Mucormycosis and COVID-19: Unraveling the Interplay of Fungal Infection in a Global Health Crisis: An Overview.

Infectious disorders drug targets Pub Date : 2024-10-31 DOI:10.2174/0118715265310191240919060621

Ali Moheb-Alian, Ali Akbari, Saghi Nooraei, Howra Bahrulolum, Zoheir Mohammadian Farsani, Negin Mokhtari, Mozhdeh Sadat Ebadi, Arezoo Mohammadian Farsani, Seyedmoein Khatami, Mohammadmahdi Esmaeili, Zahra Keykhaee, Mohammad Hossein Heydargoy, Zahra Rafiei, Gholamreza Ahmadian

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Abstract

The healthcare system has been greatly affected by the COVID-19 pandemic, result-ing in an increase in secondary and co-infections among patients. Factors like pulmonary dam-age and weakened immune systems make patients more susceptible to fungal infections. Mu-cormycosis, an opportunistic fungal infection, prospers in environments with limited oxygen, and elevated glucose levels due to conditions such as diabetes and steroid use, as well as in acidic environments from metabolic acidosis and diabetic ketoacidosis, where it demonstrates heightened germination ability. Recognizing these complications is critical to minimize harm to patients. The insights gained from this review can improve our understanding of how fungal infections develop in connection to COVID-19, leading to better predictive algorithms, tailored care plans, enhanced antifungal treatments, quicker diagnostics, and improved management strategies.

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粘孢子菌病与 COVID-19：揭示全球健康危机中真菌感染的相互作用：概述。

医疗系统受到 COVID-19 大流行的严重影响，导致患者的继发感染和合并感染增加。肺损伤和免疫系统衰弱等因素使患者更容易受到真菌感染。蕈菌病是一种机会性真菌感染，在氧气有限、糖尿病和使用类固醇等导致血糖升高的环境中，以及在代谢性酸中毒和糖尿病酮症酸中毒导致的酸性环境中生长旺盛，其发芽能力较强。认识这些并发症对于最大限度地减少对患者的伤害至关重要。从这篇综述中获得的洞察力能让我们更好地了解真菌感染是如何与 COVID-19 联系在一起发展的，从而制定出更好的预测算法、量身定制的护理计划、强化的抗真菌治疗、更快的诊断和改进的管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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