Dose-Response最新文献

Pharmacological Intervention of Post-traumatic Seizure: Advanced Research Progress. 外伤性癫痫发作的药物干预研究进展

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-29 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251384796

Weiwei Zeng, Juanfeng Ou, Ruitong Li, Yong Yin, Xiaoying Lin, Yingting Lu, Mimi Tang

{"title":"Pharmacological Intervention of Post-traumatic Seizure: Advanced Research Progress.","authors":"Weiwei Zeng, Juanfeng Ou, Ruitong Li, Yong Yin, Xiaoying Lin, Yingting Lu, Mimi Tang","doi":"10.1177/15593258251384796","DOIUrl":"10.1177/15593258251384796","url":null,"abstract":"Traumatic brain injury (TBI) is an important condition with high rates of disability and mortality worldwide. Post-traumatic seizure (PTS) frequently occur following TBI, manifesting in both early and late stages. Recurrent PTS without timely intervention may progress to post-traumatic epilepsy (PTE), which defined as the occurrence of two or more unprovoked seizures. Early pharmacological intervention is essential to mitigate the risk of PTE and enhance the prognosis for patients with TBI. Antiepileptic drugs (AEDs) offer a viable strategy for managing PTS. Recent studies indicated that AEDs are more effective in early post-traumatic seizure compared to late post-traumatic seizure, and their efficacy and safety require further evaluation. As research advances in the pathophysiological changes after TBI and the pathogenesis of PTS, current investigations are increasingly focused on neurological damage. Novel compounds targeting various pathways, including antioxidants, anti-neuroinflammatory agents, glutamate modulators and anti-oxidative stress compounds, have demonstrated promising potential in preclinical studies for PTS intervention. This review focuses on the research progress of different AEDs in PTS intervention and discusses the recent developments of emerging PTS intervention strategies based on multiple pathways, providing insights into the clinical application of AEDs and new directions for the development of new drugs for PTS intervention.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251384796"},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INWORKS Solid Cancer Mortality Risk Estimate is Much Higher than the Equivalent LSS Risk Estimate. INWORKS实体癌死亡率风险估计远高于等效的LSS风险估计。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-22 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251382312

Ken Chaplin

引用次数: 0

Retraction: Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models. 撤回：一种传统药用植物对动物模型中行为功能障碍的剂量依赖、抗抑郁和抗焦虑作用。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-20 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251379150

引用次数: 0

Toosendanin Attenuates Mycoplasma pneumonia Induced Pneumonia (MPP) in Mice via Inhibiting NF-κB-Mediated Inflammatory Response: In vivo and silico Studies. 仙丹素通过抑制NF-κ b介导的炎症反应减轻小鼠肺炎支原体诱导的肺炎（MPP）：体内和体外研究。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-18 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251367619

Yin Zhou, Xinyou Su, Cuicui Wang, Abdullah A Alarfaj, Abdurahman Hajinur Hirad

{"title":"Toosendanin Attenuates Mycoplasma pneumonia Induced Pneumonia (MPP) in Mice via Inhibiting NF-κB-Mediated Inflammatory Response: In vivo and silico Studies.","authors":"Yin Zhou, Xinyou Su, Cuicui Wang, Abdullah A Alarfaj, Abdurahman Hajinur Hirad","doi":"10.1177/15593258251367619","DOIUrl":"10.1177/15593258251367619","url":null,"abstract":"Background: In the present study, the therapeutic effects of Toosendanin (TSN) against Mycoplasma pneumoniae (MP)-induced pneumonia (MPP) in mice.Research design: Swiss albino mice were exposed to MP culture for 2 days, causing pneumonia, and then treated with TSN for 3 days. Lung weights, total protein, IgM, C-reactive protein, oxidative stress, and inflammatory cytokines were assessed. Histological alterations were evaluated in lung tissues. Molecular docking analysis was performed to test TSN's interaction with inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), transforming growth factor-beta 1 (TGF-β1), and nuclear factor kappa B (NF-κB) were evaluated targets.Results: TSN treatment significantly reduced lung weight by approximately 25% compared to the MP-infected group (P < 0.05). Total protein and C-reactive protein (CRP) levels decreased by 30% and 40%, respectively. Malondialdehyde (MDA), was reduced by 35%, while antioxidant enzyme levels (e.g., SOD, CAT) increased by 20%-25%. Pro-inflammatory cytokines such as IL-1β and IL-6 were significantly lowered by 40%-50%. Histological analysis revealed a marked reduction in inflammatory cell infiltration and alveolar damage scores (P < 0.01). Molecular docking confirmed strong binding interactions between IL-1β, IL-6, TGF-β1, NF-κB and TSN.Conclusions: The present findings confirm the beneficial effects of TSN in protecting mice from pneumonia.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251367619"},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis. 放疗FLASH-RT的疗效：从治疗肺癌到预防肺纤维化。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-15 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251379921

Tianyu Yang, Zhiming Xu, Wentao Hu, Zhifei Cao, Yongsheng Zhang

引用次数: 0

Unveiling Nephroprotective, Diuretic and Toxicity Response of Pinus roxburghii Sarg. Extract by In-vitro, In-vivo and Docking Techniques. 刺梨松的肾保护、利尿和毒性反应。体外、体内和对接提取技术。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-08 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251352705

Maddiha Nasir, Fatima Saqib, Muhammad Farhaj Latif, Codrut Loan Ciurea, Catalin Misarca, Marius Alexandru Moga, Oana Andreescu

{"title":"Unveiling Nephroprotective, Diuretic and Toxicity Response of Pinus roxburghii Sarg. Extract by In-vitro, In-vivo and Docking Techniques.","authors":"Maddiha Nasir, Fatima Saqib, Muhammad Farhaj Latif, Codrut Loan Ciurea, Catalin Misarca, Marius Alexandru Moga, Oana Andreescu","doi":"10.1177/15593258251352705","DOIUrl":"10.1177/15593258251352705","url":null,"abstract":"Objective: Pinus roxburghii Sarg. (Pinaceae) has shown useful effects in the treatment of urinary problems. This research aimed to explore P.roxburghii scientifically via in-vitro, in-vivo and in-silico techniques to find out its therapeutic benefits on kidney and bladder.Method: Pharmacologically active components of aqueous ethanolic extract of P.roxburghii were analyzed by HPLC-DAD screening. These components were predicted for multfi-mechanisms and spasmolytic effects in network pharmacology. In-vitro experiments were conducted on isolated bladder of rat to analyze the spasmolytic effects of plant extract. Spasmolytic effects were also compared with the standard drugs verapamil and oxybutynin In-vivo experiments were also performed to observe diuretic and nephroprotective potential of the plant.Result: Phytochemical analysis indicated the presence of chlorogenic acid, gallic acid, P-coumaric acid, kaempferol, salicylic acid, sinapic acid and benzoic acid. Aqueous ethanolic extract of plant relaxed the contractions induced by high K+ (80 mm) and carbachol (1 µM) in isolated urinary bladder strips of rat. In-vivo experiments revealed the nephroprotective and diuretic potential.Conclusion: So it has been proved via scientific evidence that the concerned plant possesses spasmolytic, nephroprotective and diuretic potential and may be an important therapeutic agent against urinary problems in the near future.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251352705"},"PeriodicalIF":2.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Questioning the Linear No-Threshold Model (LNT): Lessons From Hiroshima/Nagasaki and Fukushima. 质疑线性无阈模型（LNT）：广岛/长崎和福岛的教训。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-06 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251367588

Shizuyo Sutou

{"title":"Questioning the Linear No-Threshold Model (LNT): Lessons From Hiroshima/Nagasaki and Fukushima.","authors":"Shizuyo Sutou","doi":"10.1177/15593258251367588","DOIUrl":"10.1177/15593258251367588","url":null,"abstract":"Living organisms have been exposed to ionizing radiation throughout Earth's 4-billion-year history, with humans presently receiving about 2 mSv of ionizing radiation every year. While radiation generates reactive oxygen and nitrogen species (ROS and RNS), organisms have evolved mechanisms to neutralize these toxic molecules and utilize them as signal transducers. High doses of radiation are harmful, but low doses are seemingly essential, and moderate doses can provide benefits-a phenomenon known as hormesis. Radiation exposure is currently regulated by the linear no-threshold model (LNT), which assumes all radiation is harmful, even at the smallest doses. However, substantial evidence, including insights into biological defense mechanisms like DNA repair, apoptosis, and immune system, supports hormesis. Although the Life Span Study (LSS) data historically backed the LNT, closer analysis reveals that low-dose radiation is linked to increased life expectancy and reduced cancer risk, invalidating LNT. During the 2011 Fukushima nuclear disaster, the Japanese government, adhering to the LNT-based precautionary principle, evacuated residents despite low contamination levels. This decision caused over 2000 deaths, though no fatalities were directly attributed to radiation. These findings challenge the LNT model and highlight the need for regulatory standards that incorporate thresholds and/or hormesis principles, better reflecting biological evidence.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251367588"},"PeriodicalIF":2.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stachydrine Alleviates Sepsis-Induced Cardiomyopathy by Inhibiting Ferroptosis via Regulating SIRT1/GPX4 Pathway. 水仙碱通过调节SIRT1/GPX4通路抑制铁下垂减轻败血症诱导的心肌病

IF 2.4 4区医学

Dose-Response Pub Date : 2025-09-04 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251377710

Linbo Tao, Xiaoquan Huang, Feng Zhao, Xiude Wang

{"title":"Stachydrine Alleviates Sepsis-Induced Cardiomyopathy by Inhibiting Ferroptosis via Regulating SIRT1/GPX4 Pathway.","authors":"Linbo Tao, Xiaoquan Huang, Feng Zhao, Xiude Wang","doi":"10.1177/15593258251377710","DOIUrl":"10.1177/15593258251377710","url":null,"abstract":"Objectives: This study investigated the cardioprotective effects of stachydrine (STA) in lipopolysaccharide (LPS)-induced septic mice and H9c2 cardiomyocytes, focusing on its anti-apoptotic, anti-inflammatory, and anti-ferroptotic actions.Methods: We established an LPS-induced sepsis model in mice and an LPS-stimulated H9c2 cardiomyocyte model in vitro.Results: STA markedly reduced LPS-induced myocardial apoptosis, as demonstrated by decreased TUNEL-positive cells, and attenuated the elevation of serum cardiac injury markers, including creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), brain natriuretic peptide (BNP), cardiac troponin I (cTnI), and cardiac troponin T (cTnT) levels. STA also suppressed systemic inflammation, significantly reducing interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) levels at both mRNA and protein levels. Additionally, STA significantly inhibited LPS-induced production of pro-inflammatory cytokines in H9c2 cardiomyocytes. Mechanistically, STA activated the SIRT1/Nrf2 signaling axis and enhanced the expression of ferroptosis-related proteins, solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). Additionally, STA reduced oxidative stress and iron accumulation by decreasing malondialdehyde (MDA), Total Fe, and Fe2+ levels, while increasing glutathione (GSH) content in cardiomyocytes.Conclusion: Our results suggest that STA confers robust cardioprotective effects in LPS-induced models by mitigating apoptosis, inflammation, and ferroptosis, partly via SIRT1/GPX4 pathway activation.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251377710"},"PeriodicalIF":2.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Natural Background Radiation Areas: A Literature Review that Reveals Systematic Adaptive Response but Controversial Data With Single Dose. 高自然本底辐射区：揭示单剂量系统适应性反应但有争议数据的文献综述。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-08-31 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251330680

Juliette Restier-Verlet, Clément Devic, Camelia Bellemou, Michel Bourguignon, Nicolas Foray

{"title":"High Natural Background Radiation Areas: A Literature Review that Reveals Systematic Adaptive Response but Controversial Data With Single Dose.","authors":"Juliette Restier-Verlet, Clément Devic, Camelia Bellemou, Michel Bourguignon, Nicolas Foray","doi":"10.1177/15593258251330680","DOIUrl":"10.1177/15593258251330680","url":null,"abstract":"The natural radiation background contributes to the dose of ionizing radiation received by the whole population. However, the telluric component of the natural background radiation is not homogenous on Earth: while the average effective dose has been estimated to be 2.4 mSv/year worldwide, certain regions are considered as high natural background radiation areas (HBRA). To investigate the specificities of a continuous exposure to low-dose-rate irradiation, we reviewed data of the major HBRA from 98 studies published between 1973 and 2023. Three conclusions were drawn: 1) the dose received by the HBRA inhabitants is much lower than values assessed on hot spots : at Ramsar (Iran), 260 mSv/year were assessed at the highest hotspots but the maximal estimated dose-rate received by inhabitants is 80 mSv/year; 2) when DNA or chromosome breaks, cancer or accelerated aging are used as endpoints, no significant difference was observed between cells from HBRA and non-HBRA inhabitants; 3) conversely, adaptive response effect was systematically observed on ex vivo lymphocytes from HBRA inhabitants when they are exposed to a high dose ranging for 0.25 to 4 Gy. A mechanistic model based on the radiation-induced nucleoshuttling of the ATM protein provides an explanation to these last two conclusions.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251330680"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rationale and Safety of Routine Imaging in Rehabilitative Spine Care: Delayed Radiographs for Patients Presenting With Spine Disorders is Debatable. 常规影像学在脊柱康复治疗中的基本原理和安全性：脊柱疾病患者的延迟x线片是有争议的。

IF 2.4 4区医学

Dose-Response Pub Date : 2025-08-29 eCollection Date: 2025-07-01 DOI: 10.1177/15593258251374411

Paul A Oakley, Jason W Haas, Deed E Harrison

{"title":"The Rationale and Safety of Routine Imaging in Rehabilitative Spine Care: Delayed Radiographs for Patients Presenting With Spine Disorders is Debatable.","authors":"Paul A Oakley, Jason W Haas, Deed E Harrison","doi":"10.1177/15593258251374411","DOIUrl":"10.1177/15593258251374411","url":null,"abstract":"Postural alignment is a critical determinant of health status. Its degradation is associated with deformity-caused and compensation-related back pain, neurologic involvement, osteoarthritic development, as well as disability and reduced quality of life. Radiography remains the most efficient method of evaluating standard sagittal and coronal spine and pelvic metrics that are used to plan surgical and nonsurgical treatment strategies. Many current spine guidelines dissuade the use of initial screening X-rays and some chiropractic guidelines condemn repeat imaging to assess progress from treatment regimens; these are anti-scientific viewpoints that ignore alternate viewpoints and evidence. Current understanding of the relationship between different spinopelvic parameters are essential to plan biomechanically appropriate interventions that are patient-specific. There are radiographically measured parameter thresholds critically related to several spinal disorders and positive patient outcomes. Current guidelines must include a caveat for contemporary biomechanical evaluation and its consequent specific treatments and should recommend routine radiographic imaging for spine patients undergoing corrective rehabilitative interventions. The failure to radiographically diagnose spinal deformity is argued to be negligence in many cases. The prime obstacle to routine X-ray imaging lies with the presumed threat of cancer, however, this is dogma; we summarize the main evidence from recent publications why this is so.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 3","pages":"15593258251374411"},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0