Na Wang , Xiaoyan Ma , Jiajing Sun , Xiaochang Wang , Jiaxuan Wang","doi":"10.1016/j.etap.2024.104595","DOIUrl":"10.1016/j.etap.2024.104595","url":null,"abstract":"<div><div>Previous studies found that the multi-component mixtures with hormesis concentration-response curves (CRCs) were divided into three types according to the combined toxicity analysis of the segment-based method and <em>σ</em><sup>2</sup><sub>(<em>k∙ECx</em>)</sub> (the variance of <em>k∙EC</em><sub><em>x</em></sub>). In this study, the acute and long-term toxicity of six pollutants and 12 six-component mixtures were assessed using microplate toxicity analyses (MTA). The functional relationship between <em>σ</em><sup><em>2</em></sup><sub>(<em>k·ECx</em>)</sub> and effect ratio (<em>ER</em><sub><em>x</em></sub>) was determined by means of the independent action (IA) and the ER model to systematically investigate the correlation between mixture types in acute and long-term toxicity. The results indicated that across the entire concentration range, the mixture type of acute toxicity was consistent with short time exposure (0.25 h) measured in the long-term toxicity experiment. In the inhibition effect range, the types of mixtures of acute toxicity remained consistent with the chronic toxicity (exposure for 24 h) in 11 of the 12 mixtures. This study clarified the changes in the joint action of multi-component mixtures on <em>Aliivibrio fischeri</em> in terms of acute and long-term toxicity. The chronic toxicity of the mixtures can be predicted from the acute toxicity results, which provides a theoretical basis for the biological toxicity evaluation of multi-component mixtures.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104595"},"PeriodicalIF":4.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased metabolic demand reveals morpho-functional impacts caused by settleable atmospheric particulate matter on fish gills 新陈代谢需求的增加揭示了可沉降大气颗粒物对鱼鳃造成的形态功能影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-26 DOI: 10.1016/j.etap.2024.104593

C.F. De Angelis , M.P. Soares , I.L. Cardoso , E.W. Taylor , H. Sadauskas-Henrique , E.N. Fragoso-Moura , J.A.M. Milan , I.C. Souza , D.A. Wunderlin , M.V. Monferrán , M.N. Fernandes , C.A.C. Leite

{"title":"Increased metabolic demand reveals morpho-functional impacts caused by settleable atmospheric particulate matter on fish gills","authors":"C.F. De Angelis , M.P. Soares , I.L. Cardoso , E.W. Taylor , H. Sadauskas-Henrique , E.N. Fragoso-Moura , J.A.M. Milan , I.C. Souza , D.A. Wunderlin , M.V. Monferrán , M.N. Fernandes , C.A.C. Leite","doi":"10.1016/j.etap.2024.104593","DOIUrl":"10.1016/j.etap.2024.104593","url":null,"abstract":"<div><div>Exposure to environmentally relevant levels of settleable atmospheric particulate matter (SePM) limits the aerobic performance of inactive healthy adult fish. We evaluated the gill morpho-functional impacts (gill structure and ionic balance) caused by SePM exposure (96 h) in Nile tilapia when fish is impelled to maximal aerobic swimming effort. In control fish, swimming reduced epithelial filament thickness (EFT, 25 %), increased the distance between lamellae (DL, 21 %), and reduced the plasma Na<sup>+</sup> (5 %). In resting fish, SePM exposure increased EFT (11 %), reduced DL (30 %), lamellar height (LH, 18 %), and plasma Na<sup>+</sup> (4 %), whereas increased Cl<sup>-</sup> and K<sup>+</sup> (8 % and 20 %). In SePM-exposure fish, swimming reduced EFT (40 %), increased DL (30 %) and LH (30 %), while reduced Na<sup>+</sup> and Cl<sup>-</sup> (9 % and 18 %), and increased K<sup>+</sup> when compared to inactive SePM-exposed fish. These morpho-functional limitations may compromise whole-body maintenance and swimming recovery, affecting the fish ability to perform at higher activity levels.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104593"},"PeriodicalIF":4.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio) 胚胎期接触炔雌醇和克霉唑对斑马鱼（Danio rerio）行为和神经可塑性的长期影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-22 DOI: 10.1016/j.etap.2024.104592

M. Blanc-Legendre , L. Guillot , L. Chevalier , C. Malleret , K. Le Menach , P. Pardon , H. Budzinski , F. Brion , S. Sire , P. Coumailleau , T.D. Charlier , E. Pellegrini , X. Cousin

{"title":"Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio)","authors":"M. Blanc-Legendre , L. Guillot , L. Chevalier , C. Malleret , K. Le Menach , P. Pardon , H. Budzinski , F. Brion , S. Sire , P. Coumailleau , T.D. Charlier , E. Pellegrini , X. Cousin","doi":"10.1016/j.etap.2024.104592","DOIUrl":"10.1016/j.etap.2024.104592","url":null,"abstract":"<div><div>Estrogen receptors (ER) are widely expressed in the brain of many species and experimental results highlighted the role of estradiol in neuronal plasticity and behavior. Consequently, the brain is therefore a prime target for endocrine disrupting chemicals (EDCs) interacting with estrogen signaling. Very little is known about the late effects of early disruption of estrogen signaling by EDCs. We focused on: ethinylestradiol (EE2; ER agonist) and clotrimazole (inhibitor of key steroidogenesis enzymes, including aromatases). Zebrafish eleutheroembryos were exposed (0–5 days) and then raised normally until adulthood. Several behavioral tests were performed in adults, then cell proliferation and dopaminergic neurons were quantified in several brain regions using immunostaining. Overall, a developmental exposure to EDCs stimulates cell proliferation in the dorsal telencephalon. At environmentally-relevant concentrations, male fish exposed to EE2 exhibited increased activity levels and decreased social behavior, posing a potential risk to population balance and health.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104592"},"PeriodicalIF":4.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress indicators in conservative tissues of Humboldt penguin under captivity 人工饲养下洪堡企鹅保守组织的压力指标

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-22 DOI: 10.1016/j.etap.2024.104590

Montserrat Solé , Sergi Omedes , Vanessa Almagro , Manel López-Béjar , Annaïs Carbajal

{"title":"Stress indicators in conservative tissues of Humboldt penguin under captivity","authors":"Montserrat Solé , Sergi Omedes , Vanessa Almagro , Manel López-Béjar , Annaïs Carbajal","doi":"10.1016/j.etap.2024.104590","DOIUrl":"10.1016/j.etap.2024.104590","url":null,"abstract":"<div><div>Humboldt penguins (<em>Spheniscus humboldti</em>) from the Barcelona zoo (n=9) were followed to assess their physiological stress status using conservative protocols. Corticosterone levels were measured in feathers and plasma as indicative of chronic and acute physiological stress, respectively. Other markers: B-esterases, potentially indicative of xenobiotic exposure were measured in plasma of these same individuals and reported for the first time in this species. The sensitivity to chemicals of environmental concern, employed as plastic additives, was assessed <em>in vitro</em> with plasma of this species using the inhibition of carboxylesterase (CE) and acetylcholinesterase enzymatic measurements. Among the tested additives, the organophosphorus flame retardants displayed the highest <em>in vitro</em> inhibitory potential on basal CE activity, suggesting their potential utility as biomarkers of this particular chemical class. Additionally, enzymatic measurements in plasma are determined for the first time in Humboldt penguin and can be regarded as baseline values for a potential field monitoring application.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104590"},"PeriodicalIF":4.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model 合成益生菌是缓解临床前小鼠污染模型后代过敏性气道免疫反应加重的有效方法。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-20 DOI: 10.1016/j.etap.2024.104591

Ali Dehghani , Lei Wang , Johan Garssen , Eirini Styla , Thea Leusink-Muis , Ingrid Van Ark , Gert Folkerts , Jeroen Van Bergenhenegouwen , Saskia Braber

{"title":"Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model","authors":"Ali Dehghani , Lei Wang , Johan Garssen , Eirini Styla , Thea Leusink-Muis , Ingrid Van Ark , Gert Folkerts , Jeroen Van Bergenhenegouwen , Saskia Braber","doi":"10.1016/j.etap.2024.104591","DOIUrl":"10.1016/j.etap.2024.104591","url":null,"abstract":"<div><div>Exposure to pollutants like environmental cigarette smoke (CS) poses a major global health risk, affecting individuals from an early age. Therefore, this study explores how postnatal synbiotic supplementation affects allergic asthma symptoms in house-dust-mite (HDM)- challenged offspring maternally exposed to CS. In HDM-allergic offspring of CS-exposed dams, lung resistance was elevated, but synbiotic supplementation effectively reduced this resistance. Elevated eosinophil BALF counts following HDM challenge were intensified in pups maternally exposed to CS. Similarly, Th2 cell activation and serum IgE and IgG1 levels were more pronounced in HDM-allergic offspring of CS-exposed mothers. Synbiotics reduced eosinophil numbers and serum IgE and IgG1, and tended to decrease Th2 cell infiltration and activation. Synbiotics promoted beneficial gut bacteria like Bifidobacterium and Akkermansia. In conclusion, early-life synbiotic intervention mitigated allergic asthma associated with maternal air pollution exposure, highlighting the potential of synbiotics for clinical evaluation as a strategy to prevent allergy development in offspring.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104591"},"PeriodicalIF":4.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China 接触全氟和多氟烷基物质与流产漏诊之间的关系：中国上海医院病例对照研究》。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-16 DOI: 10.1016/j.etap.2024.104589

Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li

{"title":"Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China","authors":"Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li","doi":"10.1016/j.etap.2024.104589","DOIUrl":"10.1016/j.etap.2024.104589","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to reproductive disruptions. This study investigated the relationship between PFAS exposure and missed miscarriage in a hospital-based, case-control study in Shanghai, China. There were 393 women in our research, including 198 cases and 195 controls. Concentrations of 30 PFAS in plasma were quantified using HPLC-MS/MS, and 15 PFAS were detected at a rate greater than 90 percent. PFOA, L-PFOS, and PFOS isomers were significantly higher in the cases than those in the controls. 13 PFAS showed significant positive associations with miscarriage risk after adjustment for confounders, particularly PFOA (OR: 2.99, 95 % CI: 1.96–4.68) and various PFOS isomers. BKMR analysis confirmed higher overall PFAS levels were associated with increased miscarriage risk. These findings highlight the potential reproductive toxicity of PFAS and underscore the need for further investigations and regulatory actions to mitigate PFAS exposure in pregnant women.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104589"},"PeriodicalIF":4.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an insecticide, fungicide and plant growth regulator and their mixture on the survival of the springtail Folsomia candida and the potential reduction of toxicity by vitamins 杀虫剂、杀真菌剂和植物生长调节剂及其混合物对念珠绣春蜱存活的影响以及维生素的潜在减毒作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-13 DOI: 10.1016/j.etap.2024.104588

Pavla Pabiskova , Bruno Sopko , Elena Shcherbachenko , Tomas Erban

{"title":"Effect of an insecticide, fungicide and plant growth regulator and their mixture on the survival of the springtail Folsomia candida and the potential reduction of toxicity by vitamins","authors":"Pavla Pabiskova , Bruno Sopko , Elena Shcherbachenko , Tomas Erban","doi":"10.1016/j.etap.2024.104588","DOIUrl":"10.1016/j.etap.2024.104588","url":null,"abstract":"<div><div>A pesticide-free model soil was pretreated with field-realistic doses/applications of the insecticide, Biscaya 240 OD; the fungicide Tilmor; the growth regulator, Atonik and their mixture. Because <em>Folsomia candida</em> is eyeless, unpigmented, avoids light, and prefers dark, wet and cold conditions, we grew and tested it in the dark and at 18°C. Survival of springtails added to soil at 50 % moisture was assessed after 28 days. The experiments were repeated three times in order to confirm the validity of the test and results. The mixture decreased the survival most significantly. Bayesian statistics showed that pesticide treatment had a greater effect than repeating the experiment. Further tests revealed that the negative effect of the mixture on springtail survival was effectively suppressed by the application of biotin (vitamin B7), whereas riboflavin (vitamin B2) had little effect. Vitamins can reduce the toxicity of agrochemicals in the soil through potential effects on soil biological activity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104588"},"PeriodicalIF":4.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus 喷漆衍生的微塑料和掺杂物质是新热带熊蜂Bombus atratus体内的生态毒理学污染物。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-06 DOI: 10.1016/j.etap.2024.104586

Guilherme Andrade Neto Schmitz Boeing , Michele Provase , Elisabete Tsukada , Raquel F. Salla , Walter Ruggeri Waldman , Fábio Camargo Abdalla

{"title":"Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus","authors":"Guilherme Andrade Neto Schmitz Boeing , Michele Provase , Elisabete Tsukada , Raquel F. Salla , Walter Ruggeri Waldman , Fábio Camargo Abdalla","doi":"10.1016/j.etap.2024.104586","DOIUrl":"10.1016/j.etap.2024.104586","url":null,"abstract":"<div><div>While bumblebees may be exposed to microplastics (MPs), the effects on them are not well studied. Therefore, in this research, we assessed the cytotoxicity of pristine and photodegraded spray paint-derived MPs on the midgut, Malpighian tubules, and hepato-nephrocitic system cells of <em>Bombus atratus</em> workers exposed to 50 mg.L<sup>−1</sup> MPs for 96 hours. Histological and histochemical analyses revealed that pristine MPs caused subtle cellular changes, while the exposure to photodegraded MPs led to significant vacuolization, nuclear condensation, and pyknosis. These effects are possibly linked to the release of potentially toxic elements (PTEs) like Copper, Manganese, and Iron from photodegraded MPs, which exceeded Brazil's CONAMA safety limits. Photodegraded MPs also reduced body weight, disrupting homeostasis and potentially decreasing bumblebee’s fitness. These findings highlight the importance of studying the toxicity of environmentally realistic MPs, as plastic composition and weathering significantly influence their harmful effects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104586"},"PeriodicalIF":4.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pollen contaminated with a triple-action fungicide induced oxidative stress and reduced longevity though with less impact on lifespan in honey bees from well fed colonies 被三效杀真菌剂污染的花粉会诱发氧化应激并降低蜜蜂的寿命，但对喂养良好蜂群的蜜蜂寿命影响较小。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-04 DOI: 10.1016/j.etap.2024.104587

Thais R.R. Alves , Matheus F. Trivellato , Tainá A.L. Freitas , Aline Y. Kato , Cássia R.A. Gomes , Yara M.M. Ferraz , Jéssica A. Serafim , David De Jong , Evandro P. Prado , Eduardo F. Vicente , Ricardo O. Orsi , Gener T. Pereira , Camila A. Miranda , Fábio E. Mingatto , Daniel Nicodemo

{"title":"Pollen contaminated with a triple-action fungicide induced oxidative stress and reduced longevity though with less impact on lifespan in honey bees from well fed colonies","authors":"Thais R.R. Alves , Matheus F. Trivellato , Tainá A.L. Freitas , Aline Y. Kato , Cássia R.A. Gomes , Yara M.M. Ferraz , Jéssica A. Serafim , David De Jong , Evandro P. Prado , Eduardo F. Vicente , Ricardo O. Orsi , Gener T. Pereira , Camila A. Miranda , Fábio E. Mingatto , Daniel Nicodemo","doi":"10.1016/j.etap.2024.104587","DOIUrl":"10.1016/j.etap.2024.104587","url":null,"abstract":"<div><div>Experiments were conducted to determine the effects of a triple-action fungicide on bees and whether improved nutrition can ameliorate eventual negative impacts. In cage tests, newly-emerged bees from well fed and from nutritionally-restricted honey bee colonies were fed for five days with pollen from sunflowers that had been sprayed or not with a commercial fungicide containing bixafen, prothioconazole and trifloxystrobin. Bees from well-fed colonies were significantly larger and consumed more uncontaminated pollen. They also exhibited increased glutathione peroxidase activity and higher concentrations of pyridine nucleotides, both of which are involved in antioxidase defense. However, pollen contaminated with fungicide led to an increase in lipoperoxidation, regardless of nutritional status. Bee longevity was reduced by both fungicide contamination of the pollen diet and poor nutritional condition. The fungicide adversely affected bees fed with contaminated pollen, though nutritional supplementation of the bee colonies that reared the bees partially compensated for these effects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104587"},"PeriodicalIF":4.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring 构建母体暴露于 PM2.5 对后代肝脏发育和损伤影响的不良后果路径框架。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-01 DOI: 10.1016/j.etap.2024.104585

Kexin Zhang , Li Tian , Qinglin Sun , Jianong Lv , Ruiyang Ding , Yang Yu , Yang Li , Junchao Duan

{"title":"Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring","authors":"Kexin Zhang , Li Tian , Qinglin Sun , Jianong Lv , Ruiyang Ding , Yang Yu , Yang Li , Junchao Duan","doi":"10.1016/j.etap.2024.104585","DOIUrl":"10.1016/j.etap.2024.104585","url":null,"abstract":"<div><div>Ambient fine particulate matter (PM<sub>2.5</sub>) is a significant contributor to air pollution. PM<sub>2.5</sub> exposure poses a substantial hazard to public health. In recent years, the adverse effects of maternal PM<sub>2.5</sub> exposure on fetal health have gradually gained public attention. As the largest organ in the body, the liver has many metabolic and secretory functions. Liver development, as well as factors that interfere with its growth and function, are of concern. This review utilized the adverse outcome pathway (AOP) framework as the analytical approach to demonstrate the link between maternal PM<sub>2.5</sub> exposure and potential neonatal liver injury from the molecular to the population level. The excessive generation of reactive oxygen species (ROS), subsequent endoplasmic reticulum (ER) stress, and oxidative stress were regarded as the essential components in this framework, as they could trigger adverse developmental outcomes in the offspring through DNA damage, autophagy dysfunction, mitochondrial injury, and other pathways. To the best of our knowledge, this is the first article based on an AOP framework that elaborates on the influence of maternal exposure to PM<sub>2.5</sub> on liver injury occurrence and adverse effects on liver development in offspring. Therefore, this review offered mechanistic insights into the developmental toxicity of PM<sub>2.5</sub> in the liver, which provided a valuable basis for future studies and prevention strategies.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104585"},"PeriodicalIF":4.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0