Dose-Response最新文献_第2页

Characterizing Hematological Changes Following Repeated Exposure to Non-Targeted Low-Dose Ionizing Radiation in Prostate Cancer Patients. 前列腺癌患者反复暴露于非靶向低剂量电离辐射后的血液学变化特征。

IF 2.3 4区医学

Dose-Response Pub Date : 2024-10-02 eCollection Date: 2024-10-01 DOI: 10.1177/15593258241276120

Allison E Kennedy, Ian S Dayes, Sameer Parpia, Douglas R Boreham, Dawn M E Bowdish

{"title":"Characterizing Hematological Changes Following Repeated Exposure to Non-Targeted Low-Dose Ionizing Radiation in Prostate Cancer Patients.","authors":"Allison E Kennedy, Ian S Dayes, Sameer Parpia, Douglas R Boreham, Dawn M E Bowdish","doi":"10.1177/15593258241276120","DOIUrl":"10.1177/15593258241276120","url":null,"abstract":"The duration and magnitude of haematological changes following non-targeted low-dose radiation have not been well explored. We previously reported that low-dose radiation (150 mGy 2x/week for 5 consecutive weeks) was well tolerated by participants (n = 15) with minimal toxicities and no changes in quality of life. Leukocytes, platelets and erythrocytes decreased from baseline measurement 12 months following treatment, however changes were not clinically significant. T-cells, NK-cells, B-cells and neutrophils were found to decrease during treatment and return to baseline levels by 3 months. The monocyte activation marker CD64 (FcγRI) was lower in participants whose cancer did not progress during the 12 month study follow up period, potentially giving insights into a biomarker of treatment success. Herein, we provide one of the most detailed descriptions of hematologic changes during low dose radiation treatment and during one year follow up. Low-dose radiation was associated with minor hematologic changes that mostly resolved by 3 months. (Clinical Trial Registered with the United States National Library of Medicine and National Institutes of Health under the title 'Low Dose Hemi-Body Radiation for Recurrent Prostate Cancer'; ID: NCT03196778).","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Olive Leaf Extract, Mesenchymal Stem Cells or Low Radiation Dose in Alleviating Hepatic Injury in Rats. 橄榄叶提取物、间充质干细胞或低辐射剂量在缓解大鼠肝损伤中的作用

IF 2.3 4区医学

Dose-Response Pub Date : 2024-09-29 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241289301

Ola A Gharib, Hanan A Fahmy, Fatma Y Abdou

{"title":"Role of Olive Leaf Extract, Mesenchymal Stem Cells or Low Radiation Dose in Alleviating Hepatic Injury in Rats.","authors":"Ola A Gharib, Hanan A Fahmy, Fatma Y Abdou","doi":"10.1177/15593258241289301","DOIUrl":"10.1177/15593258241289301","url":null,"abstract":"Objectives: This study was conducted to determine the efficacy of mesenchymal stem cells (MSCs) or low-dose gamma radiation (LDR) on liver injury compared to the effect of olive leaf extract as a hepatoprotective agent.Methods: Rats were allocated into six groups; group I served as the negative control. Group II received 5% dextran sodium sulfate (DSS) in its drinking water for 1 week. Group III was injected with a single dose of 1 × 106 bone marrow-derived mesenchymal stem cells (BM-MSCs) intravenously. Group IV was treated as in group III after 5% DSS treatment. Group V was given 5% DSS, followed by olive leaf extract (OLE) (1000 mg/ kg, oral). Group VI: 5% DSS for 1 week, then was exposed to low-dose gamma radiation (LDR) (0.05 Gy).Results: Rats treated with OLE, BM-MSCs, or exposed to LDR exerted significant alleviation in all hepatic biomarkers, significant enhancements in oxidative stress parameters, and improvements in inflammatory biomarkers Interleukin-1 beta (IL-1β) and Interferon gamma (INF-γ) hepatic contents compared with those of the DSS group. Histological pictures emphasized the biochemical findings.Conclusions: BM-MSCs might be a valuable therapeutic approach to overcome hepatic injury. Exposure to LDR provided protective mechanisms that allow the body to survive better.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferroptosis-Associated Extracellular Matrix Remodeling in Radiation-Induced Lung Fibrosis Progression. 辐射诱导的肺纤维化进展中与铁蛋白沉积相关的细胞外基质重塑

IF 2.3 4区医学

Dose-Response Pub Date : 2024-09-28 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241289829

Xinyu Yan, Peixuan Yang, Chen Yang, Yinghui Wang, Zhijun Feng, Ting Liu, Yani Li, Cheng Zhou, Minying Li

{"title":"Ferroptosis-Associated Extracellular Matrix Remodeling in Radiation-Induced Lung Fibrosis Progression.","authors":"Xinyu Yan, Peixuan Yang, Chen Yang, Yinghui Wang, Zhijun Feng, Ting Liu, Yani Li, Cheng Zhou, Minying Li","doi":"10.1177/15593258241289829","DOIUrl":"10.1177/15593258241289829","url":null,"abstract":"Background: Radiation-induced lung fibrosis (RILF) is a life-threatening complication of thoracic radiotherapy. Ferroptosis, a recently discovered type of cell death, is believed to contribute to RILF, though the associated mechanisms are unknown. This study aimed to investigate the potential mechanism of ferroptosis in RILF and examine the contribution of different cell types to ferroptosis during RILF progression. Methods: Histopathological changes in RILF lung tissue were assessed through H&E and Masson staining. IHC staining investigated ferroptosis markers (GPX4, ACSL4, NCOA4). Ferroptosis-related genes (FRG) and pathway scores were derived from RILF transcriptome microarray data. The sc-RNAseq analysis detected FRG score dynamics across cell types, validated by IF staining for PDGFR-α and ACSL4. Results: ACSL4 and NCOA4 protein levels were significantly higher and GPX4 lower in IR than control. FRG scores were positively correlated with fibrosis-related pathway scores in the RILF transcriptome data. FRG and ECM scores were concurrently upregulated in myofibroblasts. Enhanced co-staining of PDGFR-α and ACSL4 were observed in the fibrotic areas of RILF lungs. Conclusions: Our research indicated that in RILF, fibroblasts undergoing ferroptosis may release increased levels of ECM, potentially accelerating the progression of lung fibrosis. This finding presents ferroptosis as a potential therapeutic target in RILF.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them. 使用振动处理技术制备的生物药物能够在不直接接触目标物的情况下对其产生影响。

IF 2.3 4区医学

Dose-Response Pub Date : 2024-09-25 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241284704

Elena Don, Svetlana Zakharova, Sabina Yaroshenko, Anastasia Petrova, Sergey Tarasov

{"title":"Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them.","authors":"Elena Don, Svetlana Zakharova, Sabina Yaroshenko, Anastasia Petrova, Sergey Tarasov","doi":"10.1177/15593258241284704","DOIUrl":"10.1177/15593258241284704","url":null,"abstract":"Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution's activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control (P < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corilagin Alleviates Ang II-Induced Cardiac Fibrosis by Regulating the PTEN/AKT/mTOR Pathway. 柯里拉京通过调节 PTEN/AKT/mTOR 通路缓解血管紧张素 II 诱导的心脏纤维化

IF 2.3 4区医学

Dose-Response Pub Date : 2024-09-18 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241261198

Xiaogang Zhang, Bei Tian, Xinpeng Cong, Zhongping Ning

{"title":"Corilagin Alleviates Ang II-Induced Cardiac Fibrosis by Regulating the PTEN/AKT/mTOR Pathway.","authors":"Xiaogang Zhang, Bei Tian, Xinpeng Cong, Zhongping Ning","doi":"10.1177/15593258241261198","DOIUrl":"https://doi.org/10.1177/15593258241261198","url":null,"abstract":"This research aimed to evaluate the therapeutic effect of corilagin (Cor) against angiotensin II (Ang II)-induced cardiac fibrosis and its underlying mechanisms. C57BL/6 mice (male, 8-10 weeks) received saline or Ang II (2.0 mg/kg/day) via subcutaneous infusion and intraperitoneal injection of Cor (30 mg/kg) for 28 days. Ang II induction increased the fibrotic area, whereas Cor treatment inhibited the fibrotic area significantly. Cor markedly reduced the Ang II-induced cardiac fibroblasts. Cor significantly inhibited Ang II-induced increase in expressions of smooth muscle alpha-actin (α-SMA), collagen I, collagen III, transforming growth factor beta 1 (TGF-β1), fibronectin, and connective tissue growth factor (CTGF). Cor suppressed the intracellular reactive oxygen species (ROS) production. Cor therapy reduced Ang II-induced malondialdehyde (MDA) content, whereas superoxide dismutase (SOD) and catalase (CAT) activities were increased (all, P < .001). Moreover, Ang II induction elevated the expression of phosphorylated phosphatase and tensin homolog (p-PTEN), phosphorylated protein kinase B (p-AKT) (Ser473) and phosphorylated mammalian target of rapamycin (p-mTOR) (Ser 2448), whereas Cor reduced their expressions. Cor treatment inhibited the migration ability of the cardiac fibroblast, whereas a PTEN inhibitor, VO-ohpic, increased the migration capability. Cor could have a protective effect against Ang II-induced cardiac fibrosis via inhibition of the PTEN/AKT/mTOR pathway.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Linear Association Between Climatic Parameters and Bell’s Palsy Prevalence of Hospital Outpatients: An Ecological Proof in Kunshan, Suzhou, China 气候参数与医院门诊患者贝尔氏麻痹症患病率之间的非线性关系：中国苏州昆山的生态学证明

IF 2.5 4区医学

Dose-Response Pub Date : 2024-09-17 DOI: 10.1177/15593258241282768

Lu-Yuan Zhang, Ming-Zhu Jiang, Dong-Mei Li, Ya-Qin Gong, Yun-Yu Xia, Xiao-Chun Wang, Chen Lin, Shan-Jun Yan, Rong-Zhu Lu, Chong Li

{"title":"Non-Linear Association Between Climatic Parameters and Bell’s Palsy Prevalence of Hospital Outpatients: An Ecological Proof in Kunshan, Suzhou, China","authors":"Lu-Yuan Zhang, Ming-Zhu Jiang, Dong-Mei Li, Ya-Qin Gong, Yun-Yu Xia, Xiao-Chun Wang, Chen Lin, Shan-Jun Yan, Rong-Zhu Lu, Chong Li","doi":"10.1177/15593258241282768","DOIUrl":"https://doi.org/10.1177/15593258241282768","url":null,"abstract":"ObjectiveThis study aimed to explore the relationship between climatic parameters and the daily cases of Bell’s palsy (BP) among hospital outpatients, providing ecological evidence for understanding BP etiology and prevention.MethodsRetrospective analysis was conducted on data from 2187 BP patients who attended Kunshan First People’s Hospital Outpatient Clinic from January 1, 2020, to December 31, 2022. Meteorological data, including temperature, relative humidity, precipitation, wind speed, sunshine duration, and atmospheric pressure, were collected and combined with daily BP case records. Additionally, air quality index was used as a covariate.ResultsThe number of new BP cases among outpatients showed a negative correlation with average daily temperature. A nonlinear relationship between daily average temperature and BP cases was observed through the generalized additive model (GAM). A significant negative correlation was identified between daily average temperature and BP cases, with inflection points at temperatures above 4.2°C, suggesting a potential decrease in BP risk with temperature rise beyond this threshold.ConclusionThis study provides ecological evidence of a link between climatic factors and BP occurrence. Temperature demonstrated a significant nonlinear negative correlation with daily BP incidence, highlighting temperature and cold exposure as key targets for BP prevention in Kunshan.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology 利用网络药理学确定芝麻苷的抗缺氧机制

IF 2.5 4区医学

Dose-Response Pub Date : 2024-09-10 DOI: 10.1177/15593258241282574

Dan Song, Mengjie Wang, Yiyi Zhang, Xinjie Zhao, Yanru Zhang, Hongyi Yue, Li Zhang

{"title":"The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology","authors":"Dan Song, Mengjie Wang, Yiyi Zhang, Xinjie Zhao, Yanru Zhang, Hongyi Yue, Li Zhang","doi":"10.1177/15593258241282574","DOIUrl":"https://doi.org/10.1177/15593258241282574","url":null,"abstract":"This study aims to elucidate the anti-hypoxia mechanism of sesamoside, an active component of Phlomis younghusbandii Mukerjee, through a network pharmacology approach. Sesamoside has demonstrated potential anti-oxidant and antiglycation activities. The hypoxia-related disease targets were collected from databases like GeneCards and OMIM. Protein-protein interaction (PPI) networks were constructed using the STRING database. GO/KEGG enrichment analysis was performed using the Metascape database to identify biological processes and signaling pathways. Our results indicate that sesamoside interacts with multiple targets related to glucose and lipid metabolism, nucleotide metabolism, and inflammatory, and we find that AKR1B1 (AR) plays a crucial role in sesamoside responses to hypoxia. Molecular docking studies were performed using Autodock software, revealing good binding activity between sesamoside and AR. We then use CCK-8 assay, qPCR, WB, and ELISA analysis to validate the role of sesamoside in regulating AR and participating in anti-hypoxia through cell experiments. The results show that compared with the hypoxia group, sesamoside treatment significantly improves the expression of AR and inflammation cytokines. In summary, this study sheds light on the anti-hypoxia mechanism of sesamoside using a network pharmacology approach, providing a theoretical basis and experimental foundation for its application in the prevention and treatment of hypoxic diseases.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142221091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation Dose Units: How We Got Here, Do They Serve the Purposes They are Intended to? 辐射剂量单位：我们是如何走到这一步的？

IF 2.5 4区医学

Dose-Response Pub Date : 2024-09-08 DOI: 10.1177/15593258241282019

Momina Mateen, Kaylyn Olshanoski, Nguyen Phuong Dang, Satoru Endo, Chary Rangacharyulu

引用次数: 0

Emblica officinalis Gaertn as a Potential Alternative Therapy for the Treatment of Epilepsy: An Animal Study. Emblica officinalis Gaertn 作为治疗癫痫的潜在替代疗法：一项动物研究。

IF 2.3 4区医学

Dose-Response Pub Date : 2024-09-05 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241282018

Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Juan Francisco Rodríguez-Landa, Armando Alejandro Ortega-García, Óscar Rosales-Sánchez

{"title":"Emblica officinalis Gaertn as a Potential Alternative Therapy for the Treatment of Epilepsy: An Animal Study.","authors":"Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Juan Francisco Rodríguez-Landa, Armando Alejandro Ortega-García, Óscar Rosales-Sánchez","doi":"10.1177/15593258241282018","DOIUrl":"10.1177/15593258241282018","url":null,"abstract":"Introduction: Epilepsy is a neurological disorder characterized by recurrent seizures. Although antiepileptic drugs (AEDs) reduce the frequency of epileptic seizures, they can cause renal and hepatic damage. Several preclinical studies have indicated that Emblica officinalis Gaertn (AMLA) exerts an anticonvulsant effect related to its tannin and polyphenol content. Objective: We aim to evaluate the anticonvulsant effects of chronic oral AMLA administration and its impact on biochemical and hematological parameters in rats. Methods: Twenty-eight male Wistar rats (250 to 300 g) were divided into four experimental groups (n = 7): vehicle (purified water), AMLA (500 and 700 mg/kg), and carbamazepine (CBZ) (300 mg/kg) as the pharmacological control of anticonvulsant activity. Treatments were administered orally every 24 hours for 28 days, while carbamazepine was administered every 48 hours for 5 days before the behavioral, biochemical, and hematological test. On day 29, Status epilepticus (SE) was induced using the lithium-pilocarpine model (3 mEq/kg, i.p. and 30 mg/kg, s.c.), after which the behavioral and biochemical effects were evaluated. Results: The AMLA 500 mg/kg and CBZ 300 mg/kg groups presented fewer phase V seizures than the vehicle group did. None of the treatments modified biochemical or hematological parameters. Conclusion: AMLA could be considered as a potential alternative therapy for the treatment of epilepsy.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Assessment of Aqueous Ethanolic Extract of Thalictrum Foetidum Against Haloperidol-Induced Parkinson's Like Symptoms in Animal Model: A Dose-Dependent Study With Mechanistic Approach. Thalictrum Foetidum乙醇水提取物针对氟哌啶醇诱导的帕金森病样症状动物模型的药理评估：采用机理方法进行的剂量依赖性研究。

IF 2.3 4区医学

Dose-Response Pub Date : 2024-08-31 eCollection Date: 2024-07-01 DOI: 10.1177/15593258241282020

Jiangyu Han, Xu Hao, Mishal Fatima, Zunera Chauhdary, Ayesha Jamshed, Hafiz Muhammad Abdur Rahman, Rida Siddique, Muhammad Asif, Saba Rana, Liaqat Hussain

{"title":"Pharmacological Assessment of Aqueous Ethanolic Extract of Thalictrum Foetidum Against Haloperidol-Induced Parkinson's Like Symptoms in Animal Model: A Dose-Dependent Study With Mechanistic Approach.","authors":"Jiangyu Han, Xu Hao, Mishal Fatima, Zunera Chauhdary, Ayesha Jamshed, Hafiz Muhammad Abdur Rahman, Rida Siddique, Muhammad Asif, Saba Rana, Liaqat Hussain","doi":"10.1177/15593258241282020","DOIUrl":"10.1177/15593258241282020","url":null,"abstract":"Introduction: Parkinson's disease (PD) is characterized by dopamine deficiency in the corpus striatum due to the degeneration of dopaminergic neurons in the substantia nigra. Symptoms include bradykinesia, resting tremors, unstable posture, muscular rigidity, and a shuffled gait. Thalictrum foetidum is traditionally used for neurodegenerative disorders. Objectives: This study aimed to explore the therapeutic potential of aqueous ethanolic extract of Thalictrum foetidum (AETF) against Parkinson-like symptoms and to investigate its underlying mechanism. Methodology: Thirty-six albino mice were randomly divided into 6 groups (n = 6): normal control, disease control, standard treatment (levodopa/carbidopa, 100/25 mg/kg), and 3 treatment groups (AETF at 200, 400, and 600 mg/kg). One hour before treatment, haloperidol (1 mg/kg, i. p.) was administered to induce Parkinson's disease in all groups except the normal control group. Results: Behavioral analysis showed significant improvement (P < .001) in motor function, muscular coordination, and reduced muscular rigidity and tremors. AETF also reduced oxidative stress. Histological examination of the brain showed reduced Lewy bodies, neurofibrillary tangles, and plaque formation. Conclusion: AETF alleviated PD symptoms by reducing neurodegeneration, modulating oxidative stress, and inhibiting the expression of nuclear factor-κB (NF-κB) and associated inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6).","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0