乳腺癌妇女急性暴露于蒽环类化疗后的血脂组学与心脏毒性损伤的关系：一项可行性研究

IF 3.2 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2025-09-04 DOI:10.1016/j.cdnut.2025.107552

Kate E Marris , Rachel M Cole , Daniel Addison , Patrick Ruz , Genevieve Sparagna , Ai Ni , Martha A Belury

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引用次数: 0

摘要

丹红素化疗（AC）通过诱导线粒体内部损伤和破坏电子传递链导致许多乳腺癌患者的心脏毒性。目前还不清楚为什么一些（但不是全部）接受AC治疗的女性会出现慢性心功能障碍。目的：本前瞻性可行性研究的目的是确定1个周期AC对乳腺癌患者心肌损伤和血脂变化的累积率，并估计其效应大小。方法纳入14例计划接受交流治疗的乳腺癌患者，在交流治疗方案的任何一个周期之前和之后的2次就诊中进行了心脏磁共振（CMR）成像和血液采样。测定外周血单个核细胞中红细胞（rbc）和心磷脂（CL）的脂肪酸组成。进行探索性分析。结果CMR T2测图显示，乳腺癌患者在AC治疗1个周期后心肌水肿增加。四油基（LA4）与四油基（OA4） CL的比值与心肌纤维化呈负相关，通过CMR T1制图获得。OA4CL与心肌纤维化呈正相关，红细胞中OA含量与心肌水肿呈正相关。结论：在接受AC治疗的乳腺癌患者中，红细胞中的soa4cl和OA似乎与心脏毒性的亚临床标志物有关，需要更大规模的研究来研究饮食亚油酸和LA4CL对AC的潜在心脏保护作用

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The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study

Background

Anthracycline chemotherapy (AC) leads to cardiotoxicity in many patients with breast cancer by inducing inner mitochondrial damage and disrupting the electron transport chain. It is unclear why some, but not all, women who undergo AC develop chronic cardiac dysfunction.

Objectives

The aim of this prospective feasibility study was to determine accrual rate and estimate the effect size of 1 cycle of AC on myocardial injury and blood lipidome changes in women with breast cancer.

Methods

Fourteen women with breast cancer planning to undergo AC enrolled and underwent cardiac magnetic resonance (CMR) imaging and blood sampling across 2 visits, before and after any 1 cycle of AC in the treatment regimen. Fatty acid composition of red blood cells (RBCs) and cardiolipin (CL) in peripheral blood mononuclear cells were measured. Exploratory analyses were conducted.

Results

Myocardial edema, obtained via T2 mapping using CMR, increased after 1 cycle of AC in women with breast cancer. The ratio of tetralinoleoyl (LA₄) to tetraoleoyl (OA₄) CL correlated negatively with myocardial fibrosis, obtained via T1 mapping using CMR. OA₄CL correlated positively with myocardial fibrosis, and OA content in RBCs correlated positively with myocardial edema.

Conclusions

OA₄CL and OA in RBCs appear to be related to subclinical markers of cardiotoxicity in women with breast cancer undergoing AC. Larger studies are needed to investigate potential cardioprotective effects of dietary linoleic acid and LA₄CL against AC.

This trial was registered at clinicaltrials.gov as NCT03961685

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