Environmental Health最新文献

{"title":"Per- and polyfluoroalkyl substances in drinking water and cancer prevalence in the United States.","authors":"Seigi Karasaki, Hari S Iyer, Amanda I Phipps, Trang VoPham","doi":"10.1186/s12940-026-01272-0","DOIUrl":"10.1186/s12940-026-01272-0","url":null,"abstract":"<p><strong>Background: </strong>Research concerning the adverse health effects of per- and polyfluoroalkyl substances (PFAS) continues to grow. With the recent releases of nationwide data on PFAS in drinking water and public drinking water system service boundaries, it is now possible to conduct nationwide geospatial analyses on the relationships between PFAS in drinking water and aspects of health.</p><p><strong>Objective: </strong>To examine associations between PFAS in drinking water and cancer history prevalence in the United States.</p><p><strong>Methods: </strong>We examined cancer history prevalence, at the census tract level, among adults aged ≥ 18 years diagnosed with any cancer in or prior to 2022 using the United States Population Level Analysis and Community EStimates dataset. We obtained data for PFAS in public drinking water from the Fifth Unregulated Contaminant Monitoring Rule (UCMR 5, 2023-ongoing). We used geographic information systems to spatially join water system boundaries (n = 9,733) with census tracts applying population-weighted areal interpolation. We calculated prevalence ratios (PRs) and 95% confidence intervals (CIs) for the associations between PFAS in drinking water and prevalence of cancer history, adjusted for census tract-level sociodemographics, health conditions and behaviors, and environmental factors.</p><p><strong>Results: </strong>This analysis included 76,606 census tracts with an average cancer history prevalence of 7.8%. We observed positive associations of cancer history prevalence with PFAS levels in drinking water for 6:2-FTS, PFBA, PFBS, PFHpA, PFHxA, PFHxS, PFNA, PFOA, PFPeA, and PFPeS (p < 0.01). For example, for 6:2-FTS, the adjusted PR comparing the highest quintile (0.0182-0.663 µg/L, population-weighted) to samples below the minimum reporting level (< 0.005 µg/L) was 1.04 (95% CI 1.02-1.07, p < 0.001). No associations were observed for HFPO-DA and PFOS. Models mutually adjusted for correlated PFAS showed generally similar results.</p><p><strong>Significance: </strong>Higher levels of certain PFAS in drinking water were independently associated with higher cancer history prevalence. Future research should examine the relationships between individual-level cancer outcomes and individual-level exposure to PFAS in drinking water.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to per- and polyfluoroalkyl substances and adult cardiometabolic health: a Canadian Health Measures Survey mixture analysis.","authors":"Janice M Y Hu, Michael M Borghese, Annie St-Amand","doi":"10.1186/s12940-026-01271-1","DOIUrl":"10.1186/s12940-026-01271-1","url":null,"abstract":"<p><p>BACKGROUND: Metabolic syndrome (MetS) is characterized by four cardiometabolic dimensions including central obesity, dyslipidemia, hypertension, and hyperglycemia, which collectively increase the risk of developing cardiovascular disease and type 2 diabetes mellitus. Epidemiological studies suggest that exposure to per- and polyfluoroalkyl substances (PFAS), which are a class of persistent chemicals used for their water and oil repelling properties, may also contribute to poor cardiometabolic health. We examined associations between exposure to mixture of PFAS and cardiometabolic health among a nationally representative sample of adults living in Canada. METHODS: We used cross-sectional data from 1071 adults aged 20 to 79 from the Canadian Health Measures Survey cycles 2, 5 and 6 (2009–2011, 2016–2019). We examined plasma concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA). We examined MetS, a derived cardiometabolic risk score (CMRS), and their individual cardiometabolic components. We used quantile g-computation (qgcomp) to examine joint associations between the PFAS mixture and cardiometabolic outcomes, and qgcomp weights to determine individual PFAS contributions to the overall mixture effect. Furthermore, we used modified Poisson and linear regression to estimate associations for individual PFAS plasma concentrations and compare with our qgcomp results. Analyses were stratified by sex. RESULTS: The prevalence of MetS is 27% in adults living in Canada. In qgcomp models, we observed null associations between the PFAS mixture and both MetS (prevalence ratio: 0.90; 95% CI: 0.74, 1.19) and CMRS (regression index: -0.10; 95% CI: -0.32, 0.12). Each one-quartile increase in the PFAS mixture was associated with 1.2% higher glycated hemoglobin (HbA1c) levels among total population and 1.6% among females, with PFNA contributing most to the joint associations. The PFAS mixture showed null associations with other MetS components. Results from our linear regression models corroborated the findings from the mixture analysis with directions consistent with the qgcomp effect estimates and weights. CONCLUSION: Using cross-sectional data from a nationally representative sample of adults living in Canada, our findings suggest that a mixture of PFAS may adversely affect glucose metabolism. Further prospective studies are needed to corroborate these findings and establish temporality. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of housing instability in the association between ambient temperature and preterm birth.","authors":"Jinah Park, Ho Kim, Hyojung Lee","doi":"10.1186/s12940-026-01268-w","DOIUrl":"10.1186/s12940-026-01268-w","url":null,"abstract":"<p><p>BACKGROUND: Preterm birth is a leading cause of neonatal death and long-term health issues. Both environmental and social stressors, such as heat exposure and housing stability, may contribute to adverse birth outcomes, yet their joint effects are not well studied, especially in the Korean context. Therefore, we aimed to investigate the independent and joint associations of ambient temperature and housing instability with preterm birth. METHODS: This study analyzed eight years (2015–2022) of birth outcomes among women, derived from nationwide, register-based census data covering 100% of the population. The data included a cohort of individuals born in South Korea between 1983 and 1995 and their offspring. Logistic regression was performed using the average temperature during the month prior to delivery, housing instability, individual- and district-level covariates, and year and month. RESULTS: Among 1,579,033 singleton births, 79,399 (5.0%) were preterm. A higher ambient temperature during the month before delivery was significantly associated with increased risk of preterm birth (odds ratio for each 1ºC increase: 1.002 (95% confidence interval: 1.002, 1.003)). Housing instability, defined by poor housing quality, was also independently associated with a higher risk of preterm birth (odds ratio: 1.196 (95% confidence interval: 1.054, 1.358)). Both overcrowding and aging buildings also showed an increase in risk of preterm birth (odds ratio of 1.080 (1.019, 1.145) and 1.040 (1.013, 1.068), respectively). However, no significant interaction between heat exposure and unstable housing conditions was observed (odds ratio: 0.995 (95% confidence interval: 0.987, 1.003)). CONCLUSIONS: The results highlight the compounded risks from both environmental and social stressors, highlighting the need for integrated public interventions that target both health and housing issues to help lower preterm birth rates. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The assumption of a threshold is false in risk assessments for endocrine disrupting chemicals (EDCs) when endogenous hormones being disrupted are already above any possible threshold: a policy failure by the US FDA.","authors":"Frederick S Vom Saal, Wade V Welshons","doi":"10.1186/s12940-026-01265-z","DOIUrl":"10.1186/s12940-026-01265-z","url":null,"abstract":"<p><p>The US FDA continues to assure the public that if they are exposed to an endocrine disrupting chemical (EDC), there is a threshold daily exposure level below which everyone is safe throughout the lifespan (the Acceptable or Tolerable Daily Dose). This assurance is false when the endogenous hormone systems being disrupted by EDCs are already above a threshold for producing adverse effects or there are cumulative effects of mixtures of similar chemicals. Decades of published experimental research, and multiple mathematical analyses, demonstrate the absence of a threshold (safe) dose for hormones, hormonal drugs or EDCs. However, this entire literature has been rejected in decision making by the US FDA food safety division. We review experiments directly falsifying the threshold hypothesis for hormones, drugs and EDCs. Our analysis includes application to hormone and EDC experimental data sets of the Michaelis–Menten (MM) equation, which explains mathematically hormone (or EDC)-receptor binding that mediates normal as well as adverse effects at extremely low exposures. The MM equation regresses to zero at zero hormone or EDC dose, i.e., there is no threshold dose. We derive the MM equation in Supplemental Materials for those interested in the math. We also identify that hormone and EDC potency is the consequence of a number of cell-specific mechanisms not included in the MM equation. We begin by reviewing the history of the now falsified assumption that a threshold exists for EDCs that are generally classified as systemic toxicants. In particular, the threshold hypothesis is problematic during fetus/infant/child development during which homeostatic defense systems have not yet fully developed, rendering them largely defenseless against the disruptive effects of EDCs. Published findings implicate EDC exposures at very low environmentally relevant doses with every non-communicable disease, which are all increasing in incidence on a global scale. We identify here the empirical and endocrinological evidence falsifying the determination by chemical regulatory agencies that there are safe daily exposure levels for EDCs below an estimated threshold that is not actually experimentally examined. These findings indicate that current human exposures to EDCs are harming the general population as well as causing widespread environmental harm.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":"11"},"PeriodicalIF":7.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective versus risky: the complex relationship between prenatal fluoride exposure and birth outcomes in a Chinese large-scale population study.","authors":"Liu Yang, Feifei Yan, Xiumiao Peng, Zhonghua Meng, Xingyi Geng, Wei Wei","doi":"10.1186/s12940-026-01267-x","DOIUrl":"10.1186/s12940-026-01267-x","url":null,"abstract":"<p><p>BACKGROUND: Previous studies on fluoride in drinking water and birth outcomes have yielded inconsistent findings. Furthermore, the association between fluoride exposure and gestational age (the duration of pregnancy), along with offspring characteristics at birth, has not been thoroughly explored. Given the widespread occurrence of drinking water fluorosis in China, this large-scale study aims to explore the associations between fluoride and birth outcomes. METHODS: We conducted a database study involving 352,973 participants in China from 2016 to 2022. Generalized linear models and restricted cubic spline curves were employed for the analysis, and the mediating effects on gestational age were systematically evaluated. RESULTS: The average fluoride concentration was 0.41 ± 0.16 mg/L. Each unit increase in fluoride was associated with a 0.36-week (95% confidence intervals [CI]: 0.34, 0.39) increase in gestational age and a 43.56 g (95% CI: 33.56, 53.57) increase in birth weight. Fluoride exposure exhibited dual effects: it was protective against preterm birth (odds ratio [OR] = 0.74; 95% CI: 0.67, 0.82) and low birth weight (OR = 0.69; 95% CI: 0.61, 0.78), while simultaneously elevating the risks of macrosomia (OR = 2.56; 95% CI: 2.40, 2.74), small-for-gestational age (OR = 1.72; 95% CI: 1.58, 1.88), and large-for-gestational age (OR = 1.27; 95% CI: 1.20, 1.34). Nonlinear exposure-response relationships were observed for all outcomes except low birth weight. Mediation analysis indicated that gestational age served as a significant mediator in the associations between fluoride and birth weight, as well as low birth weight and macrosomia—suggesting that fluoride may increase birth weight and reduce the risk of low birth weight through prolonged pregnancy. Notably, gestational age was not analyzed as a mediator for small-for-gestational age and large-for-gestational age due to its distinct growth deviation nature. However, its paradoxical associations with both fetal growth restriction and overgrowth (macrosomia/large-for-gestational age) warrant clinical attention, although these observational links do not establish definitive causality. CONCLUSION: Prenatal fluoride exposure exhibits dual effects in China: prolonging gestational age and reducing preterm birth and low birth weight risks, while increasing risks of abnormal fetal growth. These findings underscore the necessity for region-specific fluoride monitoring and prenatal counseling. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between prenatal exposure to ambient air pollutants and preterm birth in the Atlanta African American maternal-child cohort.","authors":"Youran Tan, Zhenjiang Li, Anne L Dunlop, Mengyuan Ren, Howard H Chang, Zhihao Jin, Jeremy A Sarnat, Anke Huels, Stephanie M Eick, Christine C Ekenga, Armistead Russell, Carmen Marsit, Donghai Liang","doi":"10.1186/s12940-026-01264-0","DOIUrl":"10.1186/s12940-026-01264-0","url":null,"abstract":"<p><p>BACKGROUND: Substantial differences in preterm birth (PTB) persist across populations, with African Americans facing the highest rate. While air pollution contributes to PTB, its role in these uneven health burdens remains poorly understood. Studies of PTB subtypes might uncover racial variation in etiology, yet the impact of air pollution is largely understudied. We assessed the associations of prenatal exposures to ambient fine particulate matters (PM2.5), carbon monoxide (CO), and nitrogen oxides (NOx) with PTB and its subtypes using data from the Atlanta African American Maternal-Child Cohort. METHODS: We conducted a prospective analysis among 567 African Americans with singleton pregnancies and without chronic medical conditions. Live births were divided into three categories: PTB, early term birth (ETB), and full-term birth, and PTB was further classified into: spontaneous (i.e., sPTB) and medically indicated (i.e., miPTB). Additionally, a composite category combining PTB and ETB was analyzed. We estimated residential air pollution exposures during five critical windows: 1 month prior to conception, entire pregnancy, the 1st, 2nd, and 3rd trimesters. We performed logistic models and discrete-time survival models for individual air pollutants and quantile g-computation models to evaluate the overall effect, with adjustment of selected covariates. We further evaluated whether infant sex modified the associations between gestational air pollution exposure and PTB risk. RESULTS: PM2.5 exposure during the 1st trimester showed a non-significant trend toward increased PTB risk (OR: 1.50, 95% CI: 0.96–2.35). PM2.5 exposure showed significant associations with miPTB during the 2nd trimester (OR: 1.90, 95%CI: 1.03–3.43). Air pollution mixture models showed similar trends, particularly for miPTB. Also, PM2.5 exposure had stronger effects on early birth (PETB, PTB + ETB), with the largest effect observed across the entire pregnancy (OR: 1.44, 95%CI: 0.90–2.10). Air pollution mixture was significantly associated with increased odds of PETB (OR: 1.33, 95%CI: 1.03–1.72) during the 2nd trimester. We found no evidence that the associations between air pollution exposure and PTB differed by infant sex. DISCUSSION: Our findings suggested that prenatal air pollution exposure, particularly to PM2.5 during early gestational periods, could elevate miPTB risk and early birth among African Americans. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":"15"},"PeriodicalIF":7.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our journal in the era of artificial intelligence.","authors":"Ruth Etzel, Philippe Grandjean","doi":"10.1186/s12940-025-01258-4","DOIUrl":"10.1186/s12940-025-01258-4","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":"6"},"PeriodicalIF":5.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal clustering of neuroblastic tumours in children and young adults from Scotland.","authors":"Nermine Basta, Min Li, Louise Hayes, Colin R Muirhead, Deborah A Tweddle, Richard J Q McNally","doi":"10.1186/s12940-026-01266-y","DOIUrl":"10.1186/s12940-026-01266-y","url":null,"abstract":"<p><strong>Background: </strong>Neuroblastic tumours (neuroblastoma and ganglioneuroblastoma) are the most common childhood solid tumours outside the central nervous system, with a median age of diagnosis of 2 years. Temporal clustering of neuroblastic tumours in northern England and Ontario, Canada has been previously reported.</p><p><strong>Methods: </strong>We extracted data from the Scottish Cancer Registry to determine whether there was evidence of temporal clustering of neuroblastic tumours. Cases diagnosed in children and young adults aged 0-24 years between 2000 and 2020 were analysed. A modified version of the Potthoff-Whittinghill method was used to test for temporal clustering. Estimates of extra-Poisson variation (EPV) and standard errors (SE) were derived.</p><p><strong>Results: </strong>One hundred and sixty-one cases of neuroblastic tumours, aged 0-24 years, were diagnosed during the study period. Overall, there was statistically significant temporal clustering between years within the full study period (EPV = 9.13, SE = 0.22, P < 0.001). In addition, for cases aged < 18 months, there was significant temporal clustering between months within quarters (EPV = 0.77, SE = 0.41, P = 0.044). For cases aged 18 months - 24 years, there was significant temporal clustering between fortnights within months (EPV = 1.00, SE = 0.47, P = 0.012).</p><p><strong>Conclusions: </strong>The finding of temporal clustering is consistent with the involvement of one or more, as yet unknown, transient environmental agents in the aetiology of neuroblastic tumours.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":"14"},"PeriodicalIF":7.3,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of arsenic exposure and folate in maternal leukocyte DNA methylation: a case-control study of mothers with spina-bifida affected children.","authors":"Amy M Inkster, Anne K Bozack, Bernardo Lemos, Tabitha Lumour-Mensah, Sudipta Kumar Mukherjee, Shekh Muhammad Ekramullah, D M Arman, Joynul Islam, Xingyan Wang, Liming Liang, Richard H Finnell, Maitreyi Mazumdar, Andres Cardenas","doi":"10.1186/s12940-025-01254-8","DOIUrl":"10.1186/s12940-025-01254-8","url":null,"abstract":"<p><p>BACKGROUND: In Bangladesh, more than a quarter of drinking water tubewells are contaminated with arsenic above the national standard (50 µg/l), while nearly half exceed the World Health Organization guideline (10 µg/l). Among other negative health consequences, arsenic is a suspected environmental risk factor for neural tube defects (NTDs), including spina bifida. Maternal folate status protects against NTDs, though recent evidence suggests arsenic attenuates folate’s protective effects. Arsenic is methylated prior to excretion with methyl groups produced in one-carbon metabolism, for which folate is a cofactor. We thus hypothesized that DNA methylation (DNAme) may provide insight into the interactions between arsenic, maternal folate levels, and offspring spina bifida. METHODS: Here we analyzed leukocyte DNAme using the Illumina MethylationEPIC v2.0 array in 374 women from Bangladesh, 246 with a previous spina-bifida affected birth and 128 controls. Chronic arsenic exposure was evaluated in maternal toenail; fasting plasma folate was measured at blood draw. Linear models evaluated DNAme associated with offspring spina bifida, arsenic, folate, and their interaction terms. RESULTS: Maternal DNAme was associated with spina bifida at 71 CpGs, arsenic at 6 CpGs, and folate at 33 CpGs (all FDR < 0.05). The spina bifida*arsenic and arsenic*folate interactions were associated with 11 and 28 CpGs, respectively, while spina bifida*folate returned no significant associations. We observed lower DNAme in mothers of spina bifida cases at significant loci, including in developmental genes such as HOXB3 and HOXB4. Arsenic’s influence on DNAme was more pronounced in individuals with low folate. CONCLUSIONS: Our work suggests that postnatal maternal leukocyte DNAme is associated with offspring spina bifida status and is modified by arsenic exposure but not plasma folate. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":"13"},"PeriodicalIF":7.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residential proximity to active and abandoned oil and gas development and risk of childhood Ewing sarcoma in California.","authors":"Cassandra J Clark, Nicholaus Johnson, Rong Wang, Eric C Stewart, Logan G Spector, Joseph L Wiemels, Catherine Metayer, Nicole C Deziel, Xiaomei Ma","doi":"10.1186/s12940-025-01259-3","DOIUrl":"10.1186/s12940-025-01259-3","url":null,"abstract":"<p><p>BACKGROUND: Oil and gas development (OGD) has been linked to increased pediatric cancer risk, but the literature to date is focused on hematologic malignancies and active wells. The emergence of suspected clusters of cancers such as Ewing sarcoma in children living near OGD and widespread presence of abandoned wells warrants investigation. METHODS: This study included 558 children born in California (1982–2015) reported to the California Cancer Registry with a diagnosis of Ewing sarcoma at 0–19 years (1988–2015), and 27,800 cancer-free controls frequency-matched to cases on birth-year (50:1 ratio). We used birth address to assign prenatal OGD exposure to active (drilled or producing) and plugged/abandoned wells separately with inverse distance-squared weighted well counts at 5 and 10 km buffer sizes from three months before conception to birth. We evaluated potential exposure disparities and estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between prenatal OGD exposure and Ewing sarcoma risk using multivariable logistic regression. RESULTS: Hispanic children were significantly more likely to be exposed to both active and abandoned OGD within 10 km than non-Hispanics (40% vs. 23% and 14% vs. 6%, respectively). There were no associations between prenatal exposure to active OGD within 10 km and Ewing sarcoma risk (OR: 0.88 [95% CI: 0.72–1.08]). However, children within 10 km of abandoned wells were 1.27 [0.96–1.66] times as likely to develop Ewing sarcoma as unexposed children; when stratified by ethnicity, this association appeared in Hispanic children only (1.33 [0.95–1.88]). CONCLUSION: We did not identify an association between exposure to active OGD and pediatric Ewing sarcoma risk in California. Abandoned wells were associated with a suggestive increase in risk among Hispanic children, who were also more likely to be exposed to any OGD activity than non-Hispanic children. This disparity could have implications for other health outcomes including childhood cancers. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":"12"},"PeriodicalIF":7.3,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}