Mudathir Abdelshafea Abdelkareem Abakar, Mohamed Ibrahim Awadab, Zohair Khalid Ibrahim Elaraki, Mohammed Elsheikh Osman, Mohamed Ahmed Ibrahim-Holi, Eltayib Hassan Ahmad-Abakur, Tarig M S Alnour
{"title":"COVID-19的类风湿因子和抗ccp滴度。","authors":"Mudathir Abdelshafea Abdelkareem Abakar, Mohamed Ibrahim Awadab, Zohair Khalid Ibrahim Elaraki, Mohammed Elsheikh Osman, Mohamed Ahmed Ibrahim-Holi, Eltayib Hassan Ahmad-Abakur, Tarig M S Alnour","doi":"10.2174/0118715265361107250829044505","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The mechanisms of Coronavirus Disease 2019 (COVID-19) remain not fully elucidated. The present study aimed to trace the presence of autoantibodies among COVID-19 patients and to determine the association between COVID-19 and these antibodies.</p><p><strong>Methods: </strong>This study is a cross-sectional, hospital-based study involving 90 participants, who were arranged into three groups: the COVID-19 group, the rheumatoid arthritis group, and the control group. The study population was tested for serum concentration of rheumatoid factor and anti-CCP antibodies.</p><p><strong>Results: </strong>The results showed significant elevations in serum levels of rheumatoid factor (P < 0.000) and anti-CCP (P < 0.000) among the rheumatoid arthritis group. Similar findings of a significant increase in rheumatoid factor (P < 0.000) were observed among the COVID-19 group compared to the control group, while an insignificant increase (P = 0.605) was reported between the Anti-CCP and COVID-19 groups.</p><p><strong>Discussion: </strong>The present study revealed a significant increase in rheumatoid factors among the COVID-19 group compared to the healthy control group. These results suggested that COVID-19 contributes to the development of autoantibodies, which might play a critical role in the pathogenesis of COVID-19.</p><p><strong>Conclusion: </strong>These findings suggest that the rheumatoid factor plays a crucial role in the pathogenesis of COVID-19 infection.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rheumatoid Factor and Anti-CCP Titers in COVID-19.\",\"authors\":\"Mudathir Abdelshafea Abdelkareem Abakar, Mohamed Ibrahim Awadab, Zohair Khalid Ibrahim Elaraki, Mohammed Elsheikh Osman, Mohamed Ahmed Ibrahim-Holi, Eltayib Hassan Ahmad-Abakur, Tarig M S Alnour\",\"doi\":\"10.2174/0118715265361107250829044505\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The mechanisms of Coronavirus Disease 2019 (COVID-19) remain not fully elucidated. The present study aimed to trace the presence of autoantibodies among COVID-19 patients and to determine the association between COVID-19 and these antibodies.</p><p><strong>Methods: </strong>This study is a cross-sectional, hospital-based study involving 90 participants, who were arranged into three groups: the COVID-19 group, the rheumatoid arthritis group, and the control group. The study population was tested for serum concentration of rheumatoid factor and anti-CCP antibodies.</p><p><strong>Results: </strong>The results showed significant elevations in serum levels of rheumatoid factor (P < 0.000) and anti-CCP (P < 0.000) among the rheumatoid arthritis group. Similar findings of a significant increase in rheumatoid factor (P < 0.000) were observed among the COVID-19 group compared to the control group, while an insignificant increase (P = 0.605) was reported between the Anti-CCP and COVID-19 groups.</p><p><strong>Discussion: </strong>The present study revealed a significant increase in rheumatoid factors among the COVID-19 group compared to the healthy control group. These results suggested that COVID-19 contributes to the development of autoantibodies, which might play a critical role in the pathogenesis of COVID-19.</p><p><strong>Conclusion: </strong>These findings suggest that the rheumatoid factor plays a crucial role in the pathogenesis of COVID-19 infection.</p>\",\"PeriodicalId\":101326,\"journal\":{\"name\":\"Infectious disorders drug targets\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious disorders drug targets\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715265361107250829044505\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious disorders drug targets","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118715265361107250829044505","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rheumatoid Factor and Anti-CCP Titers in COVID-19.
Introduction: The mechanisms of Coronavirus Disease 2019 (COVID-19) remain not fully elucidated. The present study aimed to trace the presence of autoantibodies among COVID-19 patients and to determine the association between COVID-19 and these antibodies.
Methods: This study is a cross-sectional, hospital-based study involving 90 participants, who were arranged into three groups: the COVID-19 group, the rheumatoid arthritis group, and the control group. The study population was tested for serum concentration of rheumatoid factor and anti-CCP antibodies.
Results: The results showed significant elevations in serum levels of rheumatoid factor (P < 0.000) and anti-CCP (P < 0.000) among the rheumatoid arthritis group. Similar findings of a significant increase in rheumatoid factor (P < 0.000) were observed among the COVID-19 group compared to the control group, while an insignificant increase (P = 0.605) was reported between the Anti-CCP and COVID-19 groups.
Discussion: The present study revealed a significant increase in rheumatoid factors among the COVID-19 group compared to the healthy control group. These results suggested that COVID-19 contributes to the development of autoantibodies, which might play a critical role in the pathogenesis of COVID-19.
Conclusion: These findings suggest that the rheumatoid factor plays a crucial role in the pathogenesis of COVID-19 infection.
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