Current Developments in Nutrition最新文献

{"title":"Berberine Inhibits Breast Cancer Stem Cell Development and Decreases Inflammation: Involvement of miRNAs and IL-6","authors":"Nour Ibrahim ,&nbsp;Nawal Alsadi ,&nbsp;Hamed Yasavoli-Sharahi ,&nbsp;Roghayeh Shahbazi ,&nbsp;Mary Joe Hebbo ,&nbsp;Darshan Kambli ,&nbsp;Florencia Balcells ,&nbsp;Chantal Matar","doi":"10.1016/j.cdnut.2024.104532","DOIUrl":"10.1016/j.cdnut.2024.104532","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer (BC) is a health concern worldwide and is often accompanied by depressive symptoms in patients. In BC, elevated interleukin-6 (IL-6) levels contribute to an inflammatory signature linked to cancer stem cell (CSC) stemness and depressive behaviors. Bioactive food components, such as berberine (BBR), have preventative effects against BC by targeting CSCs.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the effects of BBR on breast CSC proliferation, on levels of specific micro (mi)RNAs and IL-6 in vitro and in vivo, and in alleviating depressive-like behaviors in mice with BC.</div></div><div><h3>Methods</h3><div>Mammosphere formation assays were conducted by treating murine 4T1 and human MDA-MB-231 BC cell lines with BBR. qPCR analysis of miRNAs miR-let-7c and miR-34a-5p was performed on 4T1 CSCs exposed to BBR. BBR was administered orally to female BALB/c, followed by injection with mammary carcinoma cells to induce BC. Behavioral tests were conducted to assess depressive-like behaviors. Tumor tissues were collected for ex vivo mammosphere assays, miRNA expression analysis, and IL-6 detection by ELISA. Serum was also collected for IL-6 analysis.</div></div><div><h3>Results</h3><div>BBR treatment inhibited mammosphere formation and proliferation of CSCs derived from 4T1 and MDA-MB-231 cell lines. Quantification of mammosphere formation showed a significant decrease in both cell lines at 75 μM BBR (4T1: <em>P</em> &lt; 0.001; MDA-MB-231: <em>P</em> &lt; 0.0001). BBR upregulated the expression of miRNAs miR-let-7c and miR-34a in both cell lines, with miR-34a showing a significant increase (<em>P</em> &lt; 0.001) and let-7c showing a significant increase (<em>P</em> &lt; 0.05) in expression. In vivo, oral administration of BBR reduced mammosphere formation in breast tumor tissues (<em>P</em> &lt; 0.0001) and elevated expression of miR-145 and miR-34a, with both showing significant upregulation (<em>P</em> &lt; 0.0001), indicating its potential tumor-suppressive effects. BBR treatment resulted in a significant decrease in serum IL-6 levels (<em>P</em> &lt; 0.05), suggesting anti-inflammatory properties, while the IL-6 in tumor tissue did not show significant changes (<em>P</em> &gt; 0.05). However, no significant differences were observed in depressive-like behaviors between control and treatment groups.</div></div><div><h3>Conclusions</h3><div>BBR may have the potential to be used as an “Epi-Natural Compound” to prevent cancer by reducing inflammation and affecting epigenetics.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104532"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School Milk Programs in Latin America and the Caribbean","authors":"Ayala Wineman ,&nbsp;Maria Martinez ,&nbsp;Nicole Jacquet ,&nbsp;Eth Ludmilla Rodrigues ,&nbsp;Arlene Mitchell","doi":"10.1016/j.cdnut.2024.104541","DOIUrl":"10.1016/j.cdnut.2024.104541","url":null,"abstract":"<div><h3>Background</h3><div>School milk programs have a long history in Latin America and the Caribbean. In recent decades, the region has undergone a nutrition transition characterized by a rise in children’s overweight/obesity, which adds new challenges for school-based programs.</div></div><div><h3>Objectives</h3><div>This article aimed to unpack how school milk programs in the region have fared as of 2022 and what drives their success (or lack thereof).</div></div><div><h3>Methods</h3><div>Data from the Global Survey of School Meal Programs were analyzed descriptively to broadly summarize the current state of school feeding programs in Latin America and the Caribbean. To probe the status of school milk programs, key informant interviews were conducted with school milk stakeholders in 7 countries (Brazil, Chile, Colombia, the Dominican Republic, Ecuador, Guatemala, and Honduras), and these interviews were analyzed for thematic elements.</div></div><div><h3>Results</h3><div>Five countries were found to have operational school milk programs, whereas the programs in Guatemala and Honduras have not (thus far) endured. Programs often prioritized and took pride in local milk procurement, although there was sometimes incongruity between objectives to improve children’s diets and stimulate local agricultural development. Program implementers grapple with the taste, texture, and safety of milk, and it can be challenging to reconcile concerns over child obesity and the need to ensure the milk is appealing and accepted.</div></div><div><h3>Conclusions</h3><div>In conclusion, programs seek creatively to overcome the aformentioned challenges wherever there is fiscal capacity and political will.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104541"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Dietary Intake and Cardiorespiratory Fitness on Glycemic Variability in Adolescents: An Observational Study","authors":"Mingliang Ge ,&nbsp;Stephanie R Lebby ,&nbsp;Shivani Chowkwale ,&nbsp;Caleb Harrison ,&nbsp;Grace M Palmer ,&nbsp;Keith J Loud ,&nbsp;Diane Gilbert-Diamond ,&nbsp;Mary Ellen Vajravelu ,&nbsp;Jennifer L Meijer","doi":"10.1016/j.cdnut.2025.104547","DOIUrl":"10.1016/j.cdnut.2025.104547","url":null,"abstract":"<div><h3>Background</h3><div>Cardiorespiratory fitness (CRF), estimated by maximum oxygen consumption (VO₂ max) during exercise, is worsening among adolescents and associated with a decline in metabolic health into adulthood. Glycemic patterns may provide a mechanism between CRF and health.</div></div><div><h3>Objectives</h3><div>This study assessed the feasibility of measuring glycemic patterns using continuous glucose monitoring (CGM) in adolescents, aged 14–22 y, to estimate the relationship between VO₂ max and glucose patterns.</div></div><div><h3>Methods</h3><div>Healthy adolescents (<em>n</em> = 30) were recruited for a treadmill VO₂ max test and to complete the following activities for 7–10 d: <em>1</em>) wear a Dexcom G6 CGM, <em>2</em>) complete ≥3 24-h dietary recalls, and <em>3</em>) complete 1 at-home oral glucose tolerance test (OGTT, 75 g glucose). Glycemic patterns were extracted as mean glucose, the coefficient of variance, the mean amplitude of glycemic excursions, and the mean of daily differences. The 2-h glucose responses to the OGTT and individual meals were extracted. Statistical analyses evaluated the relationship between VO₂ max and <em>1</em>) overall glycemic patterns and <em>2</em>) the maximum glucose level and AUC response to OGTT and meals, stratified by sex.</div></div><div><h3>Results</h3><div>Participant feasibility demonstrated that 90% completed CGM data (<em>n</em> = 27), 87% ≥7 d of CGM data (<em>n</em> = 26), 97% attempted OGTT (<em>n</em> = 29), and 93% completed ≥3 dietary recalls (<em>n</em> = 28). Most participants had normal BMI (70%) with an even distribution of sex (44% male). Males exhibited an inverse relationship between VO₂ max and overall mean glucose (ß= –7.7, <em>P</em> = 0.04). Males demonstrated an inverse relationship between VO₂ max and <em>1</em>) maximum glucose (ß = –29, <em>P</em> = 0.006) and AUC (ß = –2702, <em>P</em> = 0.001) in response to the OGTT and <em>2</em>) AUC (ß = –1293, <em>P</em> = 0.03) in response to meals. No association was observed between VO₂ max and glucose patterns in females.</div></div><div><h3>Conclusions</h3><div>A sex-specific relationship between VO₂ max and glycemic patterns was observed, suggesting a unique metabolic capacity during late adolescence by sex.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT05845827.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104547"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143317187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Expectancy Gain of Implementing the Nordic Nutrition Recommendations 2023: Modeling From 8 Nordic and Baltic Countries","authors":"Elaheh Javadi Arjmand ,&nbsp;Erik K Arnesen ,&nbsp;Øystein Ariansen Haaland ,&nbsp;Jan-Magnus Økland ,&nbsp;Katherine M Livingstone ,&nbsp;John C Mathers ,&nbsp;Carlos Celis-Morales ,&nbsp;Kjell Arne Johansson ,&nbsp;Lars T Fadnes","doi":"10.1016/j.cdnut.2024.104540","DOIUrl":"10.1016/j.cdnut.2024.104540","url":null,"abstract":"<div><h3>Background</h3><div>Dietary guidelines play a key role in promoting health and preventing chronic diseases. The Nordic Nutrition Recommendations (NNR) 2023 provide updated recommendations for healthy eating relevant for the Nordic and Baltic countries, but the potential benefits have yet to be quantified.</div></div><div><h3>Objectives</h3><div>This study aimed to project the population health benefits, specifically, potential gains in life expectancy in Nordic and Baltic countries resulting from long-term dietary changes from current dietary patterns within each country to NNR2023.</div></div><div><h3>Methods</h3><div>For this population-based mathematical model, using the Food4HealthyLife 2.0 calculator, data were obtained from meta-analyses on associations between each food group and mortality, and background mortality data were derived from the Global Burden of Disease study. Standard life-table methods were used, accounting for the correlation between 14 food groups and the anticipated time delay between dietary changes and health effects.</div></div><div><h3>Results</h3><div>For 40-y-old females and males, projected life expectancy gains were from 1.8 and 2.1 y in Finland to 3.4 and 4.1 y, respectively, in Lithuania, changing to feasible NNR2023. Correspondingly, when changing to full-potential NNR2023, gains ranged from 4.4 and 5.0 y in Finland to 6.1 and 7.3 y, respectively, in Lithuania. The largest gains in life expectancy were linked to consuming more legumes (18%), nuts (17%), whole grains (12%), and less processed meat (14%) and added sugars (13%).</div></div><div><h3>Conclusions</h3><div>Adopting dietary patterns in line with the NNR2023 is associated with considerable gains in life expectancy in the Nordic and Baltic countries. The study contributes to the evidence base to support policy measures to achieve NNR2023.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104540"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Pomegranate Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis","authors":"Saba Belyani ,&nbsp;Fatemeh Kazeminasab ,&nbsp;Mahnaz Niazi ,&nbsp;Reza Bagheri ,&nbsp;Mahsa Mahabadi Hesari ,&nbsp;Sara K Rosenkranz ,&nbsp;Donny M Camera ,&nbsp;Fred Dutheil","doi":"10.1016/j.cdnut.2025.104560","DOIUrl":"10.1016/j.cdnut.2025.104560","url":null,"abstract":"<div><h3>Background</h3><div>Pomegranate supplementation has been shown to reduce oxidative stress and inflammation, with some evidence suggesting it may accelerate recovery from exercise-induced muscle damage (EIMD), including metabolic, mechanical, and neuromuscular recovery.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis aimed to investigate the effects of pomegranate supplementation on markers of EIMD.</div></div><div><h3>Methods</h3><div>A systematic search of Scopus, PubMed, and Web of Science up to January 2024 identified studies evaluating pomegranate supplementation and exercise recovery. Studies involving athletes and nonathletes aged 18–55 were included. Weighted mean differences (WMDs) were calculated for EIMD markers. Study quality was assessed using a modified physiotherapy evidence database scale. This review was registered with the International Prospective Register of Systematic Reviews (ID: CRD42024536905).</div></div><div><h3>Results</h3><div>Ten studies were included in the meta-analysis. Pomegranate supplementation did not significantly affect markers of metabolic recovery, including myoglobin (WMD: –1.344 ng/mL; 95% confidence interval (CI): –4.11, 1.42 ng/mL, <em>P</em> = 0.342) and creatine kinase (WMD: –11.990 U/L; 95% CI: –28.64, 4.66 U/L, <em>P</em> = 0.158), or neuromuscular recovery, as indicated by lactate concentrations (WMD: –0.093 mmol/L; 95% CI: –0.39, 0.21 mmol/L, <em>P</em> = 0.546). Muscle soreness also remained unchanged (WMD: 0.999; 95% CI: –0.18, 2.17, <em>P</em> = 0.097). However, a significant reduction in lactate dehydrogenase amounts (WMD: –21.152 U/L; 95% CI: –39.29, –3.01 U/L, <em>P</em> = 0.022) immediately postexercise suggests a short-term protective effect against mechanical muscle damage.</div></div><div><h3>Conclusions</h3><div>Pomegranate supplementation does not appear to enhance overall recovery markers for EIMD but may offer short-term benefits for mechanical muscle damage. Standardizing supplementation regimens, dosages, and exercise protocols is crucial to better understand the potential benefits of pomegranate supplementation in EIMD recovery.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104560"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informing the Design of Large-Scale Food Fortification Programs with Secondary Data: Pilot Results from Nigeria and Zambia","authors":"Katherine P Adams ,&nbsp;Emmanuel A Gyimah ,&nbsp;Svenja M Jungjohann ,&nbsp;Jacqueline L Hems ,&nbsp;Musonda J Mofu ,&nbsp;Olufolakemi Mercy Anjorin ,&nbsp;Jennifer Yourkavitch ,&nbsp;Silvia Alayón ,&nbsp;Heather Danton ,&nbsp;Ingrid Weiss ,&nbsp;Omar Dary ,&nbsp;Monica B Woldt","doi":"10.1016/j.cdnut.2024.104522","DOIUrl":"10.1016/j.cdnut.2024.104522","url":null,"abstract":"<div><h3>Background</h3><div>Large-scale food fortification (LSFF) can improve micronutrient intake, but low-income and middle-income countries often lack resources to collect data for LSFF decision making. We designed a methodology using existing data and methods to inform LSFF programming.</div></div><div><h3>Objectives</h3><div>This study aimed to pilot a methodology using existing diet, market, and diet cost data and assess its implementation feasibility and usefulness for LSFF decision making.</div></div><div><h3>Methods</h3><div>We used household food consumption/availability data from Nigeria and Zambia to assess dietary micronutrient inadequacy and model contributions of LSFF. Market survey (Nigeria) and agrifood information system (Zambia) data were used to estimate availability of fortifiable foods. We used Cost of the Diet software to estimate affordability of an adequate diet in Zambia. We engaged country stakeholders to determine modeling parameters and assess methodology implementation.</div></div><div><h3>Results</h3><div>The analyses took ∼6 mo and cost ∼150,000 USD (Nigeria) and ∼250,000 USD (Zambia). Results showed diets were inadequate to meet vitamin A, folate, and zinc requirements of 32%–67% of households in Nigeria and 51%–83% of households in Zambia. Modeling existing LSFF in Nigeria demonstrated improved micronutrient adequacy of diets, with further improvements possible with rice fortification. In Zambia, existing vitamin A–fortified sugar marginally reduced inadequacy. Introducing mandatory wheat flour and/or maize flour fortification could reduce folate and zinc inadequacies. The market assessment demonstrated widespread availability of fortifiable edible oil, sugar, and wheat flour, but not fortifiable maize flour. The cost of the diet in Zambia with LSFF was similar to the cost without LSFF. Stakeholders found the methodology’s components together generated useful, timely evidence for LSFF programming.</div></div><div><h3>Conclusions</h3><div>Our methodology showed opportunities for improving the micronutrient adequacy of diets in Nigeria and Zambia through LSFF. The methodology generated evidence that stakeholders agreed can support LSFF planning. Investments and strategies are needed to strengthen capacity to conduct the assessments, reduce costs, and streamline methods.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 2","pages":"Article 104522"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Protein Intake on Bone Disease, Kidney Disease, and Sarcopenia: A Systematic Review","authors":"Toyin Lamina ,&nbsp;Sallee Brandt ,&nbsp;Hamdi I Abdi ,&nbsp;Hawking Yam ,&nbsp;Ashenafi G Hayi ,&nbsp;Romil Parikh ,&nbsp;Chelsey Kirkland ,&nbsp;Amy M Claussen ,&nbsp;Kendal M Burstad ,&nbsp;Joanne L Slavin ,&nbsp;Levi Teigen ,&nbsp;Lyn M Steffen ,&nbsp;Kathleen M Hill Gallant ,&nbsp;Tasma Harindhanavudhi ,&nbsp;Anne Kouri ,&nbsp;Sue Duval ,&nbsp;Jamie Stang ,&nbsp;Mary Butler","doi":"10.1016/j.cdnut.2025.104546","DOIUrl":"10.1016/j.cdnut.2025.104546","url":null,"abstract":"<div><h3>Background</h3><div>Protein is essential for optimal growth, function, and maintenance of health. Its impact on bone, kidney health, and sarcopenia progression remains debated.</div></div><div><h3>Objectives</h3><div>This review examines the association between dietary protein intake and the risk of bone disease, kidney disease, and sarcopenia to inform protein dietary reference intake updates.</div></div><div><h3>Methods</h3><div>We searched Medline, EMBASE, AGRICOLA, and Scopus from January 2000 to May 2024, supplemented by citation searching for relevant reviews and original research. We included randomized and nonrandomized controlled trials, prospective cohort studies, and nested case-control studies examining dietary protein intake without exercise. We assessed the risk of bias (RoB), performed a qualitative synthesis of low to moderate RoB studies, and evaluated the strength of evidence.</div></div><div><h3>Results</h3><div>Of 82 articles detailing 81 unique studies, only 13 were assessed with low to moderate RoB and synthesized, comprising bone disease [4 randomized controlled trials (RCTs) and 1 prospective cohort study], kidney disease (1 RCT), and sarcopenia (9 RCTs). The overarching evidence was insufficient, largely due to the limited number of low to moderate RoB studies, the diversity of dietary protein interventions, and the broad range of outcomes, which complicated synthesis and comparison. Notably, sparse literature addressed children and adolescents, and only a single study each examined the impact of dietary protein intake on bone disease risk (yielding mixed findings) in these populations and on kidney disease risk (showing no significant effects) in adults. The findings on the impact of protein intake on bone disease in adults and sarcopenia risk were mixed; some studies showed no effect, whereas others indicated benefits.</div></div><div><h3>Conclusions</h3><div>The evidence since 2000 on associations between dietary protein intake and the risks of bone disease, kidney disease, and sarcopenia is unclear, indicating a need for more rigorous research.</div><div>This trial was registered at PROSPERO as CRD42023446621.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 3","pages":"Article 104546"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review","authors":"Grace Zhao ,&nbsp;Sarah Chondon ,&nbsp;Clint Gray ,&nbsp;Sheridan Gentili ,&nbsp;Meagan Stanley ,&nbsp;Timothy RH Regnault","doi":"10.1016/j.cdnut.2024.104510","DOIUrl":"10.1016/j.cdnut.2024.104510","url":null,"abstract":"<div><h3>Background</h3><div>Excess fructose consumption has been linked to adverse metabolic health, including impaired hepatic function and increased adiposity. The early life period, including preconception, pregnancy, and the newborn period, are critical periods in determining later metabolic health. However, the impact of excess fructose intake during this time on maternal, fetal, and offspring hepatic and whole-body adiposity, is not well defined.</div></div><div><h3>Objectives</h3><div>To understand the effects of maternal fructose consumption pre- and during pregnancy on maternal, fetal, and offspring hepatic and whole-body adiposity.</div></div><div><h3>Methods</h3><div>A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed up to October 4, 2024, to identify animal and human studies that focused on maternal fructose consumption pre- and during pregnancy on hepatic and whole-body adiposity in the mother, fetus, and offspring. Citations, abstracts, and full texts were screened in duplicate. Hepatic adiposity was defined as elevated hepatic triglycerides or overall hepatic lipid accumulation. Whole-body adiposity was defined as increased adipose tissue, serum lipids, or adipocyte hypertrophy.</div></div><div><h3>Results</h3><div>After screening 2538 citations, 37 experimental rodent studies reporting maternal fructose consumption pre- and during pregnancy in rodents were included. No human studies met the inclusion criteria. Prenatal fructose exposure was associated with maternal (9 of 12) and offspring (7 of 11) whole-body adiposity. A high proportion of studies (13 of 14) supported the association between fructose during pregnancy and increased maternal hepatic adiposity. Fetal hepatic adiposity and elevated expression of hepatic lipogenic proteins were noted in 4 studies. Offspring hepatic adiposity was supported in 16 of the 20 articles that discussed hepatic results, with 5 studies demonstrating more severe effects in female offspring.</div></div><div><h3>Conclusions</h3><div>Fructose consumption during pregnancy in rodent models is associated with maternal, fetal, and offspring hepatic and whole-body adiposity with underlying sex-specific effects. No human studies met the inclusion criteria.</div></div><div><h3>Registration number</h3><div>H8F26 on Open Science Framework (<span><span>https://doi.org/10.17605/OSF.IO/H8F26</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 1","pages":"Article 104510"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gendered Social Norms, Exceptions, and Sanctions: Implications for Maternal, Infant, and Young Child Nutrition in Nigeria","authors":"Elizabeth Costenbader ,&nbsp;Christina Memmott ,&nbsp;Kate Litvin ,&nbsp;Mackenzie Green ,&nbsp;Nnenna Mba-Oduwusi ,&nbsp;Izuchukwu Offiaeli ,&nbsp;Nemat Hajeebhoy","doi":"10.1016/j.cdnut.2024.104524","DOIUrl":"10.1016/j.cdnut.2024.104524","url":null,"abstract":"<div><h3>Background</h3><div>Nigerian pregnant and lactating women continue to experience high rates of malnutrition and Nigerian women experience long-term discrimination in the allocation and control of productive resources. Nigeria has policies and a governance architecture in place to advance nutrition, but these commitments lack recognition of how gender equity and nutrition are interwoven.</div></div><div><h3>Objective</h3><div>To address this gap, this study sought to identify and analyze the influence of gender dynamics and gender norms on nutrition and health-related practices in Nigeria.</div></div><div><h3>Methods</h3><div>This study used a combination of qualitative participatory activities and participant observation and questions to elicit information about the root causes of maternal, infant, and young child nutrition (MIYCN) and health concerns and typical nutrition and health practices in communities located across each of Nigeria’s 6 geopolitical zones. This analysis was informed by social norms theory and sought evidence of gender norms, as well as related social sanctions and norms exceptions.</div></div><div><h3>Results</h3><div>Analysis of discussions with 503 participating men and women identified 3 overarching gender meta-norms that dictate women’s mobility, gendered delineation of household tasks, and gendered decision-making and, therefore, in turn influence women’s and men’s engagement in recommended MIYCN behaviors such as involvement in production and purchasing of nutritious foods and seeking healthcare and nutrition counseling. Participants also described strong traditional gender ideologies and sanctions that uphold these restrictive norms. Encouragingly, participants described some exceptions to norms, which could indicate changing gender norms.</div></div><div><h3>Conclusions</h3><div>Nigeria currently has one of the highest rates of acute food and nutrition insecurity in Africa and contends with persistent gender inequalities. Interventions are needed that more explicitly tackle the links between gender inequality and nutrition. This analysis revealed gender meta-norms, and related sanctions and exceptions that affect multiple MIYCN behaviors and offer potential entry points for community engagement, programming, and policy around these issues.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 1","pages":"Article 104524"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Acquisition Coping Strategies Vary Based on Food Security Among University Students","authors":"Emily Sklar ,&nbsp;Gwen M Chodur ,&nbsp;Leslie Kemp ,&nbsp;Deborah S Fetter ,&nbsp;Rachel E Scherr","doi":"10.1016/j.cdnut.2024.104529","DOIUrl":"10.1016/j.cdnut.2024.104529","url":null,"abstract":"<div><h3>Background</h3><div>Food insecurity on college campuses is a pressing issue, yet the ways in which students manage challenges and disruptions to their food security status (FSS) are poorly understood.</div></div><div><h3>Objectives</h3><div>The objective of this study was to examine knowledge of food insecurity as a concept, evaluate FSS, identify food acquisition-related behaviors, and determine whether these behaviors differ among FSS.</div></div><div><h3>Methods</h3><div>University students at increased risk of experiencing food insecurity (<em>n</em> = 43) were recruited for this mixed-methods study. Participants were surveyed about their FSS, coping strategies, and use of food access resources. Subsequent interviews occurred to evaluate their understanding of food insecurity as a concept and related food acquisition behaviors. The total number of coping strategies and food access resources used were quantified, and composite variables were created. Differences based on FSS classification were examined through regression analyses. Quantitative and qualitative data were integrated using concurrent triangulation.</div></div><div><h3>Results</h3><div>Despite targeted recruitment efforts, 76% of participants were classified as food secure by the United States Department of Agriculture (USDA) Adult Food Security Survey Module (AFSSM). Participants were able to define food insecurity and identify circumstances that could contribute to an individual becoming food insecure. However, many participants described experiences that suggested the USDA AFSSM may not accurately capture students' true FSS. Most individuals faced significant challenges in maintaining food security. Participants used a series of coping strategies and food access resources to maintain or improve their food security, regardless of FSS, which included couponing, strategizing when food was low, and sharing food with housemates. Additionally, participants expressed concerns that their use of food access resources may deprive others with greater need.</div></div><div><h3>Conclusions</h3><div>Results from this study shed insight on the complexities of food insecurity in the university setting, providing useful data to inform the development of better programs, outreach, and evaluation tools that encapsulate the many unique factors that make up FSS for students.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 1","pages":"Article 104529"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}