NCRP声称有六项研究支持LNT，但它们显示至少100毫戈瑞没有效果。

IF 2.4 4区医学 Q3 PHARMACOLOGY & PHARMACY

Dose-Response Pub Date : 2025-04-15 eCollection Date: 2025-04-01 DOI:10.1177/15593258251329682

K Chaplin

{"title":"NCRP声称有六项研究支持LNT，但它们显示至少100毫戈瑞没有效果。","authors":"K Chaplin","doi":"10.1177/15593258251329682","DOIUrl":null,"url":null,"abstract":"NCRP Commentary-27 reaffirmed Linear No Threshold (LNT) as the basis for radiation protection and listed six studies with \"strong support\" for LNT. This paper looks critically at these six studies and shows that they do not support LNT in the dose range of 0-100 mGy. These studies typically admit to no increase in cancer risk at significant dose levels. More importantly this paper shows that these studies assume LNT from the outset, underestimate uncertainty, ignore confounding factors, have biased control groups, and underestimate dose.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"23 2","pages":"15593258251329682"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033839/pdf/","citationCount":"0","resultStr":"{\"title\":\"NCRP Claims Six Studies Support LNT But They Show No-Effect to At Least 100 mGy.\",\"authors\":\"K Chaplin\",\"doi\":\"10.1177/15593258251329682\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"NCRP Commentary-27 reaffirmed Linear No Threshold (LNT) as the basis for radiation protection and listed six studies with \\\"strong support\\\" for LNT. This paper looks critically at these six studies and shows that they do not support LNT in the dose range of 0-100 mGy. These studies typically admit to no increase in cancer risk at significant dose levels. More importantly this paper shows that these studies assume LNT from the outset, underestimate uncertainty, ignore confounding factors, have biased control groups, and underestimate dose.\",\"PeriodicalId\":11285,\"journal\":{\"name\":\"Dose-Response\",\"volume\":\"23 2\",\"pages\":\"15593258251329682\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033839/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dose-Response\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15593258251329682\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dose-Response","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15593258251329682","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

NCRP评论-27重申线性无阈值（LNT）是辐射防护的基础，并列出了6项对LNT“有力支持”的研究。本文对这六项研究进行了批判性的审视，并表明它们不支持0-100毫戈瑞剂量范围内的LNT。这些研究通常承认，在显著的剂量水平下，癌症风险没有增加。更重要的是，本文表明这些研究从一开始就假设了LNT，低估了不确定性，忽略了混杂因素，有偏见的对照组，并且低估了剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

NCRP Claims Six Studies Support LNT But They Show No-Effect to At Least 100 mGy.

查看原文本刊更多论文

NCRP Claims Six Studies Support LNT But They Show No-Effect to At Least 100 mGy.

NCRP Commentary-27 reaffirmed Linear No Threshold (LNT) as the basis for radiation protection and listed six studies with "strong support" for LNT. This paper looks critically at these six studies and shows that they do not support LNT in the dose range of 0-100 mGy. These studies typically admit to no increase in cancer risk at significant dose levels. More importantly this paper shows that these studies assume LNT from the outset, underestimate uncertainty, ignore confounding factors, have biased control groups, and underestimate dose.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.90

自引率

4.00%

发文量

140

审稿时长

>12 weeks

期刊介绍： Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.