Environmental Health最新文献

{"title":"Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study","authors":"Jiwon Oh, Kyoungmi Kim, Kurunthachalam Kannan, Patrick J. Parsons, Agnieszka Mlodnicka, Rebecca J. Schmidt, Julie B. Schweitzer, Irva Hertz-Picciotto, Deborah H. Bennett","doi":"10.1186/s12940-024-01065-3","DOIUrl":"https://doi.org/10.1186/s12940-024-01065-3","url":null,"abstract":"A growing body of literature investigated childhood exposure to environmental chemicals in association with attention-deficit/hyperactivity disorder (ADHD) symptoms, but limited studies considered urinary mixtures of multiple chemical classes. This study examined associations of concurrent exposure to non-persistent chemicals with ADHD symptoms in children diagnosed with autism spectrum disorder (ASD), developmental delay (DD), and typical development (TD). A total of 549 children aged 2–5 years from the Childhood Autism Risks from Genetics and Environment (CHARGE) case-control study were administered the Aberrant Behavior Checklist (ABC). This study focused on the ADHD/noncompliance subscale and its two subdomains (hyperactivity/impulsivity, inattention). Sixty-two chemicals from four classes (phenols/parabens, phthalates, organophosphate pesticides, trace elements) were quantified in child urine samples, and 43 chemicals detected in > 70% samples were used to investigate their associations with ADHD symptoms. Negative binomial regression was used for single-chemical analysis, and weighted quantile sum regression with repeated holdout validation was applied for mixture analysis for each chemical class and all chemicals. The mixture analyses were further stratified by diagnostic group. A phthalate metabolite mixture was associated with higher ADHD/noncompliance scores (median count ratio [CR] = 1.10; 2.5th, 97.5th percentile: 1.00, 1.21), especially hyperactivity/impulsivity (median CR = 1.09; 2.5th, 97.5th percentile: 1.00, 1.25). The possible contributors to these mixture effects were di-2-ethylhexyl phthalate (DEHP) metabolites and mono-2-heptyl phthalate (MHPP). These associations were likely driven by children with ASD as these were observed among children with ASD, but not among TD or those with DD. Additionally, among children with ASD, a mixture of all chemicals was associated with ADHD/noncompliance and hyperactivity/impulsivity, and possible contributors were 3,4-dihydroxy benzoic acid, DEHP metabolites, MHPP, mono-n-butyl phthalate, and cadmium. Early childhood exposure to a phthalate mixture was associated with ADHD symptoms, particularly among children with ASD. While the diverse diagnostic profiles limited generalizability, our findings suggest a potential link between phthalate exposure and the comorbidity of ASD and ADHD.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"112 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140127767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study.","authors":"Allison R Sherris, Christine T Loftus, Adam A Szpiro, Logan C Dearborn, Marnie F Hazlehurst, Kecia N Carroll, Paul E Moore, Margaret A Adgent, Emily S Barrett, Nicole R Bush, Drew B Day, Kurunthachalam Kannan, Kaja Z LeWinn, Ruby H N Nguyen, Yu Ni, Anne M Riederer, Morgan Robinson, Sheela Sathyanarayana, Qi Zhao, Catherine J Karr","doi":"10.1186/s12940-024-01066-2","DOIUrl":"10.1186/s12940-024-01066-2","url":null,"abstract":"<p><strong>Background and aim: </strong>Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in socio-demographically diverse participants from the ECHO PATHWAYS multi-cohort consortium.</p><p><strong>Methods: </strong>We included 1,081 birth parent-child dyads across five U.S. cities. Maternal urinary mono-hydroxylated PAH metabolite concentrations (OH-PAH) were measured during mid-pregnancy. Asthma at age 8-9 years and wheezing trajectory across childhood were characterized by caregiver reported asthma diagnosis and asthma/wheeze symptoms. We used logistic and multinomial regression to estimate odds ratios of asthma and childhood wheezing trajectories associated with five individual OH-PAHs, adjusting for urine specific gravity, various maternal and child characteristics, study site, prenatal and postnatal smoke exposure, and birth year and season in single metabolite and mutually adjusted models. We used multiplicative interaction terms to evaluate effect modification by child sex and explored OH-PAH mixture effects through Weighted Quantile Sum regression.</p><p><strong>Results: </strong>The prevalence of asthma in the study population was 10%. We found limited evidence of adverse associations between pregnancy OH-PAH concentrations and asthma or wheezing trajectories. We observed adverse associations between 1/9-hydroxyphenanthrene and asthma and persistent wheeze among girls, and evidence of inverse associations with asthma for 1-hydroxynathpthalene, which was stronger among boys, though tests for effect modification by child sex were not statistically significant.</p><p><strong>Conclusions: </strong>In a large, multi-site cohort, we did not find strong evidence of an association between prenatal exposure to PAHs and child asthma at age 8-9 years, though some adverse associations were observed among girls.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"26"},"PeriodicalIF":6.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response relationship between lung function and chest imaging response to silica exposures in artificial stone manufacturing workers.","authors":"Chi-Hsien Chen, Perng-Jy Tsai, Wen-Wen Chang, Cheng-Yao Chen, Chih-Yong Chen, Deborah Yates, Yue Leon Guo","doi":"10.1186/s12940-024-01067-1","DOIUrl":"10.1186/s12940-024-01067-1","url":null,"abstract":"<p><strong>Background: </strong>Occupational exposure to artificial stone, a popular material used for countertops, can cause accelerated silicosis, but the precise relationship between silica dose and disease development is unclear.</p><p><strong>Objectives: </strong>This study evaluated the impact of silica exposure on lung function and chest imaging in artificial stone manufacturing workers.</p><p><strong>Methods: </strong>Questionnaire and spirometry assessments were administered to workers in two plants. A high-exposure subset underwent further evaluation, including chest CT and DLco. Weighting factors, assigned as proxies for silica exposure, were based on work tasks. Individual cumulative exposures were estimated using area concentration measurements and time spent in specific areas. Exposure-response associations were analyzed using linear and logistic regression models.</p><p><strong>Results: </strong>Among 65 participants, the mean cumulative silica exposure was 3.61 mg/m³-year (range 0.0001 to 44.4). Each 1 mg/m³-year increase was associated with a 0.46% reduction in FVC, a 0.45% reduction in FEV1, and increased lung function abnormality risk (aOR = 1.27, 95% CI = 1.03-1.56). Weighting factors correlated with cumulative exposures (Spearman correlation = 0.59, p < 0.0001), and weighted tenure was associated with lung function abnormalities (aOR = 1.04, 95% CI = 1.01-1.09). Of 37 high-exposure workers, 19 underwent chest CT, with 12 (63%) showing abnormal opacities. Combining respiratory symptoms, lung function, and chest X-ray achieved 91.7% sensitivity and 75% specificity for predicting chest CT abnormalities.</p><p><strong>Conclusion: </strong>Lung function and chest CT abnormalities occur commonly in artificial stone workers. For high-exposure individuals, abnormalities on health screening could prompt further chest CT examination to facilitate early silicosis detection.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"25"},"PeriodicalIF":6.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"As the world turns: scientific publishing in the digital era","authors":"David Ozonoff","doi":"10.1186/s12940-024-01063-5","DOIUrl":"https://doi.org/10.1186/s12940-024-01063-5","url":null,"abstract":"&lt;p&gt;A quarter of the way into the 21st Century the technology of encoding and transmitting information in digital form is in full flower. Almost without noticing it, we are living through a historical discontinuity comparable to the one produced by Guttenberg’s invention of printing with moveable type in 1450, a technology that made possible the production of identical written texts on a scale previously unimaginable. That technology was quickly adopted, but its basic form didn’t change for hundreds of years. Today the speed of advance in digital technology is breath taking. Digital devices like the smart phone have moved from expensive prototypes to ubiquitous and essential appliances in a little over a decade. Digital technology has also substantially affected scientific publishing.&lt;/p&gt;&lt;p&gt;In 1879 John Shaw Billings, a surgeon in the Office of the US Surgeon General of the Army, began to compile an author-topic catalog of the library. In 1966 its print descendant, &lt;i&gt;Index Medicus&lt;/i&gt; (now &lt;i&gt;PubMed&lt;/i&gt;), went online [1], but as long as the journals themselves were still in print-only format, its full impact only came when most journal-published research was also available in electronic digital format. That time has come and it has had a profound effect on how scientists seek out and find research relevant to their work. Gone are the days when many of us routinely perused the latest issues of journals in our institutional libraries or went to library stacks to retrieve past issues and lug them to the copy machines at 10 cents a page. The stacks and copy machines now sit on our desks as internet-connected computers and personal printers. Some of us haven’t been in a physical library for years. Journals still appearing in paper format have been forced to have a digital format also available. At the same time advances in research methods, such as genomics or new imaging technics unimaginable in the pre-digital era have vastly expanded the scope and depth of biomedical research. Even well-defined research fields are now extensively sub-specialized and the volume of publication is potentially overwhelming. Yet online digital search makes it possible to find the needle in the haystack, and this is an essential difference compared to even a short time ago.&lt;/p&gt;&lt;p&gt;This is a seismic shift in scientific publishing and it has happened in a relatively short time without most of us being conscious of it. Just as music streaming services uncoupled song tracks from the record album or CD upon which they originally appeared, no-cost search engines like Google or the biomedical research database PubMed have uncoupled individual research articles from the journals where they originally appeared. Journal brand names remain significant, but less so than previously and they are no longer the first place we look. Now we can look everywhere at once.&lt;/p&gt;&lt;p&gt;By the year 2000 we had the routine ability to transmit our writing electronically in digital form and access to a w","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"2 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in the association between ambient temperature and preterm birth according to individual and regional characteristics: a nationwide time-stratified case-crossover study","authors":"Jieun Min, Whanhee Lee, Jongmin Oh, Youngrin Kwag, Eunji Kim, Joyce Mary Kim, Kyung A Lee, Eunhee Ha","doi":"10.1186/s12940-024-01062-6","DOIUrl":"https://doi.org/10.1186/s12940-024-01062-6","url":null,"abstract":"Several studies have reported that climate change elevates heat exposure in pregnant women and high temperatures during pregnancy are associated with preterm births (PTBs). Although the association might be disproportionate, related evidence remains sparse. We evaluated the disproportionate risk of PTB associated with ambient temperature during pregnancy by individual and regional characteristics in South Korea. We collected data on birth certificates and daily mean temperatures during the period from 2011 to 2019. A time-stratified case-crossover design was used to investigate the association between temperature and PTB and stratified analyses were conducted to examine the effect modification of individual and regional characteristics. A total of 160,067 singleton PTBs were recorded in Korea from 2011 to 2019. A 5℃ increase in the mean temperature during the last four weeks before delivery was associated with an increased risk of PTB with an odds ratio (OR) of 1.03 (95% confidence interval [CI]: 1.02, 1.05), and the association was more evident in mothers aged ≥35 years (OR: 1.06 [95% CI: 1.03, 1.10]) and with low education levels (OR: 1.04 [95% CI: 1.02, 1.05]). Additionally, the estimated risk was evident in districts with lower medical resources and more prominent disparities were shown by individual and regional characteristics in rural areas than in urban areas. This study provides evidence that the risk of PTB related to ambient temperature is disproportionate by individual and regional characteristics and suggests the need for public health policies to alleviate the disparities, especially in rural areas.","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"106 1","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139920549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of in-utero exposure to air pollution and atherogenic index of plasma in newborns.","authors":"Ali Seidkhani-Nahal, Hafez Heydari, Ayoub Tavakolian, Moslem Lari Najafi, Mohammad Miri","doi":"10.1186/s12940-024-01059-1","DOIUrl":"10.1186/s12940-024-01059-1","url":null,"abstract":"<p><strong>Background: </strong>Prenatal exposure to particulate matter (PM) and traffic was associated with the programming of cardiovascular diseases (CVDs) in early life. However, the exact underlying mechanisms are not fully understood. Therefore, we aimed to evaluate the association between in-utero exposure to PMs and traffic indicators with the atherogenic index of plasma (AIP) in newborns, which is a precise index reflecting an enhancement of lipid risk factors for CVDs.</p><p><strong>Methods: </strong>In this cross-sectional study, a total of 300 mother-newborn pairs were enrolled in Sabzevar, Iran. Spatiotemporal land-use regression models were used to estimate the level of PM₁, PM_2.5 and PM₁₀ at the mother's residential address. The total length of streets in different buffers (100,300 and 500m) and proximity to major roads were calculated as indicators of traffic. The AIP of cord blood samples was calculated using an AIP calculator. Multiple linear regression models were used to examine the association of PM concentrations as well as traffic indicators with AIP controlled for relevant covariates.</p><p><strong>Results: </strong>PM_2.5 exposure was significantly associated with higher levels of AIP in newborns. Each interquartile range (IQR) increment of PM_2.5 concentration at the mothers' residential addresses was associated with a 5.3% (95% confidence interval (CI): 0.0, 10.6%, P = 0.04) increase in the AIP. Associations between PM₁, PM₁₀ and traffic indicators with cord blood level of AIP were positive but not statistically significant.</p><p><strong>Conclusion: </strong>Our findings showed that in utero exposure to PM_2.5 may be associated with CVDs programming through the increase of atherogenic lipids.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"22"},"PeriodicalIF":6.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects.","authors":"Jinghua Long, Jun Liang, Tao Liu, Huishen Huang, Jiehua Chen, Qian Liao, Lixiang Pang, Kaiqi Yang, Manlin Chen, Qian Chen, Xiaorong Huang, Qihua Zhu, Xiaoyun Zeng, Dongping Huang, Xiaoqiang Qiu","doi":"10.1186/s12940-024-01047-5","DOIUrl":"10.1186/s12940-024-01047-5","url":null,"abstract":"<p><strong>Background: </strong>While prenatal exposure to alkylphenols (APs) has been demonstrated to be associated with neurodevelopmental impairments in animals, the evidence from epidemiological studies remains limited and inconclusive. This study aimed to explore the link between AP exposure during pregnancy and the intelligence quotient (IQ) of preschool children.</p><p><strong>Methods: </strong>A total of 221 mother-child pairs from the Guangxi Zhuang Birth Cohort were recruited. Nonylphenol (NP), 4-tert-octylphenol (4-T-OP), 4-n-nonylphenol (4-N-NP), and 4-n-octylphenol were measured in maternal serum in early pregnancy. Childhood IQ was evaluated by the Fourth Edition of Wechsler Preschool and Primary Scale of the Intelligence at 3 to 6 years of age. The impact of APs on childhood IQ were evaluated by generalized linear models (GLMs), restricted cubic spline (RCS), and Bayesian kernel machine regression (BKMR).</p><p><strong>Results: </strong>In GLMs, prenatal exposure to NP and the second tertile of 4-T-OP exhibited an inverse association with full-scale IQ (FSIQ) (β = -2.38; 95% CI: -4.59, -0.16) and working memory index (WMI) (β = -5.24; 95% CI: -9.58, -0.89), respectively. Prenatal exposure to the third tertile of 4-N-NP showed a positive association with the fluid reasoning index (β = 4.95; 95% CI: 1.14, 8.77) in total children, as well as in girls when stratified by sex. A U-shaped relationship between maternal 4-T-OP and WMI was noted in total children and girls by RCS (all P nonlinear < 0.05). The combined effect primarily driven by NP, of maternal AP mixtures at concentrations above the 50th percentile exhibited an inverse trend on FSIQ in total children and girls in BKMR.</p><p><strong>Conclusions: </strong>Prenatal exposure to various APs affects IQ in preschool children, and there may be nonmonotonic and sex-specific effects. Further investigation across the population is required to elucidate the potential neurotoxic effects of APs.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"21"},"PeriodicalIF":6.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global patterns of asthma burden related to environmental risk factors during 1990-2019: an age-period-cohort analysis for global burden of disease study 2019.","authors":"Siying Zhang, Zongshi Gao, Lihong Wu, Yumei Zhong, Hui Gao, Fang-Biao Tao, Xiulong Wu","doi":"10.1186/s12940-024-01060-8","DOIUrl":"10.1186/s12940-024-01060-8","url":null,"abstract":"<p><strong>Background: </strong>Change in asthma burden attributed to specific environmental risk factor has not been evaluated.</p><p><strong>Objective: </strong>We aimed to explore the age, period, and cohort effects on asthma burden attributable to smoking and occupational asthmagens in different socio-demographic index (SDI) regions and the region and sex disparities.</p><p><strong>Methods: </strong>Risk factor-specific asthma deaths and disability-adjusted life years (DALYs) rates were extracted from Global Burden of Disease study 2019, estimated by standard Combined Cause of Death Model and DisMod-MR 2.1 modeling tool. Age-period-cohort analysis was conducted to decompose age, period, and cohort effects on asthma burden.</p><p><strong>Results: </strong>Smoking- and occupational asthmagens-related asthma deaths and DALYs rates dropped by > 45% during 1990-2019. In 2019, Africa, South and Southeast Asia had higher asthma burden than other regions. Male had higher asthma burden than female. Among nearly all age groups, low-middle SDI region had the highest smoking-related asthma burden, and low SDI region had the highest occupational asthmagens-related asthma burden. Inverse \"V\" shaped trend was observed in the above regions with increasing age. For smoking-related asthma deaths and DALYs rates, the most significant improvement of period rate ratio (RR) occurred in high SDI region, decreased from 1.67 (1.61, 1.74) to 0.34 (0.33, 0.36) and 1.61 (1.57, 1.66) to 0.59 (0.57, 0.61), respectively, as well as the cohort effect on smoking-related asthma burden. For occupational asthmagens-related asthma deaths and DALYs rates, the most sharply decrease of period and cohort RR appeared in the high and high-middle SDI regions. Low SDI region showed least progress in period and cohort RR of smoking- and occupational asthmagens-linked asthma burden.</p><p><strong>Conclusion: </strong>Smoking- and occupational asthmagens-related asthma burden sharply decreases, but region and sex disparities exist. Policy makers from low SDI region should reinforce tobacco control and prioritize workplace protection.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"20"},"PeriodicalIF":6.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health impact of the Tajogaite volcano eruption in La Palma population (ISVOLCAN study): rationale, design, and preliminary results from the first 1002 participants.","authors":"María Cristo Rodríguez-Pérez, Manuel Enrique Fuentes Ferrer, Luis D Boada, Ana Delia Afonso Pérez, María Carmen Daranas Aguilar, Jose Francisco Ferraz Jerónimo, Ignacio García Talavera, Luis Vizcaíno Gangotena, Arturo Hardisson de la Torre, Katherine Simbaña-Rivera, Antonio Cabrera de León","doi":"10.1186/s12940-024-01056-4","DOIUrl":"10.1186/s12940-024-01056-4","url":null,"abstract":"<p><strong>Background: </strong>The eruption of the Tajogaite volcano began on the island of La Palma on September 19, 2021, lasting for 85 days. This study aims to present the design and methodology of the ISVOLCAN (Health Impact on the Population of La Palma due to the Volcanic Eruption) cohort, as well as the preliminary findings from the first 1002 enrolled participants.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with random selection of adult participants from the general population, with an estimated sample size of 2600 individuals. The results of the first 857 participants are presented, along with a group of 145 voluntary participants who served as interveners during the eruption. Data on epidemiology and volcano exposure were collected, and participants underwent physical examinations, including anthropometry, blood pressure measurement, spirometry, and venous blood extraction for toxicological assessment.</p><p><strong>Results: </strong>In the general population (n = 857), descriptive analysis revealed that the participants were mostly middle-aged individuals (50.8 ± 16.4), with a predominance of females. Before the eruption, the participants resided at a median distance of 6.7 km from the volcano in the Western region and 10.9 km in the Eastern region. Approximately 15.4% of the sample required evacuation, whose 34.8% returning to their homes on average after 3 months. A significant number of participants reported engaging in daily tasks involving cleaning of volcanic ash both indoors and outdoors. The most reported acute symptoms included ocular irritation, insomnia, mood disorders (anxiety-depression), and respiratory symptoms. Multivariate analysis results show that participants in the western region had a higher likelihood of lower respiratory tract symptoms (OR 1.99; 95% CI:1.33-2.99), depression and anxiety (OR 1.95; 95% CI:1.30-2.93), and insomnia (OR 2.03; 95% CI:1.33-3.09), compared to those in the eastern region.</p><p><strong>Conclusion: </strong>The ongoing follow-up of the ISVOLCAN cohort will provide valuable insights into the short, medium, and long-term health impact related to the material emitted during the Tajogaite eruption, based on the level of exposure suffered by the affected population.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"19"},"PeriodicalIF":6.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal blood or cord blood metal concentrations and catch-up growth in children born small for gestational age: an analysis by the Japan environment and children's study.","authors":"Tomozumi Takatani, Rieko Takatani, Akifumi Eguchi, Midori Yamamoto, Kenichi Sakurai, Yu Taniguchi, Yayoi Kobayashi, Chisato Mori, Michihiro Kamijima","doi":"10.1186/s12940-024-01061-7","DOIUrl":"10.1186/s12940-024-01061-7","url":null,"abstract":"<p><strong>Background: </strong>Catch-up growth issues among children born small for gestational age (SGA) present a substantial public health challenge. Prenatal exposure to heavy metals can cause adverse effects on birth weight. However, comprehensive studies on the accurate assessment of individual blood concentrations of heavy metals and their effect on the failure to achieve catch-up growth remain unavailable. This study aimed to evaluate the effects of uterine exposure to toxic metals cadmium, lead, and mercury and essential trace metals manganese and selenium at low concentrations on the postnatal growth of children born SGA.</p><p><strong>Methods: </strong>Data on newborn birth size and other factors were obtained from the medical record transcripts and self-administered questionnaires of participants in the Japan Environment and Children's Study. The blood concentrations of lead, cadmium, mercury, selenium, and manganese in pregnant women in their second or third trimester were determined by inductively coupled plasma mass spectrometry. These heavy metal concentrations were also assessed in pregnant women's cord blood. Furthermore, the relationship between each heavy metal and height measure/catch-up growth in SGA children aged 4 years was analyzed using linear and logistic regression methods. These models were adjusted for confounders.</p><p><strong>Results: </strong>We studied 4683 mother-child pairings from 103,060 pregnancies included in the Japan Environment and Children's Study. Of these, 278 pairs were also analyzed using cord blood. At 3 and 4 years old, 10.7% and 9.0% of children who were born below the 10th percentile of body weight had height standard deviation scores (SDSs) below 2, respectively. Cord blood cadmium concentrations were associated with the inability to catch up in growth by 3 or 4 years old and the height SDS at 3 years old. In maternal blood, only manganese was positively associated with the height SDS of SGA children aged 2 years; however, it was not significantly associated with catch-up growth in these children.</p><p><strong>Conclusion: </strong>Cadmium exposure is associated with failed catch-up development in SGA children. These new findings could help identify children highly at risk of failing to catch up in growth, and could motivate the elimination of heavy metal (especially cadmium) pollution to improve SGA children's growth.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"18"},"PeriodicalIF":6.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10858588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}