Dose-Response最新文献_第9页

Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies. 糖原合成酶激酶途径评价葡萄糖胺作为大鼠放射性保护剂的抗抑郁样作用:行为和生化研究。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-21 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231217845

Mai H Mekkawy, Heba M Karam, Marwa A Mohamed, Dina M Lotfy

{"title":"Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies.","authors":"Mai H Mekkawy, Heba M Karam, Marwa A Mohamed, Dina M Lotfy","doi":"10.1177/15593258231217845","DOIUrl":"https://doi.org/10.1177/15593258231217845","url":null,"abstract":"Radiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated group. The behavioral responses are estimated. The brain hippocampi of the rats are separated to evaluate oxidative stress biochemical parameters and glycogen synthase kinase pathway in addition to the biogenic amines. Irradiation exposure led to disturbances in the behavioral assessments (forced swimming test, light-dark box, and open field test) and a significant decrease in brain GSH, neurotransmitters (serotonin, norepinephrine, and dopamine), phosphatidylinositol 3 kinase (PI3K), and phosphorylated protein kinase-B (p-AKT) levels. Additionally, MDA and ROS levels increased significantly post-irradiation along with the phosphorylated glycogen synthase kinase (p-GSK3). Glucosamine administration before irradiation caused improvement in the behavioral valuations and the biochemical parameters in the brain as well. Glucosamine might be used as a radioprotector to improve brain function and as an antidepressant drug. It could be promising as a future therapy in managing depression occurring during radiotherapy.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231217845"},"PeriodicalIF":2.5,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insecticidal and Repellent Activities of Four Essential Oils Against Sitophilus zeamais (Coleoptera: Curculionidae). 四种精油对玉米象的杀虫驱避活性研究。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-20 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231210263

Hany Ahmed Fouad, Cláudio Augusto Gomes da Câmara, Marcílio Martins de Moraes, Wagner de Souza Tavares, Jesusa Crisostomo Legaspi, José Cola Zanuncio

{"title":"Insecticidal and Repellent Activities of Four Essential Oils Against Sitophilus zeamais (Coleoptera: Curculionidae).","authors":"Hany Ahmed Fouad, Cláudio Augusto Gomes da Câmara, Marcílio Martins de Moraes, Wagner de Souza Tavares, Jesusa Crisostomo Legaspi, José Cola Zanuncio","doi":"10.1177/15593258231210263","DOIUrl":"https://doi.org/10.1177/15593258231210263","url":null,"abstract":"Objective: This study aimed to evaluate the efficacy of Corymbia citriodora, Melaleuca alternifolia (Myrtaceae), Mentha × piperita (Lamiaceae), and Schinus terebinthifolius (Anacardiaceae) essential oils as an alternative to manage Sitophilus zeamais (Coleoptera: Curculionidae) adults.Methods: Acute contact toxicity, acute toxicity on treated maize grain, fumigation toxicity, repellency bioassays, and GC-MS analysis of the essential oils were carried out.Results: Corymbia citriodora, M. alternifolia, M. × piperita, and S. terebinthifolius oils were toxic at different levels to S. zeamais through residual contact, ingestion and via fumigation, and were also repellent to adults of this pest. Melaleuca alternifolia oil was the most active in contact (LC50 = 18.98 μL.mL-1), ingestion (LC50 = 1.03 μL.g-1), and fumigant (LC50 = 20.05 μL.L-1 air) bioassays. Citronelal (53.6% in C. citriodora), terpinen-4-ol (46.9% in M. alternifolia), menthol (44.8% in M. × piperita), and β-caryophyllene (16.2% in S terebinthifolius) are the major constituents of these oils.Conclusions: Melaleuca alternifolia and M. × piperita essential oils can be used by residual contact, while those of C. citriodora, M. alternifolia, and M. × piperita by mixing with maize grains. Melaleuca alternifolia essential oil can be used as a fumigant, while those of C. citriodora and S. terebinthifolius as repellents for S. zeamais adults.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231210263"},"PeriodicalIF":2.5,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complexing Properties of Synthesized 1,3,5-Triaza-7-Phosphaadamantane Derivatives Towards Some Lanthanides and Transition Metal Cations With Significant Antimicrobial and Antioxidant Activities. 合成的1,3,5-三氮杂-7-磷金刚烷衍生物与某些具有显著抗菌和抗氧化活性的镧系元素和过渡金属阳离子的络合性能

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-16 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231216274

Lassaad Baklouti, Besma Mellah, Waleed S Koko

{"title":"Complexing Properties of Synthesized 1,3,5-Triaza-7-Phosphaadamantane Derivatives Towards Some Lanthanides and Transition Metal Cations With Significant Antimicrobial and Antioxidant Activities.","authors":"Lassaad Baklouti, Besma Mellah, Waleed S Koko","doi":"10.1177/15593258231216274","DOIUrl":"https://doi.org/10.1177/15593258231216274","url":null,"abstract":"The synthesis of new water-soluble N-alkylated derivatives of 1,3,5-triaza-7-phosphaadamantane is presented. Ru(PPh3)2Cl2 has been used to react with 1-(4-nitrobenzyl)-3,5-triaza-1-azonia-7-phosphaadamantane bromide (PTAR). By using elemental analysis, NMR, and IR spectroscopy, the obtained compounds were identified. The UV-visible absorption spectroscopy has been used to monitor the complexation of various transition metal cations. Studies on conductivity have been utilized to validate the complexes' stoichiometries. Using the disc diffusion method, five bacteria strains were used for the study of the antimicrobial activity of compounds 1-3. All tested pathogens, including M luteus LB 141107, were found to have strong biologic activity against the compounds tested in this study. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibit excellent radical scavenging properties.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231216274"},"PeriodicalIF":2.5,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Lead Nanoparticles Induced Apoptosis and Cytotoxicity in MDA-MB-231 Cells by Inducing Reactive Oxygen Species and Caspase 3/7 Enzymes. 绿铅纳米颗粒通过诱导活性氧和Caspase 3/7诱导MDA-MB-231细胞凋亡和细胞毒性。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-10 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231214364

Wadyan Lafi Alsulami, Daoud Ali, Bader O Almutairi, Khadijah N Yaseen, Saad Alkahtani, Rafa A Almeer, Saud Alarifi

{"title":"Green Lead Nanoparticles Induced Apoptosis and Cytotoxicity in MDA-MB-231 Cells by Inducing Reactive Oxygen Species and Caspase 3/7 Enzymes.","authors":"Wadyan Lafi Alsulami, Daoud Ali, Bader O Almutairi, Khadijah N Yaseen, Saad Alkahtani, Rafa A Almeer, Saud Alarifi","doi":"10.1177/15593258231214364","DOIUrl":"10.1177/15593258231214364","url":null,"abstract":"Nanoparticles are widely used in the pharmaceutical, agriculture, and food processing industries. In this study, we have synthesized green lead nanoparticles (gPbNPs) by using an extract of Ziziphus spina-christi leaves and determined their cytotoxic and apoptotic effect on the human breast cancer MDA-MB-231 cell line. gPbNPs were characterized by using X-ray diffraction (XRD), energy dispersive X-ray (EDX) scanning electron microscope (SEM), and transmission electron microscope (TEM). The toxicity of gPbNPs was determined on the MDA-MB-231 cell line using MTT and NRU assays and as a result cell viability was reduced in a concentration-dependent manner. MDA-MB-231 cells were more sensitive at the highest concentration of gPbNPs exposure. In this experiment, we observed the production of intracellular ROS in cells, and induction of caspase 3/7 was higher in cells at 42 µg/ml of gPbNPs. Moreover, the Bax gene was upregulated and the Bcl-2 gene was downregulated and increased caspase 3/7 activity confirmed the apoptotic effect of gPbNPs in cells. Our observation showed that gPbNPs induced cell toxicity, increased generation of intracellular ROS, and gene expression of Bcl-2 and Bax in the MDA-MB-231 cell line. In conclusion, these findings demonstrated that gPbNPs executed toxic effects on the MDA-MB-231 cell line through activating caspase 3/7 activity.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231214364"},"PeriodicalIF":2.5,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Pollution and Cardiac Diseases: A Review of Experimental Studies. 空气污染与心脏病：实验研究综述。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-04 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231212793

Laura C Palacio, Diana C Pachajoa, Carlos A Echeverri-Londoño, Javier Saiz, Catalina Tobón

{"title":"Air Pollution and Cardiac Diseases: A Review of Experimental Studies.","authors":"Laura C Palacio, Diana C Pachajoa, Carlos A Echeverri-Londoño, Javier Saiz, Catalina Tobón","doi":"10.1177/15593258231212793","DOIUrl":"https://doi.org/10.1177/15593258231212793","url":null,"abstract":"Air pollution is associated with around 6.5 million premature deaths annually, which are directly related to cardiovascular diseases, and the most dangerous atmospheric pollutants to health are as follows: NO2, SO2, CO, and PM. The mechanisms underlying the observed effects have not yet been clearly defined. This work aims to conduct a narrative review of experimental studies to provide a more comprehensive and multiperspective assessment of how the effect of atmospheric pollutants on cardiac activity can result in the development of cardiac diseases. For this purpose, a review was carried out in databases of experimental studies, excluding clinical trials, and epidemiological and simulation studies. After analyzing the available information, the existence of pathophysiological effects of the different pollutants on cardiac activity from exposure during both short-term and long-term is evident. This narrative review based on experimental studies is a basis for the development of recommendations for public health.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231212793"},"PeriodicalIF":2.5,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin's Dose-Dependent Attenuation of Gastric Cancer Cell Progression Via the PI3K Pathway Blockade. 姜黄素通过PI3K通路阻断对癌症细胞进程的剂量依赖性衰减。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-11-03 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231203585

Gen Xi, Qingtao Dong, Bo Yang, Desheng Jiao, Shahanavaj Khan

{"title":"Curcumin's Dose-Dependent Attenuation of Gastric Cancer Cell Progression Via the PI3K Pathway Blockade.","authors":"Gen Xi, Qingtao Dong, Bo Yang, Desheng Jiao, Shahanavaj Khan","doi":"10.1177/15593258231203585","DOIUrl":"https://doi.org/10.1177/15593258231203585","url":null,"abstract":"Background: Gastric cancer stands as a primary cause of cancer-related deaths worldwide, making the discovery of new therapeutic agents essential for enhancing treatment outcomes. Curcumin, a polyphenolic compound found in turmeric (Curcuma longa), has demonstrated potential in multiple cancer types due to its anti-cancer characteristics. This research aimed to examine the impact of curcumin on gastric cancer cell growth, migration, and invasion, as well as its influence on the phosphoinositide 3-kinase (PI3K) signaling cascade. Methods: Gastric cancer cell lines were exposed to varying curcumin concentrations, followed by assessments of cell viability, migration, and invasion. Furthermore, gene and protein expression levels associated with the PI3K signaling cascade were evaluated using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. Results: The findings revealed a dose-dependent decrease in cell viability, migration, and invasion in gastric cancer cells treated with curcumin. Additionally, curcumin administration led to the downregulation of key genes and proteins within the PI3K signaling process, such as PI3K, Akt, and mTOR. Conclusion: These findings propose that curcumin may exercise its anti-cancer effects on gastric cancer cells, partly by suppressing the PI3K signaling pathway. This study's outcomes support curcumin's potential as a therapeutic agent for gastric cancer and encourage further exploration of its underlying molecular mechanisms and in vivo effectiveness.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231203585"},"PeriodicalIF":2.5,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Risk of Secondary Cancer Induction in Radiosensitive Organs During Trigeminal Neuralgia Treatment With Gamma Knife Radiosurgery: Impact of Extracranial Dose. 伽玛刀放射治疗三叉神经痛期间放射性敏感器官继发性癌症诱导的风险评估：颅外剂量的影响。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-10-26 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231210432

Ghazale Geraily, Ali Ameri, Atefeh Mahmoudi, Mohadese Moafee, Javad Teymouri

{"title":"Assessing the Risk of Secondary Cancer Induction in Radiosensitive Organs During Trigeminal Neuralgia Treatment With Gamma Knife Radiosurgery: Impact of Extracranial Dose.","authors":"Ghazale Geraily, Ali Ameri, Atefeh Mahmoudi, Mohadese Moafee, Javad Teymouri","doi":"10.1177/15593258231210432","DOIUrl":"https://doi.org/10.1177/15593258231210432","url":null,"abstract":"Purpose: Gamma knife radiosurgery (GKRS) delivers high-dose external radiation to a small intracranial lesion. However, scattering and leaked radiation can deposit a portion of the dose outside the radiation field, which may pose a risk to radiation-sensitive patients, such as pregnant women. Trigeminal Neuralgia (TN) is treated with one of the highest GKRS doses (80-90 Gy). This study aimed to estimate the risk of secondary cancer induction in the uterus, ovaries, thyroid gland, and eyes of TN patients undergoing GKRS.Methods: Radiation doses to the uterus, ovary, eyes, and thyroid gland were measured for 25 female TN patients, with a mean age of 35 years, utilizing Thermo Luminescent Dosimeters (TLD).Results: The mean absorbed dose for the uterus, ovary, thyroid gland, and eyes were .63 ± .24, .471 ± .2, 8.26 ± 1.01, and 10.64 ± 1.08 cGy, respectively. Lifetime Attributable Risk (LAR) has been calculated using BEIR VII (2006) method. LAR for the uterus, ovary, and thyroid gland was 1, 2, and 23, respectively.Conclusion: The results of this study and its comparison with standard values demonstrate that on average, mean doses to mentioned organs were smaller than their tolerance doses, and there is no limitation to treating patients suffering from TN by GK.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231210432"},"PeriodicalIF":2.5,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver. 苦木（Kutki）、香附（Loung）、无叶劳松（Henna）、大黄（Revand Chini）、姜黄（Haldi）对小鼠脑和肝脂质过氧化的体外抗氧化和抑制作用研究。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-10-25 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231210431

Farooq Hassan, Asmat Ullah Khan, Syed Zahoor Ul Hassan Zaidi, Madiha Khan Niazi, Muhammad Amjed Ismail

{"title":"In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver.","authors":"Farooq Hassan, Asmat Ullah Khan, Syed Zahoor Ul Hassan Zaidi, Madiha Khan Niazi, Muhammad Amjed Ismail","doi":"10.1177/15593258231210431","DOIUrl":"https://doi.org/10.1177/15593258231210431","url":null,"abstract":"The aerobic organisms not only need oxygen for survival, but oxygen is also fundamentally malignant to the aerobic organism on the grounds of free radical generation and their affiliation with free oxidative stress. This study was done to evaluate the antioxidant and protective properties of P kurroa, S aromaticum, L inermis, R emodi, and C longa against lipid peroxidation induced by different pro-oxidants. The aqueous extracts of these medicinal plants showed inhibition against thiobarbituric acid reactive species (TBARS) induced by different pro-oxidants (10 mM FeSO4 and 5 mM sodium nitroprusside) in the brain and liver of mice. Moreover, the free radical scavenging activities of the extracts were evaluated by the scavenging of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. L inermis, S aromaticum, and R emodi showed higher inhibitory effects, which could be attributed to their significantly reduced ability and free radical scavenging activities. Therefore, the oxidative stress in the brain and liver could be potentially managed or prevented by the dietary intake of L inermis, S aromaticum, and R emodi plants, which justifies the use of these plants in various degenerative diseases. C longa and P kurroa showed relatively weak antioxidant activities.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231210431"},"PeriodicalIF":2.5,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels. 牛至精油和海藻酸钠基创伤愈合水凝胶的制备、性质和稳定性。

IF 2.5 4区医学

Dose-Response Pub Date : 2023-10-09 eCollection Date: 2023-10-01 DOI: 10.1177/15593258231204186

Dure Najaf Iqbal, Asia Ashraf, Arif Nazir, Samar Z Alshawwa, Munawar Iqbal, Naveed Ahmad

{"title":"Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels.","authors":"Dure Najaf Iqbal, Asia Ashraf, Arif Nazir, Samar Z Alshawwa, Munawar Iqbal, Naveed Ahmad","doi":"10.1177/15593258231204186","DOIUrl":"https://doi.org/10.1177/15593258231204186","url":null,"abstract":"The wound dressings fabricated by polymers and oregano essential oil (OEO) can be very effective as a hydrogel. The current study has been focused on fabricating the hydrogel membranes of oregano oil encapsulated as an antibacterial agent into sodium alginate (SA) solution by solvent casting method and then evaluated the antibacterial, antioxidant activity, and physicochemical performance of SA/OEO-based polymeric membranes. The polymeric interactions, surface morphology, water absorption capability, thermal stability, and encapsulation efficiency were investigated by FT-IR, SEM, swelling ratio, DSC, and encapsulation efficiency. The percentage encapsulation efficiency of essential oil was 40.5%. FTIR validated the presence of molecular interaction between individual components. SEM images showed a rough and porous appearance for hydrogel membranes. Moreover, DSC showed that the fabricated membranes were thermally stable. The inclusion of more content OEO decreased swelling ratios. The antioxidant test was carried out by DPPH assay and antibacterial test through disc diffusion method against microbes. The results revealed that membranes containing the highest content of OEO had more excellent antioxidant and antibacterial efficacy. Therefore, the polymeric membranes of sodium alginate loaded with oregano essential oil can be employed as an effective wound-healing candidate.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"21 4","pages":"15593258231204186"},"PeriodicalIF":2.5,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/f3/10.1177_15593258231204186.PMC10563497.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Condiment Recipes Lead to Reduced Generation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Duck Variety Meat During Charcoal Grilling 调味料配方可减少木炭烧烤过程中鸭肉致癌物多环芳烃的生成

4区医学

Dose-Response Pub Date : 2023-07-01 DOI: 10.1177/15593258231203212

Gulshan Shahid, Muhammad Yousaf, Haseeb Anwar, Imran Mukhtar, Abdul Basit

{"title":"Condiment Recipes Lead to Reduced Generation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Duck Variety Meat During Charcoal Grilling","authors":"Gulshan Shahid, Muhammad Yousaf, Haseeb Anwar, Imran Mukhtar, Abdul Basit","doi":"10.1177/15593258231203212","DOIUrl":"https://doi.org/10.1177/15593258231203212","url":null,"abstract":"The current study aimed to evaluate the impact of charcoal grilling in the generation of various polycyclic aromatic hydrocarbons in the tissues of 5 different organs (leg, chest, wings, liver, and heart) of falcated ducks ( Mareca falcata) before and after pasting them with different condiment recipes (R1, R2, R3, and R4). All condiment-pasted and control samples before/after charcoal grilling were pursued in RP-HPLC for quantification of unknown PAHs. Tissues from grilled raw leg meat of the control sample showed significantly higher ( P ≤ .05) concentration (42.40 ng/g) of overall PAHs as compared to all other grilled samples. However, overall PAHs concentration (9.99 ng/g) in charcoal grilled tissues of leg meat pasted with R4 condiment recipe was decreased 76.43% significantly ( P ≤ .05) as compared to all other recipes of pasted charcoal grilled samples. All PAHs, particularly naphthalene, fluorene, phenanthrene, and acenaphthalene were decreased significantly ( P ≤ .05) to none detectable level in all tissue samples when grilled after treating with R4 condiment recipe. All condiment recipes reduced total PAHs level below MRL’s set by the international guidelines. Recipe R4, a rich source of antioxidants, significantly neutralized and reduced the generation of PAHs in duck leg meat tissue sample during wood charcoal grilling.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135807062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0