Infectious disorders drug targets最新文献_第10页

Current Approaches to Ulcerative Colitis Management: A Comprehensive Overview of Methodologies and Treatments. 目前溃疡性结肠炎的治疗方法：方法和治疗的综合概述。

Infectious disorders drug targets Pub Date : 2024-12-20 DOI: 10.2174/0118715265315472241029110236

Aman Rawat, Richa Srivastava

{"title":"Current Approaches to Ulcerative Colitis Management: A Comprehensive Overview of Methodologies and Treatments.","authors":"Aman Rawat, Richa Srivastava","doi":"10.2174/0118715265315472241029110236","DOIUrl":"https://doi.org/10.2174/0118715265315472241029110236","url":null,"abstract":"Ulcerative colitis is a chronic, idiopathic, inflammatory condition affecting the colon, primarily impacting individuals aged 30 to 40. It typically begins in the rectum and gradually progresses to the proximal regions of the colon, characterized by recurrent and remitting mucosal inflammation. Ulcerative colitis is categorized under inflammatory bowel disease, which encompasses various gastrointestinal tract disorders, but its underly-ing pathophysiology remains unclear. The development of ulcerative colitis is influenced by a combination of genetic, environmental, and inflammatory factors. The severity of the disease guides the management of ulcerative colitis. Restorative strategies include the use of TNF-α (anti-tumor necrosis factor-alpha) monoclonal antibodies. Janus Kinase inhibi-tors suppress cell signaling of the innate immune system. As ongoing research continues, the treatment options for ulcerative colitis are continually evolving and improving. Vari-ous types of dosage forms (tablets, capsules, suppositories, etc.) are available in the market for managing ulcerative colitis, with the primary goal of achieving and maintaining clinical and endoscopic remission of the disease. Ensuring a high level of patient compliance is crucial when considering the formulation of these dosage forms. This review article seeks to offer a comprehensive understanding of ulcerative colitis while highlighting the existing treatment options on various available dosage forms.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repercussion of SARS-CoV-2 on the Sexual Function in Males Updated Review. SARS-CoV-2对男性性功能影响的最新综述

Infectious disorders drug targets Pub Date : 2024-12-20 DOI: 10.2174/0118715265323126241021044252

Radheshyam Pal, Prashant Kumar, Ekta Khare, Amit Anand, Tinku Kumar, Rohit Malik, Vatan Chaudhary, Mithun Bhowmick, Sumel Ashique

{"title":"Repercussion of SARS-CoV-2 on the Sexual Function in Males Updated Review.","authors":"Radheshyam Pal, Prashant Kumar, Ekta Khare, Amit Anand, Tinku Kumar, Rohit Malik, Vatan Chaudhary, Mithun Bhowmick, Sumel Ashique","doi":"10.2174/0118715265323126241021044252","DOIUrl":"https://doi.org/10.2174/0118715265323126241021044252","url":null,"abstract":"SARS-CoV-2, also called coronavirus causes SARS-CoV-2 or severe acute respir-atory syndrome, a highly transmissible disease that has rapidly spread worldwide, straining healthcare systems and leading to a substantial number of fatalities. Interestingly, SARS-CoV-2 has revealed a gender difference, with males dying at a greater rate and with more severe cases than women. It's worth noting that the male reproductive system might be par-ticularly susceptible to damage during periods of moderate to severe sickness, which has been linked to cases of orchitis and erectile dysfunction. Furthermore, SARS-CoV-2 virus particles have been found in the tissues of the testes and penile of both living patients who have recov-ered from the virus and in post-mortem analyses of males who have died from it. For males who have recovered from SARS-CoV-2, sexual transmission is not a big concern, even though moderate to severe infections may have detrimental effects on male reproductive health. This includes the depletion of germ cells and Leydig cells that leads to a decrease in the formation of sperm, potentially decreasing the release of male sex hormones. These ad-verse effects may result in issues such as infertility and sexual dysfunction, which are of growing concern for couples looking to conceive or those in need of assisted reproduction. Numerous investigations have examined SARS-CoV-2's effects on male reproductive health from a variety of perspectives. The purpose of this review is to give a general summary of how SARS-CoV-2 has affected male reproductive health.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annual SZ: An Alternative Immunotherapy for COVID-19 and Long COVID. 年度SZ: COVID-19和长COVID的替代免疫疗法。

Infectious disorders drug targets Pub Date : 2024-12-20 DOI: 10.2174/0118715265323116241104052004

Fatemeh Heidari, Faranak Farahighasreaboonasr, Zuhair Mohammad Hassan, Pooria Fazeli, Maryam Hosseini, Masoumeh Ebtekar

引用次数: 0

Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis. 环境霍乱弧菌非 O1/O139 分离物的抗菌药耐药性：系统回顾和元分析。

Infectious disorders drug targets Pub Date : 2024-10-22 DOI: 10.2174/0118715265294870241002091842

Mana Altafi, Masoumeh Beig, Fatima Moayad Sami, Abbas Maleki, Vahab Hassan Kaviar, Ali Shahryari, Parand Khadivar, Mohammad Sholeh

{"title":"Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis.","authors":"Mana Altafi, Masoumeh Beig, Fatima Moayad Sami, Abbas Maleki, Vahab Hassan Kaviar, Ali Shahryari, Parand Khadivar, Mohammad Sholeh","doi":"10.2174/0118715265294870241002091842","DOIUrl":"https://doi.org/10.2174/0118715265294870241002091842","url":null,"abstract":"Background: The understanding of the antibiotic resistance status of environmental nonO1/nonO139 V. cholerae [NOVC] in relation to other illnesses, which can vary in severity from mild to life-threatening, is limited. However, it is important to note that NOVC-related infections are increasing and serve as a significant illustration of emerging human diseases associated with climate change. The primary objective of the present study was to assess the rates of resistance observed in environmental NOVC isolates across various years, and regions, and their resistance rates.Methods: We performed a systematic search of Scopus, PubMed, Web of Science, and EMBASE databases [until May 2024] following PRISMA guidelines. All statistical analyses were carried out using the statistical package R.Results: Our analysis included a total of 34 studies. According to the meta-regression, chlo-ramphenicol, rifampicin, ciprofloxacin, nalidixic acid, cotrimoxazole, kanamycin, trime-thoprim, amoxicillin/clavulanic acid, and tetracycline resistance rate increased over time. The lowest resistance rates were observed in Austria [amoxicillin; 0.6%], the United States [kana-mycin; 0.1% and tetracycline; 0.1%], Morocco [polymyxin B; 12%], and Spain [trimethoprim; 0.3%]. Conversely, the highest resistance rates were found in Spain [amoxicillin; 61%], Indo-nesia [kanamycin and tetracycline; 94.9%], India [polymyxin B; 97.8%], and Morocco [trime-thoprim; 48.9%].Conclusion: The meta-analysis showed significant variability in antibiotic resistance patterns among environmental NOVC isolates across time and regions, emphasizing the need for tar-geted, time-specific, and country-specific approaches to address antibiotic resistance globally.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sudden Outbreak of Conjunctivitis in the Capital of India. 印度首都突然爆发结膜炎。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265276248231205113605

Sumel Ashique

引用次数: 0

Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19. 三重负担：结核病、艾滋病毒和新冠肺炎的不可忽视的威胁。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265259959231031104820

Parakriti Gupta, Diljot Sandhu, Varsha Gupta, Lipika Singhal

{"title":"Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19.","authors":"Parakriti Gupta, Diljot Sandhu, Varsha Gupta, Lipika Singhal","doi":"10.2174/0118715265259959231031104820","DOIUrl":"10.2174/0118715265259959231031104820","url":null,"abstract":"The Coronavirus-19 (COVID-19) hasn't seen the dawn since its emergence, however waxing and waning has resulted in the emergence of deadly variants. The effects of pandemic have not been limited to its virulence, but have rather conferred multiple collateral effects, especially in developing countries; thereby, designating it as a SYNDEMIC. The same culminated in neglect of non-COVID-19 conditions like tuberculosis (TB) and human immunodeficiency virus-acquired immunodeficiency syndrome (HIV/AIDS). Besides being the prognostic factor for severe COVID-19, these infections in hidden pockets served as reservoir for emergence of the deadly Omicron. Another significant impact of this juxtaposition was on the delivery of healthcare services for TB and HIV. The unanticipated COVID-19 pandemic turned the path of ongoing progress of elimination programs. Direct consequences of the COVID-19 pandemic were pronounced on diagnosis, treatment, and services for patients with TB and HIV. Essential TB services were reallocated to the COVID-19 rapid response task force. However, despite escalating the tribulations, this triple burden has simultaneously taught lessons to escalate the progress of halted programs. The pandemic has catalyzed an unusual level of collaboration among scientists, which can be exploited for TB and HIV. Fast-track diagnostics, digitalization, contact tracing, and vaccine development have enabled world to envision the same for TB/HIV..","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria. 尼日利亚多次暴发白喉疫情，白喉再次出现。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265251299231117045940

Pius Omoruyi Omosigho, Okesanya Olalekan John, Olaniyi Abideen Adigun, Hakeem Kayode Hassan, Olaleke Noah Olabode, Abioye Sunday Micheal, Usman Abubakar Haruna, Amandeep Singh, Emery Manirambona

{"title":"The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria.","authors":"Pius Omoruyi Omosigho, Okesanya Olalekan John, Olaniyi Abideen Adigun, Hakeem Kayode Hassan, Olaleke Noah Olabode, Abioye Sunday Micheal, Usman Abubakar Haruna, Amandeep Singh, Emery Manirambona","doi":"10.2174/0118715265251299231117045940","DOIUrl":"10.2174/0118715265251299231117045940","url":null,"abstract":"Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immunization regimens. The outbreak is further aggravated by multiple epidemics, which have diverted resources and attention away from the emergency of other infectious diseases. Furthermore, there is a lack of awareness of diphtheria in Nigeria. With a focus on the difficulties in controlling the disease, methods of diagnosis, available treatments, and preventive measures, this study provides a thorough analysis of diphtheria, covering its historical context, clinical presentation, associated complications, and current outbreaks. It emphasizes how important vaccination, early detection, and better access to healthcare are in reducing diphtheria outbreaks. The study highlights the serious effects of diphtheria on public health, particularly in regions with scarce resources and vaccine resistance, and offers a number of suggestions to overcome these challenges and prevent further outbreaks.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly Evolving SARS-CoV-2: A Brief Review Regarding the Variants and their Effects on Vaccine Efficacies. 快速演变的 SARS-CoV-2 ：变种及其对疫苗效力影响的简要回顾。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265271109231129112515

Shahid Nawaz, Sara Janiad, Aiman Fatima, Maira Saleem, Urooj Fatima, Asad Ali

引用次数: 0

Different Strategies Targeting Gut Microbiota for the Management of Several Disorders: A Sustainable Approach. 针对肠道微生物群的不同策略可治疗多种疾病：一种可持续的方法。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265267536231121095634

Mahima Chowdhury, Neil Raj Chaudhary, Paranjeet Kaur, Anju Goyal, Sanjeev Kumar Sahu

{"title":"Different Strategies Targeting Gut Microbiota for the Management of Several Disorders: A Sustainable Approach.","authors":"Mahima Chowdhury, Neil Raj Chaudhary, Paranjeet Kaur, Anju Goyal, Sanjeev Kumar Sahu","doi":"10.2174/0118715265267536231121095634","DOIUrl":"10.2174/0118715265267536231121095634","url":null,"abstract":"Background: A potential limelight is flashed on the Gut Microbiota (GM) in the human body, which confers additional psychological as well as physiological attributes to health. Other than just occupying a wide portion of the gastrointestinal tract, it also plays numerous functions in the systems of the body. Gut Microbiota is largely responsible for a considerably vast array of conditions such as obesity, diabetes ,other metabolic disorders, and cardiovascular disorders. Strategies targeting the gut microbiota have been proposed as a promising approach for the management of these disorders.Objective: This review aims to summarize the different strategies targeting the gut microbiota for the management of several disorders and to highlight the importance of a sustainable approach.Methods: A comprehensive literature search was conducted using various databases between 2008 and 2022 that focused on the use of prebiotics, probiotics, synbiotics, postbiotics, fecal microbiota transplantation, dietary interventions, and antibiotics.Results: Different strategies targeting the gut microbiota for the management of several disorders were identified, including probiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, and dietary interventions. Modification in diet and lifestyle, allowing favorable microbiota growth in the stomach, intake of prebiotics and probiotics, and fecal microbiota transplantation are amongst the widely accepted recent approaches allowing the application of GM in the field of treatment.Conclusion: Although considerable steps in enhancing and understanding the mechanism of treatment with the help of gut microbiota are under progress, much diversified and elaborate research must be conducted in order to enhance and implement the use of GM with high effectiveness.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e160124225675"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV-16 Positive Woman: A Rare Encounter. 一名 HPV- 16 阳性妇女的宫颈分层粘液上皮内病变：罕见病例。

Infectious disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/0118715265284722240110114107

Naina Kumar, Mishu Mangla, Seetu Palo, Spandana Gabbeta, J Aparna

{"title":"Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV-16 Positive Woman: A Rare Encounter.","authors":"Naina Kumar, Mishu Mangla, Seetu Palo, Spandana Gabbeta, J Aparna","doi":"10.2174/0118715265284722240110114107","DOIUrl":"10.2174/0118715265284722240110114107","url":null,"abstract":"Background: Cervical cancer is the fourth most common cancer among women globally and has a strong association with Human Papillomavirus (HPV) infection. Stratified mucinproducing intraepithelial lesion (SMILE), a variant of Adenocarcinoma in situ (AIS), is a rare cervical precancer lesion that is often missed or detected incidentally.Case presentation: The present case report briefs the finding of a 39-year-old woman who presented to the gynecological outpatient department with complaints of vaginal discharge for 6-8 months. She had no history of irregular menstrual cycles or postcoital bleeding. Her routine Pap smear revealed atypical squamous cells of undetermined significance (ASCUS) and was positive for HPV-16 type. Her cervical biopsy report revealed AIS and her histopathological report of hysterectomy revealed SMILE, a variant of AIS.Discussion: The SMILE variant of AIS is a rare cervical precancerous lesion characterized by the morphological overlap of both squamous intraepithelial lesions and AIS. It is often difficult to diagnose on Pap smear and is commonly associated with high-risk HPV infections. The management of SMILE is the same as that for AIS, which is the excisional procedure followed by a hysterectomy if the margins are negative and depending on the fertility desires of the patient, followed by regular follow-up with HPV testing.Conclusion: SMILE is a rare variant of AIS, which is often missed on cytological screening of the cervix. It is commonly associated with high-risk types of HPV. Hence, incorporating HPV testing in the screening of cervical cancer is important and recommended to increase the overall sensitivity of screening for adenocarcinoma lesions.","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e290124226396"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0