Dose-Response最新文献

{"title":"Effects of Low Dose Neutron-Gamma Field on Cell Cycle and Damage of Human Lymphocytes.","authors":"Jinghong Fu, Guangfen Du, Haiqing Wang, Chenxing Liao, Yuyan Zhang, Weiguo Li","doi":"10.1177/15593258251323789","DOIUrl":"10.1177/15593258251323789","url":null,"abstract":"<p><p><b>Purpose:</b> The aim is to investigate the response of peripheral blood lymphocytes to a low-dose neutron-gamma field. <b>Methods:</b> The human peripheral blood was exposed to low-dose neutron-gamma radiation ex vivo. Flow cytometry was utilized to evaluate the changes in cell cycle and protein levels of p21, CDK2, and γH2AX. qPCR analysis was conducted to investigate the mRNA transcription of p21 and CDK2. The chromosomes aberration and micronucleus rate in peripheral blood lymphocytes were observed by microscope. <b>Results:</b> Within the radiation dose range of 0-5976 μGy, compared to the \"0\" dose group, there was an increase in the proportion of cells in G1 phase and a decrease in the proportion of cells in G2 phase. Additionally, there was an upregulation of p21 and γH2AX protein expression, a downregulation of CDK2 protein expression, and an increase in transcription levels of p21 and CDK2 mRNA. Furthermore, there was an elevation in the rate of chromosome aberrations in peripheral blood lymphocytes; however, no significant change of micronuclei rate was observed. <b>Conclusions:</b> The response of human lymphocytes to low dose neutron gamma irradiation can be reflected by the changes of cell cycle, chromosome aberration and RPS18 expression.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 1","pages":"15593258251323789"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mitigating Effect of Melatonin Against Radiation-Induced Inflammation and Disturbance of Reproductive Hormones in Female Albino Rats.","authors":"Shereen M Shedid, Nahed Abdel-Aziz, Fatma R Algeda, Helen N Saada","doi":"10.1177/15593258251323796","DOIUrl":"https://doi.org/10.1177/15593258251323796","url":null,"abstract":"<p><p><b>Objectives:</b> Melatonin has been documented as an antioxidant agent. Numerous investigations have documented melatonin's radioprotective impact; however, investigation of its role post-irradiation requires further studies. Thus, the present study investigated melatonin's mitigating effect against radiation-induced alteration in the ovaries and reproductive hormones in female albino rats. <b>Methods:</b> Melatonin (10 mg/kg body weight, i. p.) was administered to the animals for 7, 11, and 15 days after whole-body exposure to 4 Gy γ-radiation. <b>Results:</b> The results demonstrated that melatonin has significantly attenuated the radiation-induced oxidative stress in the ovary, manifested by a decrease in protein carbonyl and malondialdehyde in conjunction with an increase in total antioxidant capacity. In addition, melatonin has alleviated the radiation-induced increase of the pro-inflammatory cytokines (tumor necrotic factor alpha, interleukin-6, interleukin-1 beta) and caspase-3 levels in the serum. These results were accompanied by a noticeable improvement in serum E2-estradiol, testosterone, progesterone, follicle-stimulating hormone, and luteinizing hormone compared to their respective levels in the irradiated group. <b>Conclusion:</b> It could be concluded that melatonin is an effective agent for minimizing the deleterious impacts of radiation on the ovaries and reproductive hormones through synergistic interdependence between anti-inflammatory, antioxidant, and anti-apoptotic activities.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 1","pages":"15593258251323796"},"PeriodicalIF":2.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Concurrent vs Sequential Administration of anti-PD-1 Following Thoracic Radiotherapy: Impact on Lung Tissue Damage.","authors":"Peng Yan, Zewen Wang, Yufeng Wang, Yongliang Liu, Anna Tong, Meili Sun","doi":"10.1177/15593258251322324","DOIUrl":"10.1177/15593258251322324","url":null,"abstract":"<p><p>The combination of thoracic radiotherapy and immune checkpoint inhibitors (ICIs) had demonstrated a synergistic therapeutic effect, albeit with the occurrence of overlapping pulmonary toxicities. We established a mouse model using programmed cell death protein-1 (PD-1) antibody at different time points after thoracic radiotherapy. Hematoxylin and eosin (HE) staining, as well as TUNEL staining, were utilized for the morphological assessment of lung tissue damage. Inflammatory cells and cytokines present in bronchoalveolar lavage fluid (BALF) were analyzed using flow cytometry and cytometric bead array immunoassay (CBA). Additionally, immunohistochemistry (IHC) and immunofluorescence (IF) staining were conducted to observe the infiltration of inflammatory cells in lung tissue. Immediate administration of PD-1 antibody after thoracic radiotherapy resulted in more severe lung tissue injury compared to delayed administration. Concurrent treatment led to an increase in lymphocytes and neutrophils in BALF, as well as higher levels of inflammatory cytokines. IHC and IF analysis revealed that neutrophils, macrophages, and lymphocytes were more prominent in the concurrent treatment group. A more severe lung injury occurred when PD-1 antibody was given simultaneously with thoracic radiotherapy, possibly due to increased inflammation caused by the combination treatment.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 1","pages":"15593258251322324"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis.","authors":"Iman A Alajeyan, Jawaher Alsughayyir, Mohammad A Alfhili","doi":"10.1177/15593258251314825","DOIUrl":"10.1177/15593258251314825","url":null,"abstract":"<p><p><b>Objectives:</b> Cytokinins are plant hormones that regulate cell growth and differentiation. In particular, zeatin (ZTN) delays cellular senescence of human fibroblasts and keratinocytes and exhibits anticancer activity. Chemotherapy-induced anemia is a major side effect of anticancer therapy secondary to premature senescence of red blood cells (RBCs). Herein, we investigated the biochemical and molecular mechanisms underlying ZTN action in human RBCs. <b>Methods:</b> Colorimetric assays were used to quantify hemolysis and related markers and flow cytometric analysis was applied to examine eryptosis through phosphatidylserine (PS) exposure by annexin-V-FITC, intracellular Ca²⁺ by Fluo4/AM, reactive oxygen species (ROS) by H₂DCFDA, and cell size from forward scatter (FSC). <b>Results:</b> ZTN at 200 μM induced significant hemolysis and K⁺, Na⁺, AST, and LDH leakage. ZTN also caused a significant increase in annexin-V-positive cells along with increased Fluo4 and DCF fluorescence and reduced FSC. Importantly, L-NAME, staurosporin, D4476, urea, sucrose, and polyethylene glycol 8000 (PEG) significantly ameliorated ZTN cytotoxicity. <b>Conclusion:</b> ZTN stimulates PS exposure, intracellular Ca²⁺ elevation, oxidative stress, and cell shrinkage. The hemolytic potential of ZTN, mediated through nitric oxide synthase/protein kinase C/casein kinase 1α signaling axis, is sensitive to isosmotic urea, sucrose, and PEG availability. Altogether, the anticancer potential of ZTN must be reconsidered with prudence.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 1","pages":"15593258251314825"},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification, Characterization and Anti-inflammatory Activity of a New Flavonoid From Hibiscus mutabilis L.","authors":"Pan Hu, Lei Ye, Yuanxiang Gong, Xin Yan, Ping Huang, Xiaoqing Shi, Xi Wang","doi":"10.1177/15593258241290130","DOIUrl":"10.1177/15593258241290130","url":null,"abstract":"<p><p><i>Hibiscus mutabilis</i> L (Malvaceae) was a traditional Chinese medicine with significant anti-inflammatory activity. We isolated 3 compounds from the flowers of <i>H mutabilis</i> L , including a new flavonoid, (1″R)-8-(1-(3,4-dihydroxyphenyl)ethyl)-3,3',5,7-tetrahydroxy-4'-methoxyl flavone (<b>1</b>), and 2 known flavonoids (<b>2-3</b>). The structures of these compounds were elucidated by various spectroscopic methods. In addition, we evaluated the anti-inflammatory effect of compound <b>1</b>. The bioactivity assay showed that <b>1</b> significantly inhibit the excessive production of IL-6, TNF-α and NO in LPS-induced RAW264.7 macrophages. Western blot analysis demonstrated that <b>1</b> inhibit the expressions of COX-2 and iNOS protein in the macrophages induced by LPS in a concentration-dependent manner. In addition, <b>1</b> also significantly suppress the expression of the key proteins P65 and p-P65 in the NF-<i>κ</i>B signaling pathway. Our results revealed that <b>1</b> exert potential anti-inflammatory activity through inhibiting the activation of NF-<i>κ</i>B signaling pathway.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241290130"},"PeriodicalIF":2.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INWORKS and Hiroshima/Nagasaki Leukaemia Results.","authors":"Ken Robert Chaplin","doi":"10.1177/15593258241303476","DOIUrl":"10.1177/15593258241303476","url":null,"abstract":"<p><p>The Hiroshima/Nagasaki (H/N) studies by the Radiation Effect Research Foundation have not shown increased leukaemia for acute doses below 200 milli-gray (mGy). By contrast the INWORKS study of leukaemia in workers stated: \"This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukemia\". The INWORKS study also claimed increased leukaemia, not including Chronic Lymphocytic Leukaemia, at cumulative occupational doses of less than 100 mGy. This is contrary to the expectation that the H/N studies would show more severe effects than the worker study because the doses were acute instead of chronic and because the H/N studies included children who had higher rates of radiation induced leukaemia than adults. This paper shows that the INWORKS leukaemia study is consistent with the H/N studies in showing no increase in leukaemia in the low-dose range. In addition, any increase in leukaemia is confined to Chronic Myeloid Leukaemia, possibly from high radiation dose-rates or chemicals.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241303476"},"PeriodicalIF":2.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial and Hepatoprotective Properties of Pods of <i>Acacia nilotica</i> (L.) Willd. ex Delile: <i>In Vivo</i> and <i>In Silico</i> Approaches.","authors":"Mehak Idrees, Sana Javaid, Sumaira Nadeem, Faria Khurshid, Abida Parveen, Abdul Malik, Azmat Ali Khan, Suhail Akhtar, Sabiha Fatima","doi":"10.1177/15593258241308998","DOIUrl":"10.1177/15593258241308998","url":null,"abstract":"<p><strong>Background: </strong><i>Acacia nilotica</i> is a multipurpose plant known for its remedial properties but the antimicrobial and hepatoprotective activity of its pods remained unexplored.</p><p><strong>Objective: </strong>This study aimed to evaluate the antimicrobial and hepatoprotective activity of n-hexane (ANPH) and methanol (ANPM) extracts of pods to scientifically validate their medicinal claims.</p><p><strong>Methods: </strong>After the pharmacognostic evaluation of pods, <i>in</i> <i>vitro</i> tests were carried out to estimate phenolic and flavonoid content and antimicrobial potential. <i>In vivo</i> experiments involved testing of both extracts (250 and 500 mg/kg) paracetamol (PCM)-induced hepatotoxicity model in rats. The molecular docking studies explored insights into the potential binding capabilities of the ligands with the specific target proteins.</p><p><strong>Results: </strong>ANPH and ANPM were enriched with phenols and flavonoids and showed antimicrobial effects. In the hepatoprotective test, the rats chronically treated with extracts had a dose-dependent hepatoprotection as markers of liver functionality were notably reduced (<i>P</i> < 0.05). The <i>in</i> <i>silico</i> studies revealed strong binding interactions of ergost-5-en-3-ol and oxiranyl methyl ester 9-octadecenoic acid with target proteins for antibacterial activity and hepatoprotective activity, respectively.</p><p><strong>Conclusion: </strong>The antimicrobial and hepatoprotective potential of pods might be due to their phenols and flavonoids. The Pyrogallol, Ergost-5-en-3-and 9-octadecenoic acid might be bringing these remedial benefits through antioxidant and anti-inflammatory effects.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241308998"},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Secondary Metabolites of <i>Cyperus rotundus</i> L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes.","authors":"Muhammad Sajid Hamid Akash, Ammara Afzaal, Kanwal Rehman, Amjad Hussain, Muhammad Ibrahim, Syed Muhammad Shoaib, Mudassar Shahid, Bushra Sadaf","doi":"10.1177/15593258241308724","DOIUrl":"10.1177/15593258241308724","url":null,"abstract":"<p><strong>Background: </strong><i>Cyperus rotundus</i> L., commonly known as nutsedge or purple nutgrass, is a resilient herb in the <i>Cyperaceae</i> family with notable pharmacological potential due to its diverse secondary metabolites. This study aimed to identify these metabolites and evaluate the antioxidant and enzyme inhibitory activities of the crude methanol extract of <i>C. rotundus</i>.</p><p><strong>Methods: </strong>The crude methanol extract of <i>C. rotundus</i> was prepared, and its antioxidant activity was assessed using the DPPH scavenging assay. Additionally, <i>in</i> <i>vitro</i> inhibitory effects against the enzymes: α-amylase and α-glucosidase were evaluated. The secondary metabolites present in the extract were identified using ESI-MS/MS analysis.</p><p><strong>Results: </strong>ESI-MS/MS analysis revealed the presence of various secondary metabolites, including rutin, quercetin, β-sitosterol, limonene, and beta-pinene. The crude methanol extract exhibited strong antioxidant activity and significant inhibition of α-amylase and α-glucosidase enzymes, which play crucial roles in carbohydrate digestion.</p><p><strong>Conclusion: </strong>The findings indicate that the crude methanol extract of <i>C. rotundus</i> possesses notable antioxidant properties and the potential to inhibit key enzymes involved in carbohydrate metabolism. This study enhances our understanding of the bioactive compounds in <i>C. rotundus</i> and suggests its therapeutic applications for managing conditions related to carbohydrate metabolism.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241308724"},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Metformin on Radiation-Induced Lung Fibrosis in Mice.","authors":"Yu-Zhong Chen, Lin Zhao, Wei Wei, Jia Gu, Zhen-Hua Liu, Wen-Yue Shan, Jie Dong, Chao Li, Li-Qiang Qin, Jia-Ying Xu","doi":"10.1177/15593258241308051","DOIUrl":"10.1177/15593258241308051","url":null,"abstract":"<p><p><b>Introduction:</b> Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Metformin has been suggested to have a radioprotective effect. <b>Objective:</b> This study explored the radioprotective effects of metformin on RILF and its mechanisms. <b>Methods:</b> C57BL/6J mice were randomly divided into control, ionizing radiation (IR), low-dose metformin (L-Met), and high-dose metformin (H-Met) groups. The IR, L-Met, and H-Met groups received 15 Gy chest irradiation. The L-Met and H-Met groups were administrated 100 or 200 mg/kg metformin from 3 days before irradiation and continued for 6 months. The mice were then sacrificed, and samples were collected for further analysis. <b>Results:</b> RILF was induced in the irradiated mice. Metformin improved lung pathology, inhibited collagen deposition, and reduced inflammatory factors such as high mobility group box 1 (HMGB1), interleukin-1 beta, interleukin-6, tumor necrosis factor alpha in lung tissue, lavage fluid, and serum. Western blot and quantitative real-time PCR analyses revealed that metformin downregulated HMGB1, toll-like receptor 4 (TLR4), and nuclear factor kappaB (NF-κB) expression. Additionally, metformin reversed the irradiation-induced reduction in the abundance of Lactobacillus and Lachnospiraceae at the genus level. Conclusion: Our findings indicated that metformin ameliorates RILF by downregulating the inflammatory-related HMGB1/TLR4/NF-κB pathway and improving intestinal flora disorder.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241308051"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"J-Shaped Association Between Respiratory Rate and In-Hospital Mortality in Acute Myocardial Infarction Patients Complicated by Congestive Heart Failure in Intensive Care Unit.","authors":"Kai Zhang, Yu Shi, Yu Han, Tian Yi Cai, Fang Ming Gu, Zhao Xuan Gu, Tianqi Zhang, Mao Xun Huang","doi":"10.1177/15593258241303040","DOIUrl":"10.1177/15593258241303040","url":null,"abstract":"<p><p><b>Background:</b> While respiratory rate has proven to be a sensitive prognostic indicator in ICU settings, its relevance in the context of Acute Myocardial Infarction (AMI) patients complicated by Congestive Heart Failure (CHF) remains underexplored. Therefore, this study aims to investigate the relationship between respiratory rate and in-hospital mortality in this specific patient cohort. <b>Methods:</b> This retrospective cohort study utilized the Medical Information Mart for Intensive Care-IV database to analyze all AMI patients with concomitant CHF. The primary outcome, in-hospital mortality, was assessed through multivariate analysis. Logistic regression models, restricted cubic spline regression models, and subgroup analyses were employed to explore the association between respiratory rate and in-hospital mortality. <b>Results:</b> The study encompassed 5056 participants diagnosed with both CHF and AMI. After adjusting for confounding variables, each incremental unit rise in respiratory rate was associated with an 8% increase in the risk of patient mortality (OR = 1.08, 95% CI: 1.05∼1.11, <i>P</i> < 0.001). When comparing individuals with respiratory rates in the first tertile (≤17 breaths per minute) and the third tertile (>17-20 breaths per minute) to those in the second tertile (17-20 breaths per minute), the adjusted ORs for in-hospital mortality were 1.09 (95% CI: 0.82∼1.46, <i>P</i> = 0.546) and 1.62 (95% CI: 1.27∼2.06, <i>P</i> < 0.001), respectively. A dose-response relationship depicted a J-shaped curve between respiratory rate and the risk of in-hospital mortality, with an inflection point at approximately 19 breaths per minute. Stratified analyses confirmed the robustness of this correlation. <b>Conclusions:</b> This study reveals a J-shaped association between respiratory rate and in-hospital mortality in ICU patients suffering from both AMI and CHF.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241303040"},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}