Dose-Response最新文献

{"title":"Hydromethanolic Root Extract of Gnidia Kraussiana Demonstrates Anti-Inflammatory Effect Through Anti-Oxidant Activity Enhancement in a Rodent Model of Gout.","authors":"Elizé Dadaya,&nbsp;Benoit Koubala,&nbsp;Dieudonné Ndjonka,&nbsp;Stéphane Zingué,&nbsp;Alphonse Laya,&nbsp;Gisèle Atsang","doi":"10.1177/15593258221148015","DOIUrl":"https://doi.org/10.1177/15593258221148015","url":null,"abstract":"<p><p>Gout is a metabolic arthritis that originates from increased accumulation of monosodium urate (MSU) crystals in joints. This work aimed to evaluate the antioxidant and anti-inflammatory activities of the hydromethanolic extract of <i>Gnidia kraussiana</i> (HEGK) using model of Gouty arthritis on mice. The total polyphenol, flavonoid, tannin content and the antioxidant activity of HEGK were also evaluated. MSU-injected mice were treated daily for 3 days with HEGK (25, 50 and 100 mg/kg). Indomethacin and colchicin were used as reference drugs. Paw oedema and body temperature were measured at different time intervals post-injection. Malondialdehyde, acid phosphatase, β-Galactosidase, catalase, superoxide dismutase and glutathione levels were evaluated. HEGK is rich in polyphenol (129.93 mg/100 g), flavonoid (67.78 mg/100 g) and tannin conferring it a high antioxidant activity. Acute oral toxicity of HEGK resulted in LD50 greater than 2000 mg/kg. Oral administration of HEGK induced a significant decrease in the oedema of legs injected with urate crystals and reduced the release of acid phosphatase and β-Galactosidase. A model of oxidative damage was successfully established, revealing a significant increase in malondialdehyde and inhibition of antioxidants, including superoxide dismutase, catalase and glutathione activity. Thus, HEGK can actively inhibit the effect of inflammatory mediators in gouty arthritis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/a8/10.1177_15593258221148015.PMC9893086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9214695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apigenin and Exposure to Low Dose Gamma Radiation Ameliorate Acetic Acid-Induced Ulcerative Colitis in Rats.","authors":"Eman E Shibrya,&nbsp;Rasha R Rashed,&nbsp;Mai A Abd El Fattah,&nbsp;Mona A El-Ghazaly,&nbsp;Sanaa A Kenawy","doi":"10.1177/15593258231155787","DOIUrl":"https://doi.org/10.1177/15593258231155787","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is an inflammatory bowel disease involving chronic and recurring colon inflammation. Current management protocols are limited by adverse effects or short-term symptomatic relief. We aimed to investigate the possible therapeutic prospect of low dose gamma (γ) irradiation or apigenin treatment in acetic acid-induced UC in rats. Induction of UC was carried out by installation of acetic acid intra-rectally. One hour post-induction, rats received a sole dose of γ-radiation (0.5 Gray) or were treated with apigenin (3 mg/kg/day, peroral) for 7 successive days. Antioxidant and anti-inflammatory effects of both agents were assessed via determination of colon malondialdehyde (MDA), reduced glutathione (GSH), total nitrate/nitrite (NOx), mucosal addressin cell adhesion molecule-1 (MAdCAM-1), and interleukin-1beta (IL-1β) contents as well as myeloperoxidase (MPO) activity. Body weight (BW), colon weight/length (W/L) ratio, disease activity index (DAI), and histopathological changes were evaluated. Gamma irradiation and apigenin significantly ameliorated the acetic acid-induced biochemical and histopathological changes. Both therapeutic approaches significantly restored colon contents of the investigated biomarkers. They modulated BW, colon W/L ratio and DAI. This study proposes low dose γ-irradiation as a new therapeutic candidate for the management of UC. We also concluded that apigenin exhibited therapeutic benefits in UC management.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/61/10.1177_15593258231155787.PMC9900677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10684778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Extract of Acanthopanacis Cortex Relieves the Depression-Like Behavior and Modulates IL-17 Signaling in Chronic Mild Stress-Induced Depressive Mice.","authors":"Chuhan Liu,&nbsp;Lu Yan,&nbsp;Yiyun Qian,&nbsp;Pingping Song,&nbsp;Tao Wang,&nbsp;Min Wei","doi":"10.1177/15593258221148817","DOIUrl":"https://doi.org/10.1177/15593258221148817","url":null,"abstract":"<p><strong>Background: </strong>Acanthopanacis Cortex (AC) is a valuable Chinese medicine, which exerts beneficial effects on anti-fatigue, anti-stress, and inflammatory modulation in the periphery. However, the central nervous system (CNS) function of AC has not been clearly illustrated. As communication between the peripheral immune system and the CNS converges, it promotes a heightened neuroinflammatory environment that contributes to depression. We investigated the effect of AC against depression through neuroinflammatory modulation.</p><p><strong>Methods: </strong>Network pharmacology was used to screen for target compounds and pathways. Mice with CMS-induced depression were used to evaluate the efficacy of AC against depression. Behavioral studies and detection of neurotransmitters, neurotrophic factors, and pro-inflammatory cytokines were performed. The IL-17 signaling cascade was involved to further investigate the underlying mechanism of AC against depression.</p><p><strong>Results: </strong>Twenty-five components were screened by network pharmacology and the IL-17 mediated signaling pathway was associated with the antidepressant action of AC. This herb had a beneficial effect on CMS-induced depressive mice, including improvements in depressive behavior, modulation of neurotransmitter levels, neurotrophic factors, and pro-inflammatory cytokines.</p><p><strong>Conclusions: </strong>Our results revealed that AC exhibits effects on anti-depression and one of the mechanisms was mediated by neuroinflammatory modulation.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/4a/10.1177_15593258221148817.PMC9972068.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10823387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>Caralluma edulis</i> for its Potential Against Obesity, Atherosclerosis and Hypertension.","authors":"Adnan Akram,&nbsp;Ayesha Jamshed,&nbsp;Mariya Anwaar,&nbsp;Hafiz Muhammad Farhan Rasheed,&nbsp;Syed Ihtisham Haider,&nbsp;Naveed Aslam,&nbsp;Qaiser Jabeen","doi":"10.1177/15593258231152112","DOIUrl":"https://doi.org/10.1177/15593258231152112","url":null,"abstract":"<p><p>Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of <i>Caralluma edulis</i> (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was induced in Wistar albino rats with HFD (1% cholesterol + 0.5% cholic acid) for 28 days. Treatment groups were administered with different doses of CE.Cr (100, 300 and 500 mg/Kg, p.o.) and the standard group received atorvastatin. At the end of study, sera were analyzed for biochemical markers and the aorta was dissected for microscopic examination. Antioxidant potential was evaluated and high-performance liquid chromatography (HPLC) analysis was performed. The hypotensive potential of CE.Cr was evaluated through an invasive technique. HPLC analysis of CE.Cr showed the presence of chlorogenic acid, caffeic acid, apigenin and naringenin. Histological examination of the aorta section showed anti-atherosclerotic effects which were also evident from decrease in serum total cholesterol, triglycerides and low-density lipoproteins levels. CE.Cr decreased mean arterial blood pressure and evoked significant hypotensive effects. The crude extract of <i>C. edulis</i> showed anti-obesity, antihypertensive, anti-atherosclerotic and antioxidant potential.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/fc/10.1177_15593258231152112.PMC9841870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10604646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose Dependence of the Separate and Combined Impact of Copper-Oxide and Selenium-Oxide Nanoparticles on Oxygen Consumption by Cells In Vitro With or Without the Background Action of Some Modulators of the Mitochondrial Respiratory Function","authors":"T. Bushueva, V. Panov, I. Minigalieva, L. Privalova, Maria S. Vedernikova, V. Gurvich, M. Sutunkova, B. Katsnelson","doi":"10.1177/15593258221106612","DOIUrl":"https://doi.org/10.1177/15593258221106612","url":null,"abstract":"We had previously demonstrated on various stable cell cultures exposed to chemically different nanoparticles when assessing their cytotoxicity by different outcomes, dose-response relationships may be either monotonic or non-monotonic falling within an extended understanding of the hormesis paradigm. Presently, on human fibroblasts exposed to the copper-oxide and/or selenium-oxide nanoparticles, we assessed their cytotoxic effect by the inhibition of oxygen uptake against modulating the respiratory function of mitochondria (oligomycin, followed by carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone, and, finally, rotenone with antimycin A). It is hypothesized that a given type of this relationship is closely associated with the mitochondrial respiratory function. However, in only one case, this hypothesis was confirmed by finding that the monotonic dose-response relationship transformed into a non-monotonic one of the hormesis type under exposure to SeO-NP with the mitochondrial respiratory function fully inhibited by the effect of rotenone + antimycin А. In all other variants of the experiment, the shape of this relationship did not depend on the addition of the above agents to the cell culture. Neither did the effect of these modulators change the pattern of combined action of CuO-NP and SeO-NP, which was additive in all cases.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41951660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Phytochemical Contents, Antimicrobial, and antioxidant Potential of Haloxylon Griffithii Collected From Northern Region of Balochistan, Pakistan.","authors":"Rizwan Asif,&nbsp;Muhammad Ali,&nbsp;Modasrah Mazhar,&nbsp;Madiha Mustafa,&nbsp;Riffat Yasmin","doi":"10.1177/15593258231163389","DOIUrl":"https://doi.org/10.1177/15593258231163389","url":null,"abstract":"<p><strong>Background: </strong>The therapeutic potential of <i>Haloxylon griffithii</i> found in northern region of Balochistan, so far has been neglected.</p><p><strong>Purpose: </strong>The current study was aimed to assess the phytochemicals and pharmacological potential of fractions isolated from <i>H griffithii</i>.</p><p><strong>Research design: </strong>During phytochemicals analysis of <i>H griffithii</i> using GC/MS showed various bioactive compounds like alkaloids, flavonoids, terpenoids, tannins, saponins, and carboxylic acids. In vitro antioxidant activity of <i>H griffithii</i> was determined by 2, 2'- diphenyl-1-picrylhydrazyl (DPPH) <b>assay.</b> Disc diffusion method was used to evaluate the antimicrobial activity.</p><p><strong>Results: </strong>The quantitative analysis of ethyl acetate showed highest total flavonoid contents (1.19 ± .05) while ethanol with lowest value (.52 ± .01). The total phenolic contents in ethyle acetate was 1.50 ± .42, whereas ethanol showed lowest value (.77 ± .02). Ethanol exhibited excellent (88.68 ± 3.0) free radical scavenging potential measured by 1,1-diphenyl-2-picryl-hydrazyl radical scavenging assay. For antimicrobial activity, different bacterial and fungal strains like <i>B subtilis, S aureus, E coli, S typhi</i>, <i>C albicans,</i> and <i>A. niger</i> were selected<i>.</i> The essential oil showed maximum % inhibition diameter (9 mm) against <i>B. Subtillus</i> and (5 mm) against <i>C albicans,</i> respectively<i>.</i> The ethyl acetate presented % inhibition diameter (9 mm) against <i>S aureus</i> and (6 mm) against <i>A niger.</i> Anti-urease activity also showed positive response.</p><p><strong>Conclusions: </strong>The presence of high (%) bioactive compounds with great therapeutic potential suggest that <i>H griffithii</i> can be used as natural alternative of synthetic drugs without side effects.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/c4/10.1177_15593258231163389.PMC10026114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9518636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into the Anticancer Effects of <i>p</i>-Coumaric Acid: Focus on Colorectal Cancer.","authors":"Wafâa Tehami,&nbsp;Abdelhafid Nani,&nbsp;Naim A Khan,&nbsp;Aziz Hichami","doi":"10.1177/15593258221150704","DOIUrl":"https://doi.org/10.1177/15593258221150704","url":null,"abstract":"<p><p>Colorectal cancer is considered the second most deadly cancer in the world. Studies have indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has been an increasing interest in polyphenols due to their plausible effect on cancer prevention and treatment. <i>p</i>-Coumaric acid (<i>p</i>-CouA), a phenolic compound, is a cinnamic acid derivative found in several fruits, vegetables, and herbs. A growing body of evidence suggests that <i>p</i>-CouA may be an effective agent for preventing and managing colorectal cancer. In this current review, we briefly highlight the bioavailability of <i>p</i>-CouA. We also provide an up-to-date overview of molecular mechanisms underlying its anticancer effects, focusing on anti-inflammatory and antioxidant potentials, apoptosis induction, and cell cycle blockade. Finally, we discuss the impact of <i>p</i>-CouA on clonogenicity and multidrug resistance of colorectal cancer cells.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/fb/10.1177_15593258221150704.PMC9830577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10528020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Resveratrol Against Adenomyosis in a Mouse Model.","authors":"Bo Zhu,&nbsp;Chenhui Zhang,&nbsp;Xiaolu Shen,&nbsp;Cong Chen,&nbsp;Xuanyu Chen,&nbsp;Yiyi Lu,&nbsp;Yumei Chen,&nbsp;Min Guo","doi":"10.1177/15593258231164055","DOIUrl":"https://doi.org/10.1177/15593258231164055","url":null,"abstract":"<p><p>Adenomyosis is a uterine condition in which endometrial glands and stroma are commonly pathologically observed in the myometrium. In this study, we sought to determine the effect of resveratrol on the progression of adenomyosis. Adenomyosis was induced in mice given tamoxifen neonatally. All mice were subjected to body weight measurement and hotplate testing every four weeks beginning four weeks after birth. All mice with adenomyosis were randomly separated into 3 groups at 16 weeks: untreated, low-dose resveratrol (25 mg/kg), and high-dose resveratrol (50 mg/kg). After 3 weeks of treatment, final hotplate test and body weight measurement were performed, and the uterine horn blood samples were collected. Adenomyosis in mice caused body weight loss and uterine weight gain, reduced hotplate latency, and progression of endometrial fibrosis. The underlying biological process could be coupled with the overexpression of many cells' proliferation and immune-regulation-related genes. Resveratrol treatment could slow the progression of adenomyosis by enhancing hotplate latency, lowering endometrial fibrosis, and restoring cell proliferation- and immune-regulation-associated gene expression levels in endometrium and plasma. However, resveratrol treatment also reduced the body weight and uterine weight. In conclusion, Resveratrol might be a potential compound for treating patients with adenomyosis.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/ef/10.1177_15593258231164055.PMC10028632.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9163467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine.","authors":"Xiaofan Ma,&nbsp;Jiali Peng,&nbsp;Yelin Chen,&nbsp;Zeyi Wang,&nbsp;Qiang Zhou,&nbsp;Jia Yan,&nbsp;Hong Jiang","doi":"10.1177/15593258231157563","DOIUrl":"https://doi.org/10.1177/15593258231157563","url":null,"abstract":"<p><p>Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine. However, there are limited studies comparing the anesthetic and analgesic effects of esketamine and racemic ketamine in mice. This research was conducted to analyze the dose-dependent anesthetic and analgesic efficacy of esketamine in mice and to compare its potency with that of the racemate. We tested the anesthetic effects of different doses of esketamine and compared its potency with that of the racemate using righting reflex tests. Then, the acetic acid-induced pain model and formalin-induced pain model were used to investigate the analgesic effect. Compared with racemic ketamine, an equivalent dose of esketamine at 100 mg/kg was required to induce stable anesthesia. In contrast, 5 mg/kg esketamine was sufficient to provide analgesic effects similar to those of 10 mg/kg ketamine. Together, esketamine had a similar potency to racemic ketamine for anesthesia and a stronger potency for analgesia in mice.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/5f/10.1177_15593258231157563.PMC9926386.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9291886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.","authors":"Zhuo Li,&nbsp;Xiaomin Hou,&nbsp;Xuehua Liu,&nbsp;Linlin Ma,&nbsp;Jiewen Tan","doi":"10.1177/15593258221141579","DOIUrl":"https://doi.org/10.1177/15593258221141579","url":null,"abstract":"<p><p>Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.</p>","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/02/10.1177_15593258221141579.PMC9706077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40457849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}