Chinese Journal of Physiology最新文献_第7页

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m⁶A modification of protein arginine methyltransferase 6. MiR-141-3p通过AlkB同源物5介导的蛋白精氨酸甲基转移酶6的m6A修饰促进前列腺癌的恶性进展。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00071

Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge

{"title":"MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6.","authors":"Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge","doi":"10.4103/cjop.CJOP-D-22-00071","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00071","url":null,"abstract":"Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease. Although the functions of miR-141-3p and AlkB homolog 5 (ALKBH5) were identified in some cancers, whether they were involved in the development of PCa remains unclear. In this study, reverse transcription-quantitative polymerase chain reaction unveiled that the expression of ALKBH5 was reduced in PCa tissues and was negatively correlated with miR-141-3p. ALKBH5 attenuated the malignant development of PCa through suppressing the growth, migration, invasion, and sphere formation abilities of PCa cells. In addition, the luciferase activity assay identified that ALKBH5 was corroborated as a downstream target of miR-141-3p. Moreover, miR-141-3p expression was boosted in PCa tissues and cells and inhibition of miR-141-3p suppressed the tumor growth of PCa in vivo. Moreover, ALKBH5 was confirmed to suppress protein arginine methyltransferase 6 (PRMT6) expression through N6-methyladenosine (m6A) modification. We further identified that miR-141-3p-modulated PRMT6 level through mediating ALKBH5. Furthermore, PRMT6 level was positively correlated with miR-141-3p level and negatively associated with ALKBH5 level. Finally, rescue assays also uncovered that miR-141-3p aggravated PCa development by regulating PRMT6. In conclusion, miR-141-3p accelerated the malignant progression of PCa through ALKBH5-mediated m6A modification of PRMT6, which might offer a novel insight into the role of miR-141-3p and ALKBH5 in the treatments of PCa patients.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"43-51"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages 黄花菜可以改善人体睡眠质量，减少巨噬细胞中一氧化氮和白细胞介素-6的产生

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-22-00043

Po-Ching Wu, Kuo-Feng Hua, Li-Min Hsu, Hua-Wei Chen

{"title":"Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages","authors":"Po-Ching Wu, Kuo-Feng Hua, Li-Min Hsu, Hua-Wei Chen","doi":"10.4103/cjop.cjop-d-22-00043","DOIUrl":"https://doi.org/10.4103/cjop.cjop-d-22-00043","url":null,"abstract":"The flowers of daylily (Hemerocallis fulva Linn.) have been used as vegetable and medicinal herb for thousands of years in Taiwan and eastern Asia. Daylily flowers have been demonstrated to exert several biomedical properties. In this study, we provided the evidences show that daylily flowers exert anti-inflammatory activity in vitro and improved the sleep quality in vivo. We demonstrated that adult volunteers received water extract of daylily flowers improved sleep quality, sleep efficiency and daytime functioning, while sleep latency was reduced, compared to the adult volunteers received water. In addition, we demonstrated that aqueous and ethanol extracts of daylily flowers inhibited nitric oxide and interleukin-6 production in lipopolysaccharide-activated macrophages. Furthermore, the quantitative high performance liquid chromatography-based analysis showed the rutin content of the aqueous extract, ethanolic extract, ethyl acetate fractions of ethanolic extract, and water fractions of ethanolic extract were 7.27, 23.30, 14.71, and 57.43 ppm, respectively. These results indicate that daylily flowers have the potential to be a nutraceutical for improving inflammatory-related diseases and sleep quality in the future.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135495290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAMTS13 inhibits H₂O₂-induced human venous endothelial cell injury to attenuate deep-vein thrombosis by blocking the p38/ERK signaling pathway ADAMTS13通过阻断p38/ERK信号通路抑制h2o2诱导的人静脉内皮细胞损伤，减轻深静脉血栓形成

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-23-00101

Jianjie Rong, Guangfeng Zheng, Qiang Zhang, Chuanyong Li, Weijian Fan, Zhichang Pan, Yuting Zhou, Yan Chen

引用次数: 0

GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ_1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis. gata结合蛋白4通过小核仁RNA宿主基因1/miR-361-3p轴促进Aβ1-42原纤维灌注大鼠的神经炎症和认知功能障碍。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00057

Lidan Liu, Yanhui Peng, Wenping Liu, Jiajun Xu, Dali Li, Xiuwen Li

{"title":"GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis.","authors":"Lidan Liu, Yanhui Peng, Wenping Liu, Jiajun Xu, Dali Li, Xiuwen Li","doi":"10.4103/cjop.CJOP-D-22-00057","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00057","url":null,"abstract":"Aging with dysregulated metabolic and immune homeostasis stimulates pyroptosis, neuroinflammation, and cellular senescence, thus contributing to etiopathogenesis of Alzheimer's disease. GATA-binding protein 4 (GATA4) functions as a transcriptional factor in response to DNA damage, and is associated with neuroinflammation and cellular senescence. The role of GATA4 in Alzheimer's disease was investigated. GATA4 was elevated in hippocampus of Aβ1-42 fibril-infused rats. Injection with shRNA targeting GATA4 reduced escape latency with increase of time in target quadrant and number of platform crossings in Aβ1-42 fibril-infused rats. Moreover, knockdown of GATA4 ameliorated morphological changes of hippocampus and reduced amyloid plaque deposition in Aβ1-42 fibril-infused rats. Silence of GATA4 repressed neuroinflammation and apoptosis in Aβ1-42 fibril-infused rats. Loss of GATA4 in Aβ1-42 fibril-infused rats reduced the expression of specificity protein 1 (Sp1) to downregulate long noncoding RNA small nucleolar RNA host gene 1 (SNHG1) and upregulated miR-361-3p. Loss of SNHG1 ameliorated learning and memory impairments in Aβ1-42 fibril-infused rats. Overexpression of Sp1 attenuated GATA4 silence-induced decrease of escape latency, increase of time in target quadrant, and number of platform crossings in Aβ1-42 fibril-infused rats. In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR-361-3p.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"14-20"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholinergic deficiency in the cholinergic system as a pathogenetic link in the formation of various syndromes in COVID-19. 胆碱能系统胆碱能缺乏是COVID-19各种综合征形成的一个发病环节。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00072

Sergey Petrovich Lysenkov, Dmitriy Vitalevich Muzhenya, Aminat Ramazanovna Tuguz, Tamara Ur'evna Urakova, Dmitriy Sergeevich Shumilov, Ibragim Askarbievich Thakushinov, Rustem Askarbievich Thakushinov, Elena Anatolevna Tatarkova, Diana Muratovna Urakova

{"title":"Cholinergic deficiency in the cholinergic system as a pathogenetic link in the formation of various syndromes in COVID-19.","authors":"Sergey Petrovich Lysenkov, Dmitriy Vitalevich Muzhenya, Aminat Ramazanovna Tuguz, Tamara Ur'evna Urakova, Dmitriy Sergeevich Shumilov, Ibragim Askarbievich Thakushinov, Rustem Askarbievich Thakushinov, Elena Anatolevna Tatarkova, Diana Muratovna Urakova","doi":"10.4103/cjop.CJOP-D-22-00072","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00072","url":null,"abstract":"According to recent data, several mechanisms of viral invasion of the central nervous system (CNS) have been proposed, one of which is both direct penetration of the virus through afferent nerve fibers and damage to the endothelium of cerebral vessels. It has been proven that the SARS-CoV-2 virus affects pathologically not only the human cardiorespiratory system but is also associated with a wide range of neurological diseases, cerebrovascular accidents, and neuromuscular pathologies. However, the observed post-COVID symptom complex in patients, manifested in the form of headache, \"fog in the head,\" high temperature, muscle weakness, lowering blood pressure, does it make us think about the pathophysiological mechanisms that contribute to the development of this clinical picture? One possible explanation is a disruption in the signaling of the acetylcholine system (AChS) in the body. Viral invasions, and in particular COVID-19, can negatively affect the work of the AChS, disrupting its coordination activities. Therefore, the main goal of this literature review is to analyze the information and substantiate the possible mechanisms for the occurrence of post-COVID syndrome in people who have had COVID-19 from the standpoint of AChS dysfunctions.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Beta-hydroxy-beta-methylbutyrate supplementation preserves fat-free mass in collegiate boxers during acute body mass loss β -羟基- β -甲基丁酸盐补充保留无脂肪质量在急性体重损失的大学拳击手

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-23-00074

Chen-Kang Chang, Shih-Yen Kao, Chung-Yuan Wang

引用次数: 0

LncRNA colorectal neoplasia differentially expressed promotes glycolysis of liver cancer cells by regulating hypoxia-inducible factor 1α. LncRNA结直肠癌差异表达通过调控缺氧诱导因子1α促进肝癌细胞糖酵解。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-11-01 DOI: 10.4103/0304-4920.365458

Dan Tang, Lijin Zhao, Rui Mu, Yu Ao, Xuyang Zhang, Xiongxiong Li

{"title":"LncRNA colorectal neoplasia differentially expressed promotes glycolysis of liver cancer cells by regulating hypoxia-inducible factor 1α.","authors":"Dan Tang, Lijin Zhao, Rui Mu, Yu Ao, Xuyang Zhang, Xiongxiong Li","doi":"10.4103/0304-4920.365458","DOIUrl":"https://doi.org/10.4103/0304-4920.365458","url":null,"abstract":"LncRNAs are associated with tumorigenesis of liver cancer. LncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) was identified as an oncogenic lncRNA and involved in tumor growth and metastasis. The role of CRNDE in liver cancer was investigated. CRNDE was elevated in liver cancer cells. Knockdown of CRNDE decreased cell viability and inhibited proliferation of liver cancer. Moreover, knockdown of CRNDE reduced levels of extracellular acidification rate, glucose consumption, and lactate production to repress glycolysis of liver cancer. Silence of CRNDE enhanced the expression of miR-142 and reduced enhancer of zeste homolog 2 (EZH2) and hypoxia-inducible factor 1α (HIF-1α). Over-expression of HIF-1α attenuated CRNDE silence-induced decrease of glucose consumption and lactate production. Injection with sh-CRNDE virus reduced in vivo tumor growth of liver cancer through up-regulation of miR-142 and down-regulation of EZH2 and HIF-1α. In conclusion, knockdown of CRNDE suppressed cell proliferation, glycolysis, and tumor growth of liver cancer through EZH2/miR-142/HIF-1α.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 6","pages":"311-318"},"PeriodicalIF":1.8,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10522919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of exercise intensity on fatty liver in rats. 运动强度对大鼠脂肪肝的影响。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-11-01 DOI: 10.4103/0304-4920.365461

Xueyan Gu, Xiaocui Ma, Limin Mo, Qiyu Wang

{"title":"The role of exercise intensity on fatty liver in rats.","authors":"Xueyan Gu, Xiaocui Ma, Limin Mo, Qiyu Wang","doi":"10.4103/0304-4920.365461","DOIUrl":"https://doi.org/10.4103/0304-4920.365461","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is often caused by obesity. Currently, moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) are two effective treatments for reducing fat mass in patients with obesity and NAFLD. However, the comparative fat-reducing effects and underlying molecular mechanisms of MICT and HIIT remain unclear. This comprehensive study was performed on male Wistar rats treated with standard diet, high-fat diet, MICT, and HIIT to explore their comparative fat-reducing effects and corresponding molecular mechanisms. HIIT had a greater effect on hepatic vacuolation density and lipid content reduction than MICT, and triglyceride and total cholesterol levels in the serum and the liver demonstrated different sensitivities to different exercise training programs. At the molecular level, both MICT and HIIT altered the processes of fatty acid synthesis, fatty acid transport, fatty acid β-oxidation, and cholesterol synthesis, wherein the transcriptional and translational levels of signaling molecules peroxisome proliferator-activated receptors (PPARs) regulating fatty acid and cholesterol synthesis were strongly changed. Moreover, the metabolic pathways of amino acids, bile acids, and carbohydrates were also affected according to transcriptome analysis, and the changes in the above-mentioned processes in the HIIT group were greater than those in the MICT group. In combination with the search tool for the retrieval of interacting genes/proteins (STRING) analysis and the role of PPARs in lipid metabolism, as well as the expression pattern of PPARs in the MICT and HIIT groups, the MICT-and HIIT-induced fat loss was mediated by the PPAR pathway, causing feedback responses in fatty acid, steroid, amino acid, bile acid, and carbohydrate metabolism, and HIIT had a better fat-reducing effect, which may be initiated by PPAR-α. This study provides a theoretical basis for targeted therapy of patients with obesity and NAFLD.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 6","pages":"301-310"},"PeriodicalIF":1.8,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10466566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Optimization of exercise preconditioning duration in protecting from exhausted exercise-induced cardiac injury in rats. 优化运动预处理时间对大鼠运动性心力损伤的保护作用。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-11-01 DOI: 10.4103/0304-4920.365457

Zheng Ping, Jinyu Li, Yawei Sun, Xiaoli Zhang, Ziwen Wang, Xuebin Cao

{"title":"Optimization of exercise preconditioning duration in protecting from exhausted exercise-induced cardiac injury in rats.","authors":"Zheng Ping, Jinyu Li, Yawei Sun, Xiaoli Zhang, Ziwen Wang, Xuebin Cao","doi":"10.4103/0304-4920.365457","DOIUrl":"https://doi.org/10.4103/0304-4920.365457","url":null,"abstract":"The effect of different duration of exercise preconditioning (EP) on protecting from exhaustive exercise-induced cardiac injury (EECI) has been optimized in rats. Male Sprague-Dawley rats were divided into six groups: the control group, exhaustive exercise (EE) group, EP 20-min + EE group, EP 40-min + EE group, EP 60-min + EE group and EP 80-min + EE group. The EP groups were subjected to treadmill running at the intensity of 74.0% V̇O2 max. Changes of exercise capacity, cardiac pathology, myocardial enzymology, electrocardiogram (ECG), cardiac function, and mitochondrial respiratory function were compared. Compared to the C group, the EE group has shown significant decrease of exercise capacity, elevation of serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTn-I) levels, cardiac morphology change, ECG disturbance, cardiac dysfunction and reduction of myocardial mitochondrial respiration function. Compared to the EE group, the EP groups have shown significant elevation of exercise capacity, decrease of serum NT-proBNP and cTn-I, improvement of cardiac function and myocardial mitochondrial electron transfer pathway complex I, II and IV activity. The correlation analyses showed protection of EP was proportional to EP duration from 20-min to 60-min. EE caused cardiac injury. EP could protect from EECI by alleviating myocardial damage, improving cardiac function and mitochondrial ETP complex I, II and IV activity. EP protection was positively correlated to EP duration from 20-min to 60-min with EP intensity fixed at 74.0% V̇O2 max.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 6","pages":"290-300"},"PeriodicalIF":1.8,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10466567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of long non-coding RNA LINC00158 inhibits neuronal apoptosis by promoting autophagy in spinal cord injury. 长链非编码RNA LINC00158过表达通过促进脊髓损伤自噬抑制神经元凋亡。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-11-01 DOI: 10.4103/0304-4920.360035

Fuchuang Qin, Guorong He, Yu Sun, Guangning Chen, Qijian Yu, Xilie Ma

{"title":"Overexpression of long non-coding RNA LINC00158 inhibits neuronal apoptosis by promoting autophagy in spinal cord injury.","authors":"Fuchuang Qin, Guorong He, Yu Sun, Guangning Chen, Qijian Yu, Xilie Ma","doi":"10.4103/0304-4920.360035","DOIUrl":"https://doi.org/10.4103/0304-4920.360035","url":null,"abstract":"Spinal cord injury (SCI) is a common central nervous system disease. It is reported that long non-coding RNA LINC00158 is involved in the process of SCI. The purpose of this study was to explore the biological role of LINC00158 in the SCI. First, we established a rat SCI model by surgical method and evaluated the motor function of rats by the Basso-Beattie-Bresnahan locomotor rating scale. The results showed that the expression of LINC00158 decreased and apoptotic cells increased in the SCI model rats. Meanwhile, we found the upregulated LC3-II/LC3-I, Beclin-1, and p62 in the SCI rats. Then, primary rat spinal cord neurons were exposed to oxygen/glucose deprivation (OGD) as an in vitro cell model of SCI. After OGD treatment, the expression of LINC00158 decreased significantly and the apoptosis of spinal cord neurons increased. OGD treatment resulted in upregulation of LC3-II/LC3-I and Beclin-1 and downregulation of p62 in primary spinal cord neurons, which could be eliminated by overexpression of LINC00158. 3-Methyladenine and chloroquine (autophagy inhibitor) reversed the inhibitory effect of LINC00158 overexpression on apoptosis of primary spinal cord neurons. In conclusion, this study demonstrated that LINC00158 overexpression repressed neuronal apoptosis by promoting autophagy, suggesting that LINC00158 may be a potential therapeutic target in the SCI.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 6","pages":"282-289"},"PeriodicalIF":1.8,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10522917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1