Emerging Infectious Diseases最新文献_第10页

Diphtheria Outbreak among Persons Experiencing Homelessness, 2023, Linked to 2022 Diphtheria Outbreak, Frankfurt am Main, Germany 2023年无家可归者中爆发白喉，与2022年白喉爆发有关，德国美因河畔法兰克福

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-24 DOI: 10.3201/eid3103.241217

Jonas Haller, Anja Berger, Alexandra Dangel, Katja Bengs, Imke Friedrichs, Christian Kleine, Dorothee Schmidt, Maria Goetzens, Udo Goetsch, Michael Hogardt, Andreas Sing

{"title":"Diphtheria Outbreak among Persons Experiencing Homelessness, 2023, Linked to 2022 Diphtheria Outbreak, Frankfurt am Main, Germany","authors":"Jonas Haller, Anja Berger, Alexandra Dangel, Katja Bengs, Imke Friedrichs, Christian Kleine, Dorothee Schmidt, Maria Goetzens, Udo Goetsch, Michael Hogardt, Andreas Sing","doi":"10.3201/eid3103.241217","DOIUrl":"https://doi.org/10.3201/eid3103.241217","url":null,"abstract":"After 3 cases of Corynebacterium diphtheriae infection associated with intravenous drug use among persons experiencing homelessness (PEH) were reported to the Health Protection Authority in Frankfurt am Main, Germany, in 2023, we examined pathogen spread among PEH. Furthermore, we investigated a possible link with the 2022 outbreak of diphtheria in Europe. From swab samples collected during August–November 2023 from 36 PEH and cutaneous lesions, we detected 3 additional cases of cutaneous toxigenic C. diphtheriae. Sequence type 574 was identified in 5 case-isolates and is genetically associated with 1 of the predominant clusters in identified in the 2022 outbreak. Our findings demonstrate the need for increased detection and monitoring of cutaneous diphtheria and boosting immunity against diphtheria in groups with increased risk for infection. Genomic analyses are valuable for identifying genetic relationships between outbreaks, even when epidemiologic data are scarce.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"2 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment 大剂量异烟肼治疗耐多药结核病的疗效评价

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241473

Valentina Gerussi, Tania Petersen, Isabelle Bonnet, Alexandra Aubry, Marwa Bachir, Esther Gyde, Florence Morel, Corentin Poignon, Brigitte Rached, Valérie Pourcher, Christophe Rioux, Dorothée Vallois, Nicolas Veziris, Jérôme Robert, Lorenzo Guglielmetti

引用次数: 0

Candida auris Outbreak and Epidemiologic Response in Burn Intensive Care Unit, Illinois, United States, 2021–2023 2021-2023年美国伊利诺伊州烧伤重症监护病房的耳念珠菌暴发和流行病学反应

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241195

Hannah J. Barbian, Louise Lie, Alyse Kittner, Amanda Harrington, Joshua Carson, Mabel Frias, David H. Slade, Do Young Kim, Stephanie Black, Jorge P. Parada, Mary K. Hayden

{"title":"Candida auris Outbreak and Epidemiologic Response in Burn Intensive Care Unit, Illinois, United States, 2021–2023","authors":"Hannah J. Barbian, Louise Lie, Alyse Kittner, Amanda Harrington, Joshua Carson, Mabel Frias, David H. Slade, Do Young Kim, Stephanie Black, Jorge P. Parada, Mary K. Hayden","doi":"10.3201/eid3103.241195","DOIUrl":"https://doi.org/10.3201/eid3103.241195","url":null,"abstract":"Candida auris is an emerging fungal pathogen associated with outbreaks in healthcare settings. We report a multiyear outbreak of C. auris in a burn intensive care unit in Illinois, USA, during 2021–2023. We identified 28 C. auris cases in the unit over a 2-year period, despite outbreak response and multimodal mitigation measures. Of the 28 case-patients, 15 (53.6%) were considered colonized and 13 (46.4%) had clinical infections. Phylogenetic analysis of whole-genome sequences revealed 4 distinct clusters of closely related (0–6 SNP differences) genomes containing 3–6 cases. Clusters generally contained temporally related isolates from patients with epidemiologic links; this finding suggests that multiple introductions and within-unit spread over a limited time were responsible for the outbreak, rather than transmission from a long-term source (e.g., persistent environmental contamination or staff carriage). Here, integrated traditional and genomic epidemiology supported C. auris outbreak investigation and response and informed targeted interventions.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"28 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium ulcerans in Possum Feces before Emergence in Humans, Australia 负鼠粪便中的溃疡分枝杆菌在人类中出现之前，澳大利亚

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.240657

Bridgette J. McNamara, Jack Cornish, Kim R. Blasdell, Eugene Athan, Naomi E. Clarke, Tiffany Pe, Mohammad Akhtar Hussain, Michael Muleme, Ee Laine Tay, Michael Dunn, Victoria Boyd, Anjana Karawita, Daniel P. O’Brien

引用次数: 0

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006–2022 2006-2022年，阿根廷北部由多药耐药结核分枝杆菌引起的罕见耐药突变组合暴发

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241272

Roxana Paul, Federico Lorenzo, Beatriz López, María Gabriela Alegre, David Couvin, Nalin Rastogi, Laura Pérez-Lago, Darío García de Viedma, Ana Gamberale, Norma González, Domingo Palmero, Silvia Altabe, Norberto Simboli, Noemí Kaoru Yokobori

引用次数: 0

Simultaneous Detection of Sarcocystis hominis, S. heydorni, and S. sigmoideus in Human Intestinal Sarcocystosis, France, 2021–2024 人肠肌囊虫病中人肉囊虫、海氏梭菌和乙形梭菌的同时检测，法国，2021-2024

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241640

Maxime Moniot, Patricia Combes, Damien Costa, Nicolas Argy, Marie-Fleur Durieux, Thomas Nicol, Céline Nourrisson, Philippe Poirier

引用次数: 0

A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain 西班牙儿童非结核性分枝杆菌淋巴结炎28年多中心队列研究

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241254

Aina Martínez-Planas, Fernando Baquero-Artigao, Ana Méndez-Echevarría, Teresa Del Rosal, Paula Rodríguez-Molino, Carlos Toro-Rueda, Matilde Bustillo-Alonso, Miguel Lafuente, Anna Canet, Ángela Manzanares, Alfredo Tagarro, Francisco José Sanz-Santaeufemia, Sara Guillén-Martín, María José Cilleruelo, Lola Falcón-Neyra, Begoña Santiago, Elena Rincón, Miguel Lillo, Antoni Soriano-Arandes, Luigi Sedda, Clàudia Fortuny, Manuel Monsonís, Julián González-Martín, Marc Tebruegge, Antoni Noguera-Julian

{"title":"A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain","authors":"Aina Martínez-Planas, Fernando Baquero-Artigao, Ana Méndez-Echevarría, Teresa Del Rosal, Paula Rodríguez-Molino, Carlos Toro-Rueda, Matilde Bustillo-Alonso, Miguel Lafuente, Anna Canet, Ángela Manzanares, Alfredo Tagarro, Francisco José Sanz-Santaeufemia, Sara Guillén-Martín, María José Cilleruelo, Lola Falcón-Neyra, Begoña Santiago, Elena Rincón, Miguel Lillo, Antoni Soriano-Arandes, Luigi Sedda, Clàudia Fortuny, Manuel Monsonís, Julián González-Martín, Marc Tebruegge, Antoni Noguera-Julian","doi":"10.3201/eid3103.241254","DOIUrl":"https://doi.org/10.3201/eid3103.241254","url":null,"abstract":"We describe the epidemiology, diagnosis, and management of nontuberculous mycobacterial lymphadenitis cases detailed in a 28-year (1996–2023) multicenter cohort from Spain. The case numbers remained stable during the initial prospective phase (2013–2020), but a sharp decline was observed during 2021–2022. Disease onset occurred during spring or June in 45.9% of cases. Mycobacterium avium complex (43.1%) and M. lentiflavum (39.9%) were the most common species detected. M. lentiflavum affected mostly younger children from central Spain. The most common treatment strategy was complete surgical resection with (n = 80) or without (n = 88) antimicrobial drug treatment, followed by antimicrobial drugs alone (n = 76). Facial palsy developed in 10.4% of surgical cases. Adverse events because of antimicrobial drugs were uncommon. New fistula formation during follow-up occurred more in children managed with observation alone than in those treated with antimicrobial drugs alone (relative risk 2.7 [95% CI 1.3–5.3]; p = 0.014).","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"52 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidrug-Resistant Mycobacterium tuberculosis in a Community Hospital, Luanda, Angola 安哥拉罗安达一家社区医院的耐多药结核分枝杆菌

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241831

Ngiambudulu M. Francisco, Alberto Gaviraghi, Francesca Alladio, Ralph Huits, Bruna Carnielli, Elena Salvador, Giacomo Stroffolini, Niccolò Ronzoni, Paolo Cattaneo, Concetta Castilletti, Alberto Kalume, Cristina Mazzi, Alberto Matteelli, Dora Buonfrate, Federico G. Gobbi

引用次数: 0

Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy 阵发性夜间血红蛋白尿患者在pegcetacplan治疗期间的脑膜炎球菌败血症

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.241182

Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, Seppo Meri

引用次数: 0

Model-Based Analysis of Impact, Costs, and Cost-Effectiveness of Tuberculosis Outbreak Investigations, United States 基于模型的结核病爆发调查的影响、成本和成本效益分析，美国

IF 11.8 2区医学

Emerging Infectious Diseases Pub Date : 2025-02-21 DOI: 10.3201/eid3103.240633

Sourya Shrestha, Lucia Cilloni, Garrett R. Beeler Asay, J. Steve Kammerer, Kala Raz, Tambi Shaw, Martin Cilnis, Jonathan Wortham, Suzanne M. Marks, David Dowdy

{"title":"Model-Based Analysis of Impact, Costs, and Cost-Effectiveness of Tuberculosis Outbreak Investigations, United States","authors":"Sourya Shrestha, Lucia Cilloni, Garrett R. Beeler Asay, J. Steve Kammerer, Kala Raz, Tambi Shaw, Martin Cilnis, Jonathan Wortham, Suzanne M. Marks, David Dowdy","doi":"10.3201/eid3103.240633","DOIUrl":"https://doi.org/10.3201/eid3103.240633","url":null,"abstract":"Outbreak investigation is an essential component of tuberculosis (TB) control in the United States, but its epidemiologic impact and cost-effectiveness have not been quantified. We modeled outbreak investigation activities in the United States during 2023–2032 and estimated corresponding epidemiologic impact, economic costs (in 2022 US$), and incremental cost-effectiveness ratios from the healthcare system perspective (cost per additional quality-adjusted life-year gained). We projected that outbreak investigations would result in 1,030,000 (95% uncertainty interval [UI] 376,000–1,740,000) contacts investigated, leading to 4,130 (95% UI 1,420–7,640) TB diagnoses and 104,000 (95% UI 37,600–181,000) latent TB infection diagnoses, at a total cost of US $219 million (95% UI $80–$387 million). We estimated that 5,560 (95% UI 1,720–11,400) TB cases would be averted through early detection and treatment, and the incremental cost-effectiveness of outbreak investigations, compared with no outbreak investigations, was $27,800 per quality-adjusted life-year gained (95% UI $4,580–$68,700).","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"17 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0