Infectious disorders drug targets最新文献

{"title":"Mechanistic Insights into Shenfu Injection for COVID-19-Induced ARDS: A Combined Analysis of GEO Database, Network Pharmacology, and Molecular Docking.","authors":"Chen Juan, Ding Weichao, Chen Ke, Li Quan, Chen Xingdong, Zhang Zhe, Zhang Liang, Nie Shinan, Wang Mengmeng, Sun Zhaorui","doi":"10.2174/0118715265391729250831063548","DOIUrl":"https://doi.org/10.2174/0118715265391729250831063548","url":null,"abstract":"<p><strong>Introduction: </strong>Acute respiratory distress syndrome (ARDS) is a severe and life-threatening complication of COVID-19, for which no specific antiviral treatment currently exists. Shenfu Injection (SFI), a traditional Chinese medicine formulation, has shown clinical promise in improving respiratory function and reducing mortality in ARDS patients. However, its underlying molecular mechanisms remain poorly understood.</p><p><strong>Methods: </strong>A combined network pharmacology and bioinformatics approach was used to elucidate the potential mechanisms of SFI against COVID-19-induced ARDS. SFI-related targets were identified through multiple public databases, followed by Gene Ontology (GO) and KEGG pathway enrichment analyses. Gene expression data from GEO datasets (GSE171110 and GSE273149) were used to identify differentially expressed genes in COVID-19-induced ARDS, which were then intersected with SFI targets. Molecular docking was performed to evaluate the binding affinities between major active compounds in SFI and core viral proteins, including 3CLpro, RdRp, and ACE2.</p><p><strong>Results: </strong>A total of 398 SFI-associated targets were identified, with key targets including SRC, MAPK1, MAPK3, PIK3R1, and STAT3. Active compounds such as Gomisin B, Deoxyharringtonine, Ginsenoside-Rh4_qt, Suchilactone, and Celabenzine were highlighted. Enrichment analyses identified 2,883 GO terms and 219 KEGG pathways (P < 0.05), primarily involving the PI3K-Akt, MAPK, TNF, NF-κB, and apoptosis signaling pathways. GEO data analysis confirmed the involvement of these pathways in COVID-19-induced ARDS. Molecular docking showed strong binding affinities, particularly between Ginsenoside-Rh4_qt and 3CLpro/ACE2, and Celabenzine with RdRp.</p><p><strong>Discussion: </strong>The findings suggest that SFI exerts therapeutic effects through modulation of key inflammatory and immune pathways and by direct interaction with SARS-CoV-2 viral proteins. This multi-target mechanism aligns with the pharmacological characteristics of traditional Chinese medicine. However, further experimental validation is required to confirm these computational predictions and assess clinical relevance.</p><p><strong>Conclusion: </strong>This study provides mechanistic insights into how SFI may alleviate COVID-19-induced ARDS via modulation of critical signaling pathways and interaction with viral targets, offering a theoretical foundation for its clinical application in the management of severe COVID-19 cases.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZELSUVMI: Pioneering At-Home Treatment for Molluscum Contagiosum.","authors":"Rajni Tanwar, Dinesh Kumar","doi":"10.2174/0118715265351439250901043558","DOIUrl":"https://doi.org/10.2174/0118715265351439250901043558","url":null,"abstract":"<p><p>The Food and Drug Administration (FDA) authorized the topical gel Zelsuvmi on Jan-uary 5, 2024, to treat molluscum contagiosum in children and adults over the age of one. This is the first licensed prescription medication for this highly infectious viral skin illness, primarily af-fecting youngsters. Zelsuvmi produces nitric oxide, which has antiviral properties. The specific treatment method is unclear, but it is believed to involve processes affecting inflammation, immu-nological control, and viral replication. Clinical studies have shown Zelsuvmi to significantly de-crease the number of lesions and be easily tolerated when applied daily. Clinical trials in Phase 3, such as B-SIMPLE 4 and B-SIMPLE 2, were the basis for the FDA's clearance of Zelsuvmi. The treatment is given topically once daily for a maximum duration of 12 weeks. The product is sup-plied in two separate tubes: one contains berdazimer gel and the other contains hydrogel. The most common negative effects of Zelsuvmi are usually experienced in the applied area, such as distress-ing burning, itching, redness, and irritation. Zelsuvmi is anticipated to be commercially accessible in the United States by late 2024, broadening the spectrum of treatment choices for molluscum contagiosum.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antimicrobial Effects of Licorice Extract against Streptococcus mutans as a Potential Oral Gel against Dental Caries.","authors":"Hemad Iraji Khosrowshahi, Aziz Eftekhari, Solmaz Maleki Dizaj, Paria Motahari, Mohammad Yousef Memar, Emad Iraji Khosrowshahi","doi":"10.2174/0118715265376519250904100855","DOIUrl":"https://doi.org/10.2174/0118715265376519250904100855","url":null,"abstract":"<p><strong>Introduction: </strong>Dental caries is a prevalent chronic infectious disease primarily associated with Streptococcus mutans. Natural compounds with antimicrobial properties, such as licorice (Glycyrrhiza glabra), offer promising alternatives for oral health care.</p><p><strong>Methods: </strong>Licorice roots were authenticated by a botanist and processed into an extract. The extract was formulated into an oral gel (100 μg/mL) and sterilized using gamma irradiation. The minimum inhibitory concentration (MIC) of the gel against S. mutans was determined by the agar dilution method. Sub-MIC concentrations were used in a time-kill assay to assess antibacterial efficacy. A reduction of ≥3 log10 CFU/mL was considered indicative of antibacterial activity. Data were ana-lyzed using the Shapiro-Wilk test, Kruskal-Wallis, and Tukey's post hoc test (SPSS v25, p < 0.05).</p><p><strong>Results: </strong>The MIC of the gel was found to be 1260 μg/mL. Time-kill assays using concentrations of 1.4 and 1.8 μg/mL showed a significant reduction in bacterial count over time, demonstrating effec-tive antibacterial action against S. mutans.</p><p><strong>Discussion: </strong>The results suggest that even sub-MIC levels of licorice gel can significantly inhibit S. mutans, highlighting its potential for incorporation into preventive or therapeutic oral health products.</p><p><strong>Conclusion: </strong>Licorice extract gel exhibits promising antimicrobial activity against S. mutans and may be considered a potential natural agent in oral formulations targeting dental caries.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Resistance Patterns of Bacterial Strains in Pediatric Urinary Tract Infections (UTIs).","authors":"Mehrnoush Afsharipoor, Fatemeh Sadat Mir Rashidi, Fatemeh Dehghan, Mehran Nikvarz, Rasoul Raesi, Kiavash Hushmandi, Mohammadreza Naghibi, Salman Daneshi","doi":"10.2174/0118715265365721250908141000","DOIUrl":"https://doi.org/10.2174/0118715265365721250908141000","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary tract infections (UTIs) are among the most common bacterial infections in children and are increasingly complicated by rising rates of antimicrobial re-sistance. Recent multicenter studies have reported Escherichia coli as the predominant uropath-ogen in pediatric UTIs, with resistance rates to commonly used antibiotics such as ampicillin, cefixime, and ceftriaxone ranging from 50% to 70%. This study investigates the frequency and antibiotic resistance of bacterial strains isolated from pediatric patients with UTIs.</p><p><strong>Method: </strong>This cross-sectional descriptive analytical study was conducted on 113 children under 14 years of age with UTIs at Imam Khomeini Hospital (RA) in Jiroft city from 2022 to 2023. The data were collected by referring to the medical records of the hospital and using a checklist from the medical records of the studied patients. The data were analyzed using SPSS (version 22) with both descriptive and inferential statistical methods, applying a significance level of <0.05.</p><p><strong>Results: </strong>Escherichia coli was the most frequently isolated pathogen, responsible for 63.7% of cases, followed by Enterobacter at 19.4%.</p><p><strong>Discussion: </strong>Notably, alarming levels of antibiotic resistance were observed, with some strains exhibiting complete (100%) resistance to commonly used antibiotics such as ampicillin and cefixime. These findings underscore the necessity for continuous surveillance of uropathogens and their antimicrobial resistance patterns to guide evidence-based therapeutic decision-making.</p><p><strong>Conclusion: </strong>A comprehensive understanding of regional epidemiological trends is imperative for clinicians to optimize antibiotic stewardship programs and mitigate the escalating public health challenge of multidrug-resistant pathogens in pediatric urinary tract infections.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Factor and Anti-CCP Titers in COVID-19.","authors":"Mudathir Abdelshafea Abdelkareem Abakar, Mohamed Ibrahim Awadab, Zohair Khalid Ibrahim Elaraki, Mohammed Elsheikh Osman, Mohamed Ahmed Ibrahim-Holi, Eltayib Hassan Ahmad-Abakur, Tarig M S Alnour","doi":"10.2174/0118715265361107250829044505","DOIUrl":"https://doi.org/10.2174/0118715265361107250829044505","url":null,"abstract":"<p><strong>Introduction: </strong>The mechanisms of Coronavirus Disease 2019 (COVID-19) remain not fully elucidated. The present study aimed to trace the presence of autoantibodies among COVID-19 patients and to determine the association between COVID-19 and these antibodies.</p><p><strong>Methods: </strong>This study is a cross-sectional, hospital-based study involving 90 participants, who were arranged into three groups: the COVID-19 group, the rheumatoid arthritis group, and the control group. The study population was tested for serum concentration of rheumatoid factor and anti-CCP antibodies.</p><p><strong>Results: </strong>The results showed significant elevations in serum levels of rheumatoid factor (P < 0.000) and anti-CCP (P < 0.000) among the rheumatoid arthritis group. Similar findings of a significant increase in rheumatoid factor (P < 0.000) were observed among the COVID-19 group compared to the control group, while an insignificant increase (P = 0.605) was reported between the Anti-CCP and COVID-19 groups.</p><p><strong>Discussion: </strong>The present study revealed a significant increase in rheumatoid factors among the COVID-19 group compared to the healthy control group. These results suggested that COVID-19 contributes to the development of autoantibodies, which might play a critical role in the pathogenesis of COVID-19.</p><p><strong>Conclusion: </strong>These findings suggest that the rheumatoid factor plays a crucial role in the pathogenesis of COVID-19 infection.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-Labeled Cefixime for Targeted Imaging of Infections: Preclinical Evaluation and Potential in Postpartum Women.","authors":"Shahida Parveen, Rubaida Mehmood, Zara Jabeen, Kainat Warraich, Hafiza Samin Anjum, Daniyal Warraich, Mubashra Naz, Fatima Shams, Rida Sana","doi":"10.2174/0118715265350299250824102153","DOIUrl":"https://doi.org/10.2174/0118715265350299250824102153","url":null,"abstract":"<p><strong>Introduction: </strong>Targeted infection imaging is crucial for accurate diagnosis in postpartum women. This project uses 99mTc-labeled cefixime to develop a radiopharmaceutical for detecting, distinguishing, and treating infections and abscesses in women.</p><p><strong>Method: </strong>Technetium (TcO4-) chelated with cefixime, reduced by stannous chloride, confirmed via thin-layer chromatography. Mice injected with the labeled compound showed pyrogenicity and stability tests at one, two, and three hours. Bio distribution and SPECT (CT) imaging revealed in vivo aspects post-injection.</p><p><strong>Results: </strong>Radiolabeling achieved over 95% technetium binding to cefixime, as shown by ITLC with acetone, demonstrating high labeling efficiency. The labeled molecule remained stable for three hours, providing an adequate imaging window. SEM analysis confirmed drug presence on the complex, IR spectroscopy verified cefixime-tracer bond formation, and HPLC quantified radiolabeling yield.</p><p><strong>Discussion: </strong>Bio distribution studies revealed that radiolabeled cefixime accumulated mainly in the kidney and bladder (31.38%) and liver (30.1%), indicating renal and hepatic clearance pathways. Moderate uptake appeared in the small and large intestines (24.6%), whereas lower distribution was observed in the lungs (4.3%), heart (4.1%), stomach, and spleen (5.4%). SPECT/CT imaging demonstrated drug accumulation in infected thigh tissues, distinguishing them from inflamed sites, underscoring its diagnostic potential for differentiating infectious from inflammatory conditions. The approach shows promise for clinical translation in postpartum infection management and beyond.</p><p><strong>Conclusion: </strong>Cefixime, labeled with 99mTc, accurately detects rodent infections via scanning. Its potential extends to distinguishing healthy and malignant cells in human plasma, indicating promise in medical diagnostics, including identifying unknown-etiologic pyrexia in post-partum women.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of Extended spectrum β-lactamase (ESBL) producing ceftriaxone resistant Salmonella Typhi from western Rajasthan, India.","authors":"Kumar S Abhishek, Alisha Aggarwal, Vibhor Tak, Vidhi Jain, Sarika P Kombade","doi":"10.2174/0118715265382823250818113104","DOIUrl":"https://doi.org/10.2174/0118715265382823250818113104","url":null,"abstract":"<p><strong>Introduction: </strong>Typhoid fever, caused by Salmonella Typhi and Paratyphi, remains a sig-nificant public health concern, particularly in developing countries. The emergence of antimicrobial resistance, including resistance to first-line drugs, fluoroquinolones, and the development of re-sistance to ceftriaxone, poses a significant threat to effective treatment.</p><p><strong>Methods: </strong>This study investigated extended-spectrum β-lactamase (ESBL)-producing Salmonella Typhi isolates from blood samples of patients with suspected typhoid fever at a tertiary care hospital in Western Rajasthan, India, between April 2022 and May 2024. Antimicrobial susceptibility testing followed by PCR for ESBL-producing genes (blaTEM, blaSHV, blaCTX-M) and blaCTX-M sub-types (blaCTX-M1, blaCTX-M2, blaCTX-M8, blaCTX-M9, blaCTX-M10, blaCTX-M14, and blaCTX-M15) was performed.</p><p><strong>Results: </strong>Among 79 Salmonella Typhi isolates, 18 (22.8%) exhibited resistance to ceftriaxone. PCR analysis revealed blaCTX-M as the predominant ESBL gene, detected in 77.8% of resistant isolates. Notably, blaCTX-M1, blaCTX-M15, and blaCTX-M10 types were identified among the blaCTX-M-positive isolates.</p><p><strong>Discussion: </strong>In our study, 48% of Salmonella Typhi strains were resistant to fluoroquinolones, while chloramphenicol and co-trimoxazole showed re-emerging susceptibility (87%), likely due to their restricted use. Emerging ceftriaxone resistance, mediated by ESBL genes, predominantly blaCTX-M (especially blaCTX-M-15 and blaCTX-M-1) and blaSHV, poses challenges in clinical management. Notably, our study detected blaCTX-M10, which has not been previously reported in S. Typhi. Re-sistance gene spread is attributed to plasmids prevalent in E. coli and Klebsiella, which facilitate horizontal transfer. Study limitations include a small sample size, the absence of whole-genome sequencing, and a lack of clinical outcome data.</p><p><strong>Conclusion: </strong>This study highlights the emergence of ceftriaxone-resistant Salmonella Typhi in Western Rajasthan, India. The high prevalence of blaCTX-M-producing isolates underscores the importance of ongoing surveillance and the implementation of infection control measures to prevent the further spread of antimicrobial resistance. Additionally, this study also highlights the re-emergence of sensitivity to chloramphenicol and co-trimoxazole.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of MDR Enterobacter spp. Isolated from Clinical Specimens in Sudan: Prevalence of CTX-M and Carbapenemase Genes with Absence of SHV and TEM.","authors":"Hiba Abdel Salam Mahgoub, Hind Haidar Ahmed, Tyseer AbdelAzim Ahmed Mahgoub, Osama Mohammed Mohammed Khair, Mawada Hassan Fadlalla Mohammed, Maye Mohammed Merghani, Majdolin Ibrahim Mobark AlBushra, Elsadig Mohammed Hamdan, Rania Hashim MohammedKhair Khojli, Hisham Nour Aldaiem Altyab, Mogahid Mohammed Elhassan","doi":"10.2174/0118715265368414250818114643","DOIUrl":"https://doi.org/10.2174/0118715265368414250818114643","url":null,"abstract":"<p><strong>Introduction: </strong>The rise of Multidrug-resistant (MDR) Enterobacter species is a significant global health concern, particularly in hospital settings where they contribute to nosocomial infections. This study aimed to determine the prevalence of MDR Enterobacter spp. in clinical specimens from Khartoum State, Sudan, to detect key resistance genes (CTX-M, AmpC, OXA-48, NDM-1, VIM, IMP, MCR-1, SHV, and TEM), and to analyze the correlation between genotypic and phenotypic resistance patterns.</p><p><strong>Methods: </strong>A cross-sectional, laboratory-based study was conducted from February to October 2021. A total of 384 clinical specimens, including urine, wound swabs, sputum, and blood, were collected from hospitals in Khartoum. Enterobacter spp. isolates were identified using conventional methods such as colony morphology, Gram staining, and biochemical tests. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method. Multiplex Polymerase Chain Reaction (PCR) was employed to detect ESBL genes (CTX-M, SHV, TEM, AmpC) and carbapenemase genes (OXA-48, NDM-1, VIM, IMP, MCR-1).</p><p><strong>Results: </strong>Among the 384 clinical specimens, 14 (3.6%) were confirmed as Enterobacter spp. by PCR. All isolates exhibited multidrug resistance. CTX-M was detected in 100% of isolates, while SHV and TEM genes were absent. Other detected resistance genes included AmpC in 5 isolates (35.7%), IMP in 2 (14.3%), NDM-1 in 3 (21.4%), VIM in 5 (35.7%), OXA-48 in 7 (50.0%), and MCR-1 in 13 (92.9%). The predominance of CTX-M, car-bapenemase genes, and the absence of SHV and TEM suggest a distinct resistance profile in these isolates.</p><p><strong>Discussion: </strong>The findings highlight a concerning emergence of MDR Enterobacter spp. in Sudan, primarily driven by the widespread presence of CTX-M and carbapenemase genes. The lack of SHV and TEM genes indicates potential regional differences in genetic resistance patterns. This underscores the critical need for molecular monitoring and effective infection control policies.</p><p><strong>Conclusion: </strong>The high prevalence of MDR Enterobacter spp., particularly due to CTX-M and carbapenemase gene expression, poses a serious threat to public health in Khartoum. Regional variation in resistance mechanisms, such as the absence of SHV and TEM, necessitates targeted antimicrobial stewardship and the development of localized treatment guidelines to limit the spread of resistance in Sudanese healthcare facilities.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Preseptal Cellulitis: A 5-year Retrospective Study in an Iranian Referral Hospital.","authors":"Mahmoud Khodabandeh, Majid Mehrshadian, Narges Maham, Shima Mahmoudi","doi":"10.2174/0118715265356551250731143409","DOIUrl":"https://doi.org/10.2174/0118715265356551250731143409","url":null,"abstract":"<p><strong>Introduction: </strong>Preseptal cellulitis, the most common periorbital cellulitis manifestation, is more common in children. The aim of this cross-sectional study was to analyze the diagnosis and treatment of preseptal cellulitis infections in patients admitted to Children's Medical Center, an Ira-nian referral hospital, between 2015 and 2019.</p><p><strong>Methods: </strong>The demographic characteristics of patients, symptoms at admission, affected eye (unilat-eral/bilateral and right/left), the duration of symptoms and treatment, imaging findings, and the mi-crobial culture were recorded from patient history and medical files.</p><p><strong>Results: </strong>During 5 years, 136 children with preseptal cellulitis, of whom 71 (52.2%) were boys and 65 (47.8%) were girls. The age range of the patients was between 9 days and 15 years, with a mean age of 41.9±39.3 months. All of the children had eyelid swelling and edema upon their initial visit. The most common accompanying symptoms in patients after edema and swelling of the eyelids were fever (41.2%), followed by eye discharge in 30.1%, and tenderness in 19.9% of patients. Ocular in-volvement was 51.5% in the right eye, 44.9% in the left eye, and 3.7% in both eyes. A CT scan was performed in 58 cases (42.6%), showing preseptal cellulitis in 29 patients (21.3%), followed by eth-moid sinusitis in 14 cases (10.3%). The most commonly used antibiotics, either alone or in combina-tion, were clindamycin (72.8%, n=99), ceftriaxone (54.4%, n=74), vancomycin (27.2%, n=37), met-ronidazole (23.5%, n=32), and cefotaxime (17.6%, n=24).</p><p><strong>Discussion: </strong>Preseptal cellulitis in children presents with a spectrum of symptoms and is frequently associated with risk factors such as sinusitis, odontogenic infections, insect bites, or periocular trauma. Imaging, particularly CT, is essential for evaluating disease severity and identifying compli-cations. One limitation of this study is the occurrence of negative culture results, which could be due to factors such as sample collection, transportation, or possible issues with the culture techniques.</p><p><strong>Conclusion: </strong>According to this study, children with preseptal cellulitis might exhibit a variety of symptoms. The most common risk factors for preseptal cellulitis infection are sinusitis, odontogenic infections, animal or insect bites, and periocular trauma. Patients usually received clindamycin, ceftri-axone, and combination antibiotics.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian Influenza A(H5N1) in Children: A Critical Public Health Alert Following the First Case in Victoria, Australia.","authors":"Sharib Raza Khan, Shriyansh Srivastava, Sachin Kumar","doi":"10.2174/0118715265370142250805025143","DOIUrl":"https://doi.org/10.2174/0118715265370142250805025143","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}