Environmental Health最新文献

{"title":"Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population","authors":"Jian-Chao Qiao, Zhen-Hua Li, Yu-Bo Ma, Hui-Ya Ma, Meng-Yue Zhang, Xiu-Jun Zhang, Cheng-Yang Hu","doi":"10.1186/s12940-024-01073-3","DOIUrl":"https://doi.org/10.1186/s12940-024-01073-3","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores the association between PFAS exposure and RA prevalence. This research utilized data from the NHANES, encompassing a sample of 10,496 adults from the 2003–2018 cycles, focusing on serum levels of several PFAS. The presence of RA was determined based on self-reports. This study used multivariable logistic regression to assess the relationship between individual PFAS and RA risk, adjusting for covariates to calculate odds ratios (ORs). The combined effects of PFAS mixtures were evaluated using BKMR, WQS regression, and quantile g-computation. Additionally, sex-specific associations were explored through stratified analysis. Higher serum PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS (OR = 0.91, 95% CI: 0.83, 1.00), PFNA (OR = 0.87, 95% CI: 0.77, 0.98), and PFDA (OR = 0.89, 95% CI: 0.81, 0.99) concentration was related to lower odds of RA. Sex-specific analysis in single chemical models indicated the significant inverse associations were only evident in females. BKMR did not show an obvious pattern of RA estimates across PFAS mixture. The outcomes of sex-stratified quantile g-computation demonstrated that an increase in PFAS mixture was associated with a decreased odds of RA in females (OR: 0.76, 95% CI: 0.62, 0.92). We identified a significant interaction term of the WQS*sex in the 100 repeated hold out WQS analysis. Notably, a higher concentration of the PFAS mixture was significantly associated with reduced odds of RA in females (mean OR = 0.93, 95% CI: 0.88, 0.98). This study indicates potential sex-specific associations of exposure to various individual PFAS and their mixtures with RA. Notably, the observed inverse relationships were statistically significant in females but not in males. These findings contribute to the growing body of evidence indicating that PFAS may have immunosuppressive effects.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"8 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life exposure to secondhand tobacco smoke and eating behaviors at age 12 years","authors":"Nerea Mourino, Zhuoya Zhang, Mónica Pérez-Ríos, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Jessie P. Buckley, Heidi J. Kalkwarf, Kim M. Cecil, Joseph M. Braun","doi":"10.1186/s12940-024-01076-0","DOIUrl":"https://doi.org/10.1186/s12940-024-01076-0","url":null,"abstract":"Prenatal or early childhood secondhand tobacco smoke (SHS) exposure increases obesity risk. However, the potential mechanisms underlying this association are unclear, but obesogenic eating behaviors are one pathway that components of SHS could perturb. Our aim was to assess associations of prenatal and early childhood SHS exposure with adolescent eating behaviors. Data came from a prospective pregnancy and birth cohort (N = 207, Cincinnati, OH). With multiple informant models, we estimated associations of prenatal (mean of 16 and 26 weeks of gestation maternal serum cotinine concentrations) and early childhood cotinine (average concentration across ages 12, 24, 36, and 48 months) with eating behaviors at age 12 years (Child Eating Behaviors Questionnaire). We tested whether associations differed by exposure periods and adolescent’s sex. Models adjusted for maternal and child covariates. We found no statistically significant associations between cotinine measures and adolescent’s eating behaviors. Yet, in females, prenatal cotinine was associated with greater food responsiveness (β: 0.23; 95% CI: 0.08, 0.38) and lower satiety responsiveness (β: -0.14; 95% CI: -0.26, -0.02); in males, prenatal and postnatal cotinine was related to lower food responsiveness (prenatal: β: -0.25; 95% CI: -0.04, -0.06; postnatal: β: -0.36; 95% CI: -0.06, -0.11). No significant effect modification by sex or exposure window was found for other eating behaviors. Prenatal and early childhood SHS exposures were not related to adolescent’s eating behavior in this cohort; however, biological sex may modify these associations.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"8 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between transport modes and site-specific cancers: a systematic review and meta-analysis","authors":"Win Thu, Alistair Woodward, Alana Cavadino, Sandar Tin Tin","doi":"10.1186/s12940-024-01081-3","DOIUrl":"https://doi.org/10.1186/s12940-024-01081-3","url":null,"abstract":"Physical inactivity is a global public health problem. A practical solution would be to build physical activity into the daily routine by using active modes of transport. Choice of transport mode can influence cancer risk through their effects on levels of physical activity, sedentary time, and environmental pollution. This review synthesizes existing evidence on the associations of specific transport modes with risks of site-specific cancers. Relevant literature was searched in PubMed, Embase, and Scopus from 1914 to 17th February 2023. For cancer sites with effect measures available for a specific transport mode from two or more studies, random effects meta-analyses were performed to pool relative risks (RR) comparing the highest vs. lowest activity group as well as per 10 Metabolic Equivalent of Task (MET) hour increment in transport-related physical activity per week (∼150 min of walking or 90 min of cycling). 27 eligible studies (11 cohort, 15 case-control, and 1 case-cohort) were identified, which reported the associations of transport modes with 10 site-specific cancers. In the meta-analysis, 10 MET hour increment in transport-related physical activity per week was associated with a reduction in risk for endometrial cancer (RR: 0.91, 95% CI: 0.83–0.997), colorectal cancer (RR: 0.95, 95% CI: 0.91–0.99) and breast cancer (RR: 0.99, 95% CI: 0.89–0.996). The highest level of walking only or walking and cycling combined modes, compared to the lowest level, were significantly associated with a 12% and 30% reduced risk of breast and endometrial cancers respectively. Cycling, compared to motorized modes, was associated with a lower risk of overall cancer incidence and mortality. Active transport appears to reduce cancer risk, but evidence for cancer sites other than colorectum, breast, and endometrium is currently limited.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"56 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing health effects of air pollution exposure for respiratory diseases: a multicity study during 2017–2022","authors":"Siyu Jiang, Longjuan Tang, Zhe Lou, Haowei Wang, Ling Huang, Wei Zhao, Qingqing Wang, Ruiyun Li, Zhen Ding","doi":"10.1186/s12940-024-01083-1","DOIUrl":"https://doi.org/10.1186/s12940-024-01083-1","url":null,"abstract":"Multifaceted SARS-CoV-2 interventions have modified exposure to air pollution and dynamics of respiratory diseases. Identifying the most vulnerable individuals requires effort to build a complete picture of the dynamic health effects of air pollution exposure, accounting for disparities across population subgroups. We use generalized additive model to assess the likely changes in the hospitalisation and mortality rate as a result of exposure to PM2.5 and O3 over the course of COVID-19 pandemic. We further disaggregate the population into detailed age categories and illustrate a shifting age profile of high-risk population groups. Additionally, we apply multivariable logistic regression to integrate demographic, socioeconomic and climatic characteristics with the pollution-related excess risk. Overall, a total of 1,051,893 hospital admissions and 34,954 mortality for respiratory disease are recorded. The findings demonstrate a transition in the association between air pollutants and hospitalisation rates over time. For every 10 µg/m3 increase of PM2.5, the rate of hospital admission increased by 0.2% (95% CI: 0.1–0.7%) and 1.4% (1.0–1.7%) in the pre-pandemic and dynamic zero-COVID stage, respectively. Conversely, O3-related hospitalization rate would be increased by 0.7% (0.5–0.9%) in the pre-pandemic stage but lowered to 1.7% (1.5–1.9%) in the dynamic zero-COVID stage. Further assessment indicates a shift of high-risk people from children and young adolescents to the old, primarily the elevated hospitalization rates among the old people in Lianyungang (RR: 1.53, 95%CI: 1.46, 1.60) and Nantong (RR: 1.65, 95%CI: 1.57, 1.72) relative to those for children and young adolescents. Over the course of our study period, people with underlying diseases would have 26.5% (22.8–30.3%) and 12.7% (10.8–14.6%) higher odds of having longer hospitalisation and over 6 times higher odds of deaths after hospitalisation. Our estimates provide the first comprehensive evidence on the dynamic pollution-health associations throughout the pandemic. The results suggest that age and underlying diseases collectively determines the disparities of pollution-related health effect across population subgroups, underscoring the urgency to identifying the most vulnerable individuals to air pollution.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"30 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to ambient air pollution and cognitive function: an analysis of the English Longitudinal Study of Ageing cohort","authors":"Dylan Wood, Dimitris Evangelopoulos, Sean Beevers, Nutthida Kitwiroon, Panayotes Demakakos, Klea Katsouyanni","doi":"10.1186/s12940-024-01075-1","DOIUrl":"https://doi.org/10.1186/s12940-024-01075-1","url":null,"abstract":"An increasing number of studies suggest adverse effects of exposure to ambient air pollution on cognitive function, but the evidence is still limited. We investigated the associations between long-term exposure to air pollutants and cognitive function in the English Longitudinal Study of Ageing (ELSA) cohort of older adults. Our sample included 8,883 individuals from ELSA, based on a nationally representative study of people aged ≥ 50 years, followed-up from 2002 until 2017. Exposure to air pollutants was modelled by the CMAQ-urban dispersion model and assigned to the participants’ residential postcodes. Cognitive test scores of memory and executive function were collected biennially. The associations between these cognitive measures and exposure to ambient concentrations of NO2, PM10, PM2.5 and ozone were investigated using mixed-effects models adjusted for time-varying age, physical activity and smoking status, as well as baseline gender and level of education. Increasing long-term exposure per interquartile range (IQR) of NO2 (IQR: 13.05 μg/m3), PM10 (IQR: 3.35 μg/m3) and PM2.5 (IQR: 2.7 μg/m3) were associated with decreases in test scores of composite memory by -0.10 (95% confidence interval [CI]: -0.14, -0.07), -0.02 [-0.04, -0.01] and -0.08 [-0.11, -0.05], respectively. The same increases in NO2, PM10 and PM2.5 were associated with decreases in executive function score of -0.31 [-0.38, -0.23], -0.05 [-0.08, -0.02] and -0.16 [-0.22, -0.10], respectively. The association with ozone was inverse across both tests. Similar results were reported for the London-dwelling sub-sample of participants. The present study was based on a long follow-up with several repeated measurements per cohort participant and long-term air pollution exposure assessment at a fine spatial scale. Increasing long-term exposure to NO2, PM10 and PM2.5 was associated with a decrease in cognitive function in older adults in England. This evidence can inform policies related to modifiable environmental exposures linked to cognitive decline.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"27 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Modification of the PM2.5- and extreme heat-mortality relationships by historical redlining: A case-crossover study in thirteen U.S. states","authors":"Edgar Castro, Abbie Liu, Yaguang Wei, Anna Kosheleva, Joel Schwartz","doi":"10.1186/s12940-024-01072-4","DOIUrl":"https://doi.org/10.1186/s12940-024-01072-4","url":null,"abstract":"<p>\u0000<b>Correction</b><b>: </b>\u0000<b>Environ Health 23, 16 (2024)</b>\u0000</p><p>\u0000<b>https://doi.org/10.1186/s12940-024-01055-5</b>\u0000</p><br/><p>Following publication of [1], errors were found in the code used to prepare the cohort for a case-crossover analysis and the resulting data that was used for the analysis. Despite these errors, results were only marginally effected and all conclusions remain the same. A few typos were also found in the manuscript. A table of all affected texts is shown below.\u0000</p><table><thead><tr><th><p>Section</p></th><th><p>Lines</p></th><th><p>Text</p></th></tr></thead><tbody><tr><td><p>Abstract</p></td><td><p>48-51</p></td><td><p>Individuals who lived in redlined areas had an interaction odds ratio for mortality of <s>1.0093</s> <b>1.0104</b> (95% confidence interval [CI]: <s>1.0084</s> <b>1.0095</b>, <s>1.0101</s> <b>1.0114)</b> for each 10 µg m<sup>-3</sup> increase in same-day ambient PM2.5 compared to individuals who did not live in redlined areas. For extreme heat, the interaction odds ratio was <s>1.0218</s> <b>1.0146</b> (95% CI <s>1.0031</s> <b>1.0039</b>, <s>1.0408</s> <b>1.0457</b>).</p></td></tr><tr><td><p>Methods</p></td><td><p>159-161</p></td><td><p>To derive measures of extreme heat, we first calculated various percentiles of minimum temperature in each block group in each year. For our main analysis, we considered the <s>95</s> <sup><s>th</s></sup> <b>90</b> <sup><b>th</b></sup> percentile.</p></td></tr><tr><td><p>Methods</p></td><td><p>163-165</p></td><td><p>In other words, if the minimum temperature on a certain day met or exceeded the <s>95</s> <sup><s>th</s></sup> <b>90</b> <sup><b>th</b></sup> percentile of minimum temperature in that block group in that year, then that day was marked as an extreme heat day.</p></td></tr><tr><td><p>Results</p></td><td><p>229-237</p></td><td><p>We obtained <s>11,115,380</s> <b>11,076,020</b> mortality records from the <s>twelve</s> <b>thirteen</b> state departments of public health. From these records, we sequentially excluded <s>466,874</s> <b>453,754</b> deaths involving external causes; <s>139,908</s> <b>133,348</b> deaths involving individuals younger than 18 years old; 196,558 deaths with geocodes that were missing or coarser than block group-level; 331 deaths involving individuals whose home locations were outside of the state that reported their death; <s>1,392,423</s> <b>1,372,743</b> deaths before January 5<sup>th</sup>, 2001 or after December 31<sup>st</sup>, 2016 and 537 deaths whose home block groups had a population of zero according to the preceding Decennial Census (for which 4-day moving averages of population-weighted PM2.5 could not be calculated); and 34,016 deaths with lag days from 0 to 4 that included December 31<sup>st</sup> on leap years (for which Daymet predictions are not available; Figure 3)</p></td></tr><tr><td><p>Results</p></td><td><p>272-278</p></td><td><p>We found a significant interaction with exposure to any extreme heat (interaction odd","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"47 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140586228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systems for rating bodies of evidence used in systematic reviews of air pollution exposure and reproductive and children's health: a methodological survey.","authors":"Sophie K F Michel, Aishwarya Atmakuri, Ondine S von Ehrenstein","doi":"10.1186/s12940-024-01069-z","DOIUrl":"10.1186/s12940-024-01069-z","url":null,"abstract":"<p><strong>Background: </strong>Translating findings from systematic reviews assessing associations between environmental exposures and reproductive and children's health into policy recommendations requires valid and transparent evidence grading.</p><p><strong>Methods: </strong>We aimed to evaluate systems for grading bodies of evidence used in systematic reviews of environmental exposures and reproductive/ children's health outcomes, by conducting a methodological survey of air pollution research, comprising a comprehensive search for and assessment of all relevant systematic reviews. To evaluate the frameworks used for rating the internal validity of primary studies and for grading bodies of evidence (multiple studies), we considered whether and how specific criteria or domains were operationalized to address reproductive/children's environmental health, e.g., whether the timing of exposure assessment was evaluated with regard to vulnerable developmental stages.</p><p><strong>Results: </strong>Eighteen out of 177 (9.8%) systematic reviews used formal systems for rating the body of evidence; 15 distinct internal validity assessment tools for primary studies, and nine different grading systems for bodies of evidence were used, with multiple modifications applied to the cited approaches. The Newcastle Ottawa Scale (NOS) and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework, neither developed specifically for this field, were the most commonly used approaches for rating individual studies and bodies of evidence, respectively. Overall, the identified approaches were highly heterogeneous in both their comprehensiveness and their applicability to reproductive/children's environmental health research.</p><p><strong>Conclusion: </strong>Establishing the wider use of more appropriate evidence grading methods is instrumental both for strengthening systematic review methodologies, and for the effective development and implementation of environmental public health policies, particularly for protecting pregnant persons and children.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"32"},"PeriodicalIF":5.3,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFOA and testis cancer in the Veneto Region (Italy)","authors":"Mario Saugo, Enrico Ioverno, Armando Olivieri, Francesco Bertola, Angela Pasinato, Alan Ducatman","doi":"10.1186/s12940-024-01064-4","DOIUrl":"https://doi.org/10.1186/s12940-024-01064-4","url":null,"abstract":"The largest documented episode of human contamination by PFOA in the world (approximately 150,000 actual residents on 1 January 2020) has occurred in Italy’s Veneto Region. In this large, mostly flat plain area, a cluster of testicular cancers has also been observed. Preliminary data are reported, and the most relevant and recent recommendations regarding the health surveillance of exposed individuals are emphasized.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"70 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140314359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residents' experiences during a hydrogen sulfide crisis in Carson, California.","authors":"Arbor J L Quist, April Hovav, Alexander D Silverman, Bhavna Shamasunder, Jill E Johnston","doi":"10.1186/s12940-024-01071-5","DOIUrl":"10.1186/s12940-024-01071-5","url":null,"abstract":"<p><strong>Background: </strong>In early October 2021, thousands of residents in Carson, California began complaining of malodors and headaches. Hydrogen sulfide (H₂S), a noxious odorous gas, was measured at concentrations up to 7000 parts per billion (ppb) and remained above California's acute air quality standard of 30 ppb for a month. Intermittent elevations of H₂S continued for 3 months. After 2 months of malodor in this environmental justice community, a government agency attributed the H₂S to environmental pollution from a warehouse fire. Research has yielded conflicting results on the health effects of H₂S exposure at levels that were experienced during this event. This research fills a critical need for understanding how people perceive and experience emergent environmental health events and will help shape future responses.</p><p><strong>Methods: </strong>Through a community-academic partnership, we conducted 6 focus groups with 33 participants who resided in the Carson area during the crisis. We sought to understand how this incident affected residents through facilitated discussion on topics including information acquisition, impressions of the emergency response, health symptoms, and ongoing impacts.</p><p><strong>Results: </strong>The majority of participants were women (n = 25), identified as Latina/o (n = 19), and rent their homes (n = 21). Participants described difficulty obtaining coherent information about the emergency, which resulted in feelings of abandonment. Most participants felt that local government and healthcare providers downplayed and/or disregarded their concerns despite ongoing odors and health symptoms. Participants described experiencing stress from the odors' unknown health effects and continued fear of future odor incidents. Residents sought to take control of the crisis through information sharing, community networking, and activism. Participants experienced longer term effects from this event, including increased awareness of pollution and reduced trust in local agencies.</p><p><strong>Discussion: </strong>This study demonstrates the necessity of clear, comprehensive, and prompt responses by relevant decisionmakers to chemical emergencies to appropriately address residents' fears, curb the spread of misinformation, and minimize adverse health effects. Participant responses also point to the benefit of supporting horizontal community networks for improved information sharing. By engaging directly with community members, researchers and disaster responders can better understand the various and complex impacts of chemical disasters and can improve response.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"31"},"PeriodicalIF":6.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association between plasma chlordecone concentrations and progression of alcoholic liver fibrosis: the role of liver metabolism","authors":"Moana Gelu-Simeon, Marie-Josée Lafrance, Leah Michineau, Eric Saillard, Jean Pierre Thomé, Claude Emond, Michel Samson, Luc Multigner","doi":"10.1186/s12940-024-01054-6","DOIUrl":"https://doi.org/10.1186/s12940-024-01054-6","url":null,"abstract":"Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has been demonstrated in animal models. We investigated the relationship between environmental exposure to chlordecone and the progression of liver fibrosis. This study included 182 consecutive patients with chronic alcoholic hepatitis whose liver fibrosis was assessed using non-invasive methods. Measured plasma chlordecone concentrations at inclusion were used as surrogate of long-term exposure under steady-state conditions. As the pharmacokinetic processing of chlordecone is largely determined by the liver, we used a human physiologically based pharmacokinetic model to predict plausible changes in the steady-state blood chlordecone concentrations induced by liver fibrosis. With a median follow-up of 27.1 years after the onset of alcohol consumption, we found a significant decrease in the risk of advanced liver fibrosis with increasing plasma chlordecone concentration (adjusted hazard ratio = 0.56; 95% confidence interval: 0.34–0.95 for the highest vs. lowest tertile, p = 0.04). Changes induced by liver fibrosis influenced the pharmacokinetic processing of chlordecone, resulting in substantial modifications in its steady-state blood concentrations. According to this human model of coexposure to alcohol, reverse causality is the most plausible explanation of this inverse association between plasma chlordecone concentrations and progression of liver fibrosis. This study underlines the importance of considering the pharmacokinetic of environmental contaminants in epidemiological studies when biomarkers of exposure are used to investigate their own impact on the liver. ClinicalTrials.gov Identifier: NCT03373396.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"11 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}