当日尿酚水平与心电变化的关系:费纳尔德社区队列分析

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Jack Rubinstein, Susan M. Pinney, Changchun Xie, Hong-Sheng Wang
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引用次数: 0

摘要

在动物模型和人类群体中,接触酚类物质与心脏功能改变和心血管疾病有关,但酚类物质对人体心电特性的影响仍有待确定。本研究旨在确定与环境苯酚暴露有关的心电图(ECG)参数变化,研究对象是中西部大型队列(即费纳尔德社区队列,FCC)中的成年人。在首次全面体检的当天采集尿样并记录心电图。研究人员进行了横截面线性回归分析。双酚 A(BPA)和双酚 F(BPF)均与女性的 PR 间期延长有关(P < 0.05),这表明心房到心室的传导延迟,但与男性无关。双酚 A 联用 BPF 与 QRS 间期延长有关,这表明心室激活延迟,女性(P < 0.05)而男性(P < 0.05)不相关。三氯卡班(TCC)水平越高,男性的 QTc 间期越长(表明心室复极延迟)(P < 0.01),女性则不然。体重指数(BMI)与女性 PR 和 QTc 间期以及心室率的显著增加有关,与男性心室率的显著增加有关。在女性中,双酚 A 尿液浓度和体重指数均处于最高三分位数的综合效应是 PR 间期估计增加 10%。未发现与其他酚类有任何关联。在费尔纳德队列中,某些酚类的较高暴露量与心脏电特性的改变有特定的性别关联。我们基于人群的研究结果与临床相关参数直接相关,而这些参数与人类已知的病理生理心脏状况相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort
Exposure to phenols has been linked in animal models and human populations to cardiac function alterations and cardiovascular diseases, although their effects on cardiac electrical properties in humans remains to be established. This study aimed to identify changes in electrocardiographic (ECG) parameters associated with environmental phenol exposure in adults of a midwestern large cohort known as the Fernald Community Cohort (FCC). During the day of the first comprehensive medical examination, urine samples were obtained, and electrocardiograms were recorded. Cross-sectional linear regression analyses were performed. Bisphenol A (BPA) and bisphenol F (BPF) were both associated with a longer PR interval, an indication of delayed atrial-to-ventricle conduction, in females (p < 0.05) but not males. BPA combined with BPF was associated with an increase QRS duration, an indication of delayed ventricular activation, in females (P < 0.05) but not males. Higher triclocarban (TCC) level was associated with longer QTc interval, an indication of delayed ventricular repolarization, in males (P < 0.01) but not females. Body mass index (BMI) was associated with a significant increase in PR and QTc intervals and ventricular rate in females and in ventricular rate in males. In females, the combined effect of being in the top tertile for both BPA urinary concentration and BMI was an estimate of a 10% increase in PR interval. No associations were found with the other phenols. Higher exposure to some phenols was associated with alterations of cardiac electrical properties in a sex specific manner in the Fernald cohort. Our population-based findings correlate directly with clinically relevant parameters that are associated with known pathophysiologic cardiac conditions in humans.
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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