Scheffersomyces spartinae Fungemia among Pediatric Patients, Pakistan, 2020-2024.

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-08-01 DOI:10.3201/eid3108.241604

Kauser Jabeen,Joveria Farooqi,Lacy M Simons,Judd F Hultquist,Ramon Lorenzo-Redondo,Charlesnika T Evans,Erica M Hartmann,Mohammad Hanif,Zahra Hasan,Syed Faisal Mahmood,Javaria Ashraf,Hassan Ghayas,Sadaf Zaka,Noureen Saeed,Sayed Ali Raza Shah Bukhari,Mehreen Arshad,Larry K Kociolek,Sameer J Patel,Rumina Hasan,Egon A Ozer

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Abstract

Prevalence of emerging fungal infections is increasing, particularly among immunocompromised persons, children, and older persons. We report 108 cases of Scheffersomyces spartinae infection in pediatric patients from Karachi and other cities in Pakistan, of which 107 were identified from blood cultures. Cultures were initially misidentified as Clavispora lusitaniae by a biochemical assay before speciation as S. spartinae by whole-genome sequencing. All isolates were from children <12 years of age, and >69% were from children <1 month of age. Isolates were genetically distinct across regions of Pakistan; however, genetic diversity was low in isolates from patients in Karachi and nearby Nawabshah and had median differences of just 9 pairwise nucleotide variants. This study demonstrates S. spartinae is a potentially emerging pathogen in neonates and young infants in Pakistan. The findings highlight the limitations of phenotypic identification for detecting emerging fungal infections and underscore the value of molecular identification approaches.

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巴基斯坦儿科患者中的米叶舍虫真菌病，2020-2024。

新发真菌感染的流行率正在上升，特别是在免疫功能低下的人、儿童和老年人中。我们报告了巴基斯坦卡拉奇和其他城市的108例小儿舍弗somces spartinae感染病例，其中107例是通过血培养鉴定出来的。在通过全基因组测序确定为S. spartinae物种之前，培养物最初被生化测定误认为是lusitaniae。所有分离株均来自儿童，69%来自小于1月龄的儿童。巴基斯坦各地区的分离株在遗传上是不同的；然而，卡拉奇和附近的Nawabshah患者分离株的遗传多样性较低，只有9个成对核苷酸变异的中位数差异。本研究表明，米sparinae是巴基斯坦新生儿和幼龄婴儿的潜在新发病原体。这些发现强调了表型鉴定检测新发真菌感染的局限性，并强调了分子鉴定方法的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.