Dentistry Journal最新文献

Salivary Biomarker Analysis to Distinguish Between Health and Periodontitis Status: A Preliminary Study. 唾液生物标志物分析用于区分健康和牙周炎状态：初步研究。

IF 3.1

Dentistry Journal Pub Date : 2025-09-22 DOI: 10.3390/dj13090436

Carlo Bertoldi, Milena Nasi, Roberta Salvatori, Marcello Pinti, Silvia Montagna, Maurizio Tonetti, Luigi Generali, Elisa Bellei, Davide Zaffe, Valentina Selleri, Stefania Bergamini

{"title":"Salivary Biomarker Analysis to Distinguish Between Health and Periodontitis Status: A Preliminary Study.","authors":"Carlo Bertoldi, Milena Nasi, Roberta Salvatori, Marcello Pinti, Silvia Montagna, Maurizio Tonetti, Luigi Generali, Elisa Bellei, Davide Zaffe, Valentina Selleri, Stefania Bergamini","doi":"10.3390/dj13090436","DOIUrl":"10.3390/dj13090436","url":null,"abstract":"Objective: This study aims to explore the feasibility of a non-invasive and simple method for discriminating between health and periodontitis (PRD), facilitating early and objective diagnosis of PRD before detectable periodontal attachment loss and monitoring treatment outcomes. Methods: Salivary samples were collected from 16 PRD-free patients (G1) and 10 patients with PRD (G2). The analysis included salivary matrix metalloproteinase-8 (MMP-8), major anti-inflammatory interleukins (IL-4 and IL-10), pro-inflammatory cytokines (IL-1β, IL-8, and interferon α [IFN-α]), and the cytokine IL-6. Clinical and salivary assessments were performed at baseline (TP0) for both groups and after periodontal treatment for G2 (TP1). Results: PRD indices were significantly higher in G2-TP0, lower in G1, and intermediate in G2-TP1. Except for IL-6, the biomarkers were significantly correlated with nearly all PRD clinical indices. Logistic regression and receiver operating characteristic (ROC) curve analyses showed statistical significance for MMP-8, IL-1β, IL-4, IL-8, and IL-10 when comparing G1 and G2 at TP0. MMP-8 was also significant when comparing G2-TP0 and G2-TP1, while IL-1β and IL-10 showed borderline significance. IL-8 was significant when comparing G1 and G2-TP1. Conclusions: The molecular network demonstrated great potential for early diagnosis and monitoring of therapy response, providing a promising basis for future research. Among the biomarkers, MMP-8, IL-1β, IL-4, IL-8, and IL-10 showed the strongest statistical correlations with the clinical indices. The inflammation-related biomolecules behaved differently among untreated PRD (G2-TP0), treated (G2-TP1), and healthy individuals (G1). Healthy individuals and those with treated PRD may regulate inflammation significantly differently from those with untreated PRD.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Facial Types and Alveolar Crest Cortical Bone Thickness and CT Values Determined by Multidetector Computed Tomography. 面部类型与牙槽嵴皮质骨厚度及CT值的关系。

IF 3.1

Dentistry Journal Pub Date : 2025-09-22 DOI: 10.3390/dj13090437

Masahiro Kitano, Shin Ota, Shigeki Iijima, Ichiro Ogura

{"title":"Relationship Between Facial Types and Alveolar Crest Cortical Bone Thickness and CT Values Determined by Multidetector Computed Tomography.","authors":"Masahiro Kitano, Shin Ota, Shigeki Iijima, Ichiro Ogura","doi":"10.3390/dj13090437","DOIUrl":"10.3390/dj13090437","url":null,"abstract":"Background/Objectives: This study aimed to investigate the relationships between facial morphology and alveolar crest cortical bone thickness and to determine the computed tomography (CT) values using multidetector CT (MDCT). Methods: A total of 39 subjects were categorized into three groups based on the Frankfort mandibular plane angle: low angle, average angle, and high angle. The thickness of the alveolar crest cortical bone and CT values between the canines and first premolars and between the second premolars and first molars in the maxilla and mandible were measured and analyzed from pre-treatment MDCT images. The Kruskal-Wallis and Dunn-Bonferroni tests were applied to investigate the relationships between facial types and alveolar crest cortical bone thickness, and to determine the CT values. Results: Significant differences in cortical bone thickness between the mandibular premolar and first molar were observed when comparing the high-angle group with the low-angle group (p = 0.001) and the average-angle group with the low-angle group (p = 0.022). Conclusions: These findings indicate that examining facial type may reveal differences in anchor loss in the mandibular molar region, which could prove useful in formulating treatment plans.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular Disorders in Professional Scuba Divers-A Cross-Sectional Study. 专业水肺潜水员的颞下颌紊乱——横断面研究。

IF 3.1

Dentistry Journal Pub Date : 2025-09-21 DOI: 10.3390/dj13090434

Ivica Pelivan, Joško Viskić, Nikša Dulčić

{"title":"Temporomandibular Disorders in Professional Scuba Divers-A Cross-Sectional Study.","authors":"Ivica Pelivan, Joško Viskić, Nikša Dulčić","doi":"10.3390/dj13090434","DOIUrl":"10.3390/dj13090434","url":null,"abstract":"Objectives: Most of the published literature on this topic argues about painful teeth, masticatory muscles, and/or temporomandibular joints in scuba divers. This study aimed to determine the possible differences in the prevalence of TMD between the diver population and the general population. Methods: This was a cross-sectional epidemiological study. The standardized RDC/TMD protocol was used for both the study and the control group. A total of 84 individuals were randomly selected to participate in the study: 55 divers (study group) and 29 individuals from the general population (control group). Results: There was a significant difference in the group 2 and group 3 RDC/TMD Axis I diagnoses between the study and the control group. Logistic regression analysis showed that the diver population was 15.8 times more likely to develop a group 2 left joint and 12 times more likely to develop a group 3 right joint diagnoses than the general population. The RDC/TMD Axis II diagnoses were also significantly higher in the study group than in the control group, whereby the divers were considerably older and predominantly male. Conclusions: A higher prevalence of group 2 (disk displacements) and group 3 (other common joint disorders) diagnoses was found in the divers. However, these results should be taken considering the limitation that there was a lack of age and gender matching between the groups, which can cause confounding.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmented Reality in Implant and Tooth-Supported Prosthodontics Practice and Education: A Scoping Review. 增强现实在种植体和牙齿支持的修复实践和教育：范围审查。

IF 3.1

Dentistry Journal Pub Date : 2025-09-21 DOI: 10.3390/dj13090435

Sorana Nicoleta Rosu, Monica Silvia Tatarciuc, Anca Mihaela Vitalariu, Iulian-Costin Lupu, Diana Antonela Diaconu, Roxana-Ionela Vasluianu, Catalina Cioloca Holban, Ana Maria Dima

{"title":"Augmented Reality in Implant and Tooth-Supported Prosthodontics Practice and Education: A Scoping Review.","authors":"Sorana Nicoleta Rosu, Monica Silvia Tatarciuc, Anca Mihaela Vitalariu, Iulian-Costin Lupu, Diana Antonela Diaconu, Roxana-Ionela Vasluianu, Catalina Cioloca Holban, Ana Maria Dima","doi":"10.3390/dj13090435","DOIUrl":"10.3390/dj13090435","url":null,"abstract":"Background: Augmented reality (AR) is revolutionizing implant and tooth-supported prosthodontics (ITSP) through enhanced precision, workflow efficiency, and educational outcomes. This scoping review systematically evaluates AR's clinical applications, educational impacts, and implementation challenges. Methods: Following PRISMA-ScR guidelines, comprehensive searches were conducted in PubMed, Scopus, Web of Science, and Embase (2015-2025) for peer-reviewed studies on AR in ITSP. Eighteen studies met inclusion criteria after dual independent screening. Data extraction focused on clinical outcomes, educational benefits, and technological limitations. Results: AR applications demonstrated: ITSP Practice: Submillimeter implant placement accuracy (0.42-0.69 mm entry deviation; p < 0.001 vs. freehand), 30% faster intraoral scanning (44 s vs. 63 s), and 37% reduction in preparation errors (p < 0.05); ITSP Education: 22-30% faster skill acquisition (p < 0.05) and 99% reduction in assessment time (10.5 s vs. 2 h/case). Key Gaps: Limited to two randomized controlled trials (RCTs), hardware costs ($3500-$10,000), and lack of standardized validation protocols. Conclusions: While AR significantly enhances ITSP precision and training efficiency, widespread adoption requires longitudinal clinical validation, cost-effectiveness analyses, and interoperable digital workflows.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment Options in Impacted Maxillary Canines: A Literature Review. 上颌阻生犬的治疗方案：文献综述。

IF 3.1

Dentistry Journal Pub Date : 2025-09-18 DOI: 10.3390/dj13090433

Saverio Ceraulo, Antonio Barbarisi, Beatrice Oliva, Sharon Moretti, Gianluigi Caccianiga, Dorina Lauritano, Roberto Biagi

{"title":"Treatment Options in Impacted Maxillary Canines: A Literature Review.","authors":"Saverio Ceraulo, Antonio Barbarisi, Beatrice Oliva, Sharon Moretti, Gianluigi Caccianiga, Dorina Lauritano, Roberto Biagi","doi":"10.3390/dj13090433","DOIUrl":"10.3390/dj13090433","url":null,"abstract":"Background: Impaction of maxillary canines is a frequent clinical challenge in orthodontics. Early diagnosis is key to effective management. Methods: This narrative review included studies published from 2004 to 2024. An electronic search was conducted in PubMed, Scopus, and Google Scholar (September-November 2024), using predefined eligibility criteria. The selection and drafting were completed in the following months. Studies involving orthopedic, orthodontic, or surgical-orthodontic management of impacted maxillary canines were included. Case reports and procedures limited to avulsion or transplantation were excluded. Results: A total of 10 studies were analyzed, comprising 5529 patients, of whom 2530 met the criteria for treatment-specific analysis. Surgical exposure with orthodontic traction was the most frequent treatment (72%), followed by monitoring (12%), maxillary expansion (6%), and extractions (10%). Interceptive approaches were mainly applied in patients aged 7-18 years, with favorable outcomes especially before age 12. In adults, more invasive treatments were required, often with reduced success rates. Conclusions: Early diagnosis and interceptive extraction of deciduous canines reduce treatment complexity and improve success. Therapeutic outcomes are strongly influenced by patient age, tooth position, and angulation. A structured, radiographically guided approach, supported by the proposed decision-making flowchart, may optimize clinical outcomes. However, heterogeneity of included studies and lack of long-term follow-up limit the strength of available evidence.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal Oral Mucosal Melanoma with an Atypical Clinical Presentation. 临床表现不典型的多灶性口腔黏膜黑色素瘤。

IF 3.1

Dentistry Journal Pub Date : 2025-09-18 DOI: 10.3390/dj13090432

Klaudia Podlińska, Monika Monist, Magdalena Sławińska, Wojciech Popowski

{"title":"Multifocal Oral Mucosal Melanoma with an Atypical Clinical Presentation.","authors":"Klaudia Podlińska, Monika Monist, Magdalena Sławińska, Wojciech Popowski","doi":"10.3390/dj13090432","DOIUrl":"10.3390/dj13090432","url":null,"abstract":"Background: Oral mucosal melanoma (oral malignant melanoma-OMM) is a rare malignant neoplasm. It arises from the proliferation of atypical melanocytes-cells derived from the neural crest that produce melanin. Unlike cutaneous melanomas, which are etiologically linked to ultraviolet (UV) radiation exposure, the risk factors for mucosal melanomas remain poorly defined. According to the World Health Organization (WHO), these tumors predominantly affect older individuals, with peak incidence occurring in the seventh decade of life and are rarely observed in the first three decades. The primary treatment modality for patients with mucosal melanoma is radical surgical excision with clear margins. The 5-year overall survival rate for OMM ranges from 20% to 50%. Case Presentation: This article reports an atypical clinical manifestation of oral mucosal melanoma in a 99-year-old patient who presented to the Department of Oral Surgery at the University Dental Center, Medical University of Warsaw. The nonspecific clinical appearance did not initially suggest a melanocytic lesion. A definitive diagnosis was established through histopathological examination, which subsequently guided the treatment plan. Conclusions: This report highlights the necessity of performing microscopic evaluation even for lesions with a nonspecific or non-suspicious appearance, underlines the importance of regular dental check-ups, and stresses the need to strengthen oncological vigilance among dental practitioners.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enamel Surface and Elemental Changes Following In Vitro Bleaching: A SEM-EDS Approach. 体外漂白后牙釉质表面和元素变化：SEM-EDS方法。

IF 3.1

Dentistry Journal Pub Date : 2025-09-17 DOI: 10.3390/dj13090431

Berivan Laura Rebeca Buzatu, Ramona Dumitrescu, Magda Mihaela Luca, Roxana Buzatu, Atena Galuscan, Vanessa Bolchis, Gabriela Vlase, Titus Vlase, Daniela Elisabeta Jumanca

{"title":"Enamel Surface and Elemental Changes Following In Vitro Bleaching: A SEM-EDS Approach.","authors":"Berivan Laura Rebeca Buzatu, Ramona Dumitrescu, Magda Mihaela Luca, Roxana Buzatu, Atena Galuscan, Vanessa Bolchis, Gabriela Vlase, Titus Vlase, Daniela Elisabeta Jumanca","doi":"10.3390/dj13090431","DOIUrl":"10.3390/dj13090431","url":null,"abstract":"Background and Objectives: Chairside bleaching can alter enamel morphology and mineral content. This in vitro study compared surface changes and elemental shifts after three in-office protocols using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Materials and Methods: Forty-two human premolars/molars were sectioned; matched halves served as control or received Opalescence Quick 45% carbamide peroxide (CP), Opalescence Boost 40% hydrogen peroxide (HP), or BlancOne Ultra+ 35% HP with light activation. Gels were applied per manufacturers' instructions. SEM assessed topography (×500-×1100); EDS quantified atomic percent of O, Ca, P, C and trace elements. One-way ANOVA compared Ca and P between bleached groups (α = 0.05). Results: Controls showed compact surfaces with preserved Ca and P. After Quick, SEM revealed roughness, fissures and microcracks; Ca fell from 11.5 to 12.5 to 9.53-11.73 at% and P from 7.5 to 8.9 to 7.41-8.59 at%. Boost produced mild superficial restructuring and granular deposits with variable Ca 13.80-27.94 at% and P 7.32-14.65 at%. BlancOne Ultra+ caused diffuse erosion and loss of prismatic clarity with marked demineralization (Ca 1.42-7.85 at%, P 1.22-6.71 at%); C rose locally to 46.61 at%. Across bleached groups, Ca and P differed significantly (both p < 0.001). Oxygen remained dominant (~39-50 at%) in all spectra; occasional Al/Si/Cl/K likely reflected residues or preparation artifacts. Conclusions: All protocols produced surface and compositional alterations, with a severity gradient: BlancOne Ultra+ > Boost > Quick. High-concentration, light-activated HP yielded the largest Ca/P losses. Clinically, neutral-pH, non-activated or chemically activated regimens and immediate post-bleach remineralization should ideally be used when feasible, particularly before adhesive procedures.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical Complications and Marginal Bone Loss Depending on the Crown Material of Dental Implants in the Posterior Region: A 3-Year Randomized Clinical Study. 后牙种植体冠材料对技术并发症和边缘骨丢失的影响：一项为期3年的随机临床研究。

IF 3.1

Dentistry Journal Pub Date : 2025-09-17 DOI: 10.3390/dj13090430

Sigmar Schnutenhaus, Marla Weinmann, Max Römer, Ralph G Luthardt

{"title":"Technical Complications and Marginal Bone Loss Depending on the Crown Material of Dental Implants in the Posterior Region: A 3-Year Randomized Clinical Study.","authors":"Sigmar Schnutenhaus, Marla Weinmann, Max Römer, Ralph G Luthardt","doi":"10.3390/dj13090430","DOIUrl":"10.3390/dj13090430","url":null,"abstract":"Background/Objectives: This single-center, randomized controlled clinical trial evaluated the impact of two crown materials-lithium disilicate (LS2) and a polymer-infiltrated hybrid ceramic (HC)-on the marginal bone loss (MBL) and the technical complications in implant-supported single-tooth restorations over a three-year period. Methods: Sixty patients with posterior single-tooth gaps were randomly assigned to receive either LS2 or HC crowns on iSy (Camlog) implants. All of the restorations were fabricated as CAD/CAM-based hybrid abutment crowns bonded to prefabricated titanium bases. Standardized radiographs were taken at the baseline (T0) and at three years (T1) to assess the MBL using ImageJ software. The technical complications were prospectively recorded. The data analysis was descriptive and exploratory. Results: Fifty-eight cases were available for the final evaluation. The three-year implant survival rate was 100%. The mean marginal bone remodeling was minimal (mesial: LS2 0.15 mm, HC 0.08 mm; distal: LS2 0.13 mm, HC 0.12 mm), with no statistically significant intergroup differences. Bone apposition was observed in 74.1% of the cases. The male patients showed a significantly greater mesial bone loss (p = 0.024). Technical complications occurred more frequently in the HC group, including crown fractures (25%), decementation (17.9%), and screw loosening (14.3%). In the LS2 group, only screw loosening (12.5%) was observed. Conclusions: The lithium disilicate-based hybrid abutment crowns demonstrated a high clinical reliability with stable peri-implant bone and fewer technical complications over three years. In contrast, the hybrid ceramic crowns were associated with a higher rate of mechanical failure. Material selection should therefore be a key consideration in planning implant-supported single-tooth restorations.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Simvastatin on Odontoblastic Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study. 辛伐他汀对人牙髓干细胞成牙细胞分化影响的体外研究

IF 3.1

Dentistry Journal Pub Date : 2025-09-16 DOI: 10.3390/dj13090428

Carmela Del Giudice, Flavia Iaculli, Carlo Rengo, Alessandro Salucci, Gianrico Spagnuolo, Francesco Riccitiello, Maurizio Bossù, Antonella Polimeni, Gianni Di Giorgio

{"title":"The Effect of Simvastatin on Odontoblastic Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study.","authors":"Carmela Del Giudice, Flavia Iaculli, Carlo Rengo, Alessandro Salucci, Gianrico Spagnuolo, Francesco Riccitiello, Maurizio Bossù, Antonella Polimeni, Gianni Di Giorgio","doi":"10.3390/dj13090428","DOIUrl":"10.3390/dj13090428","url":null,"abstract":"Objectives: The aim of the current in vitro study was to assess the effect of simvastatin on the early-stage differentiation of human dental pulp stem cells (hDPSCs) in an odontogenic pattern by evaluating the expression of specific odontogenic-related genes. Methods: hDPSCs were cultured in the presence of different concentrations of simvastatin (0.1, 0.5, 1, 5, and 10 µM) to evaluate cytotoxicity. Moreover, osteogenic differentiation was assessed by Alkaline Phosphatase (ALP) activity and alizarin red staining (ARS) after 7 days of culture. Finally, odontogenic-related gene (OCN, MEPE, DSPP, and DMP-1) expression analysis was performed. Results: Three days after treatment, higher concentrations of simvastatin (1, 5, and 10 µM) significantly limited cell viability. Upregulation of ALP activity and odontoblastic cell-related genes (OCN and MEPE) was observed in the presence of 1 µM simvastatin. The expression was statistically higher for ALP (p = 0.0001) and OCN (p = 0.0231). On the other hand, comparable or slightly less effect concerning mineralization ability with respect to the control group, as well as in the expression of DSPP and DMP-1, was observed. Conclusions: Simvastatin demonstrated a positive influence on dentinogenesis by improving the expression of specific markers such as MEPE and OCN. However, its effect on inflammation reduction and the potential to be used in combination with other materials should be further assessed. Simvastatin might be successfully applied in the regeneration of damaged dental pulp tissues and promotion of reparative dentinogenesis. Additional studies should be carried out to support the obtained outcomes.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Depressive Disorder on Periodontal Status: A Comparative Study. 抑郁症对牙周状况影响的比较研究。

IF 3.1

Dentistry Journal Pub Date : 2025-09-16 DOI: 10.3390/dj13090429

Bogdan-Constantin Vasiliu, Maria Alexandra Mârțu, Alexandra Cornelia Oanță, Irina Șufaru, Liliana Păsărin, Alexandru Ionuț Luchian, Sorina Mihaela Solomon

{"title":"Impact of Depressive Disorder on Periodontal Status: A Comparative Study.","authors":"Bogdan-Constantin Vasiliu, Maria Alexandra Mârțu, Alexandra Cornelia Oanță, Irina Șufaru, Liliana Păsărin, Alexandru Ionuț Luchian, Sorina Mihaela Solomon","doi":"10.3390/dj13090429","DOIUrl":"10.3390/dj13090429","url":null,"abstract":"Background/Objectives. Periodontitis is a chronic inflammatory disease influenced by systemic and psychological factors, including depression. Selective serotonin reuptake inhibitors (SSRIs), widely used to treat depression, may also affect periodontal healing. This study aimed to evaluate the clinical efficacy of full-mouth disinfection (FMD) in patients with periodontitis, with or without comorbid depression and SSRI therapy. Methods. Eighty participants were enrolled and divided into two groups: periodontitis only (n = 40) and periodontitis with depression (n = 40), the latter subgrouped by SSRI usage. Clinical parameters, including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI), were assessed at baseline and 12 weeks after FMD. Results. Following FMD, significant improvements were observed in PD, PI, and BOP across all groups (p < 0.001). In the non-depressed group, mean PD decreased from 4.26 ± 0.97 mm to 2.76 ± 0.56 mm (p < 0.001) and PI from 3.85 ± 0.70 to 1.05 ± 0.99. Patients with depression had higher initial PD (4.98 ± 1.05 mm) but still showed improvement to 3.08 ± 0.69 mm (p < 0.001). CAL improved significantly only in non-depressed individuals (p = 0.008), while no statistically significant CAL changes were observed in depressed patients (p > 0.05). SSRI therapy did not significantly influence treatment outcomes (p > 0.05). Conclusions. FMD is clinically effective in reducing periodontal inflammation in patients with or without depression. However, improvements in CAL were more pronounced in non-depressed individuals, suggesting that depression may partially attenuate periodontal healing.","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0