Jorge Chavez, Katherine Crank, Casey Barber, Daniel Gerrity, Thomas Iverson, Joshua Mongillo, Angela Weil, Linda Rider, Nathan Lacross, Kelly Oakeson, Alessandro Rossi
{"title":"Early Introductions of Candida auris Detected by Wastewater Surveillance, Utah, USA, 2022–2023","authors":"Jorge Chavez, Katherine Crank, Casey Barber, Daniel Gerrity, Thomas Iverson, Joshua Mongillo, Angela Weil, Linda Rider, Nathan Lacross, Kelly Oakeson, Alessandro Rossi","doi":"10.3201/eid3010.240173","DOIUrl":"https://doi.org/10.3201/eid3010.240173","url":null,"abstract":"<p><em>Candida auris</em> is considered a nosocomial pathogen of high concern and is currently spreading across the United States. Infection control measures for <em>C. auris</em> focus mainly on healthcare facilities, yet transmission levels may already be significant in the community before outbreaks are detected in healthcare settings. Wastewater-based epidemiology (culture, quantitative PCR, and whole-genome sequencing) can potentially gauge pathogen transmission in the general population and lead to early detection of <em>C. auris</em> before it is detected in clinical cases. To learn more about the sensitivity and limitations of wastewater-based surveillance, we used wastewater-based methods to detect <em>C. auris</em> in a southern Utah jurisdiction with no known clinical cases before and after the documented transfer of colonized patients from bordering Nevada. Our study illustrates the potential of wastewater-based surveillance for being sufficiently sensitive to detect <em>C. auris</em> transmission during the early stages of introduction into a community.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathaniel D. Denkers, Erin E. McNulty, Caitlyn N. Kraft, Amy V. Nalls, Joseph A. Westrich, Edward A. Hoover, Candace K. Mathiason
{"title":"Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States","authors":"Nathaniel D. Denkers, Erin E. McNulty, Caitlyn N. Kraft, Amy V. Nalls, Joseph A. Westrich, Edward A. Hoover, Candace K. Mathiason","doi":"10.3201/eid3010.240159","DOIUrl":"https://doi.org/10.3201/eid3010.240159","url":null,"abstract":"<p>Chronic wasting disease (CWD) affects cervids in North America, Asia, and Scandinavia. CWD is unique in its efficient spread, partially because of contact with infectious prions shed in secreta. To assess temporal profiles of CWD prion shedding, we collected saliva, urine, and feces from white-tailed deer for 66 months after exposure to low oral doses of CWD-positive brain tissue or saliva. We analyzed prion seeding activity by using modified amyloid amplification assays incorporating iron oxide bead extraction, which improved CWD detection and reduced false positives. CWD prions were detected in feces, urine, and saliva as early as 6 months postinfection. More frequent and consistent shedding was observed in deer homozygous for glycine at prion protein gene codon 96 than in deer expressing alternate genotypes. Our findings demonstrate that improved amplification methods can be used to identify early antemortem CWD prion shedding, which might aid in disease surveillance of cervids.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuval Dadon, Francis B. Mimouni, Ariella Toren, Tal Morgenstern, Lior Barak, Joseph Mendlovic
{"title":"Economic Analysis of National Program for Hepatitis C Elimination, Israel, 2023","authors":"Yuval Dadon, Francis B. Mimouni, Ariella Toren, Tal Morgenstern, Lior Barak, Joseph Mendlovic","doi":"10.3201/eid3010.240210","DOIUrl":"https://doi.org/10.3201/eid3010.240210","url":null,"abstract":"<p>In 2021, the Israel Ministry of Health began a national hepatitis C elimination program. Implementing a World Health Organization goal, Israel’s program involved targeted screening, barrier minimization, workup simplification, awareness campaigns, and a patient registry. We evaluated program costs for testing and treatment. By May 15, 2023, the program had identified 865,382 at-risk persons, of whom 555,083 (64.3%) were serologically screened for hepatitis C virus (HCV), which was detected in 24,361 (4.4%). Among 20,928 serologically positive patients, viremia was detected in 13,379 (63.9%), of whom 10,711 (80%) were treated, and 4,618 (96.5%) of 4,786 persons receiving posttreatment HCV RNA testing had sustained virologic response. We estimated costs of ₪14,426 (new Israel shekel; ≈$3,606 USD) per person whose HCV infection was diagnosed and successfully treated. The program yielded screening and treatment in almost two thirds of the identified at-risk population. Although not eliminated, HCV prevalence will likely decrease substantially by the 2030 target.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edmilson F. de Oliveira-Filho, César Augusto Cabezas Sánchez, Dora Esther Valencia Manosalva, Maribel Dana Figueroa Romero, Nancy Susy Merino Sarmiento, Adolfo Ismael Marcelo Ñique, Edward Málaga-Trillo, Andres Moreira-Soto, Maria Paquita García Mendoza, Jan Felix Drexler
{"title":"Fort Sherman Virus Infection in Human, Peru, 2020","authors":"Edmilson F. de Oliveira-Filho, César Augusto Cabezas Sánchez, Dora Esther Valencia Manosalva, Maribel Dana Figueroa Romero, Nancy Susy Merino Sarmiento, Adolfo Ismael Marcelo Ñique, Edward Málaga-Trillo, Andres Moreira-Soto, Maria Paquita García Mendoza, Jan Felix Drexler","doi":"10.3201/eid3010.240124","DOIUrl":"https://doi.org/10.3201/eid3010.240124","url":null,"abstract":"<p>Fort Sherman virus (FSV) was isolated in Panama in 1985 from a US soldier. We report a case of human FSV infection in a febrile patient from northern coastal Peru in 2020. FSV infections spanning ≈35 years and a distance of 2,000 km warrant diagnostics, genomic surveillance, and investigation of transmission cycles.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nigel P. French, Kate M. Thomas, Nelson B. Amani, Jackie Benschop, Godfrey M. Bigogo, Sarah Cleaveland, Ahmed Fayaz, Ephrasia A. Hugho, Esron D. Karimuribo, Elizabeth Kasagama, Ruth Maganga, Matayo L. Melubo, Anne C. Midwinter, Blandina T. Mmbaga, Victor V. Mosha, Fadhili I. Mshana, Peninah Munyua, John B. Ochieng, Lynn Rogers, Emmanuel Sindiyo, Emanuel S. Swai, Jennifer R. Verani, Marc-Alain Widdowson, David A. Wilkinson, Rudovick R. Kazwala, John A. Crump, Ruth N. Zadoks
{"title":"Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa","authors":"Nigel P. French, Kate M. Thomas, Nelson B. Amani, Jackie Benschop, Godfrey M. Bigogo, Sarah Cleaveland, Ahmed Fayaz, Ephrasia A. Hugho, Esron D. Karimuribo, Elizabeth Kasagama, Ruth Maganga, Matayo L. Melubo, Anne C. Midwinter, Blandina T. Mmbaga, Victor V. Mosha, Fadhili I. Mshana, Peninah Munyua, John B. Ochieng, Lynn Rogers, Emmanuel Sindiyo, Emanuel S. Swai, Jennifer R. Verani, Marc-Alain Widdowson, David A. Wilkinson, Rudovick R. Kazwala, John A. Crump, Ruth N. Zadoks","doi":"10.3201/eid3010.231399","DOIUrl":"https://doi.org/10.3201/eid3010.231399","url":null,"abstract":"<p>Campylobacteriosis and antimicrobial resistance (AMR) are global public health concerns. Africa is estimated to have the world’s highest incidence of campylobacteriosis and a relatively high prevalence of AMR in <em>Campylobacter</em> spp. from humans and animals. Few studies have compared <em>Campylobacter</em> spp. isolated from humans and poultry in Africa using whole-genome sequencing and antimicrobial susceptibility testing. We explored the population structure and AMR of 178 <em>Campylobacter</em> isolates from East Africa, 81 from patients with diarrhea in Kenya and 97 from 56 poultry samples in Tanzania, collected during 2006–2017. Sequence type diversity was high in both poultry and human isolates, and some sequence types were common. The estimated prevalence of multidrug resistance, defined as resistance to <span>></span>3 antimicrobial classes, was higher in poultry isolates (40.9%, 95% credible interval 23.6%–59.4%) than in human isolates (2.5%, 95% credible interval 0.3%–6.8%), underlining the importance of antimicrobial stewardship in livestock systems.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Carlos Bandeira, Felicidade Mota Pereira, Arabela Leal, Sara P.O. Santos, Ana Claudia Barbosa, Marcia Sao Pedro Leal Souza, Daniele Ribeiro de Souza, Natalia Guimaraes, Vagner Fonseca, Marta Giovanetti, Luiz Carlos Junior Alcantara, André Alvarez A. Lessa, Ramon Costa Saavedra, Luiz Marcelo R. Tomé, Felipe Campos M. Iani, Rivia Mary Barros, Sandra Maria O. Purificação, Jaciara Prado de Jesus, Ricardo Rosário Fonseca, Marcio Luis Valença Araújo
{"title":"Fatal Oropouche Virus Infections in Nonendemic Region, Brazil, 2024","authors":"Antonio Carlos Bandeira, Felicidade Mota Pereira, Arabela Leal, Sara P.O. Santos, Ana Claudia Barbosa, Marcia Sao Pedro Leal Souza, Daniele Ribeiro de Souza, Natalia Guimaraes, Vagner Fonseca, Marta Giovanetti, Luiz Carlos Junior Alcantara, André Alvarez A. Lessa, Ramon Costa Saavedra, Luiz Marcelo R. Tomé, Felipe Campos M. Iani, Rivia Mary Barros, Sandra Maria O. Purificação, Jaciara Prado de Jesus, Ricardo Rosário Fonseca, Marcio Luis Valença Araújo","doi":"10.3201/eid3011.241132","DOIUrl":"https://doi.org/10.3201/eid3011.241132","url":null,"abstract":"<p>We report acute Oropouche virus infections in 2 previously healthy women from a nonendemic region of Brazil outside the Amazon Basin. Infections rapidly progressed to hemorrhagic manifestations and fatal outcomes in 4–5 days. These cases highlight the critical need for enhanced surveillance to clarify epidemiology of this neglected disease.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Davis, Jason Velez, Jeff Hamik, Kelly Fitzpatrick, Jacki Haley, Jeremy Eschliman, Amanda Panella, J. Erin Staples, Amy Lambert, Matthew Donahue, Aaron C. Brault, Holly R. Hughes
{"title":"Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023","authors":"Emily Davis, Jason Velez, Jeff Hamik, Kelly Fitzpatrick, Jacki Haley, Jeremy Eschliman, Amanda Panella, J. Erin Staples, Amy Lambert, Matthew Donahue, Aaron C. Brault, Holly R. Hughes","doi":"10.3201/eid3010.240595","DOIUrl":"https://doi.org/10.3201/eid3010.240595","url":null,"abstract":"<p>West Nile virus (WNV) is the most common cause of human arboviral disease in the contiguous United States, where only lineage 1 (L1) WNV had been found. In 2023, an immunocompetent patient was hospitalized in Nebraska with West Nile neuroinvasive disease and multisystem organ failure. Testing at the Centers for Disease Control and Prevention indicated an unusually high viral load and acute antibody response. Upon sequencing of serum and cerebrospinal fluid, we detected lineage 3 (L3) and L1 WNV genomes. L3 WNV had previously only been found in Central Europe in mosquitoes. The identification of L3 WNV in the United States and the observed clinical and laboratory features raise questions about the potential effect of L3 WNV on the transmission dynamics and pathogenicity of WNV infections. Determining the distribution and prevalence of L3 WNV in the United States and any public health and clinical implications is critical.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren Jansen, Rachael Birn, Samir Koirala, Sadie Oppegard, Brianna Loeck, Jeff Hamik, Elizabeth Wyckoff, Dana Spindola, Sue Dempsey, Amanda Bartling, Alexis Roundtree, Amy Kahler, Charlotte Lane, Nancy Hogan, Nancy Strockbine, Haley McKeel, Jonathan Yoder, Mia Mattioli, Matthew Donahue, Bryan Buss
{"title":"Campylobacteriosis Outbreak Linked to Municipal Water, Nebraska, USA, 2021","authors":"Lauren Jansen, Rachael Birn, Samir Koirala, Sadie Oppegard, Brianna Loeck, Jeff Hamik, Elizabeth Wyckoff, Dana Spindola, Sue Dempsey, Amanda Bartling, Alexis Roundtree, Amy Kahler, Charlotte Lane, Nancy Hogan, Nancy Strockbine, Haley McKeel, Jonathan Yoder, Mia Mattioli, Matthew Donahue, Bryan Buss","doi":"10.3201/eid3010.231509","DOIUrl":"https://doi.org/10.3201/eid3010.231509","url":null,"abstract":"<p>In September 2021, eight campylobacteriosis cases were identified in a town in Nebraska, USA. We assessed potential exposures for a case–control analysis. We conducted whole-genome sequencing on <em>Campylobacter</em> isolates from patients’ stool specimens. We collected large-volume dead-end ultrafiltration water samples for <em>Campylobacter</em> and microbial source tracking testing at the Centers for Disease Control and Prevention. We identified 64 cases in 2 waves of illnesses. Untreated municipal tap water consumption was strongly associated with illness (wave 1 odds ratio 15.36; wave 2 odds ratio 16.11). Whole-genome sequencing of 12 isolates identified 2 distinct <em>Campylobacter jejuni</em> subtypes (1 subtype/wave). The town began water chlorination, after which water testing detected coliforms. One dead-end ultrafiltration sample yielded nonculturable <em>Campylobacter</em> and avian-specific fecal rRNA genomic material. Our investigation implicated contaminated, untreated, municipal water as the source. Results of microbial source tracking supported mitigation with continued water chlorination. No further campylobacteriosis cases attributable to water were reported.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dallas J. Smith, Malavika Rajeev, Kristina Boyd, Kaitlin Benedict, Ian Hennessee, Laura Rothfeldt, Connie Austin, Mary-Elizabeth Steppig, Dimple Patel, Rebecca Reik, Malia Ireland, Judi Sedivy, Suzanne Gibbons-Burgener, Renee M. Calanan, Samantha L. Williams, Sarah Rockhill, Mitsuru Toda
{"title":"Associations between Minority Health Social Vulnerability Index Scores, Rurality, and Histoplasmosis Incidence, 8 US States","authors":"Dallas J. Smith, Malavika Rajeev, Kristina Boyd, Kaitlin Benedict, Ian Hennessee, Laura Rothfeldt, Connie Austin, Mary-Elizabeth Steppig, Dimple Patel, Rebecca Reik, Malia Ireland, Judi Sedivy, Suzanne Gibbons-Burgener, Renee M. Calanan, Samantha L. Williams, Sarah Rockhill, Mitsuru Toda","doi":"10.3201/eid3010.231700","DOIUrl":"https://doi.org/10.3201/eid3010.231700","url":null,"abstract":"<p>To explore associations between histoplasmosis and race and ethnicity, socioeconomic status, and rurality, we conducted an in-depth analysis of social determinants of health and histoplasmosis in 8 US states. Using the Minority Health Social Vulnerability Index (MH SVI), we analyzed county-level histoplasmosis incidence (cases/100,000 population) from the 8 states by applying generalized linear mixed hurdle models. We found that histoplasmosis incidence was higher in counties with limited healthcare infrastructure and access as measured by the MH SVI and in more rural counties. Other social determinants of health measured by the MH SVI tool either were not significantly or were inconsistently associated with histoplasmosis incidence. Increased awareness of histoplasmosis, more accessible diagnostic tests, and investment in rural health services could address histoplasmosis-related health disparities.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher K. Cote, Kevin D. Mlynek, Christopher P. Klimko, Sergei S. Biryukov, Sherry Mou, Melissa Hunter, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jeremey A. Miller, Yuli Talyansky, Michael L. Davies, J. Matthew Meinig, Stephanie A. Halasohoris, Anette M. Gray, Jade L. Spencer, Ashley L. Babyak, M. Kelly Hourihan, Bobby J. Curry, Ronald G. Toothman, Sara I. Ruiz, Xiankun Zeng, Keersten M. Ricks, Tamara L. Clements, Christina E. Douglas, Suma Ravulapalli, Christopher P. Stefan, Charles J. Shoemaker, Mindy G. Elrod, Jay E. Gee, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, Nancy A. Twenhafel, David DeShazer
{"title":"Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray","authors":"Christopher K. Cote, Kevin D. Mlynek, Christopher P. Klimko, Sergei S. Biryukov, Sherry Mou, Melissa Hunter, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jeremey A. Miller, Yuli Talyansky, Michael L. Davies, J. Matthew Meinig, Stephanie A. Halasohoris, Anette M. Gray, Jade L. Spencer, Ashley L. Babyak, M. Kelly Hourihan, Bobby J. Curry, Ronald G. Toothman, Sara I. Ruiz, Xiankun Zeng, Keersten M. Ricks, Tamara L. Clements, Christina E. Douglas, Suma Ravulapalli, Christopher P. Stefan, Charles J. Shoemaker, Mindy G. Elrod, Jay E. Gee, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, Nancy A. Twenhafel, David DeShazer","doi":"10.3201/eid3010.240084","DOIUrl":"https://doi.org/10.3201/eid3010.240084","url":null,"abstract":"<p>In the United States in 2021, an outbreak of 4 cases of <em>Burkholderia pseudomallei</em>, the etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse and subsequent harm), resulted in 2 deaths. The causative strain, <em>B. pseudomallei</em> ATS2021, was unintentionally imported into the United States in an aromatherapy spray manufactured in India. By analyzing virulence, we established that ATS2021 represents a virulent strain of <em>B. pseudomallei</em> capable of robust formation of biofilm at physiologic temperatures that may contribute to virulence. By using mouse melioidosis models, we determined median lethal dose estimates and analyzed the bacteriologic and histopathologic characters of the organism, particularly the potential neurologic pathogenesis that is probably associated with the <em>bimA<sub>Bm</sub></em> allele identified in <em>B. pseudomallei</em> strain ATS2021. Our data, combined with previous case reports and the identification of endemic <em>B. pseudomallei</em>strains in Mississippi, support the concept that melioidosis is emerging in the United States.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":11.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
