Effect of Gamma Rays on Adropin as a Potential Hepatokine Marker for Liver Damage in Male Albino Rats.

IF 2.3 4区医学 Q3 PHARMACOLOGY & PHARMACY

Dose-Response Pub Date : 2025-05-10 eCollection Date: 2025-04-01 DOI:10.1177/15593258251342304

Nadia Abdel-Magied, Amira Mk Abouelella, Hayam Mostafa, Hebatallah E Mohamed, Nehal I Hendy

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引用次数: 0

Abstract

Purpose: This work was the first study to show the impact of γ- radiation on adropin levels in the serum and liver tissue of male albino rats.

Methods: Liver tissue and blood samples of rats were collected at 1, 3, 7 and 14 days after whole-body exposure to 7.5 Gy of γ-radiation.

Results: Irradiated groups revealed a marked decrease in adropin associated with a significant increase in STAT3 in the serum and gene expression. Furthermore, lipid profile (cholesterol, T.G, HDL, LDL, VLDL), liver function (AST, ALT, albumin and total protein), complete blood count (RBCs, WBCs, PLT, Hb, Hct%, MCH, MCV, WBCs differential), glucose and insulin were exhibited more noticeable alterations at all time periods of the experiment. In addition, data exhibited an obvious elevation in some inflammatory markers (IL-6) and TOS accompanied by a decline in the TAC.

Conclusion and future scope of work: γ- radiation has adverse effects on adropin that related inversely with STAT3, leading to further damage to liver cells as well as disturbances in lipid and glucose metabolism. Therefore, adropin could be used in people exposed to radiation such radiotherapy to control the serious effects of radiation. Further study is needed to confirm these results.

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γ射线对雄性白化大鼠肝损伤潜在肝因子标志物Adropin的影响。

目的：首次研究γ-辐射对雄性白化大鼠血清和肝组织中adropin水平的影响。方法：7.5 Gy γ-辐照后1、3、7、14 d采集大鼠肝脏组织和血液标本。结果：辐照组显示adropin显著降低，血清中STAT3和基因表达显著增加。此外，血脂（胆固醇、T.G、HDL、LDL、VLDL）、肝功能（AST、ALT、白蛋白和总蛋白）、全血细胞计数（红细胞、白细胞、PLT、Hb、Hct%、MCH、MCV、白细胞差异）、葡萄糖和胰岛素在实验的各个时期都表现出更明显的变化。此外，数据显示一些炎症标志物（IL-6）和TOS明显升高，同时TAC下降。结论及未来的工作范围：γ-辐射对与STAT3负相关的adropin有不良影响，导致肝细胞进一步损伤，脂糖代谢紊乱。因此，adropin可用于放疗等放射暴露人群，以控制辐射的严重影响。需要进一步的研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.90

自引率

4.00%

发文量

140

审稿时长

>12 weeks

期刊介绍： Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.