Current Developments in Nutrition最新文献

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Knowledge, Behavior, and Influencing Factors of Coarse Grain Consumption among Chinese Adults: A Focus Group Study in Xi’an 中国成年人粗粮消费的知识、行为和影响因素:西安的一项焦点小组研究
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104474
Jiawen Xie , Junqi Li , Guoqing Ma , Menghan Wang , Yunfeng Li , Yafang He , Kun Xu , Tian Tian , Nan Yang , Qian Wang , Jie Chang , Xin Liu
{"title":"Knowledge, Behavior, and Influencing Factors of Coarse Grain Consumption among Chinese Adults: A Focus Group Study in Xi’an","authors":"Jiawen Xie ,&nbsp;Junqi Li ,&nbsp;Guoqing Ma ,&nbsp;Menghan Wang ,&nbsp;Yunfeng Li ,&nbsp;Yafang He ,&nbsp;Kun Xu ,&nbsp;Tian Tian ,&nbsp;Nan Yang ,&nbsp;Qian Wang ,&nbsp;Jie Chang ,&nbsp;Xin Liu","doi":"10.1016/j.cdnut.2024.104474","DOIUrl":"10.1016/j.cdnut.2024.104474","url":null,"abstract":"<div><h3>Background</h3><div>Coarse grains are rich in fiber, minerals, and other beneficial nutrients but are consumed at low levels in modern populations. The factors that influence coarse grain consumption in current living and dietary environments are not fully understood.</div></div><div><h3>Objectives</h3><div>This study aimed to explore the knowledge and behavior related to coarse grain consumption and identify the influencing factors among Chinese citizens.</div></div><div><h3>Methods</h3><div>Six focus group discussions were conducted with 39 participants aged 18–65 years from diverse social backgrounds in Xi'an, China. All discussions were transcribed verbatim and analyzed using inductive thematic analysis.</div></div><div><h3>Results</h3><div>The majority of participants demonstrated insufficient knowledge about coarse grains, including their definitions, health benefits, and recommended intake. A small number of the participants reported regular consumption. The barriers to coarse grain consumption were poor sensory properties, insufficient cooking skills and time, limited availability of ready-to-eat foods, established dietary habits, and high prices. Additionally, new barriers included psychological burden, concerns about food safety, the impact of processing methods on health benefits, and special health conditions. Health benefits and family influence emerged as the 2 primary factors motivating coarse grain consumption. Most participants expressed a positive attitude toward partially replacing staple foods with coarse grains. Enhancing health education, innovating food processing methods, improving labeling systems, and strengthening safety supervision have been recommended for increasing coarse grain consumption.</div></div><div><h3>Conclusions</h3><div>A gap exists between health awareness and healthy behaviors regarding coarse grain consumption; thus, collaborative efforts among government agencies, educational institutions, nutrition societies, the food industry, policymakers, and health professionals are essential to overcome these challenges.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104474"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential for Bouillon Fortification to Reduce Dietary Micronutrient Inadequacy: Modeling Analyses Using National Survey Data from Cameroon, Ghana, and Haiti 肉汤强化对减少膳食微量营养素不足的潜力:利用喀麦隆、加纳和海地全国调查数据进行的模型分析
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104485
Reina Engle-Stone , Sika M Kumordzie , Hanqi Luo , Kimberly Ryan Wessells , Seth Adu-Afarwuah , Alex Njebayi , Ismael Teta , Yves-Laurent Régis , Emmanuel Gyimah , Stephen A Vosti , Katherine P Adams
{"title":"The Potential for Bouillon Fortification to Reduce Dietary Micronutrient Inadequacy: Modeling Analyses Using National Survey Data from Cameroon, Ghana, and Haiti","authors":"Reina Engle-Stone ,&nbsp;Sika M Kumordzie ,&nbsp;Hanqi Luo ,&nbsp;Kimberly Ryan Wessells ,&nbsp;Seth Adu-Afarwuah ,&nbsp;Alex Njebayi ,&nbsp;Ismael Teta ,&nbsp;Yves-Laurent Régis ,&nbsp;Emmanuel Gyimah ,&nbsp;Stephen A Vosti ,&nbsp;Katherine P Adams","doi":"10.1016/j.cdnut.2024.104485","DOIUrl":"10.1016/j.cdnut.2024.104485","url":null,"abstract":"<div><h3>Background</h3><div>Bouillon is commonly consumed in some countries where micronutrient deficiencies are prevalent, but it has not been widely adopted as a micronutrient fortification vehicle.</div></div><div><h3>Objectives</h3><div>We modeled the potential impacts of bouillon fortification on dietary micronutrient adequacy to inform future discussions around bouillon fortification programs.</div></div><div><h3>Methods</h3><div>We analyzed the dietary intake of women of reproductive age (WRA) and 1- to 5-y-old children from a national dietary survey in Cameroon, and “apparent intake” (using the nutrient density approach) of WRA, children, and men from 3 household surveys in Cameroon, Ghana, and Haiti. We examined (apparent) intake of bouillon and simulated the impacts of bouillon fortification with varying levels of vitamin A, folic acid, vitamin B12, iron, and zinc on inadequate intake (below the estimated average requirement) and intake above the tolerable upper intake level (UL). Scenarios accounted for current mandatory fortification programs and different assumptions about iron absorption from bouillon.</div></div><div><h3>Results</h3><div>Bouillon was consumed by &gt;67% of households in Ghana and &gt;90% in Haiti and Cameroon. Median (apparent) consumption ranged from 1.6 to 2.1 g/d for WRA, 0.7 to 1.0 g/d for children, and 1.8 to 2.2 g/d for men. Bouillon fortification at the highest micronutrient concentration modeled was predicted to reduce dietary inadequacy by 21–52 percentage points (pp) for vitamin A; 3–47pp for folic acid, and 4–90pp for vitamin B12, depending on the country and population group. In contrast, predicted impacts for iron were modest (2–17pp reduction) but would increase if absorption of iron from bouillon were enhanced. Simulated zinc fortification reduced inadequacy by 12–50pp, but zinc intake above the UL exceeded 10% among children in almost all scenarios.</div></div><div><h3>Conclusions</h3><div>Modeling indicates that bouillon fortification could improve dietary micronutrient adequacy beyond existing fortification programs. Further work is needed to identify fortification levels that meet criteria for nutritional benefit, technical and commercial feasibility, affordability, and cost-effectiveness.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104485"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sculpting Success: The Importance of Diet and Physical Activity to Support Skeletal Muscle Health during Weight Loss with New Generation Anti-Obesity Medications 成功塑形:新一代抗肥胖药物减肥期间饮食和体育锻炼对支持骨骼肌健康的重要性
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104486
Gregory J Grosicki , Nikhil V Dhurandhar , Jessica L Unick , Shawn M Arent , J Graham Thomas , Holly Lofton , Madelyn C Shepherd , Jessica Kiel , Christopher Coleman , Satya S Jonnalagadda
{"title":"Sculpting Success: The Importance of Diet and Physical Activity to Support Skeletal Muscle Health during Weight Loss with New Generation Anti-Obesity Medications","authors":"Gregory J Grosicki ,&nbsp;Nikhil V Dhurandhar ,&nbsp;Jessica L Unick ,&nbsp;Shawn M Arent ,&nbsp;J Graham Thomas ,&nbsp;Holly Lofton ,&nbsp;Madelyn C Shepherd ,&nbsp;Jessica Kiel ,&nbsp;Christopher Coleman ,&nbsp;Satya S Jonnalagadda","doi":"10.1016/j.cdnut.2024.104486","DOIUrl":"10.1016/j.cdnut.2024.104486","url":null,"abstract":"<div><div>Obesity is a public health crisis, with prevalence rates tripling over the past 60 y. Although lifestyle modifications, such as diet and physical activity, remain the first-line treatments, recent anti-obesity medications (AOMs) have been shown to achieve greater reductions in body weight and fat mass. However, AOMs also reduce fat-free mass, including skeletal muscle, which has been demonstrated to account for 20% to 50% of total weight loss. This can equate to ∼6 kg or 10% of total lean mass after 12–18 mo, a loss comparable to a decade of human aging. Despite questions surrounding the clinical relevance of weight loss-induced muscle loss, the importance of adopting lifestyle behaviors such as eating a protein-rich diet and incorporating regular resistance training to support skeletal muscle health, long-term weight loss maintenance, and overall well-being among AOM users should be encouraged. Herein, we provide a rationale for the clinical significance of minimizing weight-loss-induced lean mass loss and emphasize the integration of diet and physical activity into AOM clinical care. Owing to a lack of published findings on diet and physical activity supporting skeletal muscle health with AOMs, specifically, we lean on findings from large-scale clinical weight loss and diet and exercise trials to draw evidence-based recommendations for strategies to protect skeletal muscle. We conclude by identifying gaps in the literature and emphasizing the need for future experimental research to optimize skeletal muscle and whole-body health through a balance of pharmacotherapy and healthy habits.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104486"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and User Experience Evaluation of an Experience Sampling-Based Dietary Assessment Method 基于体验采样的膳食评估方法的开发和用户体验评估
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104479
Joke Verbeke , Christophe Matthys
{"title":"Development and User Experience Evaluation of an Experience Sampling-Based Dietary Assessment Method","authors":"Joke Verbeke ,&nbsp;Christophe Matthys","doi":"10.1016/j.cdnut.2024.104479","DOIUrl":"10.1016/j.cdnut.2024.104479","url":null,"abstract":"<div><h3>Background</h3><div>Most technology-based dietary assessment methods use the same methodology as traditional dietary assessment methods resulting in similar limitations and biases. Experience sampling methodology (ESM) is a real-life real-time data-capturing method that is explored as an alternative methodology for dietary assessment to improve feasibility and data accuracy.</div></div><div><h3>Objectives</h3><div>This research aimed to develop and evaluate an experience sampling-based dietary assessment method (ESDAM) measuring habitual dietary intake.</div></div><div><h3>Methods</h3><div>Starting from a food frequency questionnaire, experience sampling principles were implemented resulting in a pilot ESDAM. Second, the pilot ESDAM was evaluated for feasibility and convergent validity compared with a 3-d food record. Mean intake with standard deviations was compared between the pilot ESDAM, food record (FR), and food frequency questionnaire (FFQ), and Spearman correlation coefficients (SCCs) were calculated. Third, following a literature review and expert opinion, the questions and design of the pilot ESDAM were further adapted to ESM and implemented in an experience sampling survey application. The resulting prototype ESDAM underwent 2 rounds of user experience (UX) evaluation in which 10 persons tested ESDAM for 1 wk followed by a structured evaluation interview.</div></div><div><h3>Results</h3><div>The pilot ESDAM, FR, and FFQ were completed by 27 participants and the evaluation questionnaire by 78 participants. Mean energy intake by the FFQ, pilot ESDAM, and FR was 1272.2 ± 308.9 kcal/d, 1592.3 ± 358.9 kcal/d, and 1664.6 ± 257.8 kcal, respectively. The evaluation revealed the limited time window (19:00–23:00) to respond was inconvenient, good acceptability, and ease of use of the pilot ESDAM. The UX evaluation study revealed overall good acceptability, ease of use, and low burden of the different prototypes of ESDAM.</div></div><div><h3>Conclusions</h3><div>ESM could advance the field beyond traditional methodologies and improve feasibility. ESDAM is unique in assessing dietary intake quantitatively through ESM. Additional assessment of validity might shed light on the data accuracy of ESDAM.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104479"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites Link Intake of a Healthy Diet to Better Insulin and Glucose Homeostasis in the Microbiome and Insulin Longitudinal Evaluation Study (MILES) 在微生物组和胰岛素纵向评估研究(MILES)中,代谢物将摄入健康饮食与改善胰岛素和葡萄糖稳态联系起来
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104462
Alexis C Wood , Danielle J Lee , Patricia A Sheridan , Elizabeth T Jensen , Gautam Ramesh , Alain G Bertoni , Stephen S Rich , Yii-Der I Chen , David M Herrington , Jerome I Rotter , Mark O Goodarzi
{"title":"Metabolites Link Intake of a Healthy Diet to Better Insulin and Glucose Homeostasis in the Microbiome and Insulin Longitudinal Evaluation Study (MILES)","authors":"Alexis C Wood ,&nbsp;Danielle J Lee ,&nbsp;Patricia A Sheridan ,&nbsp;Elizabeth T Jensen ,&nbsp;Gautam Ramesh ,&nbsp;Alain G Bertoni ,&nbsp;Stephen S Rich ,&nbsp;Yii-Der I Chen ,&nbsp;David M Herrington ,&nbsp;Jerome I Rotter ,&nbsp;Mark O Goodarzi","doi":"10.1016/j.cdnut.2024.104462","DOIUrl":"10.1016/j.cdnut.2024.104462","url":null,"abstract":"<div><h3>Background</h3><div>Dietary quality has been linked to better glycemic control, but the precise molecular mechanisms giving rise to these associations are not fully understood.</div></div><div><h3>Objectives</h3><div>To examine the association of metabolites associated with the intake of a healthy diet with measures of insulin/glucose homeostasis.</div></div><div><h3>Methods</h3><div>Using cross-sectional data from 295 United States adults, the associations between 3 diet pattern scores and metabolome-wide metabolites were estimated via linear regression models, which controlled for demographic factors and health behaviors. Subsequently, the associations between the diet-related metabolites with 6 measures of glucose/insulin homeostasis were examined in similar models. A Bonferroni correction was applied to control the family-wise error rate at 5%.</div></div><div><h3>Results</h3><div>Fifty-five metabolites were significantly associated with ≥1 diet score (all <em>P</em> &lt; 1.7∗10<sup>–5</sup>). When these were summed into each of the 3 diet-specific metabolite summary scores, all 3 aggregate measures showed strong associations with 5 out of 6 measures of glucose/insulin homeostasis (<em>P</em> = 9.7∗10<sup>–5</sup>–4.1∗10<sup>–13</sup>).</div></div><div><h3>Conclusions</h3><div>Adherence to a priori-defined “healthy diet” is associated with the plasma metabolites that, in turn, are associated with better glycemia. If the associations between replicated in future studies and examined using large-scale longitudinal data, the identified molecules could yield insights into mechanisms by which diet may support glucose and insulin homeostasis.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104462"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dairy Intake in Relation to Prediabetes and Continuous Glycemic Outcomes: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies 乳制品摄入量与糖尿病前期和持续血糖结果的关系:前瞻性队列研究的系统回顾与剂量反应元分析
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104470
Isabel AL Slurink , Yakima D Vogtschmidt , Bo Brummel , Tom Smeets , Nina Kupper , Sabita S Soedamah-Muthu
{"title":"Dairy Intake in Relation to Prediabetes and Continuous Glycemic Outcomes: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies","authors":"Isabel AL Slurink ,&nbsp;Yakima D Vogtschmidt ,&nbsp;Bo Brummel ,&nbsp;Tom Smeets ,&nbsp;Nina Kupper ,&nbsp;Sabita S Soedamah-Muthu","doi":"10.1016/j.cdnut.2024.104470","DOIUrl":"10.1016/j.cdnut.2024.104470","url":null,"abstract":"<div><h3>Background</h3><div>Modest inverse associations have been found between dairy intake, particularly yogurt, and type 2 diabetes risk. Investigating associations of dairy intake with early onset of type 2 diabetes offers opportunities for effective prevention of this condition.</div></div><div><h3>Objectives</h3><div>This study aims to investigate the relationships between the intake of different dairy types, prediabetes risk, and continuous glycemic outcomes.</div></div><div><h3>Methods</h3><div>Systematic literature searches across multiple databases were performed of studies published up to September 2023. Included were prospective cohort studies in healthy adults that examined the association between dairy intake and prediabetes risk according to diagnostic criteria, or continuous glycemic markers. A dose-response random-effects meta-analysis was used to derive incremental relative risks (RRs) for associations of total dairy, fermented dairy, milk, yogurt, cheese (all total, high-fat, and low-fat), cream, and ice cream with prediabetes risk adjusted for sociodemographic, health and cardiometabolic risk factors, and dietary characteristics.</div></div><div><h3>Results</h3><div>The meta-analyses encompassed 6653 prediabetes cases among 95,844 individuals (age range 45.5–65.5 y) including 6 articles describing 9 cohorts. A quadratic inverse association was observed for total dairy intake and prediabetes risk, with the lowest risk at 3.4 servings/d (RR: 0.75; 95% confidence interval: 0.60, 0.93; <em>I</em><sup>2</sup> = 18%). Similarly, total, and high-fat cheese exhibited nonlinear inverse associations with prediabetes risk, showing the lowest risk at 2.1 servings/d (0.86; 0.78, 0.94; <em>I</em><sup>2</sup> = 0%, and 0.90; 0.81, 0.99; <em>I</em><sup>2</sup> = 12%), but a higher risk at intakes exceeding 4 servings/d. Ice cream intake was linearly associated with prediabetes risk (0.85; 0.73, 0.99; <em>I</em><sup>2</sup> = 0% at the highest median intake of 0.23 servings/d). Other dairy types showed no statistically significant associations. The systematic review on dairy intake and glycemic outcomes showed considerable variabilities in design and results.</div></div><div><h3>Conclusions</h3><div>The findings suggest an inverse association between moderate dairy and cheese intake in preventing prediabetes. The potential for reverse causation and residual confounding highlights the need for studies with comprehensive repeated measurements.</div></div><div><h3>Trial registration number</h3><div>PROSPERO 2023 CRD42023431251.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104470"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Championing Mid-Career Success: New Initiatives and Enhanced Recognition Programs of the ASN and ASN Foundation 支持职业生涯中期的成功:ASN 和 ASN 基金会的新举措和强化表彰计划
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104482
Sarah L Booth
{"title":"Championing Mid-Career Success: New Initiatives and Enhanced Recognition Programs of the ASN and ASN Foundation","authors":"Sarah L Booth","doi":"10.1016/j.cdnut.2024.104482","DOIUrl":"10.1016/j.cdnut.2024.104482","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104482"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age 利用基于人群的区室模型和视黄醇同位素稀释研究加纳育龄妇女的维生素 A 动力学和体内总储量
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104484
Michael H Green , Veronica Lopez-Teros , Joanne Balmer Green , Georg Lietz , Sika M Kumordzie , Anthony Oxley , Ahmed D Fuseini , K Winifred Nyaaba , Emily Becher , Jennie N Davis , K Ryan Wessells , Seth Adu-Afarwuah , Reina Engle-Stone , Marjorie J Haskell
{"title":"Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age","authors":"Michael H Green ,&nbsp;Veronica Lopez-Teros ,&nbsp;Joanne Balmer Green ,&nbsp;Georg Lietz ,&nbsp;Sika M Kumordzie ,&nbsp;Anthony Oxley ,&nbsp;Ahmed D Fuseini ,&nbsp;K Winifred Nyaaba ,&nbsp;Emily Becher ,&nbsp;Jennie N Davis ,&nbsp;K Ryan Wessells ,&nbsp;Seth Adu-Afarwuah ,&nbsp;Reina Engle-Stone ,&nbsp;Marjorie J Haskell","doi":"10.1016/j.cdnut.2024.104484","DOIUrl":"10.1016/j.cdnut.2024.104484","url":null,"abstract":"<div><h3>Background</h3><div>Limited data are available on vitamin A kinetics and total body stores (TBS) in women. Such information can be obtained using compartmental modeling and retinol isotope dilution (RID).</div></div><div><h3>Objectives</h3><div>Objectives were to apply population-based (“super-subject”) modeling to determine retinol kinetics in nonpregnant Ghanaian women of reproductive age and to use RID to predict TBS in the group and its individuals.</div></div><div><h3>Methods</h3><div>Women (<em>n =</em> 89) ingested a dose of [<sup>2</sup>H<sub>6</sub>]retinyl acetate and blood samples (3/woman) were collected from 6 h to 91 d, with all participants sampled at 14 d, about half at either 21 or 28 d, and each at one other time. Composite data (plasma retinol fraction of dose; FD<sub>p</sub>) were analyzed using Simulation, Analysis and Modeling software to obtain kinetic parameters, TBS, and other state variables as well as model-derived values for the RID composite coefficient <em>FaS</em>. The latter were used in the RID equation TBS (μmol) = <em>FaS</em> × 1/SA<sub>p</sub> (where SA<sub>p</sub> is plasma retinol specific activity) to predict TBS at various times.</div></div><div><h3>Results</h3><div>Model-predicted TBS was 973 μmol (<em>n =</em> 87). Geometric mean RID-predicted TBS was 965, 926, and 1006 μmol at 14, 21, and 28 d, respectively, with wide ranges [for example, 252–3848 μmol on day 14 (<em>n =</em> 86)]; TBS predictions were similar at later times. Participants had a mean 2 y of vitamin A in stores and estimated liver vitamin A concentrations in the normal range. Model-predicted vitamin A disposal rate was 1.3 μmol/d and plasma recycling number was 37.</div></div><div><h3>Conclusions</h3><div>Super-subject modeling provides an estimate of group mean TBS as well as group-specific values for the RID coefficient <em>FaS</em>; the latter can be used to confidently predict TBS by RID for individual participants in the group under study or in similar individuals at 14 d or more after isotope ingestion.</div></div><div><h3>Trial registration number</h3><div>Trial is registered (NCT04632771) at <span><span>https://clinicaltrials.gov</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104484"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enabling Transformation of Food Systems: Some Issue to Address 促进粮食系统的转型:需要解决的一些问题
IF 3.8
Current Developments in Nutrition Pub Date : 2024-11-01 DOI: 10.1016/j.cdnut.2024.104463
Eileen Kennedy , Rosemary Green
{"title":"Enabling Transformation of Food Systems: Some Issue to Address","authors":"Eileen Kennedy ,&nbsp;Rosemary Green","doi":"10.1016/j.cdnut.2024.104463","DOIUrl":"10.1016/j.cdnut.2024.104463","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 11","pages":"Article 104463"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring Biofortification Program Performance and Potential for Impact: Indicators, Methods, and Learnings from the Commercialization of Biofortified Crops Program in Six Countries across Africa and Asia 监测生物强化计划的绩效和影响潜力:非洲和亚洲六国生物强化作物商业化计划的指标、方法和经验教训
IF 3.8
Current Developments in Nutrition Pub Date : 2024-10-29 DOI: 10.1016/j.cdnut.2024.104498
Valerie M Friesen , Bho Mudyahoto , Annette M Nyangaresi , Ishank Gorla , Mduduzi NN Mbuya
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