漆树（Rhus coriaria L.）补充成人高敏感性c反应蛋白浓度：系统评价和剂量-反应荟萃分析

IF 3.2 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2025-09-07 DOI:10.1016/j.cdnut.2025.107555

Mostafa Shahraki Jazinaki , Hossein Bahari , Iman Rahnama , Mohammad Safarian , Mahsa Malekahmadi

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引用次数: 0

摘要

背景：慢性低度炎症与各种代谢和心血管疾病的发展有关。漆树（Rhus coriaria L.）是一种具有抗炎作用的药用植物。然而，漆树补充剂对炎症生物标志物，特别是高敏c反应蛋白（hs-CRP）的影响仍然存在争议。目的：本系统综述和荟萃分析旨在评估漆树补充剂对成人hs-CRP浓度的影响。方法系统检索截至2025年2月的PubMed、Scopus、Web of Science和Cochrane Library数据库，以确定研究漆树补充对hs-CRP浓度影响的随机对照试验。筛选、数据提取和偏倚风险评估均独立进行。采用随机效应模型计算总体效应大小，即95% ci的SMD。结果7项rct符合纳入本综述的条件。合并分析显示，与对照组相比，补充漆树后hs-CRP浓度显著降低（SMD: - 0.33; 95% CI: - 0.64, - 0.02; P = 0.03）。此外，合并效应大小之间存在显著的异质性（P = 0.02; I2 = 60.2%）。亚组分析显示，在包括男女在内的试验中，或在对非酒精性脂肪肝患者、超重个体或年龄≥45岁的患者进行的研究中，漆树补充剂可显著降低成人hs-CRP浓度。需要在不同地区或健康状况的不同人群中进行进一步的高质量、大规模试验，以证实这些发现，并确定补充漆树以减少炎症的最佳剂量和持续时间。该试验在PROSPERO数据库注册为CRD420251016622。

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Sumac (Rhus coriaria L.) Supplementation on High-Sensitivity C-Reactive Protein Concentrations in Adults: A Systematic Review and Dose-Response Meta-Analysis

Background

Chronic low-grade inflammation is implicated in the development of various metabolic and cardiovascular disorders. Sumac (Rhus coriaria L.) is a medicinal plant with potential anti-inflammatory properties. However, the effects of sumac supplementation on inflammatory biomarkers, particularly high-sensitivity C-reactive protein (hs-CRP), remain controversial.

Objectives

This systematic review and meta-analysis aimed to evaluate the effect of sumac supplementation on hs-CRP concentrations in adults.

Methods

A systematic search was performed in PubMed, Scopus, Web of Science, and the Cochrane Library databases up to February 2025 to identify RCTs examining the impact of sumac supplementation on hs-CRP concentrations. Screening, data extraction, and risk of bias assessment were conducted independently. A random-effects model was used to calculate the overall effect size as the SMD with 95% CIs.

Results

Seven RCTs were eligible for inclusion in this review. The pooled analysis demonstrated a significant reduction in hs-CRP concentrations following sumac supplementation compared with that in the control groups (SMD: −0.33; 95% CI: −0.64, −0.02; P = 0.03). Moreover, a significant heterogeneity was detected among the pooled effect sizes (P = 0.02; I² = 60.2%). Subgroup analyses revealed that sumac supplementation led to a significant reduction in hs-CRP concentrations in trials that included both genders or in studies conducted on patients with nonalcoholic fatty liver disease, individuals with overweight, or those aged ≥45 y.

Conclusions

Sumac supplementation may significantly reduce hs-CRP concentrations in adults. Further high-quality, large-scale trials in various populations in terms of areas or health conditions are required to confirm these findings and determine the optimal dosage and duration for sumac supplementation to reduce inflammation.

This trial is registered at PROSPERO database as CRD420251016622.

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