Dentistry Journal最新文献

{"title":"Evaluation of the Disinfection Efficacy of Er: YAG Laser Light on Single-Species Candida Biofilms-An In Vitro Study.","authors":"Diana Dembicka-Mączka, Małgorzata Kępa, Jakub Fiegler-Rudol, Zuzanna Grzech-Leśniak, Jacek Matys, Kinga Grzech-Leśniak, Rafał Wiench","doi":"10.3390/dj13020088","DOIUrl":"10.3390/dj13020088","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Oral candidiasis is an opportunistic infection caused by Candida species. Recently, antifungal drugs have become less effective due to yeast resistance, emphasizing the need for new treatment strategies. This study aimed to assess the effect of the Er:YAG laser on the inhibition of growth and elimination of mature single-species Candida biofilms. <b>Methods:</b> The study utilized reference strains of <i>C. albicans</i>, <i>C. glabrata</i>, <i>C. parapsilosis</i>, and <i>C. krusei</i> organized in single-species biofilms on Sabouraud dextrose agar (SDA). First part: <i>Candida</i> suspensions (0.5 McFarland standard) were spread on SDA plates-two for each strain. Er:YAG laser irradiation was applied in a single pulse mode, 30 to 400 mJ, to 32 predetermined points. The growth inhibition zones (GIZs) were measured at 24-96 h of incubation. Second part: biofilms were prepared similarly and, after 96 h of incubation, exposed to Er:YAG laser irradiation at different energies (50, 100, 150, 200 mJ) for 180 s, per 1.44 cm area. Post-irradiation, impressions were taken using Rodac Agar to determine yeast counts. The count of colony-forming units (CFU) after irradiation was measured and results were analysed statistically. <b>Results</b>: First part: GIZ was found in all irradiated sites, with various <i>Candida</i> strains. The results showed a significant increase in the width of GIZ in the energy range of 30-280 mJ and a non-significant increase in the energy range of 300-400 mJ. Second part: the number of CFU remaining after the irradiation of biofilms with 150 mJ energy differed statistically significantly from other results obtained after using 50, 100, or 200 mJ energy, regardless of the <i>Candida</i> strain tested. <b>Conclusions</b>: The Er:YAG is shown to have good disinfecting properties (inhibiting biofilm growth, even at low-energy doses (50 mJ), and eliminating maturity, <i>Candida</i> spp. biofilms most effective on the 150 mJ energy dose).</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Efficacy of Benefect™ Botanical Disinfectant in Comparison with Sodium Hypochlorite and Chlorohexidine Against Multiple Endodontic Pathogens: An Ex Vivo Study.","authors":"Sarmed Toma, Joseph Ferracciolo, Mazin Askar, Eric Krukonis, Susan Paurazas","doi":"10.3390/dj13020087","DOIUrl":"10.3390/dj13020087","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Natural antibacterial agents, such as essential oils, can potentially be used for endodontic disinfection with less toxicity than other available irrigants such as sodium hypochlorite (NaOCl) and chlorhexidine (CHX). Benefect^TM is a formulation of essential oils with broad antibacterial spectrum efficacy. This study aims to compare the antibacterial efficacy of Benefect^TM to 6% NaOCl and 2% CHX irrigant solutions against multiple endodontic pathogens. <b>Methods</b>: The study utilized 100 extracted human single-canal permanent teeth. Samples were decoronated, instrumented, and autoclaved. The teeth were infected with <i>Streptococcus mutans</i>, <i>Enterococcus faecalis</i>, <i>Actinomyces naeslundii</i>, or <i>Porphyromonas gingivalis</i> for 6-24 h. The teeth were divided into four groups according to the irrigant solution used. Contact with each irrigant was maintained for 12 min. The antibacterial efficacy of each treatment was calculated relative to viable bacteria recovered after saline treatment. Statistical analysis was performed using Student's <i>t</i>-test. <b>Results</b>: All <i>S. mutans</i> samples treated with NaOCl, CHX, and Benefect^TM showed a complete absence of bacterial colonies when compared to saline (>99.9% killing). The <i>E. faecalis</i>, <i>A. naeslundii</i>, and <i>P. gingivalis</i> samples treated with all tested irrigants showed at least 99% antibacterial killing activity. There was no statistical difference in killing between these three antimicrobial treatments. <b>Conclusions</b>: Benefect^TM botanical disinfectant has comparable antibacterial efficacy to NaOCl and CHX against <i>S. mutans</i>, <i>E. faecalis</i>, <i>A. naeslundii</i>, and <i>P. gingivalis</i>.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Kefir Consumption on Dental Caries and Periodontal Disease: A Narrative Review.","authors":"Anna González-Rascón, Elda Georgina Chávez-Cortéz, Angélica Hurtado-Camarena, Nicolás Serafín-Higuera, Sandra Castillo-Uribe, Víctor Manuel Martínez-Aguilar, Bertha Arelly Carrillo-Ávila, Viviana Pitones-Rubio","doi":"10.3390/dj13020086","DOIUrl":"10.3390/dj13020086","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Dental caries and periodontal diseases are the most common illnesses in the oral cavity and represent a public health concern globally. In recent decades, diverse studies showed that Kefir, a traditional beverage that can be milk- or water-based, contains a complex microbial community and has health benefits. The goal of this review was to update the current knowledge of kefir consumption and its impact on oral health. <b>Methods:</b> The search of a combination of keywords-kefir; dental caries; probiotics; microbiota; periodontal diseases; biofilm; and oral health-was conducted using PubMed, Google Scholar, and Web of Science databases for studies in human subjects. <b>Discussion:</b> The research suggests that kefir consumption may aid in decreasing counts of microorganisms typically associated with oral illness. <b>Conclusions:</b> Kefir has the potential to inhibit certain oral pathogens and reduce biofilm formation by promoting diversity within the oral microbiota, suggesting that kefir could be a promising adjuvant treatment for dental caries and periodontal diseases by improving oral health.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Bone Regeneration Using Carbonated Apatite Granules and L-Lactic Acid/ε-Caprolactone Membranes: A Case Series and Histological Evaluation.","authors":"Yoichi Taniguchi, Tatsuro Koyanagi, Yutaro Kitanaka, Azusa Yamada, Akira Aoki, Takanori Iwata","doi":"10.3390/dj13020085","DOIUrl":"10.3390/dj13020085","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The newly developed poly L-lactic acid/ε-caprolactone (P(LA/LC)) membrane has recently been proposed as a guided bone regeneration (GBR) procedure in implant treatment. This case series details the clinical, radiographic, and histological results of ridge augmentation using bone graft comprising a P(LA/LC) membrane and carbonated apatite for implant treatment. <b>Methods</b>: Ten patients (15 sites) requiring bone augmentation and implant placement were retrospectively assessed. Simultaneous implant placement (Si) was performed at five sites in three patients. Si immediately following tooth extraction (SiIP) was performed at four sites in four patients. The staged approach (St) was performed at six sites in three patients. In the St-treated cases, hard tissue samples were taken from the implant placement site under patient consent. <b>Results</b>: The mean regenerated bone width for each treatment method was Si, 6.34 ± 2.64 mm (excluding implant diameter, 2.60 ± 2.42); SiIP, 7.55 ± 1.17 mm (excluding implant diameter, 3.90 ± 0.78) and St, 5.57 ± 1.08 mm. The mean regenerated bone width for all the cases was 6.36 ± 1.83 mm (excluding implant diameter, 4.14 ± 1.99). Significant differences were observed between the pre- and post-operative bone width in all the cases and the SiIP group (<i>p</i> < 0.001). All cases were followed up for more than 2 years after attaching the superstructure. No inflammation, shrinkage, or other problems were observed in the hard and soft tissues surrounding the implant. In the histological evaluation, there was no soft tissue ingrowth into the augmented bone, and new bone formation was observed. <b>Conclusions</b>: The use of P(LA/LC) membranes and carbonated apatite as GBR materials in implant treatment resulted in stable and favorable bone augmentation.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Vital Teeth Involved in Large Cystic Lesions After a Surgical Intervention: A Longitudinal Ambidirectional Cohort Study.","authors":"Khalid A Merdad, Maha Shawky, Khalid A Aljohani, Rawia Alghamdi, Saja Alzahrani, Omar R Alkhattab, Abdulaziz Bakhsh","doi":"10.3390/dj13020083","DOIUrl":"10.3390/dj13020083","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Large cystic lesions in the maxillofacial region present a challenge for clinicians due to their impact on the health and functionality of the involved teeth. This longitudinal, ambidirectional cohort study aimed to evaluate the prognosis of vital teeth affected by large cystic lesions following surgical intervention. <b>Methods</b>: Data were gathered from patients at King Abdulaziz University Dental Hospital and King Fahad General Hospital in Jeddah, Saudi Arabia, between July 2021 and August 2022. Seventeen individuals with large jawbone cysts were included in the study. Clinical and radiographic assessments were performed including sensibility testing and the function of teeth. The results indicated a linear relationship between the size of postoperative bony defects and the sensibility testing of teeth. <b>Results:</b> Of the 63 examined teeth, 54% did not receive endodontic treatment, 33% had pre-surgical treatment, and 12.7% had post-surgical treatment. The study revealed a high prevalence of inflammatory cysts, particularly in the maxilla. Surgical enucleation was the primary treatment modality, with few postoperative complications. <b>Conclusions:</b> This study highlights the necessity for standardized follow-up protocols and more extensive research to develop universal guidelines for managing large cystic lesions affecting vital teeth. Understanding the prognosis of cystic lesions is crucial for effective treatment planning and ensuring optimal patient outcomes.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Screening of Temporomandibular Joint Pathology in Children with Chronic Kidney Disease.","authors":"Natalia Sergeevna Morozova, Alina Alekseevna Elovskaya, Ekaterina Andreevna Maslikova, Oleg Ivanovich Admakin, Arif Fuad Allahverdiyev, Ellina Valerievna Velichko, Larisa Dmitrievna Maltseva, Pavel Pavlovich Tregub, Olga Leonidovna Morozova","doi":"10.3390/dj13020084","DOIUrl":"10.3390/dj13020084","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Chronic kidney disease (CKD) influences different organs including the temporomandibular joint (TMJ). This study aims to identify structural and functional TMJ changes in children with CKD using ultrasound as the least invasive and most accessible method. <b>Methods</b>: TMJ changes were examined using ultrasound screening in 40 children. The first group (control, <i>n</i> = 10) included children with normal occlusion without TMJ complaints. The second group (<i>n</i> = 10) included children with CKD stage 1 and 2. The third group (<i>n</i> = 10) included patients on hemodialysis after renal transplantation. The forth group (<i>n</i> = 10) included patients at least 6 months after renal transplantation. <b>Results</b>: The size of the anterior section of the right TMJ gap in the third group was the largest among all the groups studied (1.085 mm) and statistically significantly different from the first group (0.570 mm; <i>p</i> = 0.001) and the second one (0.665 mm, <i>p</i> = 0.001). The width of the middle section was also greatest in the third group and statistically significantly different when compared to the first and second groups (0.390 mm; <i>p</i> = 0.023 and 0.340 mm; <i>p</i> < 0.001, respectively). A posterior articular gap width differences between the individual patient groups under study were not statistically significant in a posteriori comparison with Bonferroni correction. Statistical significance of differences between all groups when comparing the gap width was found in all sections of the left TMJ. The frequency of anterior disc displacement between groups ranged from 50 to 100% in all groups studied and was not statistically different when comparing right and left TMJs between groups (<i>p</i> = 0.084 and <i>p</i> = 0.662, respectively). <b>Conclusions</b>: CKD children have different TMJ changes, so TMJ ultrasound could screen joint pathology at early stages, and dental specialists can start timely rehabilitation.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Surgical and Orthodontic Treatment of Complex Odontoma in Growing Patients: Presentation of Two Cases.","authors":"Natalia Muczkowska, Ewa Czochrowska, Klaudia Masłowska, Andrzej Wojtowicz, Wojciech Popowski","doi":"10.3390/dj13020082","DOIUrl":"10.3390/dj13020082","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Odontomas are the most common mixed odontogenic tumors and may cause impaction of adjacent teeth and masticatory disorders. Treatment of tooth impaction caused by the presence of odontomas is related to their stages of root development and their positions in the alveolar bone. The aim of this case report is to present the combined surgical and orthodontic treatment in growing patients with odontomas and to discuss the treatment outcomes. <b>Methods:</b> Two growing patients, an 8-year-old boy and a 17-year-old girl, with large odontomas in the posterior maxillary region of the maxilla were presented. The tumors were found during a radiological examination, and the first molars on the affected sides were impacted due to the presence of odontomas. <b>Results:</b> The treatment plans included the surgical removal of the tumors. In the case of the younger patient, the impacted developing molar erupted spontaneously in the oral cavity one year and two months after surgery. An orthodontic traction of the impacted molar was successfully applied in the older patient. <b>Conclusions:</b> The presence of a large odontoma in the posterior segments may lead to a displacement and impaction of neighboring molars and malformation of their roots. Spontaneous eruption of the affected molar can be expected if the tumor is diagnosed and removed early before its root formation is completed; otherwise, an orthodontic extrusion is needed. Interdisciplinary cooperation is important to diagnose and plan the dental treatment in young patients with odontomas.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Communication Toolkit to Assist Families Access Dental Care Services in Scotland: A Qualitative Evaluation.","authors":"Sucharita Nanjappa, Thushani I D Wijesiri, Susan J Carson, Ruth Freeman","doi":"10.3390/dj13020080","DOIUrl":"10.3390/dj13020080","url":null,"abstract":"<p><p><b>Background:</b> Childsmile is Scotland's national child oral health improvement programme designed to reduce inequalities in oral health and ensure universal access to NHS dental services by working closely with children and their families. Research has shown that parents with more dental concerns are less likely to bring their children for regular preventive dental check-ups.Therefore, a communication toolkit named 'Chatterbox' was created to help families access dental care services. <b>Methods:</b> This study aimed to evaluate the acceptability of Chatterbox from the perspective of parents with young children and from staff who work with them. Thirty parents of young children, volunteers, and staff affiliated with three third-sector family support organisations in Dundee participated in in-depth interviews, focus groups, and observations to assess the objectives of Chatterbox. A framework analysis was conducted to capture the themes, patterns, and findings triangulated using observations and field notes. <b>Results:</b> Chatterbox was found to promote effective communication, identify barriers to dental attendance, provide a platform for reflection, convey the complexities of daily life, and boost parents' confidence to seek assistance. <b>Conclusions:</b> Chatterbox has the potential to help parents in accessing preventive dental care for their young children when used with trained support workers.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and Evaluating a New Preclinical Curriculum with Focus on Prevention in Dentistry.","authors":"Ina M Schüler, Katharina Bach, Pauline Schädlich, Ute Rabe","doi":"10.3390/dj13020081","DOIUrl":"10.3390/dj13020081","url":null,"abstract":"<p><p><b>Background/Objectives:</b> New licensing regulations for dentists in Germany offered the opportunity to modernize the dental curriculum regarding content, methodology and structure. This paper aims to evaluate the newly requested preclinical curriculum \"Dental Propaedeutic-Focus on Prevention\" by dental students and dental educators and to describe the process of development. <b>Methods:</b> The curriculum was developed according to the Kern cycle and the National Competence-Based Learning Objectives Catalog for Dentistry. Lesson planning was based on Bloom's taxonomy and the taxonomy of significant learning, according to the principle of constructive alignment. A variety of evidence-based teaching methods were implemented. For evaluation, dental students answered a written questionnaire, graded eight topics and added free text. Dental educators were interviewed. <b>Results:</b> Thirty out of fifty-four dental students' enrolled in the third semester participated in the survey, giving the highest grades to the learning atmosphere. All dental educators involved in the delivery of the curriculum participated in the interview. Dental students and educators expressed satisfaction with this comprehensive teaching approach of prevention in an early stage of the dental curriculum. Dental educators reflected on the high workload for development but valued the opportunity to participate in an evidence-based development process and to introduce various modern teaching and examination methods. <b>Conclusions:</b> The expenditure of time for the development, performance and examination was high. In order to perform 240 teaching units for eight ECTS credits, 419 h of conceptualization/preparation and 344 h for examination had to be invested. This paper might help to facilitate better understanding of the chances and efforts accompanied by curricular changes.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Dentistry: Preclinical Insights and Future Applications of mRNA Vaccines in Dentistry-A Narrative Review.","authors":"Luciana Koren, Andro Koren, Robert Likić, Tomislav Katanec","doi":"10.3390/dj13020079","DOIUrl":"10.3390/dj13020079","url":null,"abstract":"<p><p><b>Background:</b> Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest in their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring the potential of mRNA-based therapies in preventing and treating oral diseases. <b>Objectives:</b> This narrative review aims to evaluate the current status of mRNA vaccine development and its preclinical applications in oral health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, and oral cancer. <b>Methods:</b> The review synthesizes findings from preclinical studies, including research conducted in animal models and in vitro, to assess the potential of mRNA-based therapies to modulate immune responses and promote tissue regeneration in the oral cavity. Clinical trials were only mentioned in the context of broader areas of mRNA vaccine implementation such as oncology and immunotherapy. <b>Results:</b> The preclinical studies highlight the capacity of mRNA vaccines to enhance the body's immune response and facilitate tissue repair processes. Despite these promising results, challenges persist in delivering mRNA vaccines effectively within the complex oral environment. These challenges include vaccine stability, delivery mechanisms, and the modulation of immune responses. <b>Conclusions:</b> While mRNA vaccines offer significant promise for revolutionizing oral health care, they face notable limitations concerning safety, efficacy, and clinical feasibility. Overcoming these obstacles through further research is essential to unlock their full translational potential and ensure their safe and effective integration into dental practice.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}