Dentistry Journal最新文献

{"title":"Chair-Time During Polishing with Different Burs and Drills After Cement Customized Brackets Bonding: An In Vitro Comparative Study.","authors":"Javier Flores-Fraile, Alba Belanche Monterde, Oscar Alonso-Ezpeleta, Cosimo Galletti, Álvaro Zubizarreta-Macho","doi":"10.3390/dj13080347","DOIUrl":"10.3390/dj13080347","url":null,"abstract":"<p><p><b>Introduction:</b> Digital planning and evolution of technology is allowing dentistry to be more efficient in time than before. In orthodontics the main purpose is to obtain fewer patient visits and to reduce the bonding time. For that, indirect bonding planned with CAD-CAM softwares is used to obtain a shorter treatment period, in general, and less chair-time. This waste of chair-time should also be reduced in other fields of dentistry such as endodontics, surgery, prosthodontics, and aesthetics. <b>Methods</b>: A total of 504 teeth were embedded into epoxy resin models mounted as a dental arch. Customized lingual multibracket appliances were bonded by a current adhesion protocol. After that, they were debonded, the polishing of cement remnants was performed with three different burs and two drills. The polishing time of each group was recorded by an iPhone 14 chronometer. <b>Results:</b> Descriptive and comparative statistical analyses were performed with the different study groups. Statistical differences (<i>p</i> < 0.005) between diamond bur and tungsten carbide and white stone burs and turbine were obtained, with the first being the slowest of them. <b>Discussion:</b> Enamel roughness was widely studied in orthodontics polishing protocol as the main variable for protocols establishment. However, in lingual orthodontics, due the difficulty of the access to the enamel surfaces, the protocol is not clear and efficiency should be considered. It was observed that the tungsten carbide bur is the safest bur. It was also recommended that a two-step protocol of polishing by tungsten carbide bur be followed by polishers. <b>Conclusions</b>: A tungsten carbide bur mounted in a turbine was the most efficient protocol for polishing after lingual bracket debonding.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen Peroxide-Free Color Correctors for Tooth Whitening in Adolescents and Young Adults: A Systematic Review of In Vitro and Clinical Evidence.","authors":"Madalina Boruga, Gianina Tapalaga, Magda Mihaela Luca, Bogdan Andrei Bumbu","doi":"10.3390/dj13080346","DOIUrl":"10.3390/dj13080346","url":null,"abstract":"<p><p><b>Background:</b> The rising demand for aesthetic dental treatments has spurred interest in peroxide-free color correctors as alternatives to traditional hydrogen peroxide formulations, which are associated with tooth sensitivity and potential enamel demineralization. This systematic review evaluates the whitening efficacy and safety profile of hydrogen peroxide-free color corrector (HPFCC) products, focusing on color change metrics, enamel and dentin integrity, and adverse effects. <b>Methods:</b> Following PRISMA guidelines, we searched PubMed, Scopus, and Web of Science throughout January 2025 for randomized controlled trials, observational studies, and in vitro experiments comparing HPFCC to placebo or peroxide-based agents. The data extraction covered study design, sample characteristics, intervention details, shade improvement (ΔE00 or CIE Lab), enamel/dentin mechanical properties (microhardness, roughness, elastic modulus), and incidence of sensitivity or tissue irritation. Risk of bias was assessed using the Cochrane tool for clinical studies and the QUIN tool for in vitro research. <b>Results:</b> Six studies (<i>n</i> = 20-80 samples or subjects) met the inclusion criteria. In vitro, HPFCC achieved mean ΔE00 values of 3.5 (bovine incisors; <i>n</i> = 80) and 2.8 (human molars; <i>n</i> = 20), versus up to 8.9 for carbamide peroxide (<i>p</i> < 0.01). Across studies, HPFCC achieved a mean ΔE00 of 2.8-3.5 surpassing the perceptibility threshold of 2.7 and approaching the clinical acceptability benchmark of 3.3. Surface microhardness increased by 12.9 ± 11.7 VHN with HPFCC (<i>p</i> < 0.001), and ultramicrohardness rose by 110 VHN over 56 days in prolonged use studies. No significant enamel erosion or dentin roughness changes were observed, and the sensitivity incidence remained below 3%. <b>Conclusions:</b> These findings derive from one clinical trial (<i>n</i> = 60) and five in vitro studies (<i>n</i> = 20-80), encompassing violet-pigment serums and gels with differing concentrations. Due to heterogeneity in designs, formulations, and outcome measures, we conducted a narrative synthesis rather than a meta-analysis. Although HPFCC ΔE00 values were lower than those of carbamide peroxide, they consistently exceeded perceptibility thresholds while maintaining enamel integrity and causing sensitivity in fewer than 3% of subjects, supporting HPFCCs as moderate but safe alternatives for young patients.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIH and Cavities as Markers of Oral Health Inequality in Children from Southwest Andalusia (Spain).","authors":"Leidy Bech Barcaz, David Ribas-Pérez, Paloma Villalva Hernandez-Franch, Luis El Khoury-Moreno, Julio Torrejón-Martínez, Antonio Castaño-Séiquer","doi":"10.3390/dj13080345","DOIUrl":"10.3390/dj13080345","url":null,"abstract":"<p><p><b>Introduction:</b> Dental caries and molar-incisor hypomineralisation (MIH) are prevalent conditions affecting children's oral health, with functional, aesthetic, and psychosocial implications. In Spain, previous studies have highlighted geographic and sociodemographic disparities in their distribution, particularly among rural and migrant populations. <b>Objective:</b> To characterise oral health status, in terms of caries and MIH, among 6-7-year-old children from the towns of Palos de la Frontera, Mazagón, and San Bartolomé. <b>Methods:</b> A cross-sectional study was conducted involving 229 children recruited from public primary schools. Sociodemographic, anthropometric, and behavioural data were collected through clinical examination and interview. Statistical analysis included univariate and multivariate logistic regression. The study protocol was approved by the Ethics Committee of Huelva. <b>Results:</b> The prevalence of caries (DMFT ≥ 1) was 53.3%, with mean DMFT and dft indices of 1.78 and 0.31, respectively. MIH affected 32.8% of the cohort, with a predominance in the first permanent molars (teeth 36 and 26). Multivariate analysis identified independent predictors of caries: African (OR = 7.47; 95% CI: 2.84-23.8) and European (OR = 4.56; 95% CI: 1.26-22.3) parental origin, poor oral hygiene (OR = 3.07; 95% CI: 1.60-6.03), and the presence of MIH (OR = 3.20; 95% CI: 1.64-6.42). The municipality of San Bartolomé was associated with a higher risk of MIH (OR = 2.90; 95% CI: 1.21-7.45). <b>Conclusions:</b> The high prevalence of caries and MIH in the Condado-Campiña district, exceeding national averages, reflects oral health inequities linked to social determinants (migrant origin, locality) and clinical factors (MIH, oral hygiene). Targeted preventive interventions are urgently needed in high-risk populations, including culturally tailored education and policies ensuring equitable access to dental care services.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bonding Orthodontic Attachments to 3D-Printed Photosensitive Definitive Resin: An In Vitro Study.","authors":"Omaika Victoria Criollo-Barrios, Carlos Roberto Luna-Domínguez, Carlos Alberto Luna-Lara, Ricardo de Jesus Figueroa-López, Ronaldo Câmara Cozza, Jorge Humberto Luna-Domínguez","doi":"10.3390/dj13080341","DOIUrl":"10.3390/dj13080341","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The increasing clinical integration of 3D-printed definitive resins requires a comprehensive understanding of their physicochemical properties and adhesive behavior. However, there is limited evidence regarding the optimal surface treatment and bonding strategies for clear aligner composite attachments on these materials. This study aimed to characterize a 3D-printed definitive resin, evaluate the effects of surface treatments on its surface topography, and compare the shear bond strength (SBS) of the bonded attachments using different adhesive systems, both before and after thermocycling. <b>Methods</b>: A total of 120 rectangular specimens were fabricated from a 3D printed dental resin (Crowntec^®, SAREMCO Dental AG-Mexico City, Mexico). For physicochemical characterization, six samples underwent scanning electron microscopy/energy-dispersive spectroscopy, X-ray diffraction, and thermogravimetric analysis. To evaluate surface topography, 42 polished specimens were assigned to three groups: untreated (control), etched with 4% hydrofluoric acid (HFA), or sandblasted with 50 µm Al₂O₃ (AA). Each group was subdivided for SEM observation and surface roughness (<i>Ra</i>) measurement. For SBS testing, 72 additional samples received the same surface treatments and were further subdivided according to the adhesive system: Transbond™ XT Primer (TXT) or Single Bond Universal (SBU). <b>Results</b>: The AA group showed the highest <i>Ra</i> (2.21 ± 0.30 µm), followed by HFA (0.81 ± 0.20 µm) and control (0.07 ± 0.30 µm) (<i>p</i> < 0.001). The highest SBS was observed in the AA + SBU group, followed by AA + TXT. <b>Conclusions</b>: Sandblasting with Al₂O₃ particles, combined with a universal adhesive, significantly improved bond strength, suggesting a viable protocol for 3D printed definitive composites in aligner attachment applications.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of a Digitally Generated Matrix for Consistent Shade Recording in Tooth Bleaching-A Case Report.","authors":"Cristian Abad-Coronel, Guissell Vallejo-Yupa, Paulina Aliaga, Nancy Mena-Córdova, Jorge Alonso Pérez-Barquero, José Amengual-Lorenzo","doi":"10.3390/dj13080339","DOIUrl":"10.3390/dj13080339","url":null,"abstract":"<p><p><b>Objectives:</b> The aim of this study was to evaluate the effectiveness of spectrophotometers for objective tooth color measurement, particularly in bleaching procedures enhanced by digital positioning templates. <b>Methods:</b> Tooth color registration was conducted using both subjective methods with shade guides and objective methods with spectrophotometers. Spectrophotometers were chosen for their ability to provide objective, quantifiable, and reproducible results, crucial for monitoring color modifications accurately. Digital workflows were implemented to enhance the registration process further. These workflows included providing a precise positioning matrix for spectrophotometer sensors and optimizing working models to ensure high-quality therapeutic splints. <b>Results</b>: The use of spectrophotometers demonstrated superior performance in registering tooth color objectively compared to subjective shade guides. Digital workflows significantly improved the precision and efficiency of spectrophotometer measurements through a digital matrix, enhancing the quality of therapeutic splints obtained. <b>Conclusions</b>: Spectrophotometers are recommended for objective and precise tooth color registration, particularly in bleaching procedures. Integrating a digital positioning matrix enhances measurement accuracy and reliability, supporting effective monitoring and treatment outcomes.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging Signatures of Temporomandibular Disorder and Burning Mouth Syndrome: A Systematic Review.","authors":"Sarah Fischer, Charalampos Tsoumpas, Pavneet Chana, Richard G Feltbower, Vishal R Aggarwal","doi":"10.3390/dj13080340","DOIUrl":"10.3390/dj13080340","url":null,"abstract":"<p><p><b>Background:</b> Chronic primary orofacial pain (COFP) affects approximately 7% of the population and often leads to reduced quality of life. Patients frequently undergo multiple assessments and treatments across healthcare disciplines, often without a definitive diagnosis. The 2019 ICD-11 classification of chronic primary pain clusters together COFP subtypes based on chronicity and associated functional and emotional impairment. <b>Objective:</b> This study aimed to evaluate whether these subtypes of COFP share common underlying mechanisms by comparing neuroimaging findings. <b>Methods:</b> A systematic review was conducted in accordance with PRISMA guidelines. Searches were performed using Medline (OVID) and Scopus up to April 2025. Inclusion criteria focused on MRI-based neuroimaging studies of participants diagnosed with COFP subtypes. Data extraction included participant demographics, imaging modality, brain regions affected, and pain assessment tools. Quality assessment used a modified Coleman methodological score. <b>Results:</b> Fourteen studies met the inclusion criteria, all utilising MRI and including two COFP subtypes (temporomandibular disorder and burning mouth syndrome). Resting- and task-state imaging revealed overlapping alterations in several brain regions, including the thalamus, somatosensory cortices (S1, S2), cingulate cortex, insula, prefrontal cortex, basal ganglia, medial temporal lobe, and primary motor area. These changes were consistent across both TMD and BMS populations. <b>Conclusions:</b> The findings suggest that chronic primary orofacial pain conditions (TMD and BMS) may share common central neuroplastic changes, supporting the hypothesis of a unified pathophysiological mechanism. This has implications for improving diagnosis and treatment strategies, potentially leading to more targeted and effective care for these patients.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal Effects of Pulsed Infrared Lasers on Zirconia Implants at Different Temperatures In Vitro.","authors":"George Kokkinos, Maryam Hafeez, Joseph De Leon, Georgios E Romanos","doi":"10.3390/dj13080342","DOIUrl":"10.3390/dj13080342","url":null,"abstract":"<p><p><b>Objectives:</b> The aim of this study was to determine the differential temperature produced on ceramic implants using laser irradiation on a pulsed setting of intrabony defects in vitro. <b>Methods:</b> A ceramic (Zr) dental implant (Zeramex, 4.8 × 12 mm) was placed into a bovine bone block. A three-wall intrabony defect (6 × 4 × 3 mm) was created to mimic an osseous peri-implant defect. Thermocouples were placed on the apical and coronal areas to measure temperature changes (∆T) during 60 s of laser irradiation. The bovine block was heated to 37 °C, and the defect walls were irradiated with the CO₂ and Er,Cr:YSGG laser. The settings used were pulsed mode for both lasers, with 30 Hz and 1.5 W for the Er,Cr:YSGG laser and 70 Hz and 2 W for the CO₂ laser. The same laser settings were repeated at room temperature (RT, 23 °C). Twenty trials were performed for each experimental group at room and body temperature for assessment of ∆T. Paired t-test were used to compare the measurements between 37 °C and 23 °C for the Er,Cr:YSGG, and CO₂ laser, respectively. <b>Results:</b> The CO₂ laser resulted in the highest ∆T (°C) at the coronal (15.22 ± 0.28/8.82 ± 0.21) and apical (5.84 ± 0.14/2.30 ± 0.28) level when this laser was used in both room temperature and body temperature, respectively. The highest ∆T (°C) for the Er,Cr:YSGG laser at body temperature at the coronal thermocouple was 7.64 ± 0.55, while for the CO₂ laser, at body temperature was 8.82 ± 0.21. <b>Conclusion:</b> Within the limitations of our study, the use of CO₂ laser and Er,Cr:YSGG laser on peri-implant defects generally appears to be safe in treating peri-implant defects around zirconia implants in vitro.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Storage Temperature and Storage Time on the pH and Oxidation-Reduction Potential of Commercial Oral Moisturizers.","authors":"Mamoru Murakami, Sara Komabashiri, Kae Harada, Takaharu Shimizu, Masahiro Nishimura","doi":"10.3390/dj13080344","DOIUrl":"10.3390/dj13080344","url":null,"abstract":"<p><p><b>Background/Objective</b>: The criteria for selecting and managing oral moisturizers have yet to be clearly defined. The purpose of this study was to examine the effects of storage temperature and storage time on the pH and oxidation-reduction potential (ORP) of oral moisturizers. <b>Methods</b>: The pH and ORP of 20 commercially available oral moisturizers stored at 37 °C, 25 °C, and 4 °C were measured immediately after opening (0M) and at 1 month (1M), 3 months (3M), and 6 months (6M) post-opening. The data were analyzed using Fisher's exact test based on the critical pH of enamel and dentin, two-way repeated-measures analysis of variance (ANOVA), and Pearson's correlation analysis. <b>Results</b>: At 0M, 25% of the products had pH values below the critical threshold for enamel, and 75% fell below that for dentin. The distribution of products significantly differed based on critical pH thresholds (<i>p</i> < 0.05). The two-way repeated-measures ANOVA showed that the pH was significantly affected by the storage time (<i>p</i> < 0.05), but not by the storage temperature or its interaction with time. By contrast, ORP was significantly affected by the storage temperature, storage time, and their interaction (<i>p</i> < 0.05). The Pearson's correlation analysis revealed a significant negative correlation between pH and ORP at 4 °C (6M), 25 °C (1M, 3M, 6M), and 37 °C (all time points) (<i>p</i> < 0.05). <b>Conclusions</b>: Many oral moisturizers exhibit acidic pH values, indicating that products with a pH of 6.7 or higher should be selected. Additionally, to minimize degradation, oral moisturizers should be stored at 4 °C and used within 3 months of opening.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Large Language Model-Based Chatbots Versus Clinicians as Sources of Information on Orthodontics: A Comparative Analysis.","authors":"Stefano Martina, Davide Cannatà, Teresa Paduano, Valentina Schettino, Francesco Giordano, Marzio Galdi","doi":"10.3390/dj13080343","DOIUrl":"10.3390/dj13080343","url":null,"abstract":"<p><p><b>Objectives</b>: The present cross-sectional analysis aimed to investigate whether Large Language Model-based chatbots can be used as reliable sources of information in orthodontics by evaluating chatbot responses and comparing them to those of dental practitioners with different levels of knowledge. <b>Methods</b>: Eight true and false frequently asked orthodontic questions were submitted to five leading chatbots (ChatGPT-4, Claude-3-Opus, Gemini 2.0 Flash Experimental, Microsoft Copilot, and DeepSeek). The consistency of the answers given by chatbots at four different times was assessed using Cronbach's α. Chi-squared test was used to compare chatbot responses with those given by two groups of clinicians, i.e., general dental practitioners (GDPs) and orthodontic specialists (Os) recruited in an online survey via social media, and differences were considered significant when <i>p</i> < 0.05. Additionally, chatbots were asked to provide a justification for their dichotomous responses using a chain-of-through prompting approach and rating the educational value according to the Global Quality Scale (GQS). <b>Results</b>: A high degree of consistency in answering was found for all analyzed chatbots (α > 0.80). When comparing chatbot answers with GDP and O ones, statistically significant differences were found for almost all the questions (<i>p</i> < 0.05). When evaluating the educational value of chatbot responses, DeepSeek achieved the highest GQS score (median 4.00; interquartile range 0.00), whereas CoPilot had the lowest one (median 2.00; interquartile range 2.00). <b>Conclusions</b>: Although chatbots yield somewhat useful information about orthodontics, they can provide misleading information when dealing with controversial topics.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of N-Acetyl Cysteine in the Treatment of Burning Mouth Syndrome-A Randomized Controlled Trial.","authors":"Lorena Horvat Aleksijević, Božana Lončar Brzak, Miroslav Sikora, Ivana Škrinjar, Vlaho Brailo, Ana Andabak Rogulj, Marko Aleksijević, Danica Vidović Juras","doi":"10.3390/dj13080336","DOIUrl":"10.3390/dj13080336","url":null,"abstract":"<p><p><b>Objectives:</b> Burning mouth syndrome (BMS) is a chronic, painful, idiopathic condition of the oral cavity, characterized by the absence of visible pathological changes on the oral mucosa and normal laboratory findings. Recent evidence from the literature supports the classification of BMS as a neuropathic condition. It has been proposed that oxidative stress may contribute to neuropathic pain. N-acetylcysteine (NAC) is an antioxidant that exhibits neuroprotective properties. The aim of the study was to evaluate the efficacy of N-acetyl cysteine in the treatment of burning mouth syndrome (BMS). <b>Methods:</b> Eighty female patients with previously diagnosed BMS were randomly assigned to one out of two groups. One group received N-acetyl cysteine (600 mg/twice a day) and the other received placebo, for an eight-week period. The outcome was measured by the Oral Health Impact Profile-14 (OHIP-14) quality of life questionnaire and Numeric Pain Rating Scale, for burning and discomfort, both before and after completing the therapy. <b>Results:</b> Both groups experienced a significant reduction in burning and discomfort sensations, along with a significant improvement in oral health-related quality of life. However, the difference between the treatment and control group was not statistically significant. <b>Conclusions:</b> NAC does not significantly improve the oral health-related quality of life, burning sensations, and discomfort in BMS subjects compared to placebo.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}