Chinese Journal of Physiology最新文献_第10页

Raspberry ketone promotes FNDC5 protein expression via HO-1 upregulation in 3T3-L1 adipocytes 树莓酮通过上调HO-1促进3T3-L1脂肪细胞中FNDC5蛋白的表达

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-03-01 DOI: 10.4103/cjp.cjp_95_21

Yung‐Chieh Tsai, Jung-Hua Chen, Yen-Mei Lee, M. Yen, P. Cheng

{"title":"Raspberry ketone promotes FNDC5 protein expression via HO-1 upregulation in 3T3-L1 adipocytes","authors":"Yung‐Chieh Tsai, Jung-Hua Chen, Yen-Mei Lee, M. Yen, P. Cheng","doi":"10.4103/cjp.cjp_95_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_95_21","url":null,"abstract":"Obesity is a global health problem and a risk factor for cardiovascular diseases and cancers. Exercise is an effective intervention to combat obesity. Fibronectin type III domain containing protein 5 (FNDC5)/irisin, a myokine, can stimulate the browning of white adipose tissue by increasing uncoupling protein 1 (UCP1) expression, and therefore may represent a link between the beneficial effects of exercise and improvement in metabolic diseases. Thus, upregulating the endogenous expression of FNDC5/irisin by administering medication would be a good approach for treating obesity. Herein, we evaluated the efficacy of raspberry ketone (RK) in inducing FNDC5/irisin expression and the underlying mechanisms. The expression of brown fat-specific proteins (PR domain containing 16 (PRDM16), CD137, and UCP1), heme oxygenase-1 (HO-1), FNDC5, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) in differentiated 3T3-L1 adipocyte was analyzed by western blotting or immunofluorescence. The level of irisin in the culture medium was also assayed using an enzyme-linked immunosorbent assay kit. Results showed that RK (50 μM) significantly induced the upregulation of FNDC5 protein in differentiated 3T3-L1 adipocytes; however, the irisin level in the culture media was unaffected. Moreover, RK significantly increased the levels of PGC1α, brown adipocyte markers (PRDM16, CD137, and UCP1), and HO-1. Furthermore, the upregulation of PGC1α and FNDC5 and the browning effect induced by RK were significantly reduced by SnPP or FNDC5 siRNA, respectively. In conclusion, RK can induce FNDC5 protein expression via the HO-1 signaling pathway, and this study provides new evidence for the potential use of RK in the treatment of obesity.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"80 - 86"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44824213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Connexin 43 mediated the angiogenesis of buyang huanwu decoction via vascular endothelial growth factor and angiopoietin-1 after ischemic stroke Connexin 43通过血管内皮生长因子和血管生成素-1介导补阳还五汤缺血性脑卒中后血管生成

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-03-01 DOI: 10.4103/cjp.cjp_94_21

Ying Zhou, Yaxian Zhang, Kailing Yang, Yu-Lian Liu, Fangfang Wu, Yusong Gao, Wei Liu

{"title":"Connexin 43 mediated the angiogenesis of buyang huanwu decoction via vascular endothelial growth factor and angiopoietin-1 after ischemic stroke","authors":"Ying Zhou, Yaxian Zhang, Kailing Yang, Yu-Lian Liu, Fangfang Wu, Yusong Gao, Wei Liu","doi":"10.4103/cjp.cjp_94_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_94_21","url":null,"abstract":"Buyang Huanwu decoction (BYHWD), a classical prescription for ischemic stroke, has been reported to promote angiogenesis after focal ischemia. However, the mechanisms of the contribution of BYHWD on angiogenesis are still unclear. Connexin 43 (Cx43) played important roles in the functions of neurogliovascular unit. Therefore, the aim of this study was to explore the potential role of Cx43 in angiogenesis of the ischemic brain after BYHWD treatment. Middle cerebral artery occlusion (MCAO) was used to establish the model of focal ischemia. BYHWD was administrated intragastrically twice a day after MCAO with or without Gap26 (a specific Cx43 inhibitor). Western blot, neurological deficits, immunofluorescent staining, and Evans blue dye were used to confirm the role of Cx43 in angiogenesis after BYHWD treatment. The expression levels of total Cx43 and phosphorylated Cx43 were upregulated by BYHWD and peaked at 7 days post MCAO. Inhibition of Cx43 with Gap26 significantly attenuated the protective role of BYHWD in neurological behavior. BYHWD treatment promoted angiogenesis demonstrated by increased microvascular density, upregulated vascular endothelial growth factor (VEGF), and angiopoietin-1 (Ang-1), while inhibition of Cx43 with Gap26 attenuated these effects of BYHWD. In addition, Gap26 inhibited the beneficial effect of BYHWD on blood-brain barrier (BBB) integrity. These results suggested that Cx43 mediated the angiogenesis of BYHWD via VEGF and Ang-1 after focal ischemic stroke.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"72 - 79"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42219675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Corrigendum: Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol], a natural phenolic compound found in the olive, alters Ca2+ signaling and viability in human HepG2 hepatoma cells 更正：羟基酪醇[2-（3，4-二羟基苯基）-乙醇]，一种在橄榄中发现的天然酚类化合物，可改变人类HepG2肝癌细胞的Ca2+信号传导和活力

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-03-01 DOI: 10.4103/0304-4920.344179

引用次数: 0

Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol], a natural phenolic compound found in the olive, alters Ca2+ signaling and viability in human HepG2 hepatoma cells 羟基酪醇[2-(3,4-二羟基苯基)-乙醇]是一种在橄榄中发现的天然酚类化合物，可改变人HepG2肝癌细胞的Ca2+信号传导和活力

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_74_21

He‐Hsiung Cheng, W. Liao, Ronghai Lin, I. Chen, Jue‐Long Wang, J. Chien, C. Kuo, Lyh-Jyh Hao, C. Chou, C. Jan

{"title":"Hydroxytyrosol [2-(3,4-dihydroxyphenyl)-ethanol], a natural phenolic compound found in the olive, alters Ca2+ signaling and viability in human HepG2 hepatoma cells","authors":"He‐Hsiung Cheng, W. Liao, Ronghai Lin, I. Chen, Jue‐Long Wang, J. Chien, C. Kuo, Lyh-Jyh Hao, C. Chou, C. Jan","doi":"10.4103/cjp.cjp_74_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_74_21","url":null,"abstract":"Hepatotoma is the leading type of primary liver cancer in adults and third cause of death in the world. Hydroxytyrosol is a natural phenol existing in olive (Olea europaea L.). Hydroxytyrosol is the chief ingredient of olive oil, which was early deemed to be the most robust antioxidant in olive oil. Hydroxytyrosol is known to inhibit various types of cancer by different methods. This study was aimed to delineate the action of hydroxytyrosol on viability and [Ca2+]i in HepG2 hepatoma cells. Fura-2 was used to detect [Ca2+]i, and WST-1 assays were applied to explore cell cytotoxicity. Hydroxytyrosol elicited [Ca2+]i raises. Eliminating external Ca2+ diminished the Ca2+ signal by 30%. Hydroxytyrosol-evoked Ca2+ influx was diminished by 20% by three inhibitors of store-operated Ca2+ channels and by a protein kinase C activator and an inhibitor. In the absence of Ca2+, thapsigargin eradicated hydroxytyrosol-provoked [Ca2+]i raises. Suppression of phospholipase C (PLC) with U73122, a PLC inhibitor, did not inhibit hydroxytyrosol-elicited [Ca2+]i raises. Hydroxytyrosol reduced cell viability. This cytotoxic action was not reversed by preincubation with BAPTA/AM, a cytosolic Ca2+ binder. In sum, in HepG2 hepatoma cells, hydroxytyrosol elicited [Ca2+]i raises by provoking PLC-unrelated discharge of Ca2+ from ER and Ca2+ influx through PKC-sensitive store-operated Ca2+ entry. In addition, hydroxytyrosol elicited Ca2+-dissociated cytotoxicity.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"30 - 36"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47307834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Epoxyeicosatrienoic acids and soluble epoxide hydrolase in physiology and diseases of the central nervous system 环氧二十碳三烯酸和可溶性环氧化物水解酶在中枢神经系统生理和疾病中的作用

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_80_21

Yi-Min Kuo, Yi-Hsuan Lee

{"title":"Epoxyeicosatrienoic acids and soluble epoxide hydrolase in physiology and diseases of the central nervous system","authors":"Yi-Min Kuo, Yi-Hsuan Lee","doi":"10.4103/cjp.cjp_80_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_80_21","url":null,"abstract":"Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 epoxygenases from arachidonic acid. The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that serves as a key regulator of tissue EETs levels. EETs act through several signaling pathways to mediate various beneficial effects, including anti-inflammation, anti-apoptosis, and anti-oxidation with relieve of endoplasmic reticulum stress, thereby sEH has become a potential therapeutic target in cardiovascular disease and cancer therapy. Enzymes for EET biosynthesis and metabolism are both widely detected in both neuron and glial cells in the central nervous system (CNS). Recent studies discovered that astrocyte-derived EETs not only mediate neurovascular coupling and neuronal excitability by maintaining glutamate homeostasis but also glia-dependent neuroprotection. Genetic ablation as well as pharmacologic inhibition of sEH has greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models. Here, we review the literature regarding the studies on the bioactivity of EETs and their metabolic enzyme sEH with special attention paid to their action mechanisms in the CNS, including their modulation of neuronal activity, attenuation of neuroinflammation, regulation of cerebral blood flow, and improvement of neuronal and glial cells survival. We further reviewed the recent advance on the potential application of sEH inhibition for treating cerebrovascular disease, epilepsy, and pain disorder.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"1 - 11"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42276357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Osteogenic differentiation from mouse adipose-derived stem cells and bone marrow stem cells 小鼠脂肪干细胞和骨髓干细胞的成骨分化

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_64_21

Cheng-Pu Huang, Keng-Chia Hsu, Chean-Ping Wu, Hsi-Tien Wu

{"title":"Osteogenic differentiation from mouse adipose-derived stem cells and bone marrow stem cells","authors":"Cheng-Pu Huang, Keng-Chia Hsu, Chean-Ping Wu, Hsi-Tien Wu","doi":"10.4103/cjp.cjp_64_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_64_21","url":null,"abstract":"Mesenchymal stem cells (MSCs) have been successfully cultured and proliferated in vitro and can differentiate into a variety of specific cell types, such as adipocytes or osteocytes, through chemical stimulation. One of the major applications of MSCs is in regenerative medicine research. MSCs can be collected from many adult tissues. In this experiment, an 8-week-old expresses green fluorescent protein (EGFP) transgenic mouse, FVB/NCrl-Tg(Pgk1-EGFP)01Narl, was used to obtain adipose-derived stem cells (ADSCs) from abdominal adipose tissue and bone marrow stem cells (BMSCs) from femur bone marrow. We compared the differences in the growth rate and differentiation ability of ADSCs and BMSCs. The growth curves of different generations (P1 and P3) of the stem cells showed that the proliferation rate of ADSCs was significantly higher than that of BMSCs. The purity of stem cells was measured by the number of colony-forming unit fibroblast. The results show that the number of colonies of ADSCs at different generations (P1 and P3) was significantly higher than that of BMSCs and that the purity of ADSCs was greater than that of BMSCs. Comparing the ability of ADSCs and BMSCs to induce osteogenic differentiation and the expression of Runx2 and Opn genes, the results show that ADSCs had a higher rate of osteogenic differentiation than BMSCs. In summary, mouse ADSCs display similar osteogenic differentiation ability to BMSCs but have a better capacity than BMSCs in terms of stem cell purity and cell proliferation in vitro.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"21 - 29"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49088283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Age and training intensity differently affect male runners' endocrine and sexual parameters 年龄和训练强度对男性跑步者内分泌和性参数的影响不同

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_91_21

G. Passavanti, A. Paoli, Alex Rizzato, I. Ceccarelli, P. Fiorenzani, I. Casini, A. Aloisi

{"title":"Age and training intensity differently affect male runners' endocrine and sexual parameters","authors":"G. Passavanti, A. Paoli, Alex Rizzato, I. Ceccarelli, P. Fiorenzani, I. Casini, A. Aloisi","doi":"10.4103/cjp.cjp_91_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_91_21","url":null,"abstract":"Physical activity is widely recognized to improve health and its inclusion in daily life at all ages is highly recommended. Gonadal hormones are known to be affected by physical activity. The exercise-induced effects on male runners of different ages were investigated by dividing 31 runners by age (Young, Y, 30–55 years; Old, O, 56–70 years) and amount of training (Light, L, <50 km/week; Heavy, H, 50 or more km/week). To test the somatic, sexual, and psychological health aspects, the Aging Male's Symptoms Scale (AMS) and the International Index of Erectile Function-6 (IIEF-6) questionnaires were administered and blood samples were drawn for adrenocorticotropic hormone, testosterone (Total-TT), free testosterone (Free-T), cortisol (C), dihydrotestosterone (DHT), estradiol, and sex hormone-binding globulin determinations. Clinical evaluations and questionnaire results showed the presence in all groups of some subclinical symptoms and “Light” dysfunctions. TT in the old-heavy (OH) group was significantly lower than in the OL group (2.38 ± 0.18 ng/mL vs. 3.36 ± 0.44 ng/ml, P = 0.05). The TT/DHT ratio was significantly higher in YH than in OH (3.64 ± 0.16 vs. 2.92 ± 0.23, P < 0.05). TT was positively correlated with AMS sexual subscale and negatively correlated with IIEF-6. Physical activity can significantly affect andrological health and testosterone levels in runners at all ages. Thus, due to the important testosterone-mediated vital functions in men, the evaluation of these parameters would be indicated in old as well as in young subjects.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"37 - 45"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49528600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Carbohydrate mouth rinsing decreases fatigue index of taekwondo frequency speed of kick test 碳水化合物漱口降低跆拳道疲劳指数踢腿频率测试速度

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_99_21

Chih-Hui Chiu, Che-Hsiu Chen, Tsung-Jen Yang, Kuei-Ming Chou, Bo-Wei Chen, Zong-Yan Lin, Yung-Chih Lin

{"title":"Carbohydrate mouth rinsing decreases fatigue index of taekwondo frequency speed of kick test","authors":"Chih-Hui Chiu, Che-Hsiu Chen, Tsung-Jen Yang, Kuei-Ming Chou, Bo-Wei Chen, Zong-Yan Lin, Yung-Chih Lin","doi":"10.4103/cjp.cjp_99_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_99_21","url":null,"abstract":"Carbohydrate mouth rinsing (CMR) potentially affects the interval training performance of taekwondo athletes. This study explored the effect of CMR on vertical jump, kicking speed, and fatigue index before and after simulated taekwondo competition. In a crossover experimental design, 13 trained taekwondo athletes were randomly divided into the CMR and control trials. After warming up, the participants used 6.6% maltodextrin (CMR trial) or mineral water (control trial) to rinse their mouth. Next, the participants underwent tests of vertical jump, kicking speed, and maximum number of kicks. After the tests, the participants rinsed their mouth again, followed by using Wingate testing bikes for 5-s sprint and 25-s rest to simulate taekwondo competitions. Four repetitions were performed in each round for 2 min for a total of three rounds. The results revealed that the fatigue index of the participants in the CMR trial before and after the simulated competition was significantly lower than that of the control trial. However, the two trials differed nonsignificantly in their performance in vertical jump, kicking speed, and the simulated competition. Overall, the study results indicated that CMR reduces the fatigue index but no change was observed in performance for vertical jump, kicking speed, and the simulated competition of trained taekwondo athletes.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 1","pages":"46 - 50"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45618541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current research status of alkaloids against breast cancer 癌症生物碱的研究现状

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-01-01 DOI: 10.4103/cjp.cjp_89_21

Zhiqiang Hu, Jing Pan, Jialing Wang, Yanmin Pei, Ru Zhou

引用次数: 3

The risk stratification of coronary vascular disease as linked to homocysteine, its modulating genes, genetic polymorphisms, conventional predictors, and with antihypertensive medicaments. 冠状动脉疾病的风险分层与同型半胱氨酸、其调节基因、遗传多态性、常规预测因子和抗高血压药物有关。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2021-11-01 DOI: 10.4103/cjp.cjp_71_21

Rizwan Masud, Aiman Farogh Anjum, Muhammad Zeeshan Anwar, Wajahat Ullah Khan, Muhammad Akram Shahzad, Ghazala Jawwad

{"title":"The risk stratification of coronary vascular disease as linked to homocysteine, its modulating genes, genetic polymorphisms, conventional predictors, and with antihypertensive medicaments.","authors":"Rizwan Masud, Aiman Farogh Anjum, Muhammad Zeeshan Anwar, Wajahat Ullah Khan, Muhammad Akram Shahzad, Ghazala Jawwad","doi":"10.4103/cjp.cjp_71_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_71_21","url":null,"abstract":"Cardiovascular disease (CVD) have multifactorial nature, and owing to their disparate etiological roots, it is difficult to ascertain exact determinants of CVD. In the current study, primary objective was to determine association of single nucleotide polymorphisms (SNP) in folate pathway genes, homocysteine, antihypertensive medication, and of known risk factors in relation to CVD outcomes. The participants numbered 477 (controls, n = 201, ischemic heart disease patients, n = 95, and myocardial infarction cases, n = 181, respectively). SNPs that were queried for homocysteine pathway genes included, “methylene tetrahydrofolate reductase (MTHFR)” gene SNPs rs1801133 and rs1801131, “methyltransferase (MTR)” SNP rs1805087, “paraoxonase 1 (PON1)” SNP rs662, and angiotensin-converting enzyme (ACE) gene polymorphisms rs4646994. Medication data were collected through questionnaire, and serum-based parameters were analyzed through commercial kits. The analysis of variance and multiple comparison scrutiny revealed that age, gender, family history, cholesterol, creatinine, triglyceride, high density lipoproteins (HDL), homocysteine, beta-blocker, ACE inhibitors, MTHFR and PON1 SNPs related to coronary artery disease (CAD). On regression, rs662 SNPs and C-reactive protein had nonsignificant odds ratio, whereas age, gender, creatinine, and HDL were nonsignificant. Family history, cholesterol, homocysteine, beta blocker, and ACE inhibitors, homocysteine, rs1801133 and rs1801131 SNP maintained significance/significant odds for CAD. The current study indicates an intricate relationship between genetic variants, traditional factors, and drug usage in etiogenesis of arterial disease. Differences in SNPs, their modulated effects in consensus with medicinal usage may be related to ailment outcomes affecting coronary vasculature.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"64 6","pages":"298-305"},"PeriodicalIF":1.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39778355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0