Chinese Journal of Physiology最新文献_第8页

ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D. ZNF561反义RNA 1通过上调血小板源性生长因子d参与肝细胞癌血管生成。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-09-01 DOI: 10.4103/0304-4920.359795

Jihu Zheng, Zijian Guo, Zhanchao Wen, Huikang Chen

{"title":"ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D.","authors":"Jihu Zheng, Zijian Guo, Zhanchao Wen, Huikang Chen","doi":"10.4103/0304-4920.359795","DOIUrl":"https://doi.org/10.4103/0304-4920.359795","url":null,"abstract":"Hepatocellular carcinoma is a common malignant tumor with high recurrence rate. Long non-coding RNA (lncRNA) ZNF561 antisense RNA 1 (ZNF561-AS1) functions as an oncogenic lncRNA to promote the tumorigenesis of colorectal cancer. The role of ZNF561-AS1 in hepatocellular carcinoma remains unknown. ZNF561-AS1 was elevated in hepatocellular carcinoma tissues and cells. Silence of ZNF561-AS1 reduced cell viability and inhibited the proliferation of hepatocellular carcinoma. The angiogenesis of hepatocellular carcinoma was also suppressed by loss of ZNF561-AS1 with a decrease of angiopoietin 2, fibroblast growth factor 1, and vascular endothelial growth factor. ZNF561-AS1 bind to miR-302a-3p, and decreased expression of miR-302a-3p in hepatocellular carcinoma. Moreover, miR-302a-3p reduced platelet-derived growth factor-D (PDGFD) in hepatocellular carcinoma, and inhibition of miR-302a-3p attenuated ZNF561-AS1 silence-induced decrease of PDGFD. In conclusion, silence of ZNF561-AS1 might inhibit cell proliferation and angiogenesis of hepatocellular carcinoma through downregulation of miR-302a-3p-mediated PDGFD.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 5","pages":"258-265"},"PeriodicalIF":1.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40456076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forkhead Box S1 inhibits the progression of lung squamous cell carcinoma cells by mediating Wnt/β-catenin pathway. Forkhead Box S1通过介导Wnt/β-catenin通路抑制肺鳞癌细胞的进展。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-09-01 DOI: 10.4103/0304-4920.359799

Fei Wang, Song Li

引用次数: 1

Prazosin improves neurogenic acute heart failure through downregulation of fibroblast growth factor 23 in rat hearts. 哌唑嗪通过下调大鼠心脏成纤维细胞生长因子23改善神经源性急性心力衰竭。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/cjp.cjp_9_22

Jun-Yen Pan, Wen-Hsien Lu, Chieh-Jen Wu, Ching-Jiunn Tseng, Hsin-Hung Chen

{"title":"Prazosin improves neurogenic acute heart failure through downregulation of fibroblast growth factor 23 in rat hearts.","authors":"Jun-Yen Pan, Wen-Hsien Lu, Chieh-Jen Wu, Ching-Jiunn Tseng, Hsin-Hung Chen","doi":"10.4103/cjp.cjp_9_22","DOIUrl":"https://doi.org/10.4103/cjp.cjp_9_22","url":null,"abstract":"Bilateral nucleus tractus solitarii (NTS) lesions, possibly caused by enterovirus 71 infection, cause severe neurogenic hypertension, leading to acute heart failure (HF), pulmonary edema, and death within hours. Alpha-adrenergic blockers attenuate blood pressure and ameliorate HF and pulmonary edema, thereby prolonging survival time. However, the molecular mechanisms of these blockers are not clear. In this study, we investigated these mechanisms in a rat model of 6-hydroxydopamine (6-OHDA)-induced HF. Sprague-Dawley rats were treated with prazosin 10 min after the microinjection of 6-OHDA into the NTS. Immunohistochemistry and dihydroethidium (DHE) staining were used for analysis. In the cardiac tissue of 6-OHDA-induced HF, in situ expression of tumor necrosis factor-alpha (TNF-α), fibroblast growth factor-23 (FGF23), and FGF receptor 1 (FGFR1) increased, but in situ expression of Vitamin D receptor (VDR) decreased. DHE staining revealed several heart cells with high reactive oxygen species production. Prazosin treatment decreased TNF-α, FGF23, and FGFR1 expression in the heart of rats with 6-OHDA-induced HF. It also prevented cardiomyopathy caused by 6-OHDA-induced bilateral NTS lesions by inhibiting the FGF23-FGFR1 pathway and downregulating TNF-α expression. In situ, FGF23, FGFR1, VDR, superoxide, and TNF-α in the heart were found to be involved in acute HF in our rat model of 6-OHDA-induced bilateral NTS lesions. These findings are potentially useful for treating fatal enterovirus 71 infection-induced NTS lesions and HF.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"179-186"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling. 18β-甘草次酸通过PERK/eIF2α/NF-κB信号通路改善内质网应激性肺动脉高压炎症。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/0304-4920.354801

Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou

{"title":"18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling.","authors":"Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou","doi":"10.4103/0304-4920.354801","DOIUrl":"https://doi.org/10.4103/0304-4920.354801","url":null,"abstract":"Endoplasmic reticulum stress (ERS)-induced inflammation participates in the occurrence of pulmonary arterial hypertension (PAH) by promoting pulmonary vascular remodeling, which involved in the activation of PERK/eIF2α/NF-κB signaling pathway. 18β-Glycyrrhetinic acid (18β-GA) has been found efficacious for attenuating PAH through its anti-remodeling effects in our previous research and it remains unclear whether 18β-GA has an effect on the remodeling caused by ERS-induced inflammation. In this study, we made observations in monocrotaline-induced PAH rats and found improvement of hemodynamic and histopathological parameters, decreases in the right ventricular hypertrophy index, and alleviation of pulmonary vascular remodeling after 18β-GA administration in vivo. Moreover, 18β-GA could significantly inhibit the proliferation and DNA synthesis of human pulmonary arterial smooth muscle cells (HPASMCs) induced by platelet-derived growth factor BB. At the cellular and molecular levels, we found that 18β-GA could significantly reduce the accumulation of misfolded protein in rat lung tissue, inhibit ERS activation, reduce the expression of GRP78, p-PERK, p-eIF2α, and p-NF-κB p65, and increase IκB protein expression. 18β-GA could inhibit the migration of NF-κB into the nucleus, reduce the contents of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and monocyte chemoattractant protein-1 (MCP-1) in the culture supernatant of HPASMCs, and reduce GRP78, p-PERK, p-eIF2α, p-NF-κB p65, TNF-α, IL-6, and MCP-1 protein expression, increase IκB protein expression in HPASMCs. According to what we observed, this study indicated that 18β-GA could treat PAH, which is related to the inhibition of PERK/eIF2α/NF-κB signaling pathway.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"187-198"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of taurine against benzo[α]pyrene-induced cell cycle arrest and reactive oxygen species-mediated nuclear factor-kappa B apoptosis via reduction of mitochondrial stress in A549 cells. 牛磺酸通过减少线粒体应激对苯并[α]芘诱导的细胞周期阻滞和活性氧介导的核因子κ B凋亡的影响。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/0304-4920.354803

Bi-Yu Liu, Jia-Zhen Chiou, Ken-Meng Huang, Tai-Yuan Chen, Deng-Fwu Hwang

{"title":"Effects of taurine against benzo[α]pyrene-induced cell cycle arrest and reactive oxygen species-mediated nuclear factor-kappa B apoptosis via reduction of mitochondrial stress in A549 cells.","authors":"Bi-Yu Liu, Jia-Zhen Chiou, Ken-Meng Huang, Tai-Yuan Chen, Deng-Fwu Hwang","doi":"10.4103/0304-4920.354803","DOIUrl":"https://doi.org/10.4103/0304-4920.354803","url":null,"abstract":"Taurine is a free amino acid that prevents reactive oxygen species (ROS) formation. ROS production is associated with oxidative stress, cell proliferation, apoptosis, inflammation, and DNA alterations in benzo[α]pyrene (BaP)-induced lung cells. Here, we assessed the effect of adding of 25 mM taurine on human pulmonary alveolar epithelial A549 cells treated with different concentrations of BaP. After culturing for 24 h, the cells were tested for biomarkers including cell viability, cellular morphology, Annexin V-FITC/propidium iodide, cell cycle regulation, ROS accumulation, mitochondrial membrane potential (MMP), and expression of related signaling genes and proteins. BaP induced cell cycle arrest and decreased cell viability in a dose-dependent manner. In addition, 50 μM BaP induced a 52.2% increase in ROS levels and inhibited MMP by up to 80%; however, taurine decreased BaP-induced ROS production by 19.5% and restored MMP. The expression of nuclear factor-kappa B (NF-κB), B-cell lymphoma-2 (BCL-2) homologous antagonist killer (Bak), BCL-2-associated X protein (Bax), and cytochrome c at both the mRNA and protein levels were increased, and the expression of BCL-2 and BCL-x1 was decreased by BaP treatment. Furthermore, BaP activated caspase-3/7 expression by up to 25%. However, taurine decreased the expression of NF-κB, Bak, Bax and cytochrome c levels, reduced caspase-3/7 activities, and increased the expression of BCL-2 and BCL-x1. Hence, taurine attenuates BaP-induced oxidative stress and mitochondrial dysfunction by inhibiting the NF-κB-mediated intrinsic apoptosis pathway in A549 cells. Taurine can be considered as a preventive molecule to prevent lung damage.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"199-208"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Corrigendum: Action of the natural compound gomisin a on Ca²⁺ movement in human prostate cancer cells. 勘误:天然化合物gomisin a对人前列腺癌细胞中Ca2+运动的作用。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/0304-4920.353680

引用次数: 0

Dose-dependent effect of retrieval-extinction on preventing reinstatement of cocaine-associated memory in mice. 提取-消退对预防小鼠可卡因相关记忆恢复的剂量依赖性作用。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/0304-4920.354804

Heng-Ai Chang, Wen Dai, Sherry Shu-Jung Hu

{"title":"Dose-dependent effect of retrieval-extinction on preventing reinstatement of cocaine-associated memory in mice.","authors":"Heng-Ai Chang, Wen Dai, Sherry Shu-Jung Hu","doi":"10.4103/0304-4920.354804","DOIUrl":"https://doi.org/10.4103/0304-4920.354804","url":null,"abstract":"As a noninvasive behavioral intervention, the retrieval-extinction (R-E) procedure has drawn much research attention for its capacity to target the reconsolidation of maladaptive memories. However, later research findings suggest that the cause and consequence of R-E may be more complicated than previously suggested. For example, the R-E procedure could increase an animal's motivation for drug-seeking under certain circumstances, and the reversed extinction-retrieval (E-R) procedure could also suppress the drug memory. Two possible mechanisms underlying the R-E procedure have been proposed: the reconsolidation-update and extinction-facilitation hypotheses. To elucidate the paradoxical prior findings and examine these two hypotheses, we systematically examined the efficacy of the extinction (E), R-E, and E-R procedures in mice's low-dose versus high-dose cocaine-induced conditioned place preference (CPP) memory. We showed that the dose of cocaine is a crucial determinant of the efficacy of the three behavioral interventions. The E procedure exerted a long-lasting suppression of the low-dose cocaine CPP memory, while the R-E procedure induced more memory defects than the E and E-R procedures in its long-term suppression of the high-dose cocaine CPP memory. It warrants further investigation of whether the R-E procedure's underlying neurochemical and molecular mechanisms differ from the E and E-R procedures.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"159-170"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antrodia salmonea extract inhibits cell proliferation through regulating cell cycle arrest and apoptosis in prostate cancer cell lines. 沙门氏菌提取物通过调节前列腺癌细胞的细胞周期阻滞和细胞凋亡抑制细胞增殖。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/cjp.cjp_78_21

Pang-Ting Cheng, Yu-Chiao Cheng, Muhammet Oner, Yu-Hsuan Li, Mei-Chih Chen, Jyh-Horng Wu, Ting-Chieh Chang, Ayse Celik, Fang-Ling Liu, Hsin-Yi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Chieh-Yin Chen, Ho Lin

{"title":"Antrodia salmonea extract inhibits cell proliferation through regulating cell cycle arrest and apoptosis in prostate cancer cell lines.","authors":"Pang-Ting Cheng, Yu-Chiao Cheng, Muhammet Oner, Yu-Hsuan Li, Mei-Chih Chen, Jyh-Horng Wu, Ting-Chieh Chang, Ayse Celik, Fang-Ling Liu, Hsin-Yi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Chieh-Yin Chen, Ho Lin","doi":"10.4103/cjp.cjp_78_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_78_21","url":null,"abstract":"Antrodia salmonea (AS) is a fungus, which belongs to a fungal family of Taiwanofungus salmoneus with the features of anti-oxidant, anti-inflammatory, and anticancer. Recent studies have shown that AS has anti-cancer functions in ovarian and breast cancer. However, the effects of AS on prostate cancer (PCa) proliferation remain unknown. Therefore, we investigated the role of AS in PCa proliferation through apoptosis, and cell cycle regulation in PCa cell lines. Our results showed that Antrodia salmonea extract (ASE) inhibited PCa cells growth with a dose-dependent manner. In addition, ASE decreased the anchorage-independent growth formation ability in PC3 cells. Moreover, ASE-induced cell growth inhibition in PCa cells (DU145, PC3) was correlated to decreased cell cycle-related proteins such as cyclin A/B and cyclin-dependent kinase CDK1/2/4, and increased cell cycle inhibitor proteins p21. Besides, ASE decreased the total protein level of epidermal growth factor receptor and its downstream signaling pathways Akt and Erk in both PCa cells. We found that apoptotic markers such as cleaved-PARP protein levels increased significantly in DU145 cells indicating ASE might induce apoptosis. In conclusion, our results suggest that ASE may have the ability to induce PCa cell death through regulating cell cycle arrest and apoptosis pathways.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"209-214"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spectral analysis of cardiovascular oscillations in the 7-day regimen of losartan administration with and without cold stress. 氯沙坦治疗伴和不伴冷应激的7天心血管振荡谱分析。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-07-01 DOI: 10.4103/0304-4920.354802

Yia-Ping Liu, Yu-Chieh Lin, Chen-Cheng Lin, Shi-Hung Tsai, Che-Se Tung

{"title":"Spectral analysis of cardiovascular oscillations in the 7-day regimen of losartan administration with and without cold stress.","authors":"Yia-Ping Liu, Yu-Chieh Lin, Chen-Cheng Lin, Shi-Hung Tsai, Che-Se Tung","doi":"10.4103/0304-4920.354802","DOIUrl":"https://doi.org/10.4103/0304-4920.354802","url":null,"abstract":"Spectral analysis of heart rate (HR) and blood pressure (BP) variabilities (BPV and HRV) is widely available and utilized in understanding the dynamic cardiovascular autonomic regulation in a variety of pathophysiological conditions. In conscious cold-stressed (CS) rats, we examined the effect of a 7-day regimen administration of losartan, a selective nonpeptide angiotensin AT1 receptor blockade, on BPV and HRV at three frequency components: very-low frequency (VLF), low frequency (LF), and high frequency (HF). Key findings in changes of systolic BP (SBP), HR, and spectral power densities for cardiopulmonary oscillations (HF), sympathetic oscillations (LF), cardiovascular myogenic oscillations (VLF), and overall autonomic activity total power (TP) showed: (I) In the resting PreCS trial, compared with the saline, losartan increased HFBPV, TPHRV, all three HRV frequency powers, and the occurrence of the dicrotic notch (DN). However, it decreased SBP, HR, and the LFBPV frequency power. (II) In the CS trial, losartan significantly decreased SBP and DN occurrence and HR and LF/HFHRV but significantly increased HFHRV, TPBPV, and all three BPV frequency powers. In addition, similar to the saline, losartan showed positively correlated LFBPV and VLFBPV. Conversely, losartan converted the original inverse correlations between LFHRV and LFBPV of CS to a positive correlation. (III) Compared with saline in PreCS and CS trials, losartan detached the corresponding sympathetic oscillations between LFBPV and LFHRV. The overall result indicates that endogenous angiotensin II, through stimulation of the AT1 receptor, augments sympathetic tone but attenuates sympathetic oscillations in rats, particularly under the stressful cooling impacts.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 4","pages":"171-178"},"PeriodicalIF":1.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of pleural fluid lactate dehydrogenase-to-adenosine deaminase ratio in differentiating the etiology of pleural effusions. 胸膜液乳酸脱氢酶与腺苷脱氨酶比值在鉴别胸腔积液病因中的作用。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-05-01 DOI: 10.4103/cjp.cjp_104_21

Chun-Yee Ho, Yu-Hui Tsai, Chih-Chun Chang, Huei-Ling Huang, N-Chi Tan, Wei-Chi Chen, Ka-I Leong

{"title":"The role of pleural fluid lactate dehydrogenase-to-adenosine deaminase ratio in differentiating the etiology of pleural effusions.","authors":"Chun-Yee Ho, Yu-Hui Tsai, Chih-Chun Chang, Huei-Ling Huang, N-Chi Tan, Wei-Chi Chen, Ka-I Leong","doi":"10.4103/cjp.cjp_104_21","DOIUrl":"https://doi.org/10.4103/cjp.cjp_104_21","url":null,"abstract":"Exudative pleural effusion includes tuberculous pleural effusion (TPE), parapneumonic pleural effusion (PPE), and malignant pleural effusion (MPE). An elevated pleural fluid adenosine deaminase (ADA) typically implies TPE, but the rule may not apply to every individual case. Recent studies proposed that the pleural fluid lactate dehydrogenase (LDH)-to-ADA ratio showed a higher diagnostic power than pleural fluid ADA alone in differentiating the etiology of pleural effusion. Hence, we aimed to investigate the performance of pleural fluid LDH-to-ADA ratio as a biomarker in assistance with the diagnosis of TPE, PPE, and MPE. All patients who underwent thoracentesis for the first time with a pleural fluid ADA >40 U/L were included in this retrospective study. The clinical data including pleural fluid ADA and LDH-to-ADA ratio were analyzed. A total of 311 patients were enrolled during the study interval. The pleural fluid LDH-to-ADA ratio <14.2 (sensitivity: 74.2%; specificity: 90.4%) favored TPE, while the pleural fluid LDH-to-ADA ratio >14.5 (sensitivity: 79.9%; specificity: 78.5%) favored PPE. Besides, the pleural fluid LDH-to-ADA ratio >46.7 (sensitivity: 56.3%; specificity: 78.3%) favored MPE owing to primary lung cancers. In conclusion, the pleural fluid LDH-to-ADA ratio was an effective indicator in differentiating the etiology of pleural effusions in the cases of high ADA level in the pleural fluid.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 3","pages":"105-108"},"PeriodicalIF":1.8,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40551784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1