Dose-Response最新文献_第4页

Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy. 二甲双胍通过激活自噬减轻tgf - β2诱导的小梁网细胞纤维化

IF 2.3 4区医学

Dose-Response Pub Date : 2025-05-20 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251341598

Jing Ren, Pengtao Wu, Mengli Liu, Xuan Zhang, Zilu Guo, Yihan Liu, Rumeng Zhao, Gang Wang, Shichao Duan, Haijun Li

{"title":"Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy.","authors":"Jing Ren, Pengtao Wu, Mengli Liu, Xuan Zhang, Zilu Guo, Yihan Liu, Rumeng Zhao, Gang Wang, Shichao Duan, Haijun Li","doi":"10.1177/15593258251341598","DOIUrl":"10.1177/15593258251341598","url":null,"abstract":"Objective: In this study, we investigated the protective effect of Metformin on fibrosis of trabecular meshwork cells induced by TGFβ2.Methods: Transformed and primary human trabecular meshwork cells (HTMCs) were treated with TGFβ2 or Metformin alone or combination, western blotting and immunofluorescence staining assays to detect autophagy activity and fibrotic proteins expression levels. TGFβ2 or Metformin alone or combination were injected into the anterior chamber of mouse eye. Mouse intraocular pressure (IOP) was measured every week, mouse eye sections were conducted immunofluorescence staining to analyze Col1 and Col3 expression. pSmad3 level and localization to evaluate TGFβ/Smad3 pathway activity. Chloroquine phosphate was used to block autophagy-lysosome pathway.Results: Metformin activates autophagy of HTMCs in a dose dependent manner and efficiently ameliorates TMCs fibrosis induced by TGFβ2 in vitro and in mouse model, and decreased elevated IOP caused by TGFβ2. Metformin promotes fibrotic proteins degradation through the autophagy-lysosome pathway.Conclusion: Our study found Metformin could alleviates fibrosis of HTMCs induced by TGFβ2 and decreased elevated IOP in mouse model.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251341598"},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Transcriptomic Analysis Unveils Divergent Effects of FLASH Versus Conventional Irradiation on Skin Cells. 比较转录组学分析揭示了FLASH与传统照射对皮肤细胞的不同影响。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-05-20 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251342837

Mengmeng Xu, Qiliang Peng, Jun Zhang, Zhiming Xu, Xinyang Cheng, Zhifei Cao, Yongsheng Zhang

{"title":"Comparative Transcriptomic Analysis Unveils Divergent Effects of FLASH Versus Conventional Irradiation on Skin Cells.","authors":"Mengmeng Xu, Qiliang Peng, Jun Zhang, Zhiming Xu, Xinyang Cheng, Zhifei Cao, Yongsheng Zhang","doi":"10.1177/15593258251342837","DOIUrl":"10.1177/15593258251342837","url":null,"abstract":"Objectives: FLASH radiotherapy is garnering attention for its capacity to diminish skin toxicity without compromising tumoricidal efficacy, presenting a stark contrast to conventional (CONV) radiotherapy. Despite its promise, the underlying molecular mechanisms of FLASH irradiation (FLASH-IR) on skin are not yet fully elucidated.Methods: This study investigated the transcriptomic responses of human foreskin fibroblast cells (HFF-1) via the FLASH-IR or CONV irradiation (CONV-IR), employing the next-generation RNA sequencing (RNA-seq) to capture the gene expression profiles. Our comparative analysis aimed to dissect the cellular and molecular pathways influenced by these two irradiation methods.Results: We identified a spectrum of differentially expressed genes (DEGs), signaling pathways, and transcriptional networks that were either shared or divergent between FLASH-IR and CONV-IR. Particularly, transcription factor NR4A1 showed significant upregulation in response to FLASH-IR, while chromatin stability factor ELF3 was markedly downregulated following CONV-IR. The top 10 up-regulated DEGs were subjected to qPCR validation, confirming their differential expression in response to FLASH-IR and CONV-IR.Conclusion: Collectively, our findings delineate unique regulatory landscapes of FLASH-IR and CONV-IR on skin cells, corroborating established effects and shedding new light on the molecular interplay within the context of ultra-high dose radiation.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251342837"},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition. Nrf2缺乏导致对IR和7,12-二甲基苯(a)蒽的敏感性增加和白血病易感性。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-05-19 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251341593

Mingxin Dong, Ping Yang, Xinyu Zhang, Shasha Nie, Xiaohui Sun

{"title":"Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition.","authors":"Mingxin Dong, Ping Yang, Xinyu Zhang, Shasha Nie, Xiaohui Sun","doi":"10.1177/15593258251341593","DOIUrl":"10.1177/15593258251341593","url":null,"abstract":"Purpose: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial cytoprotective protein that shields cells from electrophilic and oxidative stress. Mice lacking Nrf2 exhibit heightened susceptibility to myelosuppression due to impaired hematopoietic reconstitution. In this study, we examined the altered sensitivity to ionizing radiation (IR) and 7,12-dimethylbenz(a)anthracene (DMBA) in Nrf2-/- mice separately.Materials and methods: Irradiate Nrf2-/- or wild-type mice with a dose of 4 Gy to observe changes in body weight, survival rate, and blood routine at 12 months. DMBA was used to treat Nrf2-/- and wild-type mice, and the body weight and survival rate of the mice were measured. The changes of heme oxygenase-1(HO1) and NAD(P)H: quinone oxidoreductase 1(NQO1) in mice treated with IR or DMBA were detected by RT-qPCR and western blotting.Results: Our results indicate that Nrf2 deficiency leads to more severe blood and immune system injury in mice exposed to IR or DMBA. Additionally, long-term monitoring revealed that Nrf2 deletion resulted in more severe myelosuppression, leukemia-like symptoms, and higher cancer rates. At the mRNA and protein levels, there was no significant increase in HO1 and NQO1 levels in the Nrf2-/- mice treated with IR or DMBA. These adverse effects might be attributed to the inhibited protein levels of HO1 and NQO1 and significant DNA damage in hematopoietic stem and progenitor cells (HSPCs).Conclusions: We demonstrate that the genetic deficiency of Nrf2 in mice leads to reduced antioxidant capacity and suppression of hematopoietic and immune system function, resulting in increased sensitivity to IR or DMBA.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251341593"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Adaptive Response Be Considered in Radiation Risk Assessment? 辐射风险评估可以考虑适应性反应吗？

IF 2.3 4区医学

Dose-Response Pub Date : 2025-05-12 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251341601

Julianna Krasowska, Krzysztof W Fornalski

引用次数: 0

Effect of Gamma Rays on Adropin as a Potential Hepatokine Marker for Liver Damage in Male Albino Rats. γ射线对雄性白化大鼠肝损伤潜在肝因子标志物Adropin的影响。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-05-10 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251342304

Nadia Abdel-Magied, Amira Mk Abouelella, Hayam Mostafa, Hebatallah E Mohamed, Nehal I Hendy

{"title":"Effect of Gamma Rays on Adropin as a Potential Hepatokine Marker for Liver Damage in Male Albino Rats.","authors":"Nadia Abdel-Magied, Amira Mk Abouelella, Hayam Mostafa, Hebatallah E Mohamed, Nehal I Hendy","doi":"10.1177/15593258251342304","DOIUrl":"https://doi.org/10.1177/15593258251342304","url":null,"abstract":"Purpose: This work was the first study to show the impact of γ- radiation on adropin levels in the serum and liver tissue of male albino rats.Methods: Liver tissue and blood samples of rats were collected at 1, 3, 7 and 14 days after whole-body exposure to 7.5 Gy of γ-radiation.Results: Irradiated groups revealed a marked decrease in adropin associated with a significant increase in STAT3 in the serum and gene expression. Furthermore, lipid profile (cholesterol, T.G, HDL, LDL, VLDL), liver function (AST, ALT, albumin and total protein), complete blood count (RBCs, WBCs, PLT, Hb, Hct%, MCH, MCV, WBCs differential), glucose and insulin were exhibited more noticeable alterations at all time periods of the experiment. In addition, data exhibited an obvious elevation in some inflammatory markers (IL-6) and TOS accompanied by a decline in the TAC.Conclusion and future scope of work: γ- radiation has adverse effects on adropin that related inversely with STAT3, leading to further damage to liver cells as well as disturbances in lipid and glucose metabolism. Therefore, adropin could be used in people exposed to radiation such radiotherapy to control the serious effects of radiation. Further study is needed to confirm these results.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251342304"},"PeriodicalIF":2.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration. 对万古霉素谷浓度的影响因素建立多元线性回归模型。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-04-23 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251313646

Lin Wang, Yuhuang Wang, Chunyan Yang, Jia Jiang, Huifang Wang, Mingcai Wu

{"title":"Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration.","authors":"Lin Wang, Yuhuang Wang, Chunyan Yang, Jia Jiang, Huifang Wang, Mingcai Wu","doi":"10.1177/15593258251313646","DOIUrl":"https://doi.org/10.1177/15593258251313646","url":null,"abstract":"Objective: To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin. Methods: The clinical data of Vancomycin trough concentration in blood from June 2020 to December 2022 in our hospital were analyzed retrospectively. The effects of age, sex, Vancomycin administration and cumulative dose, albumin, total bilirubin, alanine aminotransferase, Creatinine (CR), urea (Bun), Creatinine clearance rate (Ccr), and time of blood sample collection on Vancomycin trough concentration were analyzed. A linear regression equation for the influencing factors of Vancomycin trough concentration in blood was constructed. Results: Sixty-six patients (82.5%) were treated with Vancomycin by intravenous drip. Significant differences existed in the influence of patients' age, Vancomycin administration, CR, Bun and Ccr on Vancomycin trough concentration (P < 0.05). Vancomycin trough concentration in blood showed negative correlated with Ccr (P < 0.05). The regression model of Vancomycin trough concentration in blood was y = 40.911 - 10.971 × method of administration - 1.715 × collection time + 1.018 × cumulative dose - 0.178 × Ccr, the model could predict 41.30% Vancomycin trough concentration in blood. Conclusion: The influencing factors of Vancomycin trough concentration in blood were complex. The constructed regression model of Vancomycin concentration in plasma may provide a scientific reference for individualized administration of Vancomycin in clinical practice.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251313646"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of DNA Repair and Immune Infiltration in Radiation-Induced Intestinal Injury. 辐射诱导肠损伤中DNA修复和免疫浸润的改变。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-04-17 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251336820

Jiale Li, Huanteng Zhang, Xiaoxiao Jia, Jiebing Guan, Xumin Zong, Shiqi Li, Xinran Lu, Ningning He, Huijuan Song, Kaihua Ji, Manman Zhang, Jianguo Li, Qiang Liu, Jinhan Wang, Chang Xu

{"title":"Alterations of DNA Repair and Immune Infiltration in Radiation-Induced Intestinal Injury.","authors":"Jiale Li, Huanteng Zhang, Xiaoxiao Jia, Jiebing Guan, Xumin Zong, Shiqi Li, Xinran Lu, Ningning He, Huijuan Song, Kaihua Ji, Manman Zhang, Jianguo Li, Qiang Liu, Jinhan Wang, Chang Xu","doi":"10.1177/15593258251336820","DOIUrl":"https://doi.org/10.1177/15593258251336820","url":null,"abstract":"Objectives: The intestine exhibits high radiosensitivity and is susceptible to damage during radiotherapy for abdominal or pelvic tumors, especially at radiation doses exceeding 5 Gy, which can lead to severe gastrointestinal complications. This study aims to elucidate the mechanisms of DNA repair and immune responses in radiation-induced intestinal injury, with the goal of enhancing radiotherapy efficacy.Methods: We employed weighted correlation network analysis (WGCNA) to analyze RNA sequencing data from intestinal tissues collected at various time points following irradiation, as well as from mice with targeted disruption of the NFE2-like bZIP transcription factor 2 (Nrf2) gene and their wild-type counterparts.Results: Our analysis revealed enhanced DNA repair capacity and attenuated immune response 3.5 days after irradiation. Histone variants and ribosomal proteins were identified as potential contributors to DNA repair processes. We also constructed a competing endogenous RNAs (ceRNA) network including genes from both the DNA repair and immune modules and identified Akr1b8, Gsta3, and Nqo1 as radiation-effect genes regulated by Nrf2.Conclusions: These findings provide valuable insights into the molecular mechanisms of radiation-induced intestinal injury and suggest potential targets for protecting normal intestinal tissue during radiotherapy. This knowledge may contribute to improved treatment outcomes and enhanced patient well-being.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251336820"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NCRP Claims Six Studies Support LNT But They Show No-Effect to At Least 100 mGy. NCRP声称有六项研究支持LNT，但它们显示至少100毫戈瑞没有效果。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-04-15 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251329682

K Chaplin

引用次数: 0

Assessment of the Validity of Carbon Ion Irradiation for C6 Gliomas in Rats. 碳离子辐照治疗大鼠C6胶质瘤的有效性评价。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-04-15 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251327505

Yufeng Li, Lei Ta, QingFeng Wu, Hongyu Zhang, Yuan Xu, Lu Gan, Jianli Liu

{"title":"Assessment of the Validity of Carbon Ion Irradiation for C6 Gliomas in Rats.","authors":"Yufeng Li, Lei Ta, QingFeng Wu, Hongyu Zhang, Yuan Xu, Lu Gan, Jianli Liu","doi":"10.1177/15593258251327505","DOIUrl":"https://doi.org/10.1177/15593258251327505","url":null,"abstract":"Purpose: Application of energy-spectrum computed tomography (CT) to assess specific efficacy of and response to carbon ion radiotherapy (CIRT) of C6 gliomas in rats.Methods: After establishing C6 glioma rat models, 3 tumor-bearing rats were randomly selected as controls. The remaining were divided into 0 Gy, 1 Gy, and 2 Gy groups for CIRT. Energy-spectrum CT scans were performed, and brain tissues were collected for histopathology and western blot Test. Survival rates in each group were compared.Results: The results demonstrated that tumors in the 1 Gy and 2 Gy groups decreased at different rates up to 14 days post-CIRT (P < 0.05). Furthermore, compared to pre-CIRT measurements, the energy-spectrum parameters gradually increased in the 0 Gy group, while they decreased in the 2 Gy group. Post-CIRT, the Ki-67 proliferation index and the expression levels of vascu-larassociated proteins in tumor tissues were significantly reduced in the 1 and 2 Gy groups. Additionally, the survival times of tumor-bearing rats were prolonged after CIRT.Conclusions: CIRT effectively restricts tumor cell growth and proliferation, leading to improved survival rates in rats with C6 gliomas. The use of energy-spectrum CT with immunohistochemistry for quantitative detection can actively support the effectiveness of carbon ion radiotherapy in inhibiting tumor proliferation.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251327505"},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Radiation Esophagitis in Patients Undergoing Synchronous Boost Radiotherapy Post-Breast-Conserving Surgery. 保乳手术后同步增强放疗患者放射性食管炎的预测。

IF 2.3 4区医学

Dose-Response Pub Date : 2025-04-15 eCollection Date: 2025-04-01 DOI: 10.1177/15593258251335802

Huai-Wen Zhang, Yi-Ren Wang, Jingao Li, Wei Huang, Bin Xu, Hao-Wen Pang, Chun-Ling Jiang

{"title":"Predicting Radiation Esophagitis in Patients Undergoing Synchronous Boost Radiotherapy Post-Breast-Conserving Surgery.","authors":"Huai-Wen Zhang, Yi-Ren Wang, Jingao Li, Wei Huang, Bin Xu, Hao-Wen Pang, Chun-Ling Jiang","doi":"10.1177/15593258251335802","DOIUrl":"https://doi.org/10.1177/15593258251335802","url":null,"abstract":"This study constructed a predictive model for occurrence of radiation esophagitis during breast-cancer radiotherapy. 308 breast-cancer patients were analyzed. Lasso regression identified crucial variables that were further integrated into a radiation esophagitis risk score, which was used to segregate patients into high- and low-risk groups. A nomogram model was designed for clinical applicability. Training and validations were performed to assess robustness and generalizability of proposed models, employing C-index, AUCs, calibration curves, and decision curves. SHAP algorithm was used for model interpretation, offering insights into the major contributory factors. Seven significant variables were identified by Lasso regression. C-indexes of nomograms of individual clinical variables and risk score were 0.795 and 0.784, respectively, exhibiting strong predictive ability. In internal validation, AUCs for risk score, nomogram, and logistic models were 0.784, 0.795, and 0.812, respectively. Calibration curves showed a close fit between predicted and observed outcomes across models. Decision curve analysis indicated logistic model's superior clinical utility when the risk threshold was above 0.2. SHAP interpretation emphasized radiation dose, pruritus, molecular type, and hepatic dysfunction as top contributory factors for radiation esophagitis. Models based on interpretable machine learning offer an intuitive tool to assess risk of radiation esophagitis in breast-cancer radiotherapy.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251335802"},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0