非怀孕、非哺乳期育龄女性使用人工甜味剂的患病率及相关因素——系统综述

IF 3.2 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2025-09-01 DOI:10.1016/j.cdnut.2025.107478

Saima Shaukat Ali , Patience Elizabeth Castleton , Kainat Meherali , Mumtaz Begum , Shao Jia Zhou , Zohra S Lassi

{"title":"非怀孕、非哺乳期育龄女性使用人工甜味剂的患病率及相关因素——系统综述","authors":"Saima Shaukat Ali , Patience Elizabeth Castleton , Kainat Meherali , Mumtaz Begum , Shao Jia Zhou , Zohra S Lassi","doi":"10.1016/j.cdnut.2025.107478","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Artificial or nonnutritive sweeteners (ASs/NNSs) are widely consumed as sugar substitutes globally. Although research often focuses on specific groups such as those with diabetes or pregnant females, nonpregnant, nonlactating females of reproductive age remain understudied despite the significant implications of dietary patterns on females’ health.</div></div><div><h3>Objectives</h3><div>This systematic review aims <em>1</em>) to summarize the global prevalence of AS/NNS consumption among nonpregnant, nonlactating females aged 15−49, and <em>2</em>) to identify the factors associated with AS/NNS use within this population.</div></div><div><h3>Methods</h3><div>Following PRISMA reporting guidelines, we conducted a comprehensive search across multiple databases, including the Cochrane Database of Systematic Reviews, CENTRAL, Campbell Library, MEDLINE, EMBASE, CINAHL, SCOPUS, Web of Science, and eLANA (World Health Organization), covering studies up to May 2024. We included observational and experimental studies involving nonpregnant and nonlactating females aged 15 to 49, focusing on AS/NNS consumption and its associated factors. Data extraction was performed in duplicates, and quality assessment was conducted using the National Heart, Lung, and Blood Institute Quality Assessment Tool.</div></div><div><h3>Results</h3><div>This review identified 15 eligible studies. The pooled prevalence of AS/NNS use among females of reproductive age was 37.1% (95% confidence interval: 25.1%, 49.9%; heterogeneity: <em>I</em><sup>2</sup> = 99.9%). Most of the studies were conducted in high-income countries, with only one from an upper-middle-income country. All studies were cross-sectional (<em>n</em> = 15), with 33% high and 67% moderate quality ratings. Factors associated with AS/NNS use included people living with obesity, ethnicity (higher prevalence among White participants), and physical activity levels. However, due to a lack of sex-disaggregated data, these factors could not be analyzed specifically for females; thus, a narrative synthesis is presented.</div></div><div><h3>Conclusion</h3><div>This review highlights significant AS/NNS consumption among nonpregnant, nonlactating females of reproductive age. The findings underscore the need for further research on the long-term health implications of AS/NNS use in this population.</div><div>The study was registered with PROSPERO as CRD42023450145.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107478"},"PeriodicalIF":3.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and Factors Associated with the Use of Artificial Sweeteners in Nonpregnant, Nonlactating Females of Reproductive Age – A Systematic Review\",\"authors\":\"Saima Shaukat Ali , Patience Elizabeth Castleton , Kainat Meherali , Mumtaz Begum , Shao Jia Zhou , Zohra S Lassi\",\"doi\":\"10.1016/j.cdnut.2025.107478\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Artificial or nonnutritive sweeteners (ASs/NNSs) are widely consumed as sugar substitutes globally. Although research often focuses on specific groups such as those with diabetes or pregnant females, nonpregnant, nonlactating females of reproductive age remain understudied despite the significant implications of dietary patterns on females’ health.</div></div><div><h3>Objectives</h3><div>This systematic review aims <em>1</em>) to summarize the global prevalence of AS/NNS consumption among nonpregnant, nonlactating females aged 15−49, and <em>2</em>) to identify the factors associated with AS/NNS use within this population.</div></div><div><h3>Methods</h3><div>Following PRISMA reporting guidelines, we conducted a comprehensive search across multiple databases, including the Cochrane Database of Systematic Reviews, CENTRAL, Campbell Library, MEDLINE, EMBASE, CINAHL, SCOPUS, Web of Science, and eLANA (World Health Organization), covering studies up to May 2024. We included observational and experimental studies involving nonpregnant and nonlactating females aged 15 to 49, focusing on AS/NNS consumption and its associated factors. Data extraction was performed in duplicates, and quality assessment was conducted using the National Heart, Lung, and Blood Institute Quality Assessment Tool.</div></div><div><h3>Results</h3><div>This review identified 15 eligible studies. The pooled prevalence of AS/NNS use among females of reproductive age was 37.1% (95% confidence interval: 25.1%, 49.9%; heterogeneity: <em>I</em><sup>2</sup> = 99.9%). Most of the studies were conducted in high-income countries, with only one from an upper-middle-income country. All studies were cross-sectional (<em>n</em> = 15), with 33% high and 67% moderate quality ratings. Factors associated with AS/NNS use included people living with obesity, ethnicity (higher prevalence among White participants), and physical activity levels. However, due to a lack of sex-disaggregated data, these factors could not be analyzed specifically for females; thus, a narrative synthesis is presented.</div></div><div><h3>Conclusion</h3><div>This review highlights significant AS/NNS consumption among nonpregnant, nonlactating females of reproductive age. The findings underscore the need for further research on the long-term health implications of AS/NNS use in this population.</div><div>The study was registered with PROSPERO as CRD42023450145.</div></div>\",\"PeriodicalId\":10756,\"journal\":{\"name\":\"Current Developments in Nutrition\",\"volume\":\"9 9\",\"pages\":\"Article 107478\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Developments in Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2475299125029397\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Developments in Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2475299125029397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

人工或非营养性甜味剂（ASs/NNSs）作为糖替代品在全球范围内广泛使用。尽管研究通常侧重于特定群体，如糖尿病患者或孕妇，但未怀孕、未哺乳的育龄女性仍未得到充分研究，尽管饮食模式对女性健康有重大影响。本系统综述的目的是：1)总结15 - 49岁非怀孕、非哺乳期女性使用AS/NNS的全球流行情况；2)确定该人群中使用AS/NNS的相关因素。方法遵循PRISMA报告指南，我们在多个数据库中进行了全面的检索，包括Cochrane系统评价数据库、CENTRAL、Campbell Library、MEDLINE、EMBASE、CINAHL、SCOPUS、Web of Science和eLANA（世界卫生组织），涵盖了截至2024年5月的研究。我们纳入了15至49岁的未怀孕和未哺乳女性的观察性和实验性研究，重点关注AS/NNS消费及其相关因素。数据提取一式两份，使用国家心肺血液研究所质量评估工具进行质量评估。结果本综述确定了15项符合条件的研究。育龄女性使用AS/NNS的总患病率为37.1%（95%可信区间：25.1%,49.9%；异质性：I2 = 99.9%）。大多数研究都是在高收入国家进行的，只有一项研究来自中高收入国家。所有的研究都是横断面的（n = 15）， 33%的高质量评分和67%的中等质量评分。与AS/NNS使用相关的因素包括肥胖人群、种族（白人参与者中患病率较高）和身体活动水平。但是，由于缺乏按性别分列的数据，这些因素无法专门针对女性进行分析；因此，提出了一种叙事综合。结论：本综述强调非怀孕、非哺乳期育龄女性显著的AS/NNS消耗。研究结果强调需要进一步研究在这一人群中使用AS/NNS对健康的长期影响。该研究在普洛斯彼罗注册为CRD42023450145。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prevalence and Factors Associated with the Use of Artificial Sweeteners in Nonpregnant, Nonlactating Females of Reproductive Age – A Systematic Review

Background

Artificial or nonnutritive sweeteners (ASs/NNSs) are widely consumed as sugar substitutes globally. Although research often focuses on specific groups such as those with diabetes or pregnant females, nonpregnant, nonlactating females of reproductive age remain understudied despite the significant implications of dietary patterns on females’ health.

Objectives

This systematic review aims 1) to summarize the global prevalence of AS/NNS consumption among nonpregnant, nonlactating females aged 15−49, and 2) to identify the factors associated with AS/NNS use within this population.

Methods

Following PRISMA reporting guidelines, we conducted a comprehensive search across multiple databases, including the Cochrane Database of Systematic Reviews, CENTRAL, Campbell Library, MEDLINE, EMBASE, CINAHL, SCOPUS, Web of Science, and eLANA (World Health Organization), covering studies up to May 2024. We included observational and experimental studies involving nonpregnant and nonlactating females aged 15 to 49, focusing on AS/NNS consumption and its associated factors. Data extraction was performed in duplicates, and quality assessment was conducted using the National Heart, Lung, and Blood Institute Quality Assessment Tool.

Results

This review identified 15 eligible studies. The pooled prevalence of AS/NNS use among females of reproductive age was 37.1% (95% confidence interval: 25.1%, 49.9%; heterogeneity: I² = 99.9%). Most of the studies were conducted in high-income countries, with only one from an upper-middle-income country. All studies were cross-sectional (n = 15), with 33% high and 67% moderate quality ratings. Factors associated with AS/NNS use included people living with obesity, ethnicity (higher prevalence among White participants), and physical activity levels. However, due to a lack of sex-disaggregated data, these factors could not be analyzed specifically for females; thus, a narrative synthesis is presented.

Conclusion

This review highlights significant AS/NNS consumption among nonpregnant, nonlactating females of reproductive age. The findings underscore the need for further research on the long-term health implications of AS/NNS use in this population.

The study was registered with PROSPERO as CRD42023450145.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊