SARS-CoV-2变体在动物物种中的ACE2受体使用情况

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-07-17 DOI:10.3201/eid3108.241844

Masato Hatta, Gloria P. Larson, Yasuko Hatta, Wei Wang, Nannan Jiang, Yu-Jin Jung, Li Wang, Xiaoyu Fan, Brenda M. Calderon, Gaston Bonenfant, Xudong Lin, Chenchen Feng, Dan Cui, Ginger Atteberry, Michael Currier, John Steel, David E. Wentworth, Bin Zhou

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引用次数: 0

摘要

我们分析了来自54种不同动物的6个代表性SARS-CoV-2细胞系表达血管紧张素转换酶2蛋白的受体结合活性和传染性。所有病毒在广泛的物种中都表现出传染性。易感动物可作为SARS-CoV-2的天然宿主或中间宿主。

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ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants

We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.