Infectious disorders drug targets最新文献_第6页

Breakthrough Opportunities of Nanotheranostics in Psoriasis: From Pathogenesis to Management Strategy. 纳米治疗银屑病的突破性机遇：从发病机制到管理策略。

Infectious disorders drug targets Pub Date : 2024-07-23 DOI: 10.2174/0118715265298802240603120251

Abhishek Singh, Prashant Kumar, Himanshu Sharma

{"title":"Breakthrough Opportunities of Nanotheranostics in Psoriasis: From Pathogenesis to Management Strategy.","authors":"Abhishek Singh, Prashant Kumar, Himanshu Sharma","doi":"10.2174/0118715265298802240603120251","DOIUrl":"https://doi.org/10.2174/0118715265298802240603120251","url":null,"abstract":"Background: In this paper, we have discussed recent advances in our understanding of the aetiology of psoriasis, particularly as they relate to aryl hydrocarbon receptors in DCs, Langerhans cells, macrophages, signal transducer and activator of transcription 3 pathways, and dermal vascular endothelial cells. Here, we have shown that the ability to target specific cellular and molecular components of psoriasis pathogenesis with nanoscale precision using phos-phodiesterase 4 inhibitors represents a transformative opportunity to address the complex nature of this dermatological condition.Objective: In this review, we have examined the molecular mechanisms behind the pathogenic features of psoriasis and new treatments being tested in clinical settings. There is research being done on new treatments created in the last ten years. This field highlights the advantages of nan-otechnological technologies as cutting-edge candidates for drug delivery systems in psoriasis and other inflammatory chronic skin disorders. Future Developments: Nanotechnology-based treatments currently under study show good effi-cacy and low side effect profiles. However, long-term prospective trials are required to demon-strate long-term safety and effectiveness. Phosphodiesterase inhibitors, Janus kinase inhibitors, nonsteroidal anti-inflammatory drugs, combinations of vitamin D3 derivatives and corticoster-oids, and coal tar formulations are some of the newer topical treatments for psoriasis.Conclusion: The psoriasis treatment continues to involve conventional medications (i.e., medi-cines that are generally acknowledged as either normal therapy or outdated remedies), whether used topically or orally. Nonetheless, we are starting to see initiatives to create pharmaceuticals and biosimilars with better therapeutic results, fewer side effects, and greater efficacy.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Role of SARS-CoV-2 or mRNA Vaccine Spike Protein in Macrophage Activation Syndrome (MAS). 揭示 SARS-CoV-2 或 mRNA 疫苗尖峰蛋白在巨噬细胞活化综合征 (MAS) 中的作用。

Infectious disorders drug targets Pub Date : 2024-07-22 DOI: 10.2174/0118715265341206240722050403

Ziad Fajloun, Layla Tajer, Ziad Abi Khattar, Jean-Marc Sabatier

引用次数: 0

India's Pink-Eye Mystery: Decoding the 2023 Conjunctivitis Outbreak. 印度的红眼病之谜：解密 2023 年结膜炎爆发。

Infectious disorders drug targets Pub Date : 2024-07-19 DOI: 10.2174/0118715265291922240625054709

Tuhin James Paul, Ayushreeya Banga, Ashmeen Kaur, Sonakshi Garg, Amandeep Singh

{"title":"India's Pink-Eye Mystery: Decoding the 2023 Conjunctivitis Outbreak.","authors":"Tuhin James Paul, Ayushreeya Banga, Ashmeen Kaur, Sonakshi Garg, Amandeep Singh","doi":"10.2174/0118715265291922240625054709","DOIUrl":"https://doi.org/10.2174/0118715265291922240625054709","url":null,"abstract":"The pink eye outbreak in 2023 was caused due to humid weather conditions in most regions of India. The most affected states include Delhi, Gujrat (21% cases), Maharashtra (30%), Himachal Pradesh (4%) and Karnataka (4%). The epidemiological data indicates that males have a high prevalence rate as compared to females; urban areas were most affected, and professionals as well as students were the population group that had the highest prevalence rate. The most common clinical manifestations were the presence of red eye, eye discharge, grittiness, and eyelashes being stuck together. One of the hallmarks of histopathology is a cobblestone formation of flattened nodules with central vascular centers. Conjunctivitis is a virusmediated immune response accompanied by inflammation, which proceeds the immune reaction, giving rise to vasodilation, pseudo membrane formation, and conjunctivital discharge. The gold standard for the diagnosis of Conjunctivitis is the Adenoplus kit using PCR technology; apart from this slit lamp biomicroscope can be used for the evaluation. It is the need of the hour to spread awareness about the Pink Eye disease and the measures to prevent it.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of COVID-19's JN.1 Subvariant Sparks Outbreak in India. COVID-19的JN.1亚变种在印度爆发。

Infectious disorders drug targets Pub Date : 2024-07-10 DOI: 10.2174/0118715265313527240705063308

Diksha, Raj Kamal, OkesanyaOlalekan John, Raj Kumar Narang, Amandeep Singh

引用次数: 0

Molecular Characterization of Antimicrobial Resistance and Virulence Genotyping among Helicobacter pylori-Positive Dyspeptic Patients in North Iran. 伊朗北部幽门螺旋杆菌阳性消化不良患者耐药性和病毒性基因分型的分子特征。

Infectious disorders drug targets Pub Date : 2024-07-09 DOI: 10.2174/0118715265294927240617201332

Ebrahim Kouhsari, Gholamreza Roshandel, Sara Hosseinzadeh, Sima Besharat, Vahid Khori, Taghi Amiriani

{"title":"Molecular Characterization of Antimicrobial Resistance and Virulence Genotyping among Helicobacter pylori-Positive Dyspeptic Patients in North Iran.","authors":"Ebrahim Kouhsari, Gholamreza Roshandel, Sara Hosseinzadeh, Sima Besharat, Vahid Khori, Taghi Amiriani","doi":"10.2174/0118715265294927240617201332","DOIUrl":"https://doi.org/10.2174/0118715265294927240617201332","url":null,"abstract":"Background: Iran has a relatively high prevalence of H. pylori, which correlates with high-risk areas for gastric cancer worldwide.Methods: Our study aimed to investigate the underlying genetic mechanisms associated with resistance to metronidazole (frxA, rdxA), clarithromycin (23S rRNA), tetracycline (16S rRNA), and fluoroquinolone (gyrA) in H. pylori-positive dyspeptic patients using PCR and sequencing. We further examined the potential correlation between resistance profiles and various virulence genotypes.Results: The rates of genetic mutations associated with resistance to metronidazole, fluoroquinolone, clarithromycin, and tetracycline were found to be 68%, 32.1%, 28.4%, and 11.1%, respectively. Well-documented multiple antibiotic resistance mutations were detected, such as rdxA and frxA (with missense and frameshift alterations), gyrA (Asp91, Asn87), 23S rRNA (A2142G, A2143G), and 16S rRNA (triple-base-pair substitutions AGA926-928→TTC). The cagA+ and vacA s1/m1 types were the predominant genotypes in our study. With the exception of metronidazole and tetracycline, no significant correlation was observed between the cagA+ and cagL+ genotypes and resistance-associated mutations.Conclusion: The prevalence of antibiotic resistance-associated mutations in H. pylori was remarkably high in this region, particularly to metronidazole, ciprofloxacin, and clarithromycin. By conducting a simultaneous screening of virulence and resistance genotypes, clinicians can make informed decisions regarding the appropriate therapeutic regimen to prevent the escalation of antibiotic resistance against H. pylori infection in this specific geographical location.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Stewardship in Clinical Microbiology: An Indispensable Component of Patient Care. 临床微生物学诊断管理：病人护理不可或缺的组成部分。

Infectious disorders drug targets Pub Date : 2024-07-03 DOI: 10.2174/0118715265294425240607110713

Lipika Singhal, Parakriti Gupta, Varsha Gupta

{"title":"Diagnostic Stewardship in Clinical Microbiology: An Indispensable Component of Patient Care.","authors":"Lipika Singhal, Parakriti Gupta, Varsha Gupta","doi":"10.2174/0118715265294425240607110713","DOIUrl":"https://doi.org/10.2174/0118715265294425240607110713","url":null,"abstract":"Emerging infectious diseases and increasing resistance to available antimicrobials are mapping the evolution of clinical microbiology and escalating the nature of undertakings required. Rapid diagnosis has become the need of the hour, which can affect diagnostic algorithms and therapeutic decisions simultaneously. Subsequently, the concept of 'diagnostic stewardship' was introduced into clinical practice for coherent implementation of available diagnostic modalities to ensure that these new rapid diagnostic technologies are conserved, rather than consumed as part of health care resources, with a view to improve the patient care and reduce Turnaround Time (TAT) and treatment expense. The present study highlights the requisite of diagnostic stewardship and outlines the infectious disease diagnostic modalities that can assist in its successful implementation. Diagnostic stewardship promotes precise, timely diagnostics, from the initial specimen collection and identification to reporting with appropriate TAT, so as to enable timely management of the patient. The main aim of diagnostic stewardship is to optimize the right choice of diagnostic test for the right patient to attain clinically significant reports with the least possible TAT for timely management and the least expected adverse effects for the patient, community, and the healthcare system. This underlines the requisite of a multifaceted approach to make technological advancements effective and successful for implementation as a part of diagnostic stewardship for the best patient care.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Global Approach to Hib: Vaccine Innovations, Epidemiological Patterns, and Worldwide Consequences. 应对乙型流感嗜血杆菌的全球方法：疫苗创新、流行病学模式和全球后果。

Infectious disorders drug targets Pub Date : 2024-06-03 DOI: 10.2174/0118715265304022240514090953

Simranjeet Kaur, Diksha, Raj Kumar Narang, Amandeep Singh

引用次数: 0

Sudden Outbreak of Conjunctivitis in the Capital of India. 印度首都突然爆发结膜炎。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265276248231205113605

Sumel Ashique

引用次数: 0

Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19. 三重负担：结核病、艾滋病毒和新冠肺炎的不可忽视的威胁。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265259959231031104820

Parakriti Gupta, Diljot Sandhu, Varsha Gupta, Lipika Singhal

{"title":"Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19.","authors":"Parakriti Gupta, Diljot Sandhu, Varsha Gupta, Lipika Singhal","doi":"10.2174/0118715265259959231031104820","DOIUrl":"10.2174/0118715265259959231031104820","url":null,"abstract":"The Coronavirus-19 (COVID-19) hasn't seen the dawn since its emergence, however waxing and waning has resulted in the emergence of deadly variants. The effects of pandemic have not been limited to its virulence, but have rather conferred multiple collateral effects, especially in developing countries; thereby, designating it as a SYNDEMIC. The same culminated in neglect of non-COVID-19 conditions like tuberculosis (TB) and human immunodeficiency virus-acquired immunodeficiency syndrome (HIV/AIDS). Besides being the prognostic factor for severe COVID-19, these infections in hidden pockets served as reservoir for emergence of the deadly Omicron. Another significant impact of this juxtaposition was on the delivery of healthcare services for TB and HIV. The unanticipated COVID-19 pandemic turned the path of ongoing progress of elimination programs. Direct consequences of the COVID-19 pandemic were pronounced on diagnosis, treatment, and services for patients with TB and HIV. Essential TB services were reallocated to the COVID-19 rapid response task force. However, despite escalating the tribulations, this triple burden has simultaneously taught lessons to escalate the progress of halted programs. The pandemic has catalyzed an unusual level of collaboration among scientists, which can be exploited for TB and HIV. Fast-track diagnostics, digitalization, contact tracing, and vaccine development have enabled world to envision the same for TB/HIV..","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria. 尼日利亚多次暴发白喉疫情，白喉再次出现。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265251299231117045940

Pius Omoruyi Omosigho, Okesanya Olalekan John, Olaniyi Abideen Adigun, Hakeem Kayode Hassan, Olaleke Noah Olabode, Abioye Sunday Micheal, Usman Abubakar Haruna, Amandeep Singh, Emery Manirambona

{"title":"The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria.","authors":"Pius Omoruyi Omosigho, Okesanya Olalekan John, Olaniyi Abideen Adigun, Hakeem Kayode Hassan, Olaleke Noah Olabode, Abioye Sunday Micheal, Usman Abubakar Haruna, Amandeep Singh, Emery Manirambona","doi":"10.2174/0118715265251299231117045940","DOIUrl":"10.2174/0118715265251299231117045940","url":null,"abstract":"Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immunization regimens. The outbreak is further aggravated by multiple epidemics, which have diverted resources and attention away from the emergency of other infectious diseases. Furthermore, there is a lack of awareness of diphtheria in Nigeria. With a focus on the difficulties in controlling the disease, methods of diagnosis, available treatments, and preventive measures, this study provides a thorough analysis of diphtheria, covering its historical context, clinical presentation, associated complications, and current outbreaks. It emphasizes how important vaccination, early detection, and better access to healthcare are in reducing diphtheria outbreaks. The study highlights the serious effects of diphtheria on public health, particularly in regions with scarce resources and vaccine resistance, and offers a number of suggestions to overcome these challenges and prevent further outbreaks.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0