Emerging Infectious Diseases最新文献_第10页

Metagenomic Identification of Fusarium solani Strain as Cause of US Fungal Meningitis Outbreak Associated with Surgical Procedures in Mexico, 2023 2023年墨西哥外科手术引起的美国真菌脑膜炎暴发的起因——茄枯菌的宏基因组鉴定

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-03 DOI: 10.3201/eid3105.241657

Charles Y. Chiu, Venice Servellita, Mikael de Lorenzi-Tognon, Patrick Benoit, Nanami Sumimoto, Abiodun Foresythe, Filipe M. Cerqueira, Natalie Williams-Bouyer, Ping Ren, Lauren Nicholas S. Herrera, David C. Gaston, Leanna Sayyad, Shannon L. Whitmer, John Klena, Holenarasipur R. Vikram, Jeremy A.W. Gold, Lalitha Gade, Lindsay Parnell, Elizabeth Misas, Tom M. Chiller, Isabel S. Griffin, Sridhar V. Basavaraju, Dallas J. Smith, Anastasia P. Litvintseva, Nancy A. Chow

{"title":"Metagenomic Identification of Fusarium solani Strain as Cause of US Fungal Meningitis Outbreak Associated with Surgical Procedures in Mexico, 2023","authors":"Charles Y. Chiu, Venice Servellita, Mikael de Lorenzi-Tognon, Patrick Benoit, Nanami Sumimoto, Abiodun Foresythe, Filipe M. Cerqueira, Natalie Williams-Bouyer, Ping Ren, Lauren Nicholas S. Herrera, David C. Gaston, Leanna Sayyad, Shannon L. Whitmer, John Klena, Holenarasipur R. Vikram, Jeremy A.W. Gold, Lalitha Gade, Lindsay Parnell, Elizabeth Misas, Tom M. Chiller, Isabel S. Griffin, Sridhar V. Basavaraju, Dallas J. Smith, Anastasia P. Litvintseva, Nancy A. Chow","doi":"10.3201/eid3105.241657","DOIUrl":"https://doi.org/10.3201/eid3105.241657","url":null,"abstract":"We used metagenomic next-generation sequencing (mNGS) to investigate an outbreak of Fusarium solani meningitis in US patients who had surgical procedures under spinal anesthesia in Matamoros, Mexico, during 2023. Using a novel method called metaMELT (metagenomic multiple extended locus typing), we performed phylogenetic analysis of concatenated mNGS reads from 4 patients (P1–P4) in parallel with reads from 28 fungal reference genomes. Fungal strains from the 4 patients were most closely related to each other and to 2 cultured isolates from P1 and an additional case (P5), suggesting that all cases arose from a point source exposure. Our findings support epidemiologic data implicating a contaminated drug or device used for epidural anesthesia as the likely cause of the outbreak. In addition, our findings show that the benefits of mNGS extend beyond diagnosis of infections to public health outbreak investigation.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-Time Use of Mpox Genomic Surveillance, King County, Washington, USA, 2022–2024 实时使用m痘基因组监测，华盛顿金县，美国，2022-2024

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 DOI: 10.3201/eid3113.241242

Kathryn M. Lau, Michaela Banks, Kaila Bryant, Joanie D. Lambert, Laura Marcela Torres, Stephanie M. Lunn, Cory Yun, Pavitra Roychoudhury, B. Ethan Nunley, Jaydee Sereewit, Alexander L. Greninger, Allison Black, Vance Kawakami, Sargis Pogosjans, Elysia Gonzales, Eric J. Chow

引用次数: 0

Antiviral Susceptibility of Influenza A(H5N1) Clade 2.3.2.1c and 2.3.4.4b Viruses from Humans, 2023-2024. 2023-2024年甲型流感（H5N1）进化支2.3.2.1c和2.3.4.4b病毒对人类的抗病毒敏感性

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 Epub Date: 2024-03-10 DOI: 10.3201/eid3104.241820

Philippe Noriel Q Pascua, Anton Chesnokov, Ha T Nguyen, Han Di, Juan De La Cruz, Yunho Jang, Andrei A Ivashchenko, Alexandre V Ivachtchenko, Erik A Karlsson, Borann Sar, Chin Savuth, Timothy M Uyeki, Charles Todd Davis, Larisa V Gubareva

{"title":"Antiviral Susceptibility of Influenza A(H5N1) Clade 2.3.2.1c and 2.3.4.4b Viruses from Humans, 2023-2024.","authors":"Philippe Noriel Q Pascua, Anton Chesnokov, Ha T Nguyen, Han Di, Juan De La Cruz, Yunho Jang, Andrei A Ivashchenko, Alexandre V Ivachtchenko, Erik A Karlsson, Borann Sar, Chin Savuth, Timothy M Uyeki, Charles Todd Davis, Larisa V Gubareva","doi":"10.3201/eid3104.241820","DOIUrl":"10.3201/eid3104.241820","url":null,"abstract":"During 2023-2024, highly pathogenic avian influenza A(H5N1) viruses from clade 2.3.2.1c caused human infections in Cambodia and from clade 2.3.4.4b caused human infections in the Americas. We assessed the susceptibility of those viruses to approved and investigational antiviral drugs. Except for 2 viruses isolated from Cambodia, all viruses were susceptible to M2 ion channel-blockers in cell culture-based assays. In the neuraminidase inhibition assay, all viruses displayed susceptibility to neuraminidase inhibitor antiviral drugs oseltamivir, zanamivir, peramivir, laninamivir, and AV5080. Oseltamivir was ≈4-fold less potent at inhibiting the neuraminidase activity of clade 2.3.4.4b than clade 2.3.2.1c viruses. All viruses were susceptible to polymerase inhibitors baloxavir and tivoxavir and to polymerase basic 2 inhibitor pimodivir with 50% effective concentrations in low nanomolar ranges. Because drug-resistant viruses can emerge spontaneously or by reassortment, close monitoring of antiviral susceptibility of H5N1 viruses collected from animals and humans by using sequence-based analysis supplemented with phenotypic testing is essential.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 4","pages":"751-760"},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutralizing Antibody Response to Influenza A(H5N1) Virus in Dairy Farm Workers, Michigan, USA. 美国密西根州奶牛场工人对甲型H5N1流感病毒的中和抗体反应

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 Epub Date: 2024-03-07 DOI: 10.3201/eid3104.250007

Min Z Levine, Feng Liu, Natasha Bagdasarian, Crystal Holiday, Stacie Jefferson, Zhu-Nan Li, Claudia Pappas, Terrence Tumpey, Timothy M Uyeki, Alexandra M Mellis, Krista Kniss, Joseph Coyle, Seth Eckel, Jeremy Kuo, Meghan Weinberg, Sarah Lyon-Callo, Lisa Mikesell, Becky Stoddard, Jennifer Morse

引用次数: 0

Population-Based Matched Cohort Study of COVID-19 Healthcare Costs, Ontario, Canada. 加拿大安大略省基于人群的COVID-19医疗成本匹配队列研究

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 DOI: 10.3201/eid3104.241463

Beate Sander, Sharmistha Mishra, Sarah Swayze, Yeva Sahakyan, Raquel Duchen, Kieran Quinn, Naveed Janjua, Hind Sbihi, Jeffrey Kwong

{"title":"Population-Based Matched Cohort Study of COVID-19 Healthcare Costs, Ontario, Canada.","authors":"Beate Sander, Sharmistha Mishra, Sarah Swayze, Yeva Sahakyan, Raquel Duchen, Kieran Quinn, Naveed Janjua, Hind Sbihi, Jeffrey Kwong","doi":"10.3201/eid3104.241463","DOIUrl":"10.3201/eid3104.241463","url":null,"abstract":"Estimates of COVID-19-related healthcare costs are key to health system planning, but attributable cost data remain limited. We characterized healthcare costs attributable to COVID-19 through a population-based matched cohort study in Ontario, Canada, by using health administrative data. We matched SARS-CoV-2-positive persons from 2020 to unexposed historical control persons from 2016-2018. We estimated phase-based and survival-adjusted COVID-19-attributable healthcare costs from the health system perspective. We matched 159,817 persons. Mean (95% CI) attributable 10-day costs per person were $1 ($-4 to $6) preindex, $240 ($231-$249) during acute care, $18 ($14-$21) in postacute phases, $3,928 ($3,471-$4,384) in the terminal phase for early deaths, and $1,781 ($1,182-$2,380) for late deaths. Mean cumulative survival-adjusted cost at 360 days was $2,553 ($2,348-$2,756) per person. SARS-CoV-2 infection is associated with substantial long-term healthcare costs, consistent with understanding of post-COVID condition. Determining phase-specific costs can inform budget and pandemic planning.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 4","pages":"710-719"},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies and Opportunities to Improve Community Health through Advanced Molecular Detection and Genomic Surveillance of Infectious Diseases 通过传染病的先进分子检测和基因组监测改善社区健康的战略和机会

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 DOI: 10.3201/eid3113.241408

Jazmyn Moore, Ruth Sanon, Yury Khudyakov, Nathelia Barnes

引用次数: 0

Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA. 美国蒙大拿州人血清样品中加利福尼亚正布尼亚病毒血清群中和抗体

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 DOI: 10.3201/eid3104.241520

Tyson A Woods, Stephen F Johnson, Alyssa B Evans, Karin E Peterson

{"title":"Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA.","authors":"Tyson A Woods, Stephen F Johnson, Alyssa B Evans, Karin E Peterson","doi":"10.3201/eid3104.241520","DOIUrl":"10.3201/eid3104.241520","url":null,"abstract":"Viral encephalitis is often underreported and undiagnosed. To understand the potential causes of viral encephalitis in the state of Montana, USA, we examined the relative incidence of human infections for the California serogroup (CSG) of Orthobunyaviruses by screening random convenience serum samples obtained from different hospitals across Montana. We initially screened deidentified samples for neutralizing antibodies against Jamestown Canyon virus (JCV), a CSG virus that has caused encephalitis in Montana. We then analyzed JCV-positive samples for neutralization of other CSG viruses, and detected neutralizing antibodies against La Crosse virus, California encephalitis virus, and Trivittatus virus. We also found a high level of cross-reactivity, particularly between JCV and California encephalitis virus. Our findings indicate that the relative CSG virus infection rates in humans are quite high, between 21% and 40%. Clinicians should consider CSG viruses in differential diagnosis for cases of encephalitis of unknown etiology in Montana.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 4","pages":"699-709"},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oz Virus Infection in 6 Animal Species, Including Macaques, Bears, and Companion Animals, Japan. 6种动物的奥兹病毒感染，包括猕猴、熊和伴侣动物，日本。

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 DOI: 10.3201/eid3104.241574

Aya Matsuu, Kango Tatemoto, Keita Ishijima, Ayano Nishino, Yusuke Inoue, Eunsil Park, Hiroo Tamatani, Junji Seto, Hideo Higashi, Yuichi Fukui, Takashi Noma, Kandai Doi, Rumiko Nakashita, Haruhiko Isawa, Shinji Kasai, Ken Maeda

{"title":"Oz Virus Infection in 6 Animal Species, Including Macaques, Bears, and Companion Animals, Japan.","authors":"Aya Matsuu, Kango Tatemoto, Keita Ishijima, Ayano Nishino, Yusuke Inoue, Eunsil Park, Hiroo Tamatani, Junji Seto, Hideo Higashi, Yuichi Fukui, Takashi Noma, Kandai Doi, Rumiko Nakashita, Haruhiko Isawa, Shinji Kasai, Ken Maeda","doi":"10.3201/eid3104.241574","DOIUrl":"10.3201/eid3104.241574","url":null,"abstract":"Oz virus (OZV) was isolated from an Amblyomma tick in Japan and shown to cause lethal viral myocarditis in humans. However, the natural reservoirs and the distribution of OZV remain unknown. We describe epidemiologic studies conducted by using serum samples collected from mammals throughout Japan. The results showed that 27.5% of wild boars, 56.1% of Sika deer, 19.6% of Japanese macaques, and 51.0% of Asian black bears were positive for virus-neutralizing antibodies against OZV. Approximately 2.8% of dogs and 1.0% of cats also were seropositive. OZV RNA was not detected in any of the examined animal serum samples. Most seropositive animals were distributed in central and western Japan. OZV infects a wide range of animal species, including companion animals and nonhuman primates, and is distributed through central and western Japan, suggesting that further countermeasures are required to prevent this tickborne zoonotic infection.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 4","pages":"720-727"},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-Circulation of 2 Oropouche Virus Lineages during Outbreak, Amazon Region of Peru, 2023-2024. 2023-2024年秘鲁亚马逊地区暴发期间2种Oropouche病毒谱系的共同传播

IF 7.2 2区医学

Emerging Infectious Diseases Pub Date : 2025-04-01 Epub Date: 2024-03-10 DOI: 10.3201/eid3104.241748

Cristhopher D Cruz, Victoria Espejo, Angelica Espinoza, Roger M Castillo-Oré, Gilda Troncos, Julia S Ampuero, Maria E Silva

引用次数: 0

Correction: Vol. 31, No. 3 更正：第31卷，第3号

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-03-26 DOI: 10.3201/eid3105.c13105

引用次数: 0