Dose-Response最新文献

{"title":"Identification of Secondary Metabolites of <i>Cyperus rotundus</i> L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes.","authors":"Muhammad Sajid Hamid Akash, Ammara Afzaal, Kanwal Rehman, Amjad Hussain, Muhammad Ibrahim, Syed Muhammad Shoaib, Mudassar Shahid, Bushra Sadaf","doi":"10.1177/15593258241308724","DOIUrl":"10.1177/15593258241308724","url":null,"abstract":"<p><strong>Background: </strong><i>Cyperus rotundus</i> L., commonly known as nutsedge or purple nutgrass, is a resilient herb in the <i>Cyperaceae</i> family with notable pharmacological potential due to its diverse secondary metabolites. This study aimed to identify these metabolites and evaluate the antioxidant and enzyme inhibitory activities of the crude methanol extract of <i>C. rotundus</i>.</p><p><strong>Methods: </strong>The crude methanol extract of <i>C. rotundus</i> was prepared, and its antioxidant activity was assessed using the DPPH scavenging assay. Additionally, <i>in</i> <i>vitro</i> inhibitory effects against the enzymes: α-amylase and α-glucosidase were evaluated. The secondary metabolites present in the extract were identified using ESI-MS/MS analysis.</p><p><strong>Results: </strong>ESI-MS/MS analysis revealed the presence of various secondary metabolites, including rutin, quercetin, β-sitosterol, limonene, and beta-pinene. The crude methanol extract exhibited strong antioxidant activity and significant inhibition of α-amylase and α-glucosidase enzymes, which play crucial roles in carbohydrate digestion.</p><p><strong>Conclusion: </strong>The findings indicate that the crude methanol extract of <i>C. rotundus</i> possesses notable antioxidant properties and the potential to inhibit key enzymes involved in carbohydrate metabolism. This study enhances our understanding of the bioactive compounds in <i>C. rotundus</i> and suggests its therapeutic applications for managing conditions related to carbohydrate metabolism.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241308724"},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Metformin on Radiation-Induced Lung Fibrosis in Mice.","authors":"Yu-Zhong Chen, Lin Zhao, Wei Wei, Jia Gu, Zhen-Hua Liu, Wen-Yue Shan, Jie Dong, Chao Li, Li-Qiang Qin, Jia-Ying Xu","doi":"10.1177/15593258241308051","DOIUrl":"10.1177/15593258241308051","url":null,"abstract":"<p><p><b>Introduction:</b> Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Metformin has been suggested to have a radioprotective effect. <b>Objective:</b> This study explored the radioprotective effects of metformin on RILF and its mechanisms. <b>Methods:</b> C57BL/6J mice were randomly divided into control, ionizing radiation (IR), low-dose metformin (L-Met), and high-dose metformin (H-Met) groups. The IR, L-Met, and H-Met groups received 15 Gy chest irradiation. The L-Met and H-Met groups were administrated 100 or 200 mg/kg metformin from 3 days before irradiation and continued for 6 months. The mice were then sacrificed, and samples were collected for further analysis. <b>Results:</b> RILF was induced in the irradiated mice. Metformin improved lung pathology, inhibited collagen deposition, and reduced inflammatory factors such as high mobility group box 1 (HMGB1), interleukin-1 beta, interleukin-6, tumor necrosis factor alpha in lung tissue, lavage fluid, and serum. Western blot and quantitative real-time PCR analyses revealed that metformin downregulated HMGB1, toll-like receptor 4 (TLR4), and nuclear factor kappaB (NF-κB) expression. Additionally, metformin reversed the irradiation-induced reduction in the abundance of Lactobacillus and Lachnospiraceae at the genus level. Conclusion: Our findings indicated that metformin ameliorates RILF by downregulating the inflammatory-related HMGB1/TLR4/NF-κB pathway and improving intestinal flora disorder.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241308051"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"J-Shaped Association Between Respiratory Rate and In-Hospital Mortality in Acute Myocardial Infarction Patients Complicated by Congestive Heart Failure in Intensive Care Unit.","authors":"Kai Zhang, Yu Shi, Yu Han, Tian Yi Cai, Fang Ming Gu, Zhao Xuan Gu, Tianqi Zhang, Mao Xun Huang","doi":"10.1177/15593258241303040","DOIUrl":"10.1177/15593258241303040","url":null,"abstract":"<p><p><b>Background:</b> While respiratory rate has proven to be a sensitive prognostic indicator in ICU settings, its relevance in the context of Acute Myocardial Infarction (AMI) patients complicated by Congestive Heart Failure (CHF) remains underexplored. Therefore, this study aims to investigate the relationship between respiratory rate and in-hospital mortality in this specific patient cohort. <b>Methods:</b> This retrospective cohort study utilized the Medical Information Mart for Intensive Care-IV database to analyze all AMI patients with concomitant CHF. The primary outcome, in-hospital mortality, was assessed through multivariate analysis. Logistic regression models, restricted cubic spline regression models, and subgroup analyses were employed to explore the association between respiratory rate and in-hospital mortality. <b>Results:</b> The study encompassed 5056 participants diagnosed with both CHF and AMI. After adjusting for confounding variables, each incremental unit rise in respiratory rate was associated with an 8% increase in the risk of patient mortality (OR = 1.08, 95% CI: 1.05∼1.11, <i>P</i> < 0.001). When comparing individuals with respiratory rates in the first tertile (≤17 breaths per minute) and the third tertile (>17-20 breaths per minute) to those in the second tertile (17-20 breaths per minute), the adjusted ORs for in-hospital mortality were 1.09 (95% CI: 0.82∼1.46, <i>P</i> = 0.546) and 1.62 (95% CI: 1.27∼2.06, <i>P</i> < 0.001), respectively. A dose-response relationship depicted a J-shaped curve between respiratory rate and the risk of in-hospital mortality, with an inflection point at approximately 19 breaths per minute. Stratified analyses confirmed the robustness of this correlation. <b>Conclusions:</b> This study reveals a J-shaped association between respiratory rate and in-hospital mortality in ICU patients suffering from both AMI and CHF.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241303040"},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valproic Acid Inhibits Endoplasmic Reticulum Stress and Reduces Ferroptosis After Traumatic Brain Injury.","authors":"Jie Chen, Lei Li, Lei Huang, Chengyu Zhao, Zhanwei Ruan","doi":"10.1177/15593258241303646","DOIUrl":"https://doi.org/10.1177/15593258241303646","url":null,"abstract":"<p><strong>Backgound: </strong>Traumatic brain injury (TBI) is a severe neurological disorders, which invloving complicated molecular mechanisms, such as endoplasmic reticulum (ER) stress and ferroptosis. , However, the mechanism underlying TBI remains unclear.</p><p><strong>Objectives: </strong>The Objective was to determine the effect of VPA on ER stress and ferroptosis, and affirm the relationship between ER stress and ferroptosis. Methods: The expression levels of GRP78, ATF6, CHOP and GPX4 in brain tissues were detected via western blot, histological staining, and immunofluorescence. The effect of VPA on ER stress and ferroptosis on OS cellswas evaluated in vitro and in vivo.</p><p><strong>Results: </strong>In our study, we found that VPA suppressed ER stress after TBI by inhibiting the GRP78-ATF6-CHOP signaling pathway, which ameliorated ferroptosis by reversing the reduction of the ferroptosis protein GPX4. Furthermore, tissue defects, bleeding, and iron accumulation also reduced. Moreover, 4-phenylbutyric acid was used to further confirm our assumption.</p><p><strong>Conclusion: </strong>VPA plays a neuroprotective role by inhibiting ER stress levels and subsequently inhibiting ferroptosis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241303646"},"PeriodicalIF":2.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Neoadjuvant Chemoradiotherapy Sensitivity in Patients With Esophageal Squamous Cell Carcinoma Using CT-Based Radiomics Combined With Clinical Features.","authors":"Xindi Li, Jigang Dong, Baosheng Li, Ouyang Aimei, Yahong Sun, Xia Wu, Wenjuan Liu, Ruobing Li, Zhongyuan Li, Yu Yang","doi":"10.1177/15593258241301525","DOIUrl":"10.1177/15593258241301525","url":null,"abstract":"<p><p><b>Background:</b> For patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC), the current standard treatment is neoadjuvant chemoradiotherapy (nCRT) plus radical surgery. <b>Objective:</b> This study aimed to establish a predictive model, based on computed tomography (CT) radiomics features and clinical parameters, to predict sensitivity to nCRT in patients with ESCC pre-treatment. The goal was to provide risk stratification and decision-making recommendations for clinical treatments and offer more valuable information for developing personalized therapies. <b>Methods:</b> This retrospective study involved 102 patients diagnosed with ESCC through biopsy who underwent nCRT. To select radiomics features, we used the least absolute shrinkage and selection operator (LASSO) algorithm. A combined model was constructed, integrating the selected clinically relevant parameters with the Rad-Score. To assess the performance of this combined model, we utilized calibration curves and receiver operating characteristic (ROC) curves. <b>Results:</b> Nine optimal radiomics features were selected using the LASSO algorithm. The support vector machine (SVM) classifier was identified as having the best predictive performance. The area under the curve (AUC) of the SVM training group was 0.937 (95% CI: 0.856-1.000), and of the validation group was 0.831 (95% CI: 0.679-0.983). Smoking and alcohol history, neutrophil to lymphocyte ratio, serum aspartate aminotransferase to alanine aminotransferase ratio, and carcinoembryonic antigen and fibrinogen levels were independent predictors of sensitivity to nCRT in patients with ESCC. The AUCs of the combined model for the training and validation groups were 0.870 (95% CI: 0.774-0.964) and 0.821 (95% CI: 0.669-0.972), respectively. The calibration curve showed that the nomogram's predictions were close to the actual clinical observations, indicating that the model exhibited good predictive performance. <b>Conclusion:</b> Our combined model based on Rad-Score and clinical characteristics showed high predictive performance for predicting sensitivity to nCRT in patients with ESCC. It may be useful for predicting treatment effects in clinical practice and demonstrates the significant potential of radiomics in predicting and optimizing treatment decisions.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241301525"},"PeriodicalIF":2.3,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of α-Particle Radiation on DNA Methylation in Human Hepatocytes.","authors":"Xiangming Xue, Lixia Su, Teng Zhang, Jingming Zhan, Xiaona Gu","doi":"10.1177/15593258241297871","DOIUrl":"10.1177/15593258241297871","url":null,"abstract":"<p><p><i>Objective:</i> This paper explores the role of DNA methylation in α-irradiation damage at the cellular level. <i>Methods:</i> Human normal hepatocytes L-02 were irradiated using a 241 Am α source at doses of 0, 1.0, and 2.0 Gy. The methylation levels of the six differentially methylated genes were examined by pyrophosphate sequencing, and the mRNA expression levels of the six differentially methylated genes were examined by real-time fluorescence quantitative PCR. <i>Results:</i> The rate of γH2AX foci positive cells was significantly higher than that of the control group after irradiation of cells in different dose groups for 1 h and 2 h respectively (<i>P</i> < .05). The proportion of S-phase cells was significantly increased in the 1.0 Gy and 2.0 Gy dose groups compared with the control group (<i>P</i> < .05). The methylation levels of CDK2AP1, PDGFRL, PCDHB16 and FAS genes were significantly increased, while the mRNA expression levels were significantly decreased (<i>P</i> < .05). The expression levels of CDK2Apl, PCDHB16 and FAS were significantly negatively correlated with the methylation levels (<i>P</i> < .05). <i>Conclusion:</i> The α-particle radiation can affect gene expression at the epigenetic level, which led to the speculation that altered methylation levels of CDK2AP1, PCDHB16, and FAS genes may be involved in the α radiation damage process.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241297871"},"PeriodicalIF":2.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hawthorn Fruit Extract Drink in Chinese Patients With Mild Hypertension and/or Hyperlipidaemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.","authors":"Weiwei Zeng, Tanya T W Chu, Benny S P Fok, Walter K K Ho, Juliana C N Chan, Brian Tomlinson","doi":"10.1177/15593258241303136","DOIUrl":"10.1177/15593258241303136","url":null,"abstract":"<p><p><b>Objectives:</b> The purpose of this study was to examine the effect of hawthorn extract drink in mildly hypertensive and/or hyperlipidaemic Chinese patients. <b>Methods:</b> We performed a randomized double-blind placebo-controlled crossover study. Subjects who were randomly divided into 2 groups and asked to consume either hawthorn fruit extract drink or placebo with the same sugar content for 8-weeks with crossover to the alternative drink separated by a 4-weeks washout period. Adverse effects, lipid profile, fasting plasma glucose and blood pressure were recorded. <b>Results:</b> In 61 participants, body weight increased by mean (95% CI) 0.42 kg (-0.85, 1.69 kg) with the hawthorn drink and 0.94 kg (0.52, 1.36 kg) with placebo (<i>P</i> > .05). Systolic blood pressure and plasma total cholesterol increased significantly with both treatments and cholesterol sub-fractions showed no significant changes. Significant increases were seen in fasting plasma glucose with placebo. The increase in plasma glucose was reversed during the 4-week washout period. <b>Conclusions:</b> Although our results didn't show significant effects of hawthorn drink compared to placebo, there was a trend toward fewer adverse metabolic effects. A longer study with hawthorn fruit extract without additional calories would be useful to determine if beneficial effects occur in patients with mild hyperlipidaemia or hypertension.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241303136"},"PeriodicalIF":2.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antiurolithiatic Effects of <i>Moringa oleifera</i> Lam. Leaves Extract: <i>In-vitro</i>, <i>in-silico</i> and <i>in-vivo</i> Approaches.","authors":"Hina Ali, Qaiser Jabeen, Ayesha Jamshed, Syeda Abida Ejaz, Maria Qadeer, Mariya Anwaar, Hafiz Muhammad Farhan Rasheed","doi":"10.1177/15593258241301222","DOIUrl":"10.1177/15593258241301222","url":null,"abstract":"<p><p><b>Objective:</b> <i>Moringa oleifera</i> Lam. (Moringaceae), has traditionally been used for various renal diseases including urolithiasis. Considering the therapeutic and nutritional values, the present study was designed to investigate the antiurolithiatic potential of <i>M. oleifera</i> leaves through <i>in-vitro</i>, <i>in-silico</i> and <i>in-vivo</i> approaches. <b>Methods:</b> Methanolic aqueous extract of <i>M. oleifera</i>. leaves (MoL.Cr) was prepared and screened for phytoconstituents through FTIR and HPLC analysis, while antioxidant potential was determined by DPPH assay. Crystal nucleation, aggregation and growth assays were carried out to ascertain the <i>in-vitro</i> inhibitory effects of MoL.Cr. Molecular docking was performed to analyze the interactions between phytoconstituents and targeted proteins (Glycolate oxidase, Albumin and Tamm-Horsfall). Whereas, ethylene glycol-induced urolithiasis model (1% ammonium chloride +0.75% ethylene glycol) was used for <i>in-vivo</i> study. Presence of alkaloids, phenols, glycosides and flavonoids was confirmed by FTIR and HPLC analysis. <b>Results:</b> MoL.Cr significantly inhibited the CaOx crystal nucleation, aggregation as well as growth and normalized urinary and serum parameters. Histological studies showed that MoL.Cr significantly restored hyperoxaluria-induced irregular epithelial lining, interstitial inflammation and dilated proximal tubules. <b>Conclusions:</b> Thus, <i>M. oleifera</i> demonstrated marked stone inhibiting potential which can be due to its antioxidant, lowering of urinary concentration of stone forming constituents and anti-crystallization effects.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241301222"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter re: Overestimation of Adverse Effects of Low-Dose Low-Rate Ionizing Radiation: Cui Bono?","authors":"Sergei V Jargin","doi":"10.1177/15593258241301951","DOIUrl":"10.1177/15593258241301951","url":null,"abstract":"","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241301951"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salidroside Pre-Treatment Inhibits Hypertensive Renal Injury and Fibrosis Through Inhibiting Wnt/β-Catenin Pathway.","authors":"Jie Zhu, Liang Li, Yuting Luan, Ziqing Zhang, Yi Wang, Zhenyu Xu","doi":"10.1177/15593258241298045","DOIUrl":"10.1177/15593258241298045","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the protective effects and underlying mechanisms of salidroside (SAL) in angiotensin II (Ang II)-induced hypertensive renal injury and fibrosis, using in vivo and in vitro models.</p><p><strong>Methods: </strong>In this study, we generated Ang II-induced hypertensive renal injury and fibrosis in mice and the recombinant interferon-gamma (IFN-γ)-stimulated murine podocyte clone 5 (MPC5) model in vitro. Histological and oxidative stress analyses were performed to evaluate the renal injury.</p><p><strong>Results: </strong>SAL pre-treatment reduced systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), and attenuated serum creatinine (Scr), blood urea nitrogen (BUN), and serum cystatin C (Cys-C) levels in Ang II-infused mice (all, <i>P</i> < 0.001). SAL reduced renal fibrosis and related molecules expression, including Collagen I, Collagen III, and α-smooth muscle actin (α-SMA) (all, <i>P</i> < 0.001). SAL decreased the content of malondialdehyde (MDA) while increasing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in Ang II-treated mice (all, <i>P</i> < 0.001). In addition, SAL pre-treatment inhibited AT1R, Wnt1, Wnt3a, and β-catenin expressions (all, <i>P</i> < 0.001), both in vivo <i>and</i> in vitro.</p><p><strong>Conclusion: </strong>Our experimental data demonstrate that SAL pre-treatment protects against Ang II-induced hypertensive renal injury and fibrosis by suppressing the Wnt/β-catenin pathway in vivo and in vitro.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"22 4","pages":"15593258241298045"},"PeriodicalIF":2.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}