Hannah Padda, Claire Y-H Huang, Kacie Grimm, Brad J Biggerstaff, Jeremy P Ledermann, Janae Raetz, Karen Boroughs, Eric C Mossel, Stacey W Martin, Jennifer A Lehman, Rebecca L Townsend, David Krysztof, Paula Saá, Emily T N Dinh, Mary Grace Stobierski, Brenda Esponda-Morrison, Karen Ann A Wolujewicz, Matthew Osborne, Catherine M Brown, Brandi Hopkins, Elizabeth K Schiffman, Alex Garvin, Xia Lee, Rebecca A Osborn, Ryan J Wozniak, Aaron C Brault, Sridhar V Basavaraju, Susan L Stramer, J Erin Staples, Carolyn V Gould
{"title":"Powassan and Eastern Equine Encephalitis Virus Seroprevalence in Endemic Areas, United States, 2019-2020.","authors":"Hannah Padda, Claire Y-H Huang, Kacie Grimm, Brad J Biggerstaff, Jeremy P Ledermann, Janae Raetz, Karen Boroughs, Eric C Mossel, Stacey W Martin, Jennifer A Lehman, Rebecca L Townsend, David Krysztof, Paula Saá, Emily T N Dinh, Mary Grace Stobierski, Brenda Esponda-Morrison, Karen Ann A Wolujewicz, Matthew Osborne, Catherine M Brown, Brandi Hopkins, Elizabeth K Schiffman, Alex Garvin, Xia Lee, Rebecca A Osborn, Ryan J Wozniak, Aaron C Brault, Sridhar V Basavaraju, Susan L Stramer, J Erin Staples, Carolyn V Gould","doi":"10.3201/eid3105.240893","DOIUrl":"https://doi.org/10.3201/eid3105.240893","url":null,"abstract":"<p><p>Powassan virus (POWV) and Eastern equine encephalitis virus (EEEV) are regionally endemic arboviruses in the United States that can cause neuroinvasive disease and death. Recent identification of EEEV transmission through organ transplantation and POWV transmission through blood transfusion have increased concerns about infection risk. After historically high numbers of cases of both viruses were reported in 2019, we conducted a seroprevalence survey using blood donation samples from selected endemic counties. Specimens were screened for virus-specific neutralizing antibodies, and population seroprevalence was estimated using weights calibrated to county population census data. For POWV, median county seroprevalence in 4 states was 0.84%, ranging from 0% (95% CI 0%-2.28%) to 11.5% (95% CI 0.82%-40.9%). EEEV infection was identified in a single county (estimated seroprevalence 1.62% [95% CI 0.04%-8.75%]). Although seroprevalence estimates in sampled areas were generally low, additional investigation of higher-prevalence areas could inform risk for transmission from asymptomatic blood and organ donors.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 5","pages":"929-936"},"PeriodicalIF":7.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Napoleon Bonaparte-A Possible Case of Trench Fever.","authors":"Éric Faure","doi":"10.3201/eid3105.240970","DOIUrl":"https://doi.org/10.3201/eid3105.240970","url":null,"abstract":"<p><p>In 1789, Napoleon Bonaparte reported having a recurrent febrile illness that initially subsided for 4 days and then had multiple relapses of similar duration. A speculative diagnosis of trench fever would be supported by poor hygiene conditions, prolonged exposure to cold, and the presence of lice in Napoleon's barracks environment.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 5","pages":"1038"},"PeriodicalIF":7.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Prevalence of Influenza D Virus Infection in Swine, Northern Ireland.","authors":"Paula Lagan, Ken Lemon","doi":"10.3201/eid3105.241948","DOIUrl":"https://doi.org/10.3201/eid3105.241948","url":null,"abstract":"<p><p>We detected influenza D virus in multiple swine herds in Northern Ireland. Whole-genome sequencing showed several circulating genotypes and novel mutations in the receptor-binding site and esterase domains of the hemagglutinin-esterase fusion protein. Transmission routes of influenza D virus to swine remain to be clarified but could be direct or indirect.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 5","pages":"1023-1027"},"PeriodicalIF":7.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012-2018.","authors":"Lise Bertin-Biasutto,Olivier Paccoud,Dea Garcia-Hermoso,Blandine Denis,Karine Boukris-Sitbon,Olivier Lortholary,Stéphane Bretagne,Maud Gits-Muselli,Raoul Herbrecht,Valérie Letscher-Bru,François Danion,Sophie Cassaing,Florent Morio,Céline Nourrisson,Marc Pihet,Milène Sasso,Guillaume Desoubeaux,Marie-Fleur Durieux,Julie Bonhomme,Elisabeth Chachaty,Taieb Chouaki,Nicole Desbois-Nogard,Alexandre Alanio,Jean-Pierre Gangneux,Fanny Lanternier","doi":"10.3201/eid3105.241392","DOIUrl":"https://doi.org/10.3201/eid3105.241392","url":null,"abstract":"Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012-2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA.","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"48 1","pages":"896-905"},"PeriodicalIF":11.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean-Claude Makangara-Cigolo, Kelly-Michel Kenye, Lygie Lunyanga, Daan Jansen, Eddy Kinganda-Lusamaki, Sifa Kavira, Adrienne Amuri-Aziza, Emile Malembi, Yvon Anta, Prince Akil-Bandali, Emmanuel Lokilo-Lofiko, Emmanuel Hasivirwe Vakaniaki, Sabin Sabiti Nundu, Elisabeth Pukuta-Simbu, Princesse Paku-Tshambu, Rilia Ola-Mpumbe, Raphael Lumembe-Numbi, Gabriel Kabamba-Lungenyi, Gradi Luakanda, Cris Kacita, Robert Shongo-Lushima, Dieudonné Mwamba, Áine O'Toole, Sydney Merritt, Megan Halbrook, Daniel Mukadi-Bamuleka, Nicole A Hoff, Nicola Low, Isaac Bogoch, Muge Cevik, Gregg Gonsalves, Souradet Shaw, Lorenzo Subissi, Laurens Liesenborghs, Ahidjo Ayouba, Martine Peeters, Eric Delaporte, Sofonias Tessema, Anne W Rimoin, Jean-Jacques Muyembe-Tamfum, Andrew Rambaut, Koen Vercauteren, Steve Ahuka-Mundeke, Jason Kindrachuk, Tony Wawina-Bokalanga, Placide Mbala-Kingebeni
{"title":"Clade Ia Monkeypox Virus Linked to Sexual Transmission, Democratic Republic of the Congo, August 2024.","authors":"Jean-Claude Makangara-Cigolo, Kelly-Michel Kenye, Lygie Lunyanga, Daan Jansen, Eddy Kinganda-Lusamaki, Sifa Kavira, Adrienne Amuri-Aziza, Emile Malembi, Yvon Anta, Prince Akil-Bandali, Emmanuel Lokilo-Lofiko, Emmanuel Hasivirwe Vakaniaki, Sabin Sabiti Nundu, Elisabeth Pukuta-Simbu, Princesse Paku-Tshambu, Rilia Ola-Mpumbe, Raphael Lumembe-Numbi, Gabriel Kabamba-Lungenyi, Gradi Luakanda, Cris Kacita, Robert Shongo-Lushima, Dieudonné Mwamba, Áine O'Toole, Sydney Merritt, Megan Halbrook, Daniel Mukadi-Bamuleka, Nicole A Hoff, Nicola Low, Isaac Bogoch, Muge Cevik, Gregg Gonsalves, Souradet Shaw, Lorenzo Subissi, Laurens Liesenborghs, Ahidjo Ayouba, Martine Peeters, Eric Delaporte, Sofonias Tessema, Anne W Rimoin, Jean-Jacques Muyembe-Tamfum, Andrew Rambaut, Koen Vercauteren, Steve Ahuka-Mundeke, Jason Kindrachuk, Tony Wawina-Bokalanga, Placide Mbala-Kingebeni","doi":"10.3201/eid3105.241690","DOIUrl":"https://doi.org/10.3201/eid3105.241690","url":null,"abstract":"<p><p>Several concurrent mpox outbreaks are ongoing in the Democratic Republic of the Congo. We report a case of severe clade Ia mpox in an adult woman with indeterminate HIV status who died 16 days after symptom onset. She self-identified as a sex worker and had spent time in the capital city, Kinshasa.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"31 5","pages":"1033-1037"},"PeriodicalIF":7.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Anne J. Guagliardo, Stacey Martin, Carolyn V. Gould, Rebekah Sutter, Daniel Jacobs, Kevin O’Laughlin, Ralph Huits, Concetta Castilletti, J. Erin Staples
{"title":"Estimation of Incubation Period for Oropouche Virus Disease among Travel-Associated Cases, 2024–2025","authors":"Sarah Anne J. Guagliardo, Stacey Martin, Carolyn V. Gould, Rebekah Sutter, Daniel Jacobs, Kevin O’Laughlin, Ralph Huits, Concetta Castilletti, J. Erin Staples","doi":"10.3201/eid3107.250468","DOIUrl":"https://doi.org/10.3201/eid3107.250468","url":null,"abstract":"<p>Determining the incubation period of Oropouche virus disease can inform clinical and public health practice. We analyzed data from 97 travel-associated cases identified by the Centers for Disease Control and Prevention (n = 74) or the GeoSentinel Network (n = 13) and 10 cases from published literature. Using log-normal interval-censored survival analysis, we estimated the median incubation period to be 3.2 (95% CI 2.5–3.9) days. Symptoms developed by 1.1 (95% CI 0.6–1.5) days for 5% of patients, 9.7 (95% CI 6.9–12.5) days for 95% of patients, and 15.4 (95% CI 9.6–21.3) days for 99% of patients. The estimated incubation period range of 1–10 days can be used to assess timing and potential source of exposure in patients with Oropouche symptoms. For patients with symptom onset >2 weeks after travel, clinicians and public health responders should consider the possibility of local vectorborne transmission or alternative modes of transmission.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"48 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Marcela Torres, Jared Johnson, Audrey Valentine, Audrey Brezak, Emily C. Schneider, Marisa D’Angeli, Jennifer Morgan, Claire Brostrom-Smith, Chi N. Hua, Michael Tran, Darren Lucas, Joenice Gonzalez De Leon, Drew MacKellar, Philip Dykema, Kelly J. Kauber, Allison Black
{"title":"Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA","authors":"Laura Marcela Torres, Jared Johnson, Audrey Valentine, Audrey Brezak, Emily C. Schneider, Marisa D’Angeli, Jennifer Morgan, Claire Brostrom-Smith, Chi N. Hua, Michael Tran, Darren Lucas, Joenice Gonzalez De Leon, Drew MacKellar, Philip Dykema, Kelly J. Kauber, Allison Black","doi":"10.3201/eid3113.241227","DOIUrl":"https://doi.org/10.3201/eid3113.241227","url":null,"abstract":"<p>Mitigating antimicrobial resistance (AMR) is a public health priority to preserve antimicrobial treatment options. The Washington State Department of Health in Washington, USA, piloted a process to leverage longitudinal genomic surveillance on the basis of whole-genome sequencing (WGS) and a genomics-first cluster definition to enhance AMR surveillance. Here, we outline the approach to collaborative surveillance and describe the pilot using 6 carbapenemase-producing organism outbreaks of 3 species: <em>Pseudomonas aeruginosa</em>, <em>Acinetobacter baumannii</em>, and <em>Klebsiella pneumoniae.</em> We also highlight how we applied the approach to an emerging outbreak. We found that genomic and epidemiologic data define highly congruent outbreaks. By layering genomic and epidemiologic data, we refined linkage hypotheses and addressed gaps in traditional epidemiologic surveillance. With the accessibility of WGS, public health agencies must leverage new approaches to modernize surveillance for communicable diseases.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"148 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duncan MacCannell, Bronwyn MacInnis, Scott Santibanez, Margaret A. Honein, Wendi Kuhnert, Christopher Braden
{"title":"A Decade of Partnerships and Progress in Pathogen Genomics in Public Health Practice","authors":"Duncan MacCannell, Bronwyn MacInnis, Scott Santibanez, Margaret A. Honein, Wendi Kuhnert, Christopher Braden","doi":"10.3201/eid3113.241670","DOIUrl":"https://doi.org/10.3201/eid3113.241670","url":null,"abstract":"Partnerships and Progress in Pathogen Genomics","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"74 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelsey R. Florek, Erin L. Young, Kutluhan Incekara, Kevin G. Libuit, Curtis J. Kapsak
{"title":"Advantages of Software Containerization in Public Health Infectious Disease Genomic Surveillance","authors":"Kelsey R. Florek, Erin L. Young, Kutluhan Incekara, Kevin G. Libuit, Curtis J. Kapsak","doi":"10.3201/eid3113.241363","DOIUrl":"https://doi.org/10.3201/eid3113.241363","url":null,"abstract":"<p>Bioinformatic software containerization, the process of packaging software that encapsulates an application together with all necessary dependencies to simplify installation and use, has improved the deployment and management of next-generation sequencing workflows in both clinical and public health laboratories. Containers have increased next-generation sequencing workflow reproducibility and broadened their usage across different laboratories. We highlight the value of the State Public Health Bioinformatics community’s containerized software repository during the COVID-19 pandemic.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"69 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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