Short-term effects of acetamiprid on common carp: Genotoxic, biochemical, and histopathological responses

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI:10.1016/j.etap.2025.104787

Göktuğ Gül , Pınar Arslan Yüce , Aysel Çağlan Günal , Caterina Faggio

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引用次数: 0

Abstract

Neonicotinoids such as acetamiprid are used extensively in veterinary medicine and agricultural practices. Acetamiprid has been reported to have effects on non-target organisms. This study investigates the effects of acetamiprid on common carp. Fish were exposed to 50 and 100 mg/L acetamiprid concentrations for 48 h and 96 h. Then, blood, gill and liver samples were taken from the fish. As a result of micronucleus analysis, it was determined that acetamiprid increased the number of micronuclei after 48 h of exposure at all concentrations 4-fold and after 96 h of exposure, at 50 mg/L concentration 2.5-fold and the 100 mg/L concentration 3-fold. According to the hematocrit values, a decrease was observed in the acetamiprid-exposure groups. While a small change was detected in AOPP and MDA values in gills and livers, histopathological analyses showed that 96 h exposure caused damage in both tissues. As a result, sublethal concentrations of acetamiprid caused toxic effects on common carp.

查看原文本刊更多论文

对乙酰氨脒对鲤鱼的短期影响：基因毒性、生化和组织病理学反应。

新烟碱类如醋氨脒广泛用于兽药和农业实践。据报道，扑热息痛对非目标生物有影响。本研究探讨了醋氨虫对鲤鱼的影响。将50和100mg/L浓度的啶虫脒分别暴露48小时和96小时。然后，从鱼身上提取血液、鳃和肝脏样本。微核分析结果表明，在所有浓度下，啶虫脒在48h后使微核数量增加4倍，在50mg/L浓度下增加2.5倍，在100mg/L浓度下增加3倍。根据红细胞压积值，在对乙酰米虫啉暴露组观察到下降。虽然在鳃和肝脏中检测到AOPP和MDA值的微小变化，但组织病理学分析表明，96小时暴露对两组织都造成了损伤。结果，亚致死浓度的醋氨脒对鲤鱼产生了毒性作用。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.