委内瑞拉疟疾患者CYP2D6基因型和伯氨喹治疗

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-08-04 DOI:10.3201/eid3109.250316

César Pacheco, Adán Hernández-Acosta, Narviz Pulido, Yvanna Ceballos, Daniel Saavedra, Cruz Gómez, Nancy Moreno, Flor Herrera

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引用次数: 0

摘要

我们检测了委内瑞拉96例疑似疟疾患者的CYP2D6*4和CYP2D6*基因型和代谢物表型，发现约25%的病例中存在中等或较差的代谢物表型。44例疟疾患者中有9例间日疟原虫复发。公共卫生当局应评估增加用于治疗的伯氨喹总剂量的益处。

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CYP2D6 Genotype and Primaquine Treatment in Patients with Malaria, Venezuela

We determined CYP2D6*4 and CYP2D6* genotypes and metabolizer phenotypes in 96 patients with suspected malaria in Venezuela and found intermediate or poor metabolizer phenotypes in ≈25% of cases. Nine of 44 malaria patients had Plasmodium vivax recurrence. Public health authorities should evaluate the benefits of increasing total doses of primaquine for treatment.

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.