Dentistry Journal最新文献

{"title":"Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.","authors":"Mario Dioguardi, Ciro Guerra, Pietro Laterza, Gaetano Illuzzi, Diego Sovereto, Enrica Laneve, Angelo Martella, Lorenzo Lo Muzio, Andrea Ballini","doi":"10.3390/dj13050215","DOIUrl":"10.3390/dj13050215","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The correlation between cardiovascular diseases, particularly infective endocarditis, and oral disorders such as periodontitis and dental caries has been widely discussed in the scientific literature. In this mapping review, we aim to examine the available evidence on the link between these conditions, focusing on the pathogenetic mechanisms that underlie the development of endocarditis in patients with oral diseases. <b>Methods:</b> A systematic search was conducted across three major databases-PubMed, Scopus, and ScienceDirect-as well as grey literature in Google Scholar. Relevant articles were selected based on inclusion and exclusion criteria, focusing primarily on systematic reviews. The data extracted included study characteristics, main outcomes, and risk-of-bias evaluations. <b>Results:</b> A total of 13 systematic reviews were included in this mapping review. The findings suggest there is a significant connection between periodontal disease, dental caries, and the incidence of infective endocarditis. The evidence highlights that oral bacteria, particularly <i>Streptococcus</i> species, can enter the bloodstream during daily activities and invasive dental procedures, contributing to the development of endocarditis in susceptible individuals. However, the role of antibiotic prophylaxis in preventing endocarditis following dental procedures remains controversial. <b>Conclusions:</b> This review reinforces the importance of oral health in preventing cardiovascular complications, especially infective endocarditis. Although antibiotic prophylaxis may reduce the risk in high-risk individuals, further research is needed to clarify its effectiveness. Enhanced awareness of and education on the shared risks between oral and cardiovascular health could improve prevention strategies and patient outcomes.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Loading of Implants-Supported Fixed Partial Prostheses in Posterior Regions: A Systematic Review.","authors":"Giuseppe D'Albis, Marta Forte, Abdulrahman Omar Alrashadah, Lorenzo Marini, Massimo Corsalini, Andrea Pilloni, Saverio Capodiferro","doi":"10.3390/dj13050213","DOIUrl":"10.3390/dj13050213","url":null,"abstract":"<p><p><b>Background</b>: Modern dentistry strives to achieve increasingly less invasive procedures as the ultimate therapeutic goal. The careful selection of suitable candidates for immediate dental implants can offer an opportunity to reduce treatment time, lower the relative costs and improve overall patient satisfaction. <b>Methods</b>: A systematic search was conducted in March 2025, without any time restrictions, in Medline, Pubmed and Web of Science databases. To identify other related references, further research was performed. Articles related to current knowledge about the immediate loading of dental implants supporting fixed partial prosthesis in the posterior region were included. Articles not available in abstract form and articles not published in the English language were excluded. <b>Results</b>: A total of ten studies were eligible for inclusion in the current study. The search strategy resulted in a survival rate ranging from 86% to 100%, and a failure rate of less than 21.6%, with a mean follow-up of 55.6 months. Statistical analysis revealed no significant differences in survival rates between implants placed in the maxilla and mandible (χ² = 0.42, <i>p</i> = 0.81, df = 2). Follow-up varied from one to ten years, reflecting variability both in study design and duration. <b>Conclusions</b>: The selected studies highlight the heterogeneity in immediate loading protocols for implant-supported fixed partial prosthesis in the posterior regions, emphasizing the variability in prosthetic materials and implant types, suggesting that immediate loading is a reliable, patient-centered therapeutic option with favorable long-term outcomes.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Pathogens Correlate with Rheumatoid Arthritis Disease Parameters: A Systematic Review Based on Clinical Studies.","authors":"Luki Astuti, Sri Lelyati Chaidar Masulili, Indrayadi Gunardi, Benso Sulijaya, Yuniarti Soeroso","doi":"10.3390/dj13050214","DOIUrl":"10.3390/dj13050214","url":null,"abstract":"<p><p><b>Background</b>: Numerous studies have found higher levels of autoantibodies including anti citrullinated protein antibodies (ACPAs), anti-cyclic citrullinated peptides (aCCP), or rheumatoid factor (RF) against periodontal microorganisms in rheumatoid arthritis (RA). Objective: To evaluate the correlation between periodontal bacteria and RA disease parameters. <b>Methods</b>: We utilized PubMed, Scopus, ScienceDirect, and manual search databases up until March 2024 using PRISMA 2020 guidelines. The data were obtained from microbiological assays by RT-PCR/qPCR, sequencing, and serological testing of disease parameters (ACPA, aCCP, and RF) utilizing ELISA method. <b>Results</b>: A total of 1514 documents were discovered based on the inclusion criteria. <i>Porphyromonas gingivalis</i>, <i>Aggregatibacter actinomycetemcomitans</i>, and <i>Prevotella_9</i> were associated with elevated levels of ACPA/aCCP and RF in RA with periodontitis. A positive correlation was found between <i>Peptococcus simiae</i>, <i>Aminipila butyrica</i>, <i>Leptotrichia</i> spp., <i>Leptotrichia wadei</i>, and <i>Neisseria bacilliformis</i> with ACPA, and <i>Treponema</i> sp. canine oral taxon 087 with RF. <b>Conclusions</b>: This study found that several oral microorganisms correlate with elevated ACPA/aCCP and RF in RA with periodontitis. Future studies of the oral microbiome and the molecular mechanisms are anticipated to discover new therapies and diagnostic methods for periodontitis and RA.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Prophylactic Polishing Pastes on the Surface Roughness, Color, and Stain Resistance of CAD/CAM Restorative Materials.","authors":"Betul Arkan, Ipek Iscan, Neslihan Tinastepe","doi":"10.3390/dj13050212","DOIUrl":"10.3390/dj13050212","url":null,"abstract":"<p><p><b>Background:</b> Prophylactic polishing pastes (PPPs) are widely used to clean teeth and dental restorations; however, their effects on restorative materials are crucial for clinical outcomes. This study investigates the impact of PPPs on the susceptibility of CAD/CAM restorative materials to staining and the relationship between surface roughness and discoloration. <b>Methods:</b> Samples of tested materials (resin nanoceramic, hybrid ceramic, feldspathic ceramic, and lithium disilicate-reinforced glass ceramic) were treated with various PPPs (Cleanic, CleanJoy, Detartrine, Proxyt). Surface roughness and color parameters were recorded before and after the PPP application and following coffee immersion for 12 days. Initial measurements of surface roughness (Ra1) and color were taken. The specimens were divided into groups based on the PPP applied. After PPP application, secondary roughness (Ra2) and color values were measured. Changes in roughness (ΔRa), color (ΔE*ab, ΔE00), and whiteness index (ΔWID) were calculated post-application and after coffee immersion. Data normality was tested with the Shapiro-Wilks test. Two-way ANOVA evaluated the effects of material type and PPP on ΔE, ΔWID, and ΔRa. One-way ANOVA, Tukey HDS test, and Pearson correlation were used for further analysis, with significance set at <i>p</i> < 0.05. <b>Results:</b> The Vita Enamic-Detartrine group showed the highest ΔEab 1 and ΔE001 values, while Cerasmart-control showed the lowest. The Vita Enamic-Proxyt group had the lowest ΔWID1, and Vita Enamic-Cleanjoy exhibited the highest values of ΔEab 2, ΔE002, and ΔWID2. The E.MAX-control group had the lowest values for these metrics. No significant correlation was found between ΔRa and color changes (ΔE*ab 2, ΔE002, ΔWID2); however, a moderate positive correlation was found between values of ΔE1 and ΔE2. <b>Conclusions:</b> These findings indicate that PPPs significantly affect the discoloration and surface features of CAD/CAM materials, with both types of PPPs and materials.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT Evaluation of Maxillary Incisive Canal Characteristics Among Population in Regard to Possibility of Implant Cortical Anchorage-A Multicenter Study.","authors":"Fodor Calin, Bartosz Dalewski, Maciej Ellmann, Paweł Kiczmer, Stefan Ihde, Marta Bieńkowska, Jacek Kotuła, Łukasz Pałka","doi":"10.3390/dj13050211","DOIUrl":"10.3390/dj13050211","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Implant placement in cases of severe bone atrophy or compromised alveolar bone requires careful planning, especially in the anterior maxilla. The nasopalatine canal (NPC) and its cortical walls offer potential anchorage sites. This study evaluates the NPC's anatomical characteristics using cone beam computed tomography (CBCT) to assess its suitability for implant anchorage. <b>Methods:</b> A retrospective analysis of 150 CBCT scans from three dental clinics in Poland was conducted. NPC measurements-including length, width, number of canals, and distances to adjacent anatomical structures-were taken in the sagittal, coronal, and axial planes. Statistical tests included Pearson correlation and Student's <i>t</i>-test to explore relationships between NPC dimensions and gender. <b>Results:</b> The mean NPC length was 10.27 mm and mean width 3.55 mm. Significant gender differences were observed in the canal length, width, and distances to the labial and palatal plates (<i>p</i> < 0.05). Strong positive correlations were found between the canal width at the palate base and other parameters, such as the midpoint width (r = 0.58) and diameter (r = 0.44). The distance from the palatal opening to the labial plate showed the strongest correlation (r = 0.67), indicating enhanced cortical anchorage potential with increased canal dimensions. <b>Discussion:</b> NPC morphology varied (cylindrical, funnel-like, hourglass), aligning with prior studies. Larger diameters were linked to single-canal configurations. Implant placement strategies-such as direct canal insertion or lateralization-can be effective, especially with polished, single-piece implants that reduce soft tissue ingrowth and improve primary stability. <b>Conclusions:</b> Understanding NPC anatomy is crucial for implant planning in atrophic maxillae. With the proper technique, NPC use for cortical anchorage is a viable treatment option.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Eradication of Mature Oral Biofilm on Titanium Implant Surfaces Using Cold Atmospheric Plasma.","authors":"Markus Jörg Altenburger, Michael Eckhard Bergmann, Loic Alain Ledernez, Georgios Romanos","doi":"10.3390/dj13050210","DOIUrl":"10.3390/dj13050210","url":null,"abstract":"<p><p><b>Objective:</b> This study evaluated the effectiveness of a new cold atmospheric plasma device (AmbiJet) for eradicating mature oral biofilm on titanium implant surfaces, aiming to improve decontamination methods for the treatment of peri-implant infections. <b>Material and methods:</b> Mature oral biofilms were grown on titanium disks placed in participants' mouths. These disks were divided into control and plasma treatment groups. The AmbiJet device delivered plasma directly to the implant surface for 3 min per 20 mm², utilizing the applicator nozzle and implant as electrodes. Biofilm reduction was quantified by counting colony-forming units (CFUs). <b>Results:</b> Cold plasma treatment rendered approximately 90% of samples bacteria-free. A > 6-log₁₀ reduction (≈99.9999%) in bacterial load was achieved in 30% of samples, with an overall average reduction of 4.9-log₁₀ across all treated samples. The temperature during treatment remained below 40 °C. <b>Conclusions:</b> Within the study's limitations, cold atmospheric plasma effectively eradicates mature oral biofilm on titanium surfaces. This high disinfection efficacy is likely due to the combined action of reactive species and electrical phenomena, which does not cause significant temperature increases.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Upper Airway Airflow After Rapid Maxillary Expansion Beyond the Peak Period of Adenoidal Growth-A CBCT Study Using Computer Fluid Dynamics and Considering Adenoidal Dimensions as a Factor.","authors":"Giuseppe Palazzo, Rosalia Leonardi, Gaetano Isola, Manuel Lagravere, Antonino Lo Giudice","doi":"10.3390/dj13050209","DOIUrl":"10.3390/dj13050209","url":null,"abstract":"<p><strong>Background/objectives: </strong>This retrospective study used computer fluid dynamics (CFD) to evaluate the medium-term changes in the upper airways (UA) airflow after rapid maxillary expansion (RME) in three age-matched groups with different degrees of adenoidal obstruction.</p><p><strong>Methods: </strong>The sample included Cone-Beam Computed Tomography (CBCT) of 67 adolescents taken before (T0) and 12 months after RME (T1) and divided into three cohorts: Control Group (CG, <25% obstruction: 24 subjects, mean age = 11.8 ± 1.3), Adenoids Group 1 (AG1, >25% <75% obstruction: = 22 subjects, mean age = 10.9 ± 1.5), Adenoids Group 2 (AG2, >75% obstruction: = 21 subjects, mean age = 11.2 ± 1.6). The airflow pressure, velocity and obstruction were simulated using computer fluid dynamics (CFD).</p><p><strong>Results: </strong>The pressure significantly improved in CG and AG1 groups while the velocity improved in AG1 as well as the prevalence of obstruction improvement. The airflow pressure and velocity changes could be attributed to the reduction of the resistances in the adenotonsillar region, which was remarkably more marked in the AG1.</p><p><strong>Conclusions: </strong>Alterations in the adenotonsillar region likely represent the most substantial factors influencing airflow changes after RME. The integration of anatomical and functional data, along with the identification of baseline patient characteristics, may facilitate the characterization of phenotypes most appropriate for initial management through either Rapid Maxillary Expansion (RME) or otolaryngologic (ENT) interventions.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Obstructive Sleep Apnea Among the Adult Population in the Northeastern Region of Romania.","authors":"Olja Tanellari, Adela Alushi, Celiana Toti, Carina Balcos, Adina Oana Armencia, Tinela Panaite, Irina Zetu","doi":"10.3390/dj13050208","DOIUrl":"10.3390/dj13050208","url":null,"abstract":"<p><p><b>Background</b>: Sleep apnea is a breathing affliction that affects sleep quality, with significant implications for overall physical and oral health, as well as mental health. <b>Aim</b>: The aim of this study was to evaluate the validity of the STOP-Bang and Epworth questionnaires as preoperative screening tools for obstructive sleep apnea (OSA) in the adult population from the NE region of Romania. <b>Materials and Methods</b>: A total of 222 participants were selected. The questionnaire method was used, with the subjects completing the STOP-Bang and Epworth questionnaires. A chi-squared test, an ANOVA, and Student's <i>t</i>-tests were used for the statistical analysis. <b>Results</b>: the STOP-Bang questionnaire revealed an increased risk of OSA among those with a high BMI, an age over 50 years, or a large neck circumference. Regarding the Epworth questionnaire, daytime sleepiness was more frequent among obese individuals and those with associated pathologies. Significant correlations were found between OSA and obesity, age, and associated pathologies, with limited observations on the influence of gender on the risk of OSA. <b>Conclusions</b>: The studied questionnaires are effective and easy-to-use tools for the preoperative screening of OSA, demonstrating a significant correlation between the identified risk factors and the disease severity.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Selection of Materials and Luting Agents for Single-Crown Restorations.","authors":"Ahmad Alsahli, Mirza Rustum Baig, Jagan Kumar Baskaradoss, Shoug Alsanea, Athoub AlMousawi","doi":"10.3390/dj13050207","DOIUrl":"10.3390/dj13050207","url":null,"abstract":"<p><p><b>Objective:</b> Selecting suitable materials and luting agents for single crowns is critical yet challenging, as dentists must consider different factors. This study aimed to assess dentists' preferences for materials and luting agents under different clinical conditions and evaluate the nonclinical factors influencing their preferences. <b>Methods:</b> A paper-based survey supplemented with photographs illustrating anterior and posterior single-crown preparation designs was used, incorporating three clinical scenarios for each as examples. Participants provided demographic data and were asked to select their preferred material and luting agent for each scenario. Comparisons between the crown material/luting agent choices and dentist/practice characteristics were performed. Significant differences were determined using the chi-square test. <b>Results:</b> Overall, 262 (87.3%) dentists participated in this survey. The top-selected material for anterior preparation designs was lithium disilicate; monolithic zirconia was the most selected for posterior preparation designs. Dual-cure resin was the most selected luting agent for all anterior and posterior clinical scenarios, except for posterior subgingival preparation design. There was a significant association between the dentist's age and the selection of material and luting agent (<i>p</i> < 0.05) in all clinical scenarios, except for the luting agent selection in the posterior subgingival preparation designs (<i>p</i> < 0.05). Other nonclinical factors yielded mixed results; some preparation designs showed significant differences, while others did not, depending on the clinical scenario. <b>Conclusions:</b> Reliance on new materials and luting agents that require minimally invasive treatment with dental ceramics and resin cement is increasing. However, the choice of materials and luting agents is influenced by clinical presentation and nonclinical factors, making it crucial for dentists to be aware of these factors when selecting materials for single-crown restorations. <b>Clinical Implications:</b> An overall trend was observed for the use of strong monolithic ceramics with adhesive resin cements. These findings could assist dentists in reviewing and re-evaluating material choices in their clinical practices, both at a national and regional level. Additionally, the findings could be useful for dental policy makers, wholesale suppliers, and retail distributors in making future decisions.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel Ion Release in Nickel-Containing Orthodontics Archwires: A Narrative Review of In Vitro and In Vivo Studies.","authors":"Angelina Stoyanova-Ivanova, Velizar Georgiev, Jorge N R Martins","doi":"10.3390/dj13050206","DOIUrl":"10.3390/dj13050206","url":null,"abstract":"<p><p>Nickel-containing orthodontic archwires, particularly those made of nickel-titanium (NiTi) and stainless steel (SS), play a crucial role in orthodontic treatment using the fixed technique due to their mechanical properties. However, concerns regarding nickel-induced allergic reactions, cytotoxicity, and metal ion release, especially nickel-related ones, persist. This narrative review aims to explore recent findings on nickel release from orthodontic appliances, building upon prior systematic reviews by analyzing both in vitro and in vivo studies under various environmental conditions. The databases Web of Science, Scopus, and PubMed were searched for relevant studies that examined the relationship between nickel ion release from nickel-containing archwires and various environmental conditions. The studies found indicate that while metal ion release occurs during short-term treatment, the levels are lower than harmful thresholds, with factors such as pH, corrosion, length of treatment, and environmental influences affecting release rates. Despite this, long-term studies are few and are usually conducted only in an in vitro or in vivo environment, but not both. To establish causal relationships regarding metal ion release, in vivo monitoring of ions like Ni is critical, with further research needed to assess its prolonged effects. Furthermore, collaborative efforts among practitioners, researchers, and regulatory bodies are vital for developing evidence-based guidelines for orthodontic material selection, prioritizing patient safety and addressing metal ion release risks.</p>","PeriodicalId":11269,"journal":{"name":"Dentistry Journal","volume":"13 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}