Emerging Infectious Diseases最新文献_第9页

Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241485

Valerie Le Sage, Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, Seema S. Lakdawala

{"title":"Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity","authors":"Valerie Le Sage, Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, Seema S. Lakdawala","doi":"10.3201/eid3103.241485","DOIUrl":"https://doi.org/10.3201/eid3103.241485","url":null,"abstract":"The emergence of highly pathogenic avian influenza A(H5N1) virus in dairy cattle herds across the United States in 2024 caused several human infections. Understanding the risk for spillover infections into humans is crucial for protecting public health. We investigated whether immunity from influenza A(H1N1)pdm09 (pH1N1) virus would provide protection from death and severe clinical disease among ferrets intranasally infected with H5N1 virus from dairy cows from the 2024 outbreak. We observed differential tissue tropism among pH1N1-immune ferrets. pH1N1-immune ferrets also had little H5N1 viral dissemination to organs outside the respiratory tract and much less H5N1 virus in nasal secretions and the respiratory tract than naive ferrets. In addition, ferrets with pH1N1 immunity produced antibodies that cross-reacted with H5N1 neuraminidase protein. Taken together, our results suggest that humans with immunity to human seasonal influenza viruses may experience milder disease from the 2024 influenza A(H5N1) virus strain.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"50 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241488

Danila Zimenkov, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, Natalia Stavitskaya

{"title":"High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia","authors":"Danila Zimenkov, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, Natalia Stavitskaya","doi":"10.3201/eid3103.241488","DOIUrl":"https://doi.org/10.3201/eid3103.241488","url":null,"abstract":"Bedaquiline is a cornerstone drug for treating drug-resistant tuberculosis. We analyzed 11 isolates from 9 patients who were treated with a bedaquiline-based regimen and remained culture-positive long after treatment start. In 4 of 8 resistant isolates, we found substitutions in AtpE, which encodes subunit c of the Mycobacterium tuberculosis ATP synthase and is rarely identified in clinical isolates. We found Ile66Met and Glu61Asp substitutions in 2 cases each. Additional mutations in mmpL5, mmpL4, and atpB genes could affect the susceptibility to bedaquiline. MmpL5(Asn772Thr) emerged during bedaquiline treatment, whereas AtpB(Val165Leu) was found in 1 case simultaneously with the loss-of-function mmpR5 mutation in a susceptible strain. The loss-of-function mutation in the mmpL4 efflux gene was identified in the mixed state, pointing to ongoing selection in a bedaquiline-resistant isolate. Another case of the emergence of the mmpL4 mutation, accompanied by a proportional increase in bedaquiline MIC, was identified by retrospective analysis of genomes from bedaquiline-resistant isolates.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"26 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241489

Xiangjie Sun, Jessica A. Belser, Zhu-Nan Li, Nicole Brock, Joanna A. Pulit-Penaloza, Troy J. Kieran, Claudia Pappas, Hui Zeng, Jessie C. Chang, Paul J. Carney, Brandon L. Bradley-Ferrell, James Stevens, Terrence M. Tumpey, Min Z. Levine, Taronna R. Maines

{"title":"Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model","authors":"Xiangjie Sun, Jessica A. Belser, Zhu-Nan Li, Nicole Brock, Joanna A. Pulit-Penaloza, Troy J. Kieran, Claudia Pappas, Hui Zeng, Jessie C. Chang, Paul J. Carney, Brandon L. Bradley-Ferrell, James Stevens, Terrence M. Tumpey, Min Z. Levine, Taronna R. Maines","doi":"10.3201/eid3103.241489","DOIUrl":"https://doi.org/10.3201/eid3103.241489","url":null,"abstract":"Reports of human infections with an influenza A(H5N1) clade 2.3.4.4b virus associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. We serologically evaluated ferrets previously infected with an influenza A(H1N1)pdm09 virus for cross-reactive antibodies and then challenged 3 months later with either highly pathogenic H5N1 clade 2.3.4.4b or low pathogenicity H7N9 virus. Our results showed that prior influenza A(H1N1)pdm09 virus infection more effectively reduced the replication and transmission of the H5N1 virus than did the H7N9 virus, a finding supported by the presence of group 1 hemagglutinin stalk and N1 neuraminidase antibodies in preimmune ferrets. Our findings suggest that prior influenza A(H1N1)pdm09 virus infection may confer some level of protection against influenza A(H5N1) clade 2.3.4.4.b virus.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"3 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corynebacterium diphtheriae Infections, South Africa, 2015–2023

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241211

Mignon du Plessis, Rito Mikhari, Linda de Gouveia, Noluthando Duma, Tamsin Lovelock, Charlene Lawrence, Prasha Mahabeer, Yesholata Mahabeer, Nevashan Govender, Susan Nzenze, Jonathan Featherston, Mishalan Moodley, Jocelyn Moyes, Sibongile Walaza, Cheryl Cohen, Anne von Gottberg

{"title":"Corynebacterium diphtheriae Infections, South Africa, 2015–2023","authors":"Mignon du Plessis, Rito Mikhari, Linda de Gouveia, Noluthando Duma, Tamsin Lovelock, Charlene Lawrence, Prasha Mahabeer, Yesholata Mahabeer, Nevashan Govender, Susan Nzenze, Jonathan Featherston, Mishalan Moodley, Jocelyn Moyes, Sibongile Walaza, Cheryl Cohen, Anne von Gottberg","doi":"10.3201/eid3103.241211","DOIUrl":"https://doi.org/10.3201/eid3103.241211","url":null,"abstract":"We reviewed Corynebacterium spp. infection cases reported in South Africa during 2015–2023. We analyzed 84 isolates from 83 patients with C. diphtheriae, as well as 1 C. belfantii and 3 C. ulcerans isolates. Among C. diphtheriae cases, we observed respiratory diphtheria (26/83 patients [31%]), endocarditis (14/83 [17%]), cutaneous diphtheria (22/83 [27%]), nonspecific respiratory illnesses (5/83 [6%]), and asymptomatic carriage (16/83 [19%]). The median patient age was 19 (range 0–88) years. Diphtheria-tetanus-pertussis vaccination was incomplete for 26% (5/19) or unknown for 68% (13/19) of children 0–9 years of age. C. diphtheriae was intermediately resistant to penicillin (82/84 [98%] isolates; MIC90 0.5 μg/mL) but susceptible to erythromycin (83/84 [99%] isolates; MIC90 0.25 μg/mL). Eighteen unique sequence types were identified, corroborating C. diphtheriae heterogeneity. Toxin-producing strains were detected among cutaneous and respiratory diphtheria cases, indicating all forms of disease require monitoring and prompt public health action to curb transmission.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"96 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National Active Case-Finding Program for Tuberculosis in Prisons, Peru, 2024

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241727

Esther Jung, Valentina A. Alarcón, Wilfredo Santos Solís Tupes, Tatiana Avalos-Cruz, Marco Tovar, Erika Abregu, Max Z. Yang, Jason R. Andrews, Moises A. Huaman

引用次数: 0

Amebiasis in Mexico, 2014-2023.

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-01 DOI: 10.3201/eid3102.241507

Alberto Antonio-Campos, Keity J Farfán-Pira, Alfonso D Díaz-Fonseca, Carlos Ochoa-Velasco, Paola Hernández-Carranza, Diana M Torres-Cifuentes

引用次数: 0

Bayou Hantavirus Cardiopulmonary Syndrome, Louisiana, USA, 2022-2023.

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-01 DOI: 10.3201/eid3102.241069

Emma Ortega, Sean Simonson, Elizabeth Shedroff, Shannon Whitmer, Amy Whitesell, Mary J Choi, Trevor Shoemaker, Joel M Montgomery, John D Klena, Joseph Hennig, Theresa Sokol

引用次数: 0

Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England.

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-01 DOI: 10.3201/eid3102.240880

Matthew A Davies, Brechje de Gier, Rebecca L Guy, Juliana Coelho, Alje P van Dam, Robin van Houdt, Sébastien Matamoros, Marit van den Berg, Patrick E Habermehl, Kartyk Moganeradj, Yan Ryan, Steve Platt, Henry Hearn, Eleanor Blakey, Darren Chooneea, Bart J M Vlaminckx, Theresa Lamagni, Nina M van Sorge

{"title":"Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England.","authors":"Matthew A Davies, Brechje de Gier, Rebecca L Guy, Juliana Coelho, Alje P van Dam, Robin van Houdt, Sébastien Matamoros, Marit van den Berg, Patrick E Habermehl, Kartyk Moganeradj, Yan Ryan, Steve Platt, Henry Hearn, Eleanor Blakey, Darren Chooneea, Bart J M Vlaminckx, Theresa Lamagni, Nina M van Sorge","doi":"10.3201/eid3102.240880","DOIUrl":"10.3201/eid3102.240880","url":null,"abstract":"A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines in iGAS incidence during the summer of 2023, simultaneous, rapid expansion of a previously rare emm type 3.93 was seen beginning in November, increasing to 20% of all cases in England and 60% of all cases in the Netherlands within 4 months. emm3.93 was associated with iGAS in children 6-17 years of age and with increased risk for pneumonia or pleural empyema and meningitis in both countries. No excess risk of death was identified for emm3.93 compared with other types. Genomic analysis of historic and contemporary emm3.93 isolates revealed the emergence of 3 new clades with a potentially advantageous genomic configuration. Our findings demonstrate the value of molecular surveillance, including long-read sequencing, in identifying clinical and public health threats.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 2","pages":"229-236"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclospora Genotypic Variations and Associated Epidemiologic Characteristics, United States, 2018-2021.

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-01 DOI: 10.3201/eid3102.240399

John Shen, Vitaliano A Cama, David Jacobson, Joel Barratt, Anne Straily

{"title":"Cyclospora Genotypic Variations and Associated Epidemiologic Characteristics, United States, 2018-2021.","authors":"John Shen, Vitaliano A Cama, David Jacobson, Joel Barratt, Anne Straily","doi":"10.3201/eid3102.240399","DOIUrl":"10.3201/eid3102.240399","url":null,"abstract":"Seasonal cyclosporiasis outbreaks occur in the United States every year. To better understand the disease, the Centers for Disease Control and Prevention developed a novel genotyping system that successfully clusters nonclonal eukaryotes. We examined temporal-geographic distributions of Cyclospora cluster consensus genotypes (CCGs) and applied regression analyses to identify correlations between Cyclospora spp. parasites and clinical manifestations or epidemiologic risk factors, using data collected during 2018-2021. No CCG was uniquely associated with or consistently detected in a state during the study, suggesting that cyclosporiasis in the United States is likely caused by frequent parasite introductions. We identified positive associations between infection with C. ashfordi and C. cayetanensis and consumption of specific produce items: cilantro, mango, and onion for C. ashfordi and iceberg lettuce, carrot, and cauliflower for C. cayetanensis. Our findings can guide future research into public health interventions aimed at reducing the burden of cyclosporiasis in the United States.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 2","pages":"256-266"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National Surveillance of Human Ehrlichiosis Caused by Ehrlichia ewingii, United States, 2013-2021.

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-01 DOI: 10.3201/eid3102.240279

Sydney N Adams, Nicolette C Bestul, Kimberly N Calloway, Gilbert J Kersh, Johanna S Salzer

{"title":"National Surveillance of Human Ehrlichiosis Caused by Ehrlichia ewingii, United States, 2013-2021.","authors":"Sydney N Adams, Nicolette C Bestul, Kimberly N Calloway, Gilbert J Kersh, Johanna S Salzer","doi":"10.3201/eid3102.240279","DOIUrl":"10.3201/eid3102.240279","url":null,"abstract":"Human ehrlichiosis is a potentially fatal tickborne disease caused by 3 species: Ehrlichia chaffeensis, E. ewingii, and E. muris eauclairensis. In the United States, 234 confirmed cases of E. ewingii ehrlichiosis were reported to the Centers for Disease Control and Prevention through the National Notifiable Diseases Surveillance System during 2013-2021; average annual incidence was 0.08 cases/1 million population. E. ewingii ehrlichiosis was reported more commonly among older, White, non-Hispanic, and male patients. Incidence and case counts generally increased yearly, except for 2020 and 2021. The highest number of cases were reported from Missouri and Arkansas. We report the geographic expansion of E. ewingii ehrlichiosis and the continued public health challenge of clarifying clinical manifestations of this infection. Clinician education will be essential to implement molecular assays to properly diagnose E. ewingii infection in patients and gain a better understanding of the epidemiology of this emerging disease.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 2","pages":"222-227"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0