Antibacterial Effect of Co-Loaded Curcumin and Rutin in Mesoporous Silica Nanoparticles Compared to their Loading Alone.

Infectious disorders drug targets Pub Date : 2024-09-20 DOI:10.2174/0118715265304913240826065228

Mohammad Yousef Memar, Mina Yekani, Simin Sharifi, Solmaz Maleki Dizaj

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Abstract

Aims: The present study aimed to assess the antibacterial effect of co-loaded rutin and curcumin in mesoporous silica nanoparticles (Cur-Rut-MSNs).

Background: Rutin is a nontoxic phytochemical that is present expansively in vegetables and fruits. Curcumin is an active ingredient of Curcuma longa. Curcumin and rutin have a variety of therapeutic effects, essentially antimicrobial, anti-inflammatory, and antioxidant actions.

Objective: Low aqueous solubility and poor bioavailability of rutin and curcumin limit their application in therapeutic goals. One of the advantageous routes to improve their bioavailability and solubility is nanoformulation. Co-delivery of therapeutic agents has been reported to have better therapeutic effects than monotherapy.

Methods: The present study has evaluated the antibacterial properties of Cur-Rut-MSNs. The Minimum Inhibitory Concentration (MIC) of Cur-Rut-MSNs has been assessed against different bacteria.

Results: Cur-Rut-MSNs exerted significantly higher antibacterial effect than curcumin-loaded MSNs (Cur-MSNs) and rutin-loaded MSNs (Rut-MSNs) against Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis (p<0.05).

Conclusion: The antibacterial effect was enhanced by the co-loading of rutin and curcumin in MSNs. According to the findings of this study, Cur-Rut-MSNs exhibit an antibacterial effect and can be a favorable nanoformulation against planktonic bacteria.

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介孔二氧化硅纳米颗粒中姜黄素和芦丁的抗菌效果与单独添加相比

目的：本研究旨在评估介孔二氧化硅纳米颗粒（Cur-Rut-MSNs）中芦丁和姜黄素的抗菌效果：背景：芦丁是一种无毒的植物化学物质，广泛存在于蔬菜和水果中。姜黄素是姜黄的活性成分。姜黄素和芦丁具有多种治疗作用，主要是抗菌、消炎和抗氧化作用：芦丁和姜黄素的水溶性低、生物利用度差，限制了它们在治疗目标中的应用。提高它们的生物利用度和溶解度的有利途径之一是纳米制剂。据报道，与单一疗法相比，联合给药具有更好的治疗效果：本研究评估了 Cur-Rut-MSNs 的抗菌特性。方法：本研究评估了 Cur-Rut-MSNs 的抗菌特性，评估了 Cur-Rut-MSNs 对不同细菌的最低抑菌浓度（MIC）：结果：Cur-Rut-MSNs 对鲍曼不动杆菌、大肠杆菌、金黄色葡萄球菌和粪肠球菌（pCN）的抗菌效果明显高于姜黄素负载型 MSNs（Cur-MSNs）和芦丁负载型 MSNs（Rut-MSNs）：芦丁和姜黄素在 MSN 中的共同负载增强了抗菌效果。根据这项研究的结果，姜黄素-芦丁-MSNs 具有抗菌效果，是一种抗浮游细菌的良好纳米制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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