Current Developments in Nutrition最新文献

{"title":"Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh","authors":"Sulagna Bandyopadhyay ,&nbsp;Anjan Kumar Roy ,&nbsp;Sarah Baker ,&nbsp;Katherine K. Stephenson ,&nbsp;Ximing Ge ,&nbsp;Yuwei Wang ,&nbsp;Khalid Bin Ahsan ,&nbsp;Eleonor Zavala ,&nbsp;Hasmot Ali ,&nbsp;Rezwanul Haque ,&nbsp;Lee Shu Fune Wu ,&nbsp;Brooke Langevin ,&nbsp;Mathangi Gopalakrishnan ,&nbsp;Towfida Jahan Siddiqua ,&nbsp;S.M. Tafsir Hasan ,&nbsp;Parul Christian ,&nbsp;Kerry J Schulze","doi":"10.1016/j.cdnut.2025.107546","DOIUrl":"10.1016/j.cdnut.2025.107546","url":null,"abstract":"<div><h3>Background</h3><div>Comprehensive documentation of micronutrient biomarker assessments, capturing status from deficiency to excess, remains limited, specifically in the context of multiple micronutrient supplementation (MMS) trials.</div></div><div><h3>Objectives</h3><div>We document biomarker selection, preanalytical and analytical methods, assay performance evaluation, and biomarker interpretation for modeling the dose–response effects of MMS in 2 parallel bioefficacy trials among women of reproductive age and pregnant women in rural Bangladesh.</div></div><div><h3>Methods</h3><div>Blinded analysis of biomarker assays is being performed in the field and at 2 laboratories. Automated clinical chemistry analyzers are used to measure conventional serum and plasma biomarkers of vitamin D, B12, folate, iron, inflammation, iodine, and bone turnover. Plasma vitamers of A, E, B2, and B6, and urinary B1, B2, and B3 are measured by ultra-performance liquid chromatography (UPLC). A serum mineral panel is analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Urinary iodine and functional assays for vitamin B1, B2, and B12, iron, and selenium are measured using 96-well plate methods. Point-of-care tests are performed for hemoglobin in venous blood, whereas liver and kidney function, glucose, and a lipid panel are performed in plasma.</div></div><div><h3>Results</h3><div>Limits of detection and quantitation for biomarker assays are reported. Interassay coefficient of variations of quality control (QC) materials for primary outcome biomarkers are 4%–10% for automated analyzers, ICP-MS, and 96-well plate, and 2%–11% for UPLC assays, where available. Measurements of two-thirds of the primary outcome biomarkers could be evaluated using established external QC materials to ensure assay performance.</div></div><div><h3>Conclusions</h3><div>The detailed account of micronutrient biomarker assays in the dose–response MMS trials provides a useful framework for designing future research involving comprehensive assessments of micronutrient status in vulnerable populations. External quality assurance tools are warranted for UPLC-based B1, B2, and B3 vitamers, and for kinetic assays of B1, B2, and selenium.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107546"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Effects of Dietary Intake on Gut Microbiome Diversity and Composition of Older Adults with Type 1 Diabetes: A Pilot Study","authors":"Aastha S Dubal ,&nbsp;Angelica Cristello Sarteau ,&nbsp;Maria Andrea Azcarate-Peril ,&nbsp;Zorka Djukic ,&nbsp;Gabriella Ercolino ,&nbsp;Angela Fruik ,&nbsp;Julia Ho ,&nbsp;Zoe Lee ,&nbsp;Jeffrey Roach ,&nbsp;Michael Valancius ,&nbsp;Laura A Young ,&nbsp;Ian M Carroll ,&nbsp;Anna R Kahkoska","doi":"10.1016/j.cdnut.2025.107550","DOIUrl":"10.1016/j.cdnut.2025.107550","url":null,"abstract":"<div><h3>Background</h3><div>Gut microbiome diversity and composition have been associated with type 1 diabetes (T1D) onset and progression. These features have not been explored among the growing number of older adults with T1D, including how they may differ by diet.</div></div><div><h3>Objectives</h3><div>In the present observational study, we investigated differences in gut microbiome diversity and composition across quantiles of high and low macronutrient, fiber, and simple sugar intake.</div></div><div><h3>Methods</h3><div>We collected observational data on routine diabetes management, diet, and other health indicators from older adults with T1D over 7–9 d, including 2 24-h dietary recall interviews, diabetes technology, and medical record data. Stool samples were collected for gut microbiome characterization using high-throughput sequencing of the 16S ribosomal RNA gene. Gut microbiome characteristics were assessed by Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC2), Shannon index, and Bray–Curtis distances.</div></div><div><h3>Results</h3><div>Among 17 older adults [mean (SD) age 73.5 (6.2) y; diabetes duration: 34.0 (16.0) y, and glycated hemoglobin: 7.0 (0.9) %], increased fat intake was associated with enriched genus <em>Lactococcus</em>, increased fiber intake was associated with enriched genus <em>Hemophilus</em> and unclassified <em>Clostridium</em> within family <em>CAG:508</em>, and increased fructose intake was associated with enrichment of unclassified genus <em>SFMI01</em> within family <em>Christensenellaceae</em>. Greater carbohydrate intake was associated with depletion of the family <em>Enterobacteriaceae</em>. Microbial diversity differed significantly with greater fiber and fructose intake.</div></div><div><h3>Conclusions</h3><div>We found statistically significant evidence suggesting that the gut microbiome of older adults with T1D may be modulated by macronutrient, fiber, and fructose intake. Similar trends between fiber intake differences and significantly different microbial community structure have been found in younger populations. Together with the literature, our other findings suggest that macronutrient, fiber, and fructose intakes may impact the gut microbiome differently in older adults with T1D.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107550"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hitchhiker Story? Exploring HDL as an Overlooked Vitamin D Carrier","authors":"Jennifer D Bean,&nbsp;Catherine A Peterson","doi":"10.1016/j.cdnut.2025.107499","DOIUrl":"10.1016/j.cdnut.2025.107499","url":null,"abstract":"<div><h3>Background</h3><div>Twenty-five-hydroxyvitamin D, used to assess vitamin status, is the primary circulating form of vitamin D having a half-life measured in weeks, and 1,25-dihydroxyvitamin D is the active metabolite having a half-life measured in hours. Although there has been a preponderance of research on the roles of the active metabolite in health, there remains a limited understanding of the transport of the true vitamin forms, ergocalciferol and cholecalciferol.</div></div><div><h3>Objective</h3><div>This study proposes an alternative mechanism for vitamin D transport, hypothesizing that high-density lipoprotein (HDL) facilitates its movement from the intestine to the liver using cholesterol transporters.</div></div><div><h3>Methods</h3><div>This perspective challenges the sole reliance on the classical chylomicron pathway, proposing an alternative mechanism based on vitamin D's striking structural similarity to cholesterol. Both are steroids sharing key features, suggesting analogous intestinal absorption and transport routes. Evidence indicates vitamin D utilizes known enteric cholesterol transporters for uptake. We hypothesize that high-density lipoprotein (HDL) functions as an important interorgan carrier, facilitating vitamin D's movement from the intestine to the liver, using shared cholesterol transporters. This proposed HDL-mediated delivery is particularly relevant given vitamin D-binding protein's lower affinity for vitamin D compared with 25-hydroxyvitamin D.</div></div><div><h3>Results</h3><div>This mechanism offers a plausible explanation for observed correlations between vitamin D status (plasma 25-hydroxyvitamin D concentrations) and factors affecting HDL cholesterol concentration (HDLc). Modulators that increase HDLc (e.g., fibrates, oral contraceptives, and exercise) are associated with improved vitamin D status, whereas those that decrease HDLc or inhibit vitamin D absorption (e.g., smoking and ezetimibe) are linked to lower vitamin D status. Although current human data are largely correlative and confounded by numerous factors affecting vitamin D status, the consistent associations warrant further investigation into vitamin D’s precise trafficking among lipoprotein fractions.</div></div><div><h3>Conclusions</h3><div>Re-evaluating vitamin D’s absorption and transport to include a role for HDL holds implications for optimizing vitamin D status.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107499"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Guidelines on Dietary Protein Intake for Patients with Diabetic Kidney Disease: A Scoping Review","authors":"Siyanga Ravi,&nbsp;Alexandra Fahrner,&nbsp;Frank Rühli,&nbsp;Nicole Bender","doi":"10.1016/j.cdnut.2025.107551","DOIUrl":"10.1016/j.cdnut.2025.107551","url":null,"abstract":"<div><h3>Background</h3><div>International nutritional guidelines vary in their recommendations, as well as in the reporting quality of the underlying evidence. An underreported recommendation in guidelines for people with type II diabetes concerns the optimal protein intake in the case of chronic kidney disease (CKD).</div></div><div><h3>Objectives</h3><div>In this review, we analyze the protein intake recommendations from worldwide practice guidelines for type II diabetes and CKD.</div></div><div><h3>Methods</h3><div>We conducted a systematic search in the online databases PubMed, Embase, and Cochrane Database of Systematic Reviews, as well as websites, according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, and up to 31 January, 2023. We included nutritional and clinical practice guidelines on protein intake in patients with type II diabetes and CKD of different stages. We assessed the quality of the guidelines using the instruments Appraisal of Guidelines for Research &amp; Evaluation Instrument (AGREE II) and AGREE Recommendation Excellence. We assessed the quality of the underlying scientific evidence using the evidence pyramid and the level of evidence categorization.</div></div><div><h3>Results</h3><div>Of 24 included guidelines, 5 met the quality assessment of all instruments. Their evidence was based on an overlapping number of randomized controlled trials (RCTs). Nevertheless, their protein intake recommendations differed, ranging from no restriction to restriction to 0.8 g/kg body weight/d.</div></div><div><h3>Conclusions</h3><div>The reason for the discrepancy of protein intake recommendations between different guidelines could not be determined conclusively, as the methodology of evidence assessment was often insufficiently reported. More long-term and good-quality RCTs are needed. We recommend the use of rigorous development and quality assessment tools in the development of clinical practice guidelines for patients with CKD and type II diabetes.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107551"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Beyond Hunger: Uncovering the Link between Food Insecurity and Depression, Anxiety, and Stress in Adolescents [Current Developments in Nutrition 9 (2025) 107453]","authors":"Emily Cisneros-Vásquez ,&nbsp;Lee Smith ,&nbsp;Rodrigo Yañéz-Sepúlveda ,&nbsp;Jorge Olivares-Arancibia ,&nbsp;Héctor Gutiérrez-Espinoza ,&nbsp;Dong Keon Yon ,&nbsp;Jae Il Shin ,&nbsp;José Francisco López-Gil","doi":"10.1016/j.cdnut.2025.107570","DOIUrl":"10.1016/j.cdnut.2025.107570","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107570"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145326389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sumac (Rhus coriaria L.) Supplementation on High-Sensitivity C-Reactive Protein Concentrations in Adults: A Systematic Review and Dose-Response Meta-Analysis","authors":"Mostafa Shahraki Jazinaki ,&nbsp;Hossein Bahari ,&nbsp;Iman Rahnama ,&nbsp;Mohammad Safarian ,&nbsp;Mahsa Malekahmadi","doi":"10.1016/j.cdnut.2025.107555","DOIUrl":"10.1016/j.cdnut.2025.107555","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation is implicated in the development of various metabolic and cardiovascular disorders. Sumac (<em>Rhus coriaria</em> L.) is a medicinal plant with potential anti-inflammatory properties. However, the effects of sumac supplementation on inflammatory biomarkers, particularly high-sensitivity C-reactive protein (hs-CRP), remain controversial.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis aimed to evaluate the effect of sumac supplementation on hs-CRP concentrations in adults.</div></div><div><h3>Methods</h3><div>A systematic search was performed in PubMed, Scopus, Web of Science, and the Cochrane Library databases up to February 2025 to identify RCTs examining the impact of sumac supplementation on hs-CRP concentrations. Screening, data extraction, and risk of bias assessment were conducted independently. A random-effects model was used to calculate the overall effect size as the SMD with 95% CIs.</div></div><div><h3>Results</h3><div>Seven RCTs were eligible for inclusion in this review. The pooled analysis demonstrated a significant reduction in hs-CRP concentrations following sumac supplementation compared with that in the control groups (SMD: −0.33; 95% CI: −0.64, −0.02; <em>P</em> = 0.03). Moreover, a significant heterogeneity was detected among the pooled effect sizes (<em>P</em> = 0.02; <em>I</em>² = 60.2%). Subgroup analyses revealed that sumac supplementation led to a significant reduction in hs-CRP concentrations in trials that included both genders or in studies conducted on patients with nonalcoholic fatty liver disease, individuals with overweight, or those aged ≥45 y.</div></div><div><h3>Conclusions</h3><div>Sumac supplementation may significantly reduce hs-CRP concentrations in adults. Further high-quality, large-scale trials in various populations in terms of areas or health conditions are required to confirm these findings and determine the optimal dosage and duration for sumac supplementation to reduce inflammation.</div><div>This trial is registered at PROSPERO database as CRD420251016622.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107555"},"PeriodicalIF":3.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study","authors":"Kate E Marris ,&nbsp;Rachel M Cole ,&nbsp;Daniel Addison ,&nbsp;Patrick Ruz ,&nbsp;Genevieve Sparagna ,&nbsp;Ai Ni ,&nbsp;Martha A Belury","doi":"10.1016/j.cdnut.2025.107552","DOIUrl":"10.1016/j.cdnut.2025.107552","url":null,"abstract":"<div><h3>Background</h3><div>Anthracycline chemotherapy (AC) leads to cardiotoxicity in many patients with breast cancer by inducing inner mitochondrial damage and disrupting the electron transport chain. It is unclear why some, but not all, women who undergo AC develop chronic cardiac dysfunction.</div></div><div><h3>Objectives</h3><div>The aim of this prospective feasibility study was to determine accrual rate and estimate the effect size of 1 cycle of AC on myocardial injury and blood lipidome changes in women with breast cancer.</div></div><div><h3>Methods</h3><div>Fourteen women with breast cancer planning to undergo AC enrolled and underwent cardiac magnetic resonance (CMR) imaging and blood sampling across 2 visits, before and after any 1 cycle of AC in the treatment regimen. Fatty acid composition of red blood cells (RBCs) and cardiolipin (CL) in peripheral blood mononuclear cells were measured. Exploratory analyses were conducted.</div></div><div><h3>Results</h3><div>Myocardial edema, obtained via T2 mapping using CMR, increased after 1 cycle of AC in women with breast cancer. The ratio of tetralinoleoyl (LA₄) to tetraoleoyl (OA₄) CL correlated negatively with myocardial fibrosis, obtained via T1 mapping using CMR. OA₄CL correlated positively with myocardial fibrosis, and OA content in RBCs correlated positively with myocardial edema.</div></div><div><h3>Conclusions</h3><div>OA₄CL and OA in RBCs appear to be related to subclinical markers of cardiotoxicity in women with breast cancer undergoing AC. Larger studies are needed to investigate potential cardioprotective effects of dietary linoleic acid and LA₄CL against AC.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT03961685</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107552"},"PeriodicalIF":3.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily Intake of Recommended Servings of Fruit Improves Nutrient Intake but Shows no Major - Effect on Cardiovascular Health or Cognition in Low Fruit Consumers","authors":"Shania Zingales,&nbsp;Jessica Martinez,&nbsp;Apryl Hazle Stepp,&nbsp;Chelsie Miller,&nbsp;Nate Jason,&nbsp;Mee Young Hong,&nbsp;Changqi Liu,&nbsp;Mark Kern,&nbsp;Shirin Hooshmand","doi":"10.1016/j.cdnut.2025.107544","DOIUrl":"10.1016/j.cdnut.2025.107544","url":null,"abstract":"<div><h3>Background</h3><div>Research has demonstrated that fruit consumption may benefit cardiometabolic health, cognition, and motor function; however, consumption among American adults falls well below the recommended intake of 2 cups per day.</div></div><div><h3>Objectives</h3><div>The hypothesis of the study was that consuming 2 cups of fruits, as recommended by the Dietary Guidelines for Americans, would improve cardiometabolic health, cognition, and motor function.</div></div><div><h3>Methods</h3><div>A total of 40 healthy men and women aged 30–70 y were assigned to consume 2-cup equivalents (2C) of fruits per day and to restrict fruit (RF) intake to &lt;½ cup in a 2-period, 8-wk randomized crossover trial, with an 8-wk washout period. Anthropometrics, blood pressure, cardiometabolic biomarkers, brachial artery flow-mediated dilation, cognition, motor function, and balance measurements were assessed before and after each trial.</div></div><div><h3>Results</h3><div>Insulin concentrations and insulin resistance were significantly lower, and high-density lipoprotein cholesterol levels were significantly higher after the RF trial compared with the 2C trial. Processing speed scores increased during both trials, whereas 9-Hole Pegboard performance of the dominant hand improved during the 2C trial only. Energy intake, carbohydrates, fiber, vitamin K, vitamin C, thiamin, magnesium, potassium, copper, total anthocyanins, and total flavonoids intake were higher after the 2C trial compared with the RF trial. Glycemic index was lower and glycemic load was higher during the 2C trial compared with the RF trial.</div></div><div><h3>Conclusions</h3><div>Daily intake of 2C of fruit for 8 wk did not consistently impact cardiovascular biomarkers, body composition, cognition, or balance in habitually low fruit consumers and minimally impacted motor function; however, it improved intake of certain nutrients. Our findings suggest the need for further investigation into the optimal quantity and composition of fruit intake in diverse populations. As data accumulate, recommendations for fruit intake by the United States Department of Agriculture and the United States Department of Health and Human Services should be revisited and further studied.</div><div>This trial was registered at clinicaltrials.gov as NCT05063929.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107544"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Development of Infant Satiation Cues and Maternal Feeding Behaviors during Infancy","authors":"Alison K Ventura ,&nbsp;Kevin J Ross ,&nbsp;Alison L Miller ,&nbsp;Jasmine M DeJesus ,&nbsp;Cin Cin Tan ,&nbsp;Julie C Lumeng","doi":"10.1016/j.cdnut.2025.107542","DOIUrl":"10.1016/j.cdnut.2025.107542","url":null,"abstract":"<div><h3>Background</h3><div>Although prior research has identified infant behaviors signaling hunger, receptiveness to feeding, needs to disengage from feeding, and satiation, further research is needed to better understand variability in the extent to which infants exhibit these behaviors and how infants’ feeding cues and caregivers’ responses to these cues may co-develop over time.</div></div><div><h3>Objectives</h3><div>To describe age differences in the number and types of disengagement and satiation behaviors infants display during feeding, mothers’ feeding behaviors, and the correspondence between infants’ and mothers’ behaviors across the first year.</div></div><div><h3>Methods</h3><div>Mother-infant dyads (<em>n</em> = 227) were video-recorded during naturalistic bottle-feeding interactions in their homes when infants were age 1 mo, 2 mo, 4 mo, 6 mo, 9 mo, and 12 mo. Videos were coded using the Baby Behaviors when Satiated (BABES) coding scheme to assess relevant infant and mother behaviors.</div></div><div><h3>Results</h3><div>Infants exhibited a significantly greater variety of behaviors and total number of behaviors at 2 mo compared to 1 mo. Infant disengagement and satiation behaviors transitioned from behaviors characterized by decreased activity levels during early infancy to increased alertness, activity, and interest in surroundings during later infancy. Mothers also showed developmental shifts in behavior—moving from more direct involvement to increased verbal responses—with a decline in the total number of behaviors over time. Infants’ and mothers’ behavior rates were not significantly associated at 1 mo (r = ‒0.24, <em>P</em> = 0.061) or 2 mo (r = 0.15, <em>P</em> = 0.107), but were positively associated at 4 mo (r = 0.35, <em>P</em> &lt; 0.001), 6 mo (r = 0.21, <em>P</em> = 0.008), 9 mo (r = 0.46, <em>P</em> &lt; 0.001), and 12 mo (r = 0.26, <em>P</em> = 0.022).</div></div><div><h3>Conclusions</h3><div>Findings highlight age-related changes in infant communication of satiation and maternal responsiveness, as well as evidence that infants’ and mothers’ feeding behaviors co-develop and may become more aligned over time.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT04723264.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107542"},"PeriodicalIF":3.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dietary Fiber Intake on Chronic Low-Grade Inflammation in Children and Adolescents: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Mª Isabel Benedicto-Toboso ,&nbsp;Andressa Freire Salviano ,&nbsp;María L Miguel-Berges ,&nbsp;Isabel Rueda-De Torre ,&nbsp;Luis A Moreno ,&nbsp;Alba M Santaliestra-Pasías","doi":"10.1016/j.cdnut.2025.107511","DOIUrl":"10.1016/j.cdnut.2025.107511","url":null,"abstract":"<div><div>Previous research suggests that dietary fiber (DF) intake may help reduce chronic low-grade inflammation (CLGI), a condition linked to the early development of cardiometabolic risk factors. Childhood and adolescence represent critical periods for preventing noncommunicable diseases, when adopting healthy eating habits, including adequate fiber consumption, could effectively control CLGI. However, the evidence on DF’s impact on CLGI in the pediatric population remains inconsistent and has not been comprehensively reviewed in a single article. Therefore, we aimed to conduct a systematic review and meta-analysis to assess the effect of DF intake on CLGI in children and adolescents. A systematic search was performed in 4 databases up to January 2025. Two reviewers screened 2030 studies based on inclusion criteria: randomized controlled trials involving participants ≤18 y, interventions (Is) with any type of DF (supplementation, fiber-rich foods, or fiber intake advice) and reporting serum CLGI markers, including C-reactive protein (CRP), interleukin (IL)-6 and TNF-α, among others. Twenty-five randomized controlled trials were included in the systematic review, which showed that DF may have beneficial effects on CRP, IL-10, adiponectin, IL-1β, and IL-6 concentrations; though findings were inconsistent, with some studies reporting no significant changes. Meta-analysis was conducted for CRP, IL-6, and TNF-α. Meta-analysis for CRP concentrations included 10 studies and revealed a significant decrease following DF Is compared to controls (mean difference: –0.640; 95% CI: –1.075, –0.204). Meta-regression revealed that Is based on fiber supplementation resulted in significantly greater CRP reductions compared to those involving fiber-rich foods. Meta-analysis for IL-6 and TNF-α concentrations showed no significant effect after DF I. In conclusion, this review provides evidence that fiber Is may have a beneficial impact on certain markers of CLGI in children and adolescents, particularly by reducing serum CRP concentrations. However, the findings also reveal inconsistencies in the effects of fiber intake on other inflammatory markers.</div><div>This trial was registered at PROSPERO as CRD42024516794.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107511"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}