The PARK2_e01(-697) Polymorphism does not Associate with Susceptibil-ity to Typhoid in Punjabi Population, Pakistan: A Case Control Study.

Infectious disorders drug targets Pub Date : 2024-09-27 DOI:10.2174/0118715265305304240918063848

Rizwana Kousar, Ayesha Waheed, Rida Naz, Ghazala Kaukab Raja, Umm-E Kalsoom, Sadia Latif

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Abstract

Background: SNP based association studies have revolutionized the field of biomed-icines. Enteric fever is a systemic disease with etiologic agents Salmonella enterica serovar typhi and paratyphi. It is a serious health issue worldwide and presents wide variations in incidence, rates, and severity. Previous investigations have revealed that genetic variations may lead to sus-ceptibility to typhoid fever. A current study was performed to investigate the potential association of PARK2_e01(-697) polymorphism with the susceptibility to typhoid in the Punjabi population.

Methods: For this case-control study, blood samples obtained from typhoid patients with positive Typhidot or blood culture test (n=72) and healthy controls (n=73) were processed for DNA ex-traction. The polymorphism PARK2_e01(-697) analysis was carried out by using PCR and RFLP.

Results: No allelic association was found between PARK2_e01(-697) and susceptibility to ty-phoid fever in the understudy population.

Conclusion: This case control study is the demonstration of the non-association of PARK2_e01(-697) with typhoid in the Pakistani population. Future research, using a larger population size, will help to elucidate the role of PARK2_e01(-697) polymorphism in typhoid pathogenesis.

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巴基斯坦旁遮普人的 PARK2_e01(-697) 多态性与伤寒易感性无关：病例对照研究。

背景：基于 SNP 的关联研究给生物医学领域带来了革命性的变化。肠热病是一种全身性疾病，病原体是肠炎沙门氏菌（Salmonella enterica serovar typhi and paratyphi）。它是全球范围内一个严重的健康问题，在发病率、发病率和严重程度上存在很大差异。以往的调查显示，基因变异可能导致对伤寒的易感性。本研究旨在调查 PARK2_e01(-697) 多态性与旁遮普人伤寒易感性的潜在关联：在这项病例对照研究中，对伤寒患者（72 人）和健康对照组（73 人）的血液样本进行了 DNA 提取。结果显示，PARK2_e01(-697)的等位基因与伤寒患者的血型没有关联：结果：在研究对象中未发现 PARK2_e01(-697) 与伤寒易感性之间的等位基因关联：这项病例对照研究表明，在巴基斯坦人群中，PARK2_e01(-697)与伤寒无关。未来的研究将使用更大规模的人群，这将有助于阐明 PARK2_e01（-697）多态性在伤寒发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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