Chinese Journal of Physiology最新文献_第6页

Protocatechuic acid reduces H₂O₂-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway. 原儿茶酸通过激活Nrf2-Keap1信号通路，降低h2o2诱导的类风湿性关节炎成纤维细胞样滑膜细胞的迁移和氧化应激。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00087

Yan Liu, Yucheng Zhang, Keke Zhang, Yue Wang

{"title":"Protocatechuic acid reduces H2O2-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway.","authors":"Yan Liu, Yucheng Zhang, Keke Zhang, Yue Wang","doi":"10.4103/cjop.CJOP-D-22-00087","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00087","url":null,"abstract":"Honeycomb (Nidus vespae) is traditional Chinese medicine and can treat rheumatoid arthritis (RA), and protocatechuic acid (PCA) is a bioactive component of honeycomb. This study aimed to investigate whether PCA could reduce the H2O2-induced migration and oxidative stress of RA fibroblast-like synoviocytes (RA-FLSs). H2O2-induced RA-FLSs were used to simulate the in vitro model of RA. The viability, apoptosis, migration, invasion, and oxidative stress of RA-FLSs were detected by Cell Counting Kit-8 (CCK-8), terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, wound healing, transwell assays, DCFDA staining, and malonaldehyde and superoxide dismutase enzyme-linked immunosorbent assay kits. The expression of migration and invasion-related proteins and Nrf2/Keap1 signaling pathway-related proteins was analyzed by western blotting. As a result, PCA suppressed the viability, migration, invasion, and oxidative and promoted apoptosis of H2O2-induced RA-FLSs by activating the Nrf2/Keap1 signaling pathway. ML-385, an Nrf2 inhibitor, could enhance the viability, migration, invasion, and oxidative and inhibited apoptosis of H2O2-induced RA-FLSs. In conclusion, PCA reduced H2O2-induced migration and oxidative stress of RA-FLSs by activating the Nrf2-Keap1 signaling pathway.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"28-35"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Long non-coding RNA LINC00565 regulates ADAM19 expression through sponging MicroRNA-532-3p, thereby facilitating clear cell renal cell carcinoma progression 长链非编码RNA LINC00565通过海绵化MicroRNA-532-3p调控ADAM19的表达，从而促进透明细胞肾细胞癌的进展

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-23-00078

Chengquan Yan, Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai

{"title":"Long non-coding RNA LINC00565 regulates ADAM19 expression through sponging MicroRNA-532-3p, thereby facilitating clear cell renal cell carcinoma progression","authors":"Chengquan Yan, Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai","doi":"10.4103/cjop.cjop-d-23-00078","DOIUrl":"https://doi.org/10.4103/cjop.cjop-d-23-00078","url":null,"abstract":"Proven by publications, long non-coding RNAs (lncRNAs) play critical roles in the development of clear cell renal cell carcinoma (ccRCC). Although lncRNA LINC00565 has been implicated in the progression of various cancers, its biological effects on ccRCC remain unknown. This study aimed to investigate the biological functions of LINC00565, as well as its potential mechanism in ccRCC. Here, the expression data of mature microRNAs (miRNAs) (normal: 71, tumor: 545), messenger RNAs (mRNAs), and lncRNAs (normal: 72, tumor: 539) of ccRCC were acquired from The Cancer Genome Atlas (TCGA) database and subjected to differential expression analysis. Quantitative reverse transcriptase polymerase chain reaction analyzed the expression levels of LINC00565, miR-532-3p, and ADAM19 mRNA. TCGA database, dual-luciferase report detection, and Argonaute 2 RNA immunoprecipitation were utilized to confirm the relationships between LINC00565 and miR-532-3p and between miR-532-3p and ADAM19, respectively. The progression of ccRCC cells was determined via CCK-8, colony formation, scratch healing, and transwell assays. Western blot was applied to detect the protein levels of epithelial-mesenchymal transition markers and ADAM19. We herein suggested that LINC00565 was prominently upregulated in ccRCC tissues and cells. Knockdown of LINC00565 repressed cell progression. We further predicted and validated miR-532-3p as a target of LINC00565, and miR-532-3p could target ADAM19. Knockdown of LINC00565 resulted in ADAM19 level downregulation in ccRCC cells and suppressed miR-532-3p could restore ADAM19 level. Thus, the three RNAs constructed a ceRNA network. Overexpressed ADAM19 could eliminate the anticancer effects caused by knocking down LINC00565 on ccRCC cells. In conclusion, LINC00565 upregulated ADAM19 via absorbing miR-532-3p, thereby facilitating the progression of ccRCC cells.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative anemia: Predictor of free flap reconstruction complications in head and neck cancer. 术前贫血:头颈癌游离皮瓣重建并发症的预测因子。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00115

Cheng Hung Tu, San Fu Hong

{"title":"Preoperative anemia: Predictor of free flap reconstruction complications in head and neck cancer.","authors":"Cheng Hung Tu, San Fu Hong","doi":"10.4103/cjop.CJOP-D-22-00115","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00115","url":null,"abstract":"Free flap reconstruction has been the mainstay among reconstruction surgeries for head and neck cancer. Intraoperative and postoperative hemoglobin (Hb) levels were both possible risk factors of flap failure and had been discussed widely. However, few investigations of preoperative Hb were seen in the previous study with its effect to flap condition remain uncertain and no conclusions in the literature. Patients who underwent free flap reconstruction after head and neck surgery in our institution between May 2014 and May 2019 were enrolled. The postoperative flap condition was observed carefully, and re-exploration was performed if necessary. We then retrospectively collected patient data with several intraoperative and postoperative indices. A total of 598 patients were enrolled in our study. The total major flap complication rate was 10.6%, with an overall success rate of 89.4%. They were predominantly male (95%), and most of them underwent free flap reconstruction for the first time (91%). A total of 81 (13%) patients received radiotherapy before reconstruction. Among all factors, the preoperative Hb level and free flap type showed significance in univariate and multivariate analyses. A previous history of radiotherapy, body mass index, nutrition status, or poorly controlled diabetes mellitus showed no significant results in either univariate or multivariate analysis. Our study showed that a lower preoperative Hb level affects free flap survival. Meanwhile, preoperative radiotherapy history has no significant influence in either univariate or multivariate analysis.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"21-27"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m⁶A modification of protein arginine methyltransferase 6. MiR-141-3p通过AlkB同源物5介导的蛋白精氨酸甲基转移酶6的m6A修饰促进前列腺癌的恶性进展。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00071

Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge

{"title":"MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6.","authors":"Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge","doi":"10.4103/cjop.CJOP-D-22-00071","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00071","url":null,"abstract":"Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease. Although the functions of miR-141-3p and AlkB homolog 5 (ALKBH5) were identified in some cancers, whether they were involved in the development of PCa remains unclear. In this study, reverse transcription-quantitative polymerase chain reaction unveiled that the expression of ALKBH5 was reduced in PCa tissues and was negatively correlated with miR-141-3p. ALKBH5 attenuated the malignant development of PCa through suppressing the growth, migration, invasion, and sphere formation abilities of PCa cells. In addition, the luciferase activity assay identified that ALKBH5 was corroborated as a downstream target of miR-141-3p. Moreover, miR-141-3p expression was boosted in PCa tissues and cells and inhibition of miR-141-3p suppressed the tumor growth of PCa in vivo. Moreover, ALKBH5 was confirmed to suppress protein arginine methyltransferase 6 (PRMT6) expression through N6-methyladenosine (m6A) modification. We further identified that miR-141-3p-modulated PRMT6 level through mediating ALKBH5. Furthermore, PRMT6 level was positively correlated with miR-141-3p level and negatively associated with ALKBH5 level. Finally, rescue assays also uncovered that miR-141-3p aggravated PCa development by regulating PRMT6. In conclusion, miR-141-3p accelerated the malignant progression of PCa through ALKBH5-mediated m6A modification of PRMT6, which might offer a novel insight into the role of miR-141-3p and ALKBH5 in the treatments of PCa patients.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"43-51"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages 黄花菜可以改善人体睡眠质量，减少巨噬细胞中一氧化氮和白细胞介素-6的产生

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-22-00043

Po-Ching Wu, Kuo-Feng Hua, Li-Min Hsu, Hua-Wei Chen

{"title":"Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages","authors":"Po-Ching Wu, Kuo-Feng Hua, Li-Min Hsu, Hua-Wei Chen","doi":"10.4103/cjop.cjop-d-22-00043","DOIUrl":"https://doi.org/10.4103/cjop.cjop-d-22-00043","url":null,"abstract":"The flowers of daylily (Hemerocallis fulva Linn.) have been used as vegetable and medicinal herb for thousands of years in Taiwan and eastern Asia. Daylily flowers have been demonstrated to exert several biomedical properties. In this study, we provided the evidences show that daylily flowers exert anti-inflammatory activity in vitro and improved the sleep quality in vivo. We demonstrated that adult volunteers received water extract of daylily flowers improved sleep quality, sleep efficiency and daytime functioning, while sleep latency was reduced, compared to the adult volunteers received water. In addition, we demonstrated that aqueous and ethanol extracts of daylily flowers inhibited nitric oxide and interleukin-6 production in lipopolysaccharide-activated macrophages. Furthermore, the quantitative high performance liquid chromatography-based analysis showed the rutin content of the aqueous extract, ethanolic extract, ethyl acetate fractions of ethanolic extract, and water fractions of ethanolic extract were 7.27, 23.30, 14.71, and 57.43 ppm, respectively. These results indicate that daylily flowers have the potential to be a nutraceutical for improving inflammatory-related diseases and sleep quality in the future.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135495290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAMTS13 inhibits H₂O₂-induced human venous endothelial cell injury to attenuate deep-vein thrombosis by blocking the p38/ERK signaling pathway ADAMTS13通过阻断p38/ERK信号通路抑制h2o2诱导的人静脉内皮细胞损伤，减轻深静脉血栓形成

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-23-00101

Jianjie Rong, Guangfeng Zheng, Qiang Zhang, Chuanyong Li, Weijian Fan, Zhichang Pan, Yuting Zhou, Yan Chen

引用次数: 0

GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ_1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis. gata结合蛋白4通过小核仁RNA宿主基因1/miR-361-3p轴促进Aβ1-42原纤维灌注大鼠的神经炎症和认知功能障碍。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00057

Lidan Liu, Yanhui Peng, Wenping Liu, Jiajun Xu, Dali Li, Xiuwen Li

{"title":"GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis.","authors":"Lidan Liu, Yanhui Peng, Wenping Liu, Jiajun Xu, Dali Li, Xiuwen Li","doi":"10.4103/cjop.CJOP-D-22-00057","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00057","url":null,"abstract":"Aging with dysregulated metabolic and immune homeostasis stimulates pyroptosis, neuroinflammation, and cellular senescence, thus contributing to etiopathogenesis of Alzheimer's disease. GATA-binding protein 4 (GATA4) functions as a transcriptional factor in response to DNA damage, and is associated with neuroinflammation and cellular senescence. The role of GATA4 in Alzheimer's disease was investigated. GATA4 was elevated in hippocampus of Aβ1-42 fibril-infused rats. Injection with shRNA targeting GATA4 reduced escape latency with increase of time in target quadrant and number of platform crossings in Aβ1-42 fibril-infused rats. Moreover, knockdown of GATA4 ameliorated morphological changes of hippocampus and reduced amyloid plaque deposition in Aβ1-42 fibril-infused rats. Silence of GATA4 repressed neuroinflammation and apoptosis in Aβ1-42 fibril-infused rats. Loss of GATA4 in Aβ1-42 fibril-infused rats reduced the expression of specificity protein 1 (Sp1) to downregulate long noncoding RNA small nucleolar RNA host gene 1 (SNHG1) and upregulated miR-361-3p. Loss of SNHG1 ameliorated learning and memory impairments in Aβ1-42 fibril-infused rats. Overexpression of Sp1 attenuated GATA4 silence-induced decrease of escape latency, increase of time in target quadrant, and number of platform crossings in Aβ1-42 fibril-infused rats. In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR-361-3p.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"14-20"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholinergic deficiency in the cholinergic system as a pathogenetic link in the formation of various syndromes in COVID-19. 胆碱能系统胆碱能缺乏是COVID-19各种综合征形成的一个发病环节。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.CJOP-D-22-00072

Sergey Petrovich Lysenkov, Dmitriy Vitalevich Muzhenya, Aminat Ramazanovna Tuguz, Tamara Ur'evna Urakova, Dmitriy Sergeevich Shumilov, Ibragim Askarbievich Thakushinov, Rustem Askarbievich Thakushinov, Elena Anatolevna Tatarkova, Diana Muratovna Urakova

{"title":"Cholinergic deficiency in the cholinergic system as a pathogenetic link in the formation of various syndromes in COVID-19.","authors":"Sergey Petrovich Lysenkov, Dmitriy Vitalevich Muzhenya, Aminat Ramazanovna Tuguz, Tamara Ur'evna Urakova, Dmitriy Sergeevich Shumilov, Ibragim Askarbievich Thakushinov, Rustem Askarbievich Thakushinov, Elena Anatolevna Tatarkova, Diana Muratovna Urakova","doi":"10.4103/cjop.CJOP-D-22-00072","DOIUrl":"https://doi.org/10.4103/cjop.CJOP-D-22-00072","url":null,"abstract":"According to recent data, several mechanisms of viral invasion of the central nervous system (CNS) have been proposed, one of which is both direct penetration of the virus through afferent nerve fibers and damage to the endothelium of cerebral vessels. It has been proven that the SARS-CoV-2 virus affects pathologically not only the human cardiorespiratory system but is also associated with a wide range of neurological diseases, cerebrovascular accidents, and neuromuscular pathologies. However, the observed post-COVID symptom complex in patients, manifested in the form of headache, \"fog in the head,\" high temperature, muscle weakness, lowering blood pressure, does it make us think about the pathophysiological mechanisms that contribute to the development of this clinical picture? One possible explanation is a disruption in the signaling of the acetylcholine system (AChS) in the body. Viral invasions, and in particular COVID-19, can negatively affect the work of the AChS, disrupting its coordination activities. Therefore, the main goal of this literature review is to analyze the information and substantiate the possible mechanisms for the occurrence of post-COVID syndrome in people who have had COVID-19 from the standpoint of AChS dysfunctions.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"66 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Beta-hydroxy-beta-methylbutyrate supplementation preserves fat-free mass in collegiate boxers during acute body mass loss β -羟基- β -甲基丁酸盐补充保留无脂肪质量在急性体重损失的大学拳击手

4区医学

Chinese Journal of Physiology Pub Date : 2023-01-01 DOI: 10.4103/cjop.cjop-d-23-00074

Chen-Kang Chang, Shih-Yen Kao, Chung-Yuan Wang

引用次数: 0

LncRNA colorectal neoplasia differentially expressed promotes glycolysis of liver cancer cells by regulating hypoxia-inducible factor 1α. LncRNA结直肠癌差异表达通过调控缺氧诱导因子1α促进肝癌细胞糖酵解。

IF 1.8 4区医学

Chinese Journal of Physiology Pub Date : 2022-11-01 DOI: 10.4103/0304-4920.365458

Dan Tang, Lijin Zhao, Rui Mu, Yu Ao, Xuyang Zhang, Xiongxiong Li

{"title":"LncRNA colorectal neoplasia differentially expressed promotes glycolysis of liver cancer cells by regulating hypoxia-inducible factor 1α.","authors":"Dan Tang, Lijin Zhao, Rui Mu, Yu Ao, Xuyang Zhang, Xiongxiong Li","doi":"10.4103/0304-4920.365458","DOIUrl":"https://doi.org/10.4103/0304-4920.365458","url":null,"abstract":"LncRNAs are associated with tumorigenesis of liver cancer. LncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) was identified as an oncogenic lncRNA and involved in tumor growth and metastasis. The role of CRNDE in liver cancer was investigated. CRNDE was elevated in liver cancer cells. Knockdown of CRNDE decreased cell viability and inhibited proliferation of liver cancer. Moreover, knockdown of CRNDE reduced levels of extracellular acidification rate, glucose consumption, and lactate production to repress glycolysis of liver cancer. Silence of CRNDE enhanced the expression of miR-142 and reduced enhancer of zeste homolog 2 (EZH2) and hypoxia-inducible factor 1α (HIF-1α). Over-expression of HIF-1α attenuated CRNDE silence-induced decrease of glucose consumption and lactate production. Injection with sh-CRNDE virus reduced in vivo tumor growth of liver cancer through up-regulation of miR-142 and down-regulation of EZH2 and HIF-1α. In conclusion, knockdown of CRNDE suppressed cell proliferation, glycolysis, and tumor growth of liver cancer through EZH2/miR-142/HIF-1α.","PeriodicalId":10251,"journal":{"name":"Chinese Journal of Physiology","volume":"65 6","pages":"311-318"},"PeriodicalIF":1.8,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10522919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0