b支猴痘病毒的出现——证据的现状。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-08-01 DOI:10.3201/eid3108.241551

Panayampalli S Satheshkumar,Crystal M Gigante,Placide Mbala-Kingebeni,Yoshinori Nakazawa,Mark Anderson,Stephen Balinandi,Sophia Mulei,James Fuller,Jennifer H McQuiston,Andrea M McCollum,Christina L Hutson

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引用次数: 0

摘要

麻疹是在消灭天花运动的背景下首次发现的。猴痘病毒（MPXV）是引起猴痘的病原体，在西非和中非森林地区的动物储存库中被维持为两个不同的分支；从历史上看，进化支I在中非造成的感染比历史上在西非发现的进化支II更严重。然而，通过新的传播途径，两种MPXV分支的迅速重新出现和传播对m痘的已知特征提出了挑战。我们总结了m痘的人口统计学分布、临床严重程度和因MPXV基因不同亚支系而导致的病死率，并将重点放在最近发现的MPXV亚支系Ib上。需要广泛的国际援助，以制止流行性腮腺炎病毒分支在流行性腮腺炎流行地区和非流行地区的传播，以防止今后的疫情。

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Emergence of Clade Ib Monkeypox Virus-Current State of Evidence.

Mpox was first identified against the backdrop of the smallpox eradication campaign. Monkeypox virus (MPXV), the causative agent of mpox, has been maintained in animal reservoirs in the forested regions of West and Central Africa as 2 distinct clades; clade I has historically caused more severe infection in Central Africa than clade II, historically found in West Africa. However, rapid reemergence and spread of both MPXV clades through novel routes of transmission have challenged the known characteristics of mpox. We summarize mpox demographic distribution, clinical severity, and case-fatality rates attributed to genetically distinct MPXV subclades and focus on MPXV clade Ib, the more recently identified subclade. Broad worldwide assistance will be necessary to halt the spread of both MPXV clades within mpox endemic and nonendemic regions to prevent future outbreaks.

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.