Tonje Skarpengland, Anders A. Tveita, Christopher F. Berntsen, Erik. E. Christensen, Magnhild E. Macpherson, Birgitte Stiksrud, Nils O. Hermansen, Pitt F. Niehusmann, Tine S. Oldereid, Espen Stjernstrøm, Hanne Brekke, Henrik V. Nielsen, Frank O.D. Pettersen
{"title":"Neurosarcocystosis in Patient with HIV-Induced Immunodeficiency","authors":"Tonje Skarpengland, Anders A. Tveita, Christopher F. Berntsen, Erik. E. Christensen, Magnhild E. Macpherson, Birgitte Stiksrud, Nils O. Hermansen, Pitt F. Niehusmann, Tine S. Oldereid, Espen Stjernstrøm, Hanne Brekke, Henrik V. Nielsen, Frank O.D. Pettersen","doi":"10.3201/eid3103.241361","DOIUrl":"https://doi.org/10.3201/eid3103.241361","url":null,"abstract":"<p><em>Sarcocystis</em> is a genus of protozoan parasites that can infect various vertebrates. In humans, <em>Sarcocystis</em> infection usually is asymptomatic but might manifest as a mild gastroenteritis or extraintestinal myositis. We report a case of human central nervous system infection in Norway caused by <em>S. nesbitti</em> parasites.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"26 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Ewing, Sydney Haldeman, Megan J. Job, Caitlin Otto, Adam J. Ratner
{"title":"Haemophilus influenzae Type b Meningitis in Infants, New York, New York, USA, 2022–2023","authors":"Anne Ewing, Sydney Haldeman, Megan J. Job, Caitlin Otto, Adam J. Ratner","doi":"10.3201/eid3103.240946","DOIUrl":"https://doi.org/10.3201/eid3103.240946","url":null,"abstract":"<p>Two unvaccinated infants residing in the same borough of New York, New York, USA, had <em>Haemophilus influenzae</em> type b meningitis develop 1 year apart. Whole-genome sequencing and phylogenetic analysis revealed the isolates shared a previously undescribed multilocus sequence type and were more closely related to each other than to other sequenced strains.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"26 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youxing Shao, Mingliang Chen, Jiehao Cai, Yohei Doi, Min Chen, Minggui Wang, Mei Zeng, Qinglan Guo
{"title":"Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis","authors":"Youxing Shao, Mingliang Chen, Jiehao Cai, Yohei Doi, Min Chen, Minggui Wang, Mei Zeng, Qinglan Guo","doi":"10.3201/eid3103.241493","DOIUrl":"https://doi.org/10.3201/eid3103.241493","url":null,"abstract":"<p>We explored the role of commensal <em>Neisseria</em> in the emergence of third-generation cephalosporin-resistant <em>N. meningitidis</em>. Cefotaxime resistance–conferring <em>penA795</em> was prevalent among commensal <em>Neisseria</em> isolates in Shanghai, China, and was acquired by a serogroup C quinolone-resistant sequence type 4821 <em>N. meningitidis,</em> Nm507, causing fulminant meningitis in an unvaccinated 2-year-old child.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"33 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerie Le Sage, Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, Seema S. Lakdawala
{"title":"Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity","authors":"Valerie Le Sage, Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, Seema S. Lakdawala","doi":"10.3201/eid3103.241485","DOIUrl":"https://doi.org/10.3201/eid3103.241485","url":null,"abstract":"<p>The emergence of highly pathogenic avian influenza A(H5N1) virus in dairy cattle herds across the United States in 2024 caused several human infections. Understanding the risk for spillover infections into humans is crucial for protecting public health. We investigated whether immunity from influenza A(H1N1)pdm09 (pH1N1) virus would provide protection from death and severe clinical disease among ferrets intranasally infected with H5N1 virus from dairy cows from the 2024 outbreak. We observed differential tissue tropism among pH1N1-immune ferrets. pH1N1-immune ferrets also had little H5N1 viral dissemination to organs outside the respiratory tract and much less H5N1 virus in nasal secretions and the respiratory tract than naive ferrets. In addition, ferrets with pH1N1 immunity produced antibodies that cross-reacted with H5N1 neuraminidase protein. Taken together, our results suggest that humans with immunity to human seasonal influenza viruses may experience milder disease from the 2024 influenza A(H5N1) virus strain.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"50 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Prevalence of atpE Mutations in Bedaquiline-Resistant Mycobacterium tuberculosis Isolates, Russia","authors":"Danila Zimenkov, Anastasia Ushtanit, Elizaveta Gordeeva, Elena Guselnikova, Yakov Schwartz, Natalia Stavitskaya","doi":"10.3201/eid3103.241488","DOIUrl":"https://doi.org/10.3201/eid3103.241488","url":null,"abstract":"<p>Bedaquiline is a cornerstone drug for treating drug-resistant tuberculosis. We analyzed 11 isolates from 9 patients who were treated with a bedaquiline-based regimen and remained culture-positive long after treatment start. In 4 of 8 resistant isolates, we found substitutions in AtpE, which encodes subunit <em>c</em> of the <em>Mycobacterium tuberculosis</em> ATP synthase and is rarely identified in clinical isolates. We found Ile66Met and Glu61Asp substitutions in 2 cases each. Additional mutations in <em>mmpL5</em>, <em>mmpL4</em>, and <em>atpB</em> genes could affect the susceptibility to bedaquiline. MmpL5(Asn772Thr) emerged during bedaquiline treatment, whereas AtpB(Val165Leu) was found in 1 case simultaneously with the loss-of-function <em>mmpR5</em> mutation in a susceptible strain. The loss-of-function mutation in the <em>mmpL4</em> efflux gene was identified in the mixed state, pointing to ongoing selection in a bedaquiline-resistant isolate. Another case of the emergence of the <em>mmpL4</em> mutation, accompanied by a proportional increase in bedaquiline MIC, was identified by retrospective analysis of genomes from bedaquiline-resistant isolates.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"26 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiangjie Sun, Jessica A. Belser, Zhu-Nan Li, Nicole Brock, Joanna A. Pulit-Penaloza, Troy J. Kieran, Claudia Pappas, Hui Zeng, Jessie C. Chang, Paul J. Carney, Brandon L. Bradley-Ferrell, James Stevens, Terrence M. Tumpey, Min Z. Levine, Taronna R. Maines
{"title":"Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model","authors":"Xiangjie Sun, Jessica A. Belser, Zhu-Nan Li, Nicole Brock, Joanna A. Pulit-Penaloza, Troy J. Kieran, Claudia Pappas, Hui Zeng, Jessie C. Chang, Paul J. Carney, Brandon L. Bradley-Ferrell, James Stevens, Terrence M. Tumpey, Min Z. Levine, Taronna R. Maines","doi":"10.3201/eid3103.241489","DOIUrl":"https://doi.org/10.3201/eid3103.241489","url":null,"abstract":"<p>Reports of human infections with an influenza A(H5N1) clade 2.3.4.4b virus associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. We serologically evaluated ferrets previously infected with an influenza A(H1N1)pdm09 virus for cross-reactive antibodies and then challenged 3 months later with either highly pathogenic H5N1 clade 2.3.4.4b or low pathogenicity H7N9 virus. Our results showed that prior influenza A(H1N1)pdm09 virus infection more effectively reduced the replication and transmission of the H5N1 virus than did the H7N9 virus, a finding supported by the presence of group 1 hemagglutinin stalk and N1 neuraminidase antibodies in preimmune ferrets. Our findings suggest that prior influenza A(H1N1)pdm09 virus infection may confer some level of protection against influenza A(H5N1) clade 2.3.4.4.b virus.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"3 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mignon du Plessis, Rito Mikhari, Linda de Gouveia, Noluthando Duma, Tamsin Lovelock, Charlene Lawrence, Prasha Mahabeer, Yesholata Mahabeer, Nevashan Govender, Susan Nzenze, Jonathan Featherston, Mishalan Moodley, Jocelyn Moyes, Sibongile Walaza, Cheryl Cohen, Anne von Gottberg
{"title":"Corynebacterium diphtheriae Infections, South Africa, 2015–2023","authors":"Mignon du Plessis, Rito Mikhari, Linda de Gouveia, Noluthando Duma, Tamsin Lovelock, Charlene Lawrence, Prasha Mahabeer, Yesholata Mahabeer, Nevashan Govender, Susan Nzenze, Jonathan Featherston, Mishalan Moodley, Jocelyn Moyes, Sibongile Walaza, Cheryl Cohen, Anne von Gottberg","doi":"10.3201/eid3103.241211","DOIUrl":"https://doi.org/10.3201/eid3103.241211","url":null,"abstract":"<p>We reviewed <em>Corynebacterium</em> spp. infection cases reported in South Africa during 2015–2023. We analyzed 84 isolates from 83 patients with <em>C. diphtheriae</em>, as well as 1 <em>C. belfantii</em> and 3 <em>C. ulcerans</em> isolates. Among <em>C. diphtheriae</em> cases, we observed respiratory diphtheria (26/83 patients [31%]), endocarditis (14/83 [17%]), cutaneous diphtheria (22/83 [27%]), nonspecific respiratory illnesses (5/83 [6%]), and asymptomatic carriage (16/83 [19%]). The median patient age was 19 (range 0–88) years. Diphtheria-tetanus-pertussis vaccination was incomplete for 26% (5/19) or unknown for 68% (13/19) of children 0–9 years of age. <em>C. diphtheriae</em> was intermediately resistant to penicillin (82/84 [98%] isolates; MIC<sub>90</sub> 0.5 μg/mL) but susceptible to erythromycin (83/84 [99%] isolates; MIC<sub>90</sub> 0.25 μg/mL). Eighteen unique sequence types were identified, corroborating <em>C. diphtheriae</em> heterogeneity. Toxin-producing strains were detected among cutaneous and respiratory diphtheria cases, indicating all forms of disease require monitoring and prompt public health action to curb transmission.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"96 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther Jung, Valentina A. Alarcón, Wilfredo Santos Solís Tupes, Tatiana Avalos-Cruz, Marco Tovar, Erika Abregu, Max Z. Yang, Jason R. Andrews, Moises A. Huaman
{"title":"National Active Case-Finding Program for Tuberculosis in Prisons, Peru, 2024","authors":"Esther Jung, Valentina A. Alarcón, Wilfredo Santos Solís Tupes, Tatiana Avalos-Cruz, Marco Tovar, Erika Abregu, Max Z. Yang, Jason R. Andrews, Moises A. Huaman","doi":"10.3201/eid3103.241727","DOIUrl":"https://doi.org/10.3201/eid3103.241727","url":null,"abstract":"<p>During January–September 2024, a national active case-finding program in Peru’s prisons screened >38,000 persons for tuberculosis (TB) using chest radiography with automated interpretation and rapid molecular tests. The program found high percentages of TB, rifampin-resistant TB, and asymptomatic infections, demonstrating the urgent need for systematic screening among incarcerated populations.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"3 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Antonio-Campos, Keity J Farfán-Pira, Alfonso D Díaz-Fonseca, Carlos Ochoa-Velasco, Paola Hernández-Carranza, Diana M Torres-Cifuentes
{"title":"Amebiasis in Mexico, 2014-2023.","authors":"Alberto Antonio-Campos, Keity J Farfán-Pira, Alfonso D Díaz-Fonseca, Carlos Ochoa-Velasco, Paola Hernández-Carranza, Diana M Torres-Cifuentes","doi":"10.3201/eid3102.241507","DOIUrl":"10.3201/eid3102.241507","url":null,"abstract":"<p><p>Amebiasis remains a public health challenge in Mexico, especially in areas with poor sanitation. Despite declining prevalence (2014-2023), hotspots persist because of socioeconomic factors such as poverty. Addressing regional disparities through targeted interventions, improved infrastructure, and education is crucial to further reduce the disease burden and prevent future outbreaks.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 2","pages":"359-362"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emma Ortega, Sean Simonson, Elizabeth Shedroff, Shannon Whitmer, Amy Whitesell, Mary J Choi, Trevor Shoemaker, Joel M Montgomery, John D Klena, Joseph Hennig, Theresa Sokol
{"title":"Bayou Hantavirus Cardiopulmonary Syndrome, Louisiana, USA, 2022-2023.","authors":"Emma Ortega, Sean Simonson, Elizabeth Shedroff, Shannon Whitmer, Amy Whitesell, Mary J Choi, Trevor Shoemaker, Joel M Montgomery, John D Klena, Joseph Hennig, Theresa Sokol","doi":"10.3201/eid3102.241069","DOIUrl":"10.3201/eid3102.241069","url":null,"abstract":"<p><p>During 2020-2023, we sequenced Bayou virus from 2 patients in Louisiana, USA, with hantavirus cardiopulmonary syndrome. Direct virus sequencing demonstrated an inferred evolutionary relationship to previous cases. Our findings demonstrate that separate virus spillovers cause isolated cases and probable wide distribution of Bayou hantavirus in rodents across Louisiana.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 2","pages":"401-403"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}