Dose-Response最新文献

{"title":"Friend or Foe: Dietary Restriction and Its Protective Effects on Responses to Ionizing Radiation.","authors":"Yi Shang, Takanori Katsube, Nathupakorn Dechsupa, Takamitsu Morioka, Shizuko Kakinuma, Bing Wang, Jiraporn Kantapan","doi":"10.1177/15593258261469165","DOIUrl":"10.1177/15593258261469165","url":null,"abstract":"<p><p>Dietary restriction (DR) has been extensively investigated for its capacity to extend lifespan and mitigate age-associated pathologies. In the context of ionizing radiation (IR), DR-implemented through caloric reduction, selective nutrient restriction, or fasting-based regimens-has emerged as a significant modulator of both cellular and systemic responses to radiation exposure. Growing evidence suggests that DR influences radiation outcomes in a highly context-dependent manner, exerting either protective or sensitizing effects depending on tissue type, metabolic status, timing of intervention, and radiation conditions. This review synthesizes current knowledge regarding the mechanisms through which DR modulates responses to IR, with particular emphasis on oxidative stress regulation, inflammatory signaling, mitochondrial homeostasis, DNA damage responses, cellular quality-control pathways, and carcinogenic processes. We further discuss how distinct dietary paradigms interact with nutrient-sensing and stress-adaptive networks to influence radiation sensitivity and tissue recovery. Emerging evidence indicates that the timing, intensity, and composition of dietary interventions critically shape tissue responses to IR, underscoring the importance of considering nutritional status in radiation risk assessment and therapeutic planning. By integrating established findings with emerging mechanistic insights, this review highlights the translational potential of DR for improving outcomes in radiation oncology and reducing radiation-induced injury.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 3","pages":"15593258261469165"},"PeriodicalIF":2.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Flucytosine and Amphotericin B Coadministration Induces Dose-Related Renal Injury.","authors":"","doi":"10.1177/15593258261456955","DOIUrl":"https://doi.org/10.1177/15593258261456955","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1177/1559325817703461.].</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261456955"},"PeriodicalIF":2.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA-Targeted Herbal Compounds Against Gastric Precancerous Evolution in Chronic Atrophic Gastritis.","authors":"Chenlin Wang, Nan Zhang, Xiaoge Wang, Xinyu Yang, Erping Xu","doi":"10.1177/15593258261464174","DOIUrl":"10.1177/15593258261464174","url":null,"abstract":"<p><p>Gastric cancer (GC) ranks third globally in cancer mortality. It develops via a well-defined pathological sequence: normal gastric mucosa progresses sequentially to superficial gastritis, chronic atrophic gastritis (CAG), intestinal metaplasia, dysplasia, and ultimately invasive carcinoma. Given this stepwise carcinogenic cascade, early intervention during the precancerous stage, particularly in CAG, is paramount for secondary GC prevention. Emerging evidence underscores that microRNAs (miRNAs), a major subclass of non-coding RNAs (ncRNAs), exert crucial regulatory effects on gastric carcinogenesis. Dysregulated miRNAs are frequently detected in Helicobacter pylori-infected gastric mucosa, driving chronic inflammation, epithelial-mesenchymal transition (EMT), and subsequent malignant transformation. Recently, traditional Chinese medicine (TCM) has gained increasing recognition as a promising therapeutic approach for precancerous lesions of gastric cancer (PLGC). Classical TCM formulations and bioactive herbal compounds have been shown to exert multi-targeted and multi-pathway efficacy in inhibiting the progression of this disease. This review integrates available evidence and indicates that TCM interventions, including herbal prescriptions and acupuncture, exert anti-inflammatory, anti-fibrotic and anti-metastatic effects by regulating microRNA expression profiles, thereby alleviating chronic inflammation, pathological remodeling and tumor cell invasion. Collectively, these findings demonstrate TCM's adjunctive potential in CAG treatment and GC prevention, providing a novel mechanistic approach to halt precancerous gastric carcinogenesis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261464174"},"PeriodicalIF":2.8,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Mediated Fabrication of Iron and Zinc Oxide Nanoparticles for Anticancer Efficacy Against HT-29 and HepG2 Cells.","authors":"Arif Nazir, Rahat Mustafa, Mazhar Abbas, Munawar Iqbal, Shahana Rahat, Abid Ali, Osama A Mohammed, Abida Kausar, Samiah H Al-Mijalli","doi":"10.1177/15593258261428427","DOIUrl":"10.1177/15593258261428427","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to valorize <i>Fagonia arabica</i> (Dhamasa booti) herbal waste by synthesizing bioactive iron oxide (FeO) and zinc oxide (ZnO) nanoparticles for anticancer applications.</p><p><strong>Methods: </strong>Aqueous extracts of <i>F. arabica</i> were utilized to green-synthesize FeO and ZnO NPs. The nanoparticles were characterized for morphology, size, crystallinity and zeta potential. Their antioxidant activity, brine shrimp lethality, and hemolytic assays were performed to determine bioactivity and cyto-compatibility.</p><p><strong>Results: </strong>FeO and ZnO NPs were spherical, monodispersed and polycrystalline with particle sizes of 28.8 nm and 30.4 nm, respectively. ZnO NPs showed stronger antioxidant activity (80.81% scavenging at 150 μg/mL) and higher cytotoxicity in the brine shrimp assay (LC₅₀ = 0.98 μg/mL), compared to FeO NPs and the crude extract. Minimal hemolytic activity, confirmed their favorable biocompatibility. Zeta potential values of -36 mV (FeO) and +33.6 mV (ZnO) indicate moderate colloidal stability. In vitro anticancer analysis revealed superior performance of ZnO NPs with IC₅₀ values of 43.79 µg/mL (HepG2) and 66.71 µg/mL (HT-29).</p><p><strong>Conclusion: </strong><i>Fagonia Arabica-</i>derived ZnO NPs exhibit potent antioxidant, cytotoxic and anticancer activities, along with favorable biocompatibility. Their significant therapeutic performance highlights their role as effective plant-mediated antineoplastic agents and supports the value-added utilization of <i>F</i>. <i>arabica</i> herbal waste.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261428427"},"PeriodicalIF":2.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total <i>Sanghuangporus vaninii</i> Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation.","authors":"Yankai Xu, Jiesi Zhou, Xiaobin Zhou, Yong Li, Senyuan Yang, Zebin Xue","doi":"10.1177/15593258261454529","DOIUrl":"10.1177/15593258261454529","url":null,"abstract":"<p><strong>Objectives: </strong>Ferroptosis is a distinct form of programmed cell death characterized by iron (Fe)-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. Cisplatin (CPT), a chemotherapeutic agent, can induce ferroptosis in glioma cells and act synergistically with erastin (EST). The total extract of the fungus <i>Sanghuangporus vaninii</i> (TSV) has anticancer and antioxidant activities. This investigation aimed to assess the properties of TSV on CPT-induced inflammatory response and ferroptosis-related changes in glioma cells.</p><p><strong>Methods: </strong>LNZ308 glioma cells were exposed to CPT and EST, followed by treatment with different TSV concentrations. Cell viability was assessed. Intracellular reactive oxygen species (ROS), glutathione peroxidase 4 (GPX4), glutathione (GSH), labile iron pool (LIP), LPO, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were examined, and cell migration was assessed using a scratch assay.</p><p><strong>Results: </strong>TSV (25 µg/mL) exhibited limited toxicity to LNZ308 cells but failed to reverse the CPT-induced loss of cell viability. TSV markedly reduced ROS levels, LIP, and LPO, while restoring GSH and GPX4 levels. Moreover, it diminished IL-1β, TNF-α, and IL-6 in CPT-treated LNZ308 cells in a dose-responsive manner. L-ascorbic acid diminished ROS levels during oxidative stress. TSV also promoted scratch closure in both untreated and CPT-treated LNZ308 cells.</p><p><strong>Conclusion: </strong>The results indicate that TSV modulates CPT-induced oxidative, inflammatory, and ferroptotic responses in LNZ308 glioma cells in vitro, supporting further investigation of its potential as an adjunct to chemotherapy.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261454529"},"PeriodicalIF":2.8,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Association Between Gut Microbiota, Plasma Metabolites, and Prostate Cancer: Two-Step Mendelian Randomization Study.","authors":"Junxiong Li, Jian Hou, Haolin Liu, Shicheng Fan, Yumin Wang, Pinyao Liang, Jingbo Qin, Peng Gu, Xiaodong Liu, Xiangyang Wen","doi":"10.1177/15593258261444912","DOIUrl":"10.1177/15593258261444912","url":null,"abstract":"<p><strong>Objectives: </strong>The specific role of metabolites in mediating the relationship between gut microbiota (GM) and prostate cancer (PCa) remains unclear. In this study, we utilized Mendelian randomization (MR) analyses to investigate the causal relationship between 430 GM traits, 1,400 plasma metabolites, and PCa.</p><p><strong>Methods: </strong>Inverse variance weighted (IVW) method is the primary analytical approach, with supplementary validation using MR-Egger, weighted median, and weighted mode methods. Mediation analysis was performed to assess the contribution of metabolites to the GM-PCa association.</p><p><strong>Results: </strong>IVW analysis identified 18 GM traits and 66 plasma metabolites showing a causal association with PCa. For instance, P_Firmicutes exhibited a causally protective effect against PCa (IVW: OR=0.937, P=0.008), while Parasutterella showed a causally risk-increasing effect (IVW: OR=1.029, P=0.039). Notably, four metabolites mediated the causal effects of GM on PCa: Subdoligranulum via unidentified metabolite X-25422 (20.785% mediation proportion, P=0.022), Bacteroides via N-acetylarginine (6.706%, P=0.020), and Parasutterella and G_Roseburia via N-acetyl-L-glutamine (-9.382%, P=0.031 and -9.094%, P=0.036, respectively). No significant heterogeneity or horizontal pleiotropy was detected.</p><p><strong>Conclusion: </strong>These findings offer new insights into the metabolite-mediated pathways linking GM to PCa, which may serve as novel potential biomarkers and therapeutic targets for precision therapies.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261444912"},"PeriodicalIF":2.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DMSO Protects Against Radiation-Induced Ovarian Injury by Preserving Mitochondrial Function and Alleviating DNA Damage.","authors":"Jie Zhou, Renjun Peng, Zhongmin Chen, Yiying Zhang, Jing Dai, Suhe Dong, Huijie Yu, Sinian Wang, Qisheng Jiang, Wei Li, Bowen Shi, Fengsheng Li, Wei Wang","doi":"10.1177/15593258261457619","DOIUrl":"10.1177/15593258261457619","url":null,"abstract":"<p><strong>Background and purpose: </strong>Radiation-induced ovarian injury (RIOI) compromises the clinical utility of pelvic radiotherapy and reduces fertility in young female patients. Dimethyl sulfoxide (DMSO) exhibits antioxidant property. Hearin, we aimed to explore the protective effect and underlying mechanism of DMSO on RIOI.</p><p><strong>Materials and methods: </strong>C57BL/6J female mice were treated with DMSO prior to undergoing lower abdominal radiation. Intragenerational and transgenerational fertility were assessed by mating experiment. Ovaries were harvested to evaluate follicle count and morphology. Granulosa cells were analyzed by immunohistochemical staining of TUNEL and Ki67. An ovary explant organ culture system was established to evaluate the effect of DMSO. Fluorescent probes were employed to evaluate mitochondrial mass and function. DNA double-strand breaks were detected by immunoblotting of γ-H2AX.</p><p><strong>Results: </strong>DMSO preserved the fertility of irradiated mice and even safeguarded the reproductive capacity of their unirradiated female offspring. Histological analyses revealed that DMSO preserves the ovarian follicle reserve, including both primordial and developing follicles. Additionally, DMSO demonstrated radioprotective effects in <i>ex vivo</i> ovarian tissue. Moreover, DMSO reduced apoptosis and enhanced proliferation in granulosa cells. Mechanistically, DMSO alleviated radiation-induced oxidative stress and preserved mitochondrial function, as evidenced by increased mitochondrial mass, reduced oxidant levels, and enhanced mitochondrial membrane potential. Moreover, DMSO reduced the levels of DNA damage accumulation <i>in vivo</i> and <i>in vitro</i>.</p><p><strong>Conclusion: </strong>Our data suggest that DMSO may offer a potential pharmacological treatment option for fertility impairment in women undergoing radiotherapy, which warrants further investigation in clinical settings.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261457619"},"PeriodicalIF":2.8,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Modern Odyssey of Prevention: Integrating Nutrition and Lifestyle in Radiation Mitigation- A Narrative Review.","authors":"Polash Chandra Karmakar, Tusher- Al-Arafat, Cuihua Liu, Takanori Katsube, Bing Wang","doi":"10.1177/15593258261444920","DOIUrl":"10.1177/15593258261444920","url":null,"abstract":"<p><p>Ionizing radiation, though indispensable in medicine, energy, and space exploration, imposes complex biological stresses that disrupt redox homeostasis, inflammation control, and genomic integrity, ultimately contributing to fibrosis, immunosuppression, and carcinogenesis. Despite advances in pharmacological radioprotectors and technological safeguards, their incomplete efficacy and safety concerns highlight the need for integrative and sustainable mitigation strategies. Emerging evidence supports that nutrition- and lifestyle-based interventions can attenuate radiation-induced injury and enhance intrinsic defense mechanisms without compromising therapeutic efficacy. Nutritional modulation through balanced energy intake, micronutrients, and bioactive compounds such as antioxidants, vitamins, omega-3 fatty acids, and phytochemicals helps stabilize redox balance, suppress inflammatory signaling, and promote DNA repair and mitochondrial stability. Micronutrients including selenium and zinc stimulate antioxidant enzymes and DNA repair systems, while phytochemicals such as resveratrol, curcumin, and epigallocatechin gallate activate Nrf2 and inhibit NF-κB pathways, restoring cellular homeostasis. Complementary lifestyle factors including regular physical activity, adequate sleep, circadian rhythm alignment, and stress management, further enhance immune surveillance, genomic stability, and metabolic adaptation. Collectively, these integrative approaches provide synergistic, multi-pathway protection against radiation-induced damage. Future directions should focus on multi-omics-guided mechanistic studies and well-designed clinical trials to establish personalized, evidence-based frameworks for radiation mitigation.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261444920"},"PeriodicalIF":2.8,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Radioactivity From Nuclear Power Plants Raise the Risk of Cancer? Harvard School of Public Health: Yes. Biology: No.","authors":"Gregory Meyerson, Bill Sacks, James S Welsh","doi":"10.1177/15593258261454638","DOIUrl":"10.1177/15593258261454638","url":null,"abstract":"","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261454638"},"PeriodicalIF":2.8,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Tibetan Medicine Renqing Changjue Extracts on Cyclophosphamide-Induced Immunosuppression in a Mouse Model.","authors":"Zhao Jiang, Xiumei Kong, Xiaoying Zhang, Yaxin Lv, Siqi Wu, Xu Ji, Qin Zhao","doi":"10.1177/15593258261454535","DOIUrl":"10.1177/15593258261454535","url":null,"abstract":"<p><strong>Objectives: </strong>Renqing Changjue (RQCJ) is a form of Tibetan medicine recognized for its immunomodulatory effects. However, the underlying mechanisms through which it exerts these effects remain to be elucidated.</p><p><strong>Methods: </strong>We randomly divided 180 male Kunming mice into five groups: control, model (CTX), and high-, medium-, low-dose RQCJ (RQCJH, RQCJM, and RQCJL respectively). The mice received appropriate medications for 15 days. We measured body weight, thymus, spleen index, immune-related cytokines, T cells, and antibodies to evaluate the immunomodulatory effects. Finally, the impact of RQCJ on immunocompromised mice was examined using spleen transcriptome sequencing analysis.</p><p><strong>Results: </strong>The RQCJ can significantly enhance immune function by regulating specific and non-specific immunity. Transcriptome analysis revealed significant changes in the cytosolic DNA-sensing pathway, TNF signaling pathway, ECM-receptor interactions, and Chagas disease within the RQCJH group. The Jag1 and Tgtp1 genes showed significant upregulation and demonstrated noteworthy correlations with the proportions of T-cell subsets and levels of cytokine expression. Additionally, these genes, along with Rtp4, Irf7, Dhx58, Il1b, Ifi44, and Ifi35 may be the important gene targets for the action of RQCJ.</p><p><strong>Conclusion: </strong>This study provides new insights into the mechanisms by which RQCJ modulates immune responses, offering theoretical foundations for tumor treatment and clinical application.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"24 2","pages":"15593258261454535"},"PeriodicalIF":2.8,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13195208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}