Infectious disorders drug targets最新文献

{"title":"The Intriguing Connection between Cholestasis and the Renin-Angiotensin System Dysregulation Induced by SARS-CoV-2 and/or the Vaccinal Spike Protein.","authors":"Ziad Fajloun, Ziad Abi Khattar, Jean-Marc Sabatier","doi":"10.2174/0118715265304515240220105152","DOIUrl":"10.2174/0118715265304515240220105152","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e080324227802"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease X: Beyond Fear, Toward Preparedness.","authors":"Rajendra Awasthi","doi":"10.2174/0118715265285021240104091449","DOIUrl":"10.2174/0118715265285021240104091449","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e230124226003"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox Virus (MPXV) Infection: A Review.","authors":"Rosy Kumari, Pooja Arya, Surya Prakash Yadav, Ratish Chandra Mishra, Jaya Parkash Yadav","doi":"10.2174/0118715265258451231214063506","DOIUrl":"10.2174/0118715265258451231214063506","url":null,"abstract":"<p><p>Monkeypox is a viral disease; its outbreak was recently declared a global emergency by the World Health Organization. For the first time, a monkeypox virus (MPXV)-infected patient was found in India. Various researchers back-to-back tried to find the solution to this health emergency just after COVID-19. In this review, we discuss the current outbreak status of India, its transmission, virulence factors, symptoms, treatment, and the preventive guidelines generated by the Indian Health Ministry. We found that monkeypox virus (MPXV) disease is different from smallpox, and the age group between 30-40 years old is more prone to MPXV disease. We also found that, besides homosexuals, gays, bisexuals, and non-vegetarians, it also affects normal straight men and women who have no history of travel. Close contact should be avoided from rats, monkeys and sick people who are affected by monkeypox. To date, there are no monkeypox drugs, but Tecovirimat is more effective than other drugs that are used for other viral diseases like smallpox. Therefore, we need to develop an effective antiviral agent against the virulence factor of MXPV.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cracking the Code of Lumpy Skin Disease: Identifying Causes, Symptoms and Treatment Options for Livestock Farmers.","authors":"Devdhar Yadav, G S N Koteswara Rao, Deepika Paliwal, Amit Singh, Aftab Alam, Pramod Kumar Sharma, Amareswarapu V Surendra, Prachi Varshney, Yogesh Kumar","doi":"10.2174/0118715265261364231120053105","DOIUrl":"10.2174/0118715265261364231120053105","url":null,"abstract":"<p><p>The novel bovine viral infection known as lumpy skin disease is common in most African and Middle Eastern countries, with a significant likelihood of disease transfer to Asia and Europe. Recent rapid disease spread in formerly disease-free zones highlights the need of understanding disease limits and distribution mechanisms. Capripox virus, the causal agent, may also cause sheeppox and Goatpox. Even though the virus is expelled through several bodily fluids and excretions, the most common causes of infection include sperm and skin sores. Thus, vulnerable hosts are mostly infected mechanically by hematophagous arthropods such as biting flies, mosquitoes, and ticks. As a result, milk production lowers, abortions, permanent or temporary sterility, hide damage, and mortality occur, contributing to a massive financial loss for countries that raise cattle. These illnesses are economically significant because they affect international trade. The spread of Capripox viruses appears to be spreading because to a lack of effectual vaccinations and poverty in rural areas. Lumpy skin disease has reached historic levels; as a consequence, vaccination remains the only viable option to keep the illness from spreading in endemic as well as newly impacted areas. This study is intended to offer a full update on existing knowledge of the disease's pathological characteristics, mechanisms of spread, transmission, control measures, and available vaccinations.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e150124225632"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating Hidden Population Size of COVID-19 using Respondent-Driven Sampling Method - A Systematic Review.","authors":"SeyedAhmad SeyedAlinaghi, Arian Afzalian, Mohsen Dashti, Afsaneh Ghasemzadeh, Zohal Parmoon, Ramin Shahidi, Sanaz Varshochi, Ava Pashaei, Samaneh Mohammadi, Fatemeh Khajeh Akhtaran, Amirali Karimi, Khadijeh Nasiri, Esmaeil Mehraeen, Daniel Hackett","doi":"10.2174/0118715265277789240110043215","DOIUrl":"10.2174/0118715265277789240110043215","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, the ongoing COVID-19 pandemic is posing a challenge to health systems worldwide. Unfortunately, the true number of infections is underestimated due to the existence of a vast number of asymptomatic infected individual's proportion. Detecting the actual number of COVID-19-affected patients is critical in order to treat and prevent it. Sampling of such populations, so-called hidden or hard-to-reach populations, is not possible using conventional sampling methods. The objective of this research is to estimate the hidden population size of COVID-19 by using respondent-driven sampling (RDS) methods.</p><p><strong>Methods: </strong>This study is a systematic review. We have searched online databases of PubMed, Web of Science, Scopus, Embase, and Cochrane to identify English articles published from the beginning of December 2019 to December 2022 using purpose-related keywords. The complete texts of the final chosen articles were thoroughly reviewed, and the significant findings are condensed and presented in the table.</p><p><strong>Results: </strong>Of the 7 included articles, all were conducted to estimate the actual extent of COVID-19 prevalence in their region and provide a mathematical model to estimate the asymptomatic and undetected cases of COVID-19 amid the pandemic. Two studies stated that the prevalence of COVID-19 in their sample population was 2.6% and 2.4% in Sierra Leone and Austria, respectively. In addition, four studies stated that the actual numbers of infected cases in their sample population were significantly higher, ranging from two to 50 times higher than the recorded reports.</p><p><strong>Conclusions: </strong>In general, our study illustrates the efficacy of RDS in the estimation of undetected asymptomatic cases with high cost-effectiveness due to its relatively trouble-free and low-cost methods of sampling the population. This method would be valuable in probable future epidemics.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e310124226549"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into the Natural Biomolecules (BMs): Promising Candidates as Zika Virus Inhibitors.","authors":"Kiran Dobhal, Ruchika Garg, Alka Singh, Amit Semwal","doi":"10.2174/0118715265272414231226092146","DOIUrl":"10.2174/0118715265272414231226092146","url":null,"abstract":"<p><p>Zika virus (ZIKV) is among the relatively new infectious disease threats that include SARS-CoV-2, coronavirus, monkeypox (Mpox) virus, <i>etc</i>. ZIKV has been reported to cause severe health risks to the fetus. To date, satisfactory treatment is still not available for the treatment of ZIKV infection. This review examines the last five years of work using natural biomolecules (BMs) to counteract the ZIKV through virtual screening and <i>in vitro</i> investigations. Virtual screening has identified doramectin, pinocembrin, hesperidins, epigallocatechin gallate, pedalitin, and quercetin as potentially active versus ZIKV infection. <i>In vitro</i>, testing has shown that nordihydroguaiaretic acid, mefloquine, isoquercitrin, glycyrrhetinic acid, patentiflorin-A, rottlerin, and harringtonine can reduce ZIKV infections in cell lines. However, <i>in vivo</i>, testing is limited, fortunately, emetine, rottlerin, patentiflorin-A, and lycorine have shown <i>in vivo</i> anti- ZIKV potential. This review focuses on natural biomolecules that show a particularly high selective index (>10). There is limited <i>in vivo</i> and clinical trial data for natural BMs, which needs to be an active area of investigation. This review aims to compile the known reference data and discuss the barriers associated with discovering and using natural BM agents to control ZIKV infection.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e020224226681"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Vaccination with Various Types of Vaccines Make Communities Safer against COVID-19?","authors":"SeyedAhmad SeyedAlinaghi, Pegah Mirzapour, Esmaeil Mehraeen","doi":"10.2174/0118715265264961231025092542","DOIUrl":"10.2174/0118715265264961231025092542","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e031123223119"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Waves of Autoimmune Diseases Occur after the COVID-19 Pandemic?","authors":"SeyedAhmad SeyedAlinaghi, Pegah Mirzapour, Esmaeil Mehraeen","doi":"10.2174/0118715265272448231211101718","DOIUrl":"10.2174/0118715265272448231211101718","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"67-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential and Pharmacological Activities of (+)-Nantenine in Medicine: An Aporphine Class Phytocomponent of Nandina domestica Thunberg.","authors":"Dinesh Kumar Patel, Kanika Patel","doi":"10.2174/0118715265244269231010090316","DOIUrl":"10.2174/0118715265244269231010090316","url":null,"abstract":"<p><p>Plant material and their derived byproducts have been used in medicine for the treatment of human disorders and complications. Plants give us a distinct class of natural compounds, commonly called secondary metabolites and better examples are the flavonoids, phenols, terpenoids, alkaloids, tannins, and carotenoids. Plant derived phytoproducts have been used for the treatment of human disorders in both traditional as well as modern medicine. Naturally occurring aporphines and their synthetic derivatives are well known in medicine for their pharmacological activities, including an affinity for dopaminergic, adrenergic and serotonergic receptors. (+)-nantenine is an aporphine alkaloid isolated from Nandina domestica and other plants. The aim of the present study is to analyze the biological potential and therapeutic effectiveness of nantenine in medicine. In the present work scientific information of nantenine for their medicinal uses and pharmacological activities have been collected from scientific databases such as Google, Google Scholar, PubMed, Scopus, and Science Direct . Scientific information of nantenine was further analyzed to know their health beneficial aspects in medicine. However, the detail pharmacological activity of nantenine has been discussed in the present work with its analytical aspects. Scientific data analysis described the medicinal importance and pharmacological activities of nantenine. Nantenine revealed adrenergic response, behavioral response, cardiovascular effect, vasorelaxant effect, acetylcholinesterase inhibitory potential, cytotoxicity, and biphasic tracheal relaxation. Present work also signified the biological potential of nantenine for their anti-inflammatory activity, anticonvulsant effect, antiserotonergic activities, anti-MDMA effect, antileishmanial activity, effect on histamine and serotonin, human 5-hydroxytryptamine (5-HT(2A)) and h5-HT(2B) receptors and isolated tissues. Further, the analytical techniques used for the separation, isolation and identification of nantenine have also been described in this work. The present scientific data describes the therapeutic potential and pharmacological activities of (+)-nantenine in medicine.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e201023222495"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50164297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Size of the Hidden Population of COVID-19.","authors":"Esmaeil Mehraeen, Fatemeh Khajeh Akhtaran, Mohammad Reza Faridrohani, Arian Afzalian, Hengameh Mojdeganlou, Zeinab Ghanbari, Yasamin Fathzadeh, Mohadeseh Gholizadeh, SeyedAhmad SeyedAlinaghi, Daniel Hackett","doi":"10.2174/0118715265255039231018113634","DOIUrl":"10.2174/0118715265255039231018113634","url":null,"abstract":"<p><strong>Introduction: </strong>An asymptomatic population has the same infection as symptomatic individuals, so these individuals can unknowingly spread the virus. It is not possible to predict the rate of epidemic growth by considering only the identified isolated or hospitalized population. In this study, we want to estimate the size of the COVID-19 population, based on information derived from patients visiting medical centers. So, individuals who do not receive a formal diagnosis in those medical centers can be considered as hidden.</p><p><strong>Methodology: </strong>To estimate the Bayesian size of the hidden population of COVID-19 a respondentdriven sampling (RDS) method was used. Twenty-three people infected with COVID-19 seeds and who had positive PCR test results were selected as seeds. These participants were asked whether any of their friends and acquaintances who had COVID-19 did not visit a medical center or hid their illness. Access to other patients was gained through friendship and kinship, hence allowing the sampling process to proceed.</p><p><strong>Results: </strong>Out of 23 selected seeds, only 15 seeds remained in the sample and the rest were excluded due to not participating in the further sampling process. After 5 waves, 50 people with COVID-19 who had hidden their disease and were not registered in the official statistics were included in the sample. It was estimated that 12,198 people were infected with COVID-19 in Khalkhal city in 2022. This estimate was much higher than recorded in the official COVID-19 statistics.</p><p><strong>Conclusions: </strong>The study findings indicate that the estimated 'true' numbers of COVID-19 patients in one town in Iran were significantly higher compared to the official numbers. The RDS method can help capture the potential size of infections in further pandemics or outbreaks globally.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e311023222945"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}