Infectious disorders drug targets最新文献

{"title":"Avian Influenza A(H5N1) in Children: A Critical Public Health Alert Following the First Case in Victoria, Australia.","authors":"Sharib Raza Khan, Shriyansh Srivastava, Sachin Kumar","doi":"10.2174/0118715265370142250805025143","DOIUrl":"10.2174/0118715265370142250805025143","url":null,"abstract":"","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265370142"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of MDR Enterobacter spp. Isolated from Clinical Specimens in Sudan: Prevalence of CTX-M and Carbapenemase Genes with Absence of SHV and TEM.","authors":"Hiba Abdel Salam Mahgoub, Hind Haidar Ahmed, Tyseer AbdelAzim Ahmed Mahgoub, Osama Mohammed Mohammed Khair, Mawada Hassan Fadlalla Mohammed, Maye Mohammed Merghani, Majdolin Ibrahim Mobark AlBushra, Elsadig Mohammed Hamdan, Rania Hashim MohammedKhair Khojli, Hisham Nour Aldaiem Altyab, Mogahid Mohammed Elhassan","doi":"10.2174/0118715265368414250818114643","DOIUrl":"10.2174/0118715265368414250818114643","url":null,"abstract":"<p><strong>Introduction: </strong>The rise of Multidrug-resistant (MDR) Enterobacter species is a significant global health concern, particularly in hospital settings where they contribute to nosocomial infections. This study aimed to determine the prevalence of MDR Enterobacter spp. in clinical specimens from Khartoum State, Sudan, to detect key resistance genes (CTXM, AmpC, OXA-48, NDM-1, VIM, IMP, MCR-1, SHV, and TEM), and to analyze the correlation between genotypic and phenotypic resistance patterns.</p><p><strong>Methods: </strong>A cross-sectional, laboratory-based study was conducted from February to October 2021. A total of 384 clinical specimens, including urine, wound swabs, sputum, and blood, were collected from hospitals in Khartoum. Enterobacter spp. isolates were identified using conventional methods such as colony morphology, gram staining, and biochemical tests. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method. Multiplex Polymerase Chain Reaction (PCR) was employed to detect ESBL genes (CTX-M, SHV, TEM, AmpC) and carbapenemase genes (OXA-48, NDM-1, VIM, IMP, MCR-1).</p><p><strong>Results: </strong>Among the 384 clinical specimens, 14 (3.6%) were confirmed as Enterobacter spp. by PCR. All isolates exhibited multidrug resistance. CTX-M was detected in 100% of isolates, while SHV and TEM genes were absent. Other detected resistance genes included AmpC in 5 isolates (35.7%), IMP in 2 (14.3%), NDM-1 in 3 (21.4%), VIM in 5 (35.7%), OXA-48 in 7 (50.0%), and MCR-1 in 13 (92.9%). The predominance of CTX-M, carbapenemase genes, and the absence of SHV and TEM suggest a distinct resistance profile in these isolates.</p><p><strong>Discussion: </strong>The findings highlight a concerning emergence of MDR Enterobacter spp. in Sudan, primarily driven by the widespread presence of CTX-M and carbapenemase genes. The lack of SHV and TEM genes indicates potential regional differences in genetic resistance patterns. This underscores the critical need for molecular monitoring and effective infection control policies.</p><p><strong>Conclusion: </strong>The high prevalence of MDR Enterobacter spp., particularly due to CTX-M and carbapenemase gene expression, poses a serious threat to public health in Khartoum. Regional variation in resistance mechanisms, such as the absence of SHV and TEM, necessitates targeted antimicrobial stewardship and the development of localized treatment guidelines to limit the spread of resistance in Sudanese healthcare facilities.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265368414"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"^99mTc-Labeled Cefixime for Targeted Imaging of Infections: Preclinical Evaluation and Potential in Postpartum Women.","authors":"Shahida Parveen, Rubaida Mehmood, Zara Jabeen, Kainat Warraich, Hafiza Samin Anjum, Daniyal Warraich, Mubashra Naz, Fatima Shams, Rida Sana","doi":"10.2174/0118715265350299250824102153","DOIUrl":"10.2174/0118715265350299250824102153","url":null,"abstract":"<p><strong>Introduction: </strong>Targeted infection imaging is crucial for accurate diagnosis in postpartum women. This project uses ^99mTc-labeled cefixime to develop a radiopharmaceutical for detecting, distinguishing, and treating infections and abscesses in women.</p><p><strong>Method: </strong>Technetium (TcO₄-) chelated with cefixime, reduced by stannous chloride, confirmed via thin-layer chromatography. Mice injected with the labeled compound showed pyrogenicity and stability tests at one, two, and three hours. Biodistribution and SPECT (CT) imaging revealed in vivo aspects post-injection.</p><p><strong>Results: </strong>Radiolabeling achieved over 95% technetium binding to cefixime, as shown by ITLC with acetone, demonstrating high labeling efficiency. The labeled molecule remained stable for three hours, providing an adequate imaging window. SEM analysis confirmed drug presence on the complex, IR spectroscopy verified cefixime-tracer bond formation, and HPLC quantified radiolabeling yield.</p><p><strong>Discussion: </strong>Biodistribution studies revealed that radiolabeled cefixime accumulated mainly in the kidney and bladder (31.38%) and liver (30.1%), indicating renal and hepatic clearance pathways. Moderate uptake appeared in the small and large intestines (24.6%), whereas lower distribution was observed in the lungs (4.3%), heart (4.1%), stomach, and spleen (5.4%). SPECT/CT imaging demonstrated drug accumulation in infected thigh tissues, distinguishing them from inflamed sites, underscoring its diagnostic potential for differentiating infectious from inflammatory conditions. The approach shows promise for clinical translation in postpartum infection management and beyond.</p><p><strong>Conclusion: </strong>Cefixime, labeled with ^99mTc, accurately detects rodent infections via scanning. Its potential extends to distinguishing healthy and malignant cells in human plasma, indicating promise in medical diagnostics, including identifying unknown-etiologic pyrexia in post-partum women.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265350299"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZELSUVMI: Pioneering At-Home Treatment for Molluscum Contagiosum.","authors":"Rajni Tanwar, Dinesh Kumar","doi":"10.2174/0118715265351439250901043558","DOIUrl":"10.2174/0118715265351439250901043558","url":null,"abstract":"<p><p>The Food and Drug Administration (FDA) authorized the topical gel Zelsuvmi on January 5, 2024, to treat molluscum contagiosum in children and adults over the age of one. This is the first licensed prescription medication for this highly infectious viral skin illness, primarily affecting youngsters. Zelsuvmi produces nitric oxide, which has antiviral properties. The specific treatment method is unclear, but it is believed to involve processes affecting inflammation, immunological control, and viral replication. Clinical studies have shown Zelsuvmi to significantly decrease the number of lesions and be easily tolerated when applied daily. Clinical trials in Phase 3, such as B-SIMPLE 4 and B-SIMPLE 2, were the basis for the FDA's clearance of Zelsuvmi. The treatment is given topically once daily for a maximum duration of 12 weeks. The product is supplied in two separate tubes: one contains berdazimer gel and the other contains hydrogel. The most common negative effects of Zelsuvmi are usually experienced in the applied area, such as distressing burning, itching, redness, and irritation. Zelsuvmi is anticipated to be commercially accessible in the United States by late 2024, broadening the spectrum of treatment choices for molluscum contagiosum.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265351439"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Benefits of <i>Nigella sativa</i> (Black Seeds) in the Management of Coronavirus Disease-2019 (COVID-19)-Associated New-Onset Diabetes Mellitus (NODM): An Overview.","authors":"Naina Mohamed Pakkir Maideen, Abdurazak Hassan Jumale, Ayesha Khalifa Albasti, Danish Ahmed Abdul Kadir, Maher Yassein Alkhawalda, Murtaza Canani, Ahmed Fathy Shokr","doi":"10.2174/0118715265400793251021092651","DOIUrl":"10.2174/0118715265400793251021092651","url":null,"abstract":"<p><p>After recovering from COVID-19, several patients experienced beta-cell dysfunction, insulin resistance, pancreatic dysfunction, reduced insulin production, and New Onset Diabetes Mellitus (NODM). The purpose of this review was to examine the potential advantages of black seeds (Nigella sativa or N. sativa) in the treatment of post-COVID NODM. With a focus on pertinent publications, the literature search was carried out utilizing electronic databases such as Medline, PubMed, PMC, Scopus, Web of Science, Science Direct, Google Scholar, and reference lists. Numerous RCTs, systematic reviews, and meta-analyses have established N. sativa's antidiabetic potential as well as its other pleiotropic effects, such as its anti-inflammatory, antioxidant, and anti-COVID properties. Through a variety of possible mechanisms, N. sativa may reduce glycated Hemoglobin (HbA1c), Postprandial Blood Glucose (PPBG), Fasting Blood Glucose (FBG), and other indices. The longterm effects of N. sativa in the treatment of COVID-associated NODM should be investigated in future studies.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265400793"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Acaricidal Activity of Coumarin Derivatives Obtained by Chemical Synthesis Against the Cattle Tick <i>Rhipicephalus (Boophilus) microplus</i>.","authors":"Carlos Eduardo Rodríguez Molano, Jose Jobanni Martínez Zambrano, Nidya Alexandra Segura Guerrero, Sergio Ulloa Torres, Valentina Rodríguez Montana, Melisa Daniela Munevar Romero, Nestor Julian Pulido Suarez","doi":"10.2174/0118715265355668250812114823","DOIUrl":"10.2174/0118715265355668250812114823","url":null,"abstract":"<p><strong>Introduction: </strong>Rhipicephalus (Boophilus) microplus is a parasitic tick that significantly impacts livestock production through economic losses and the transmission of diseases. Resistance to conventional acaricides, such as organophosphates, has prompted the search for alternative control strategies. Coumarin derivatives (Cds), due to their structural diversity and biological activity, have emerged as promising candidates for tick management.</p><p><strong>Methods: </strong>Twelve CDs were synthesized via Pechmann condensation under eco-friendly conditions and evaluated for acaricidal activity using the Adult Immersion Test (AIT) on engorged female ticks of the R. (B.) microplus Montecitos strain. Survival was monitored every 24 hours for 96 hours. Data were analyzed using Cox proportional hazards regression and Kaplan-Meier survival estimators to assess the effect of time, concentration, and compound type on tick mortality.</p><p><strong>Results: </strong>Survival decreased with increasing Cd concentration. Compounds C2 (5,7-dihydroxy-4- methylcoumarin), C4 (5-hydroxy-3,4,7-trimethyl-coumarin), and C11 (7-cinnamyloxy-4-methylcoumarin) achieved the survival rates of ≤3% at 10 mg/ml within 96 hours, showing significantly greater efficacy than the organophosphate ethion, to which the Montecitos strain showed resistance (survival >98%). A hormetic response was observed in some treatments, with low concentrations inducing moderate tolerance.</p><p><strong>Discussion: </strong>The acaricidal activity of Cds was closely related to structural features, particularly substitutions at C-4 and C-7 positions. The multifunctional mechanisms of coumarins, including interference with calcium signaling and detoxification pathways, may reduce resistance development. The ineffectiveness of ethion reinforces the need for novel control strategies. Ethanol as a solvent did not affect tick survival, confirming the bioactivity was due to the Cds themselves.</p><p><strong>Conclusion: </strong>Coumarin derivatives synthesized under sustainable conditions demonstrate strong acaricidal potential, especially C2, C4, and C11. These compounds could serve as eco-friendly alternatives to conventional acaricides in controlling R. (B.) microplus, particularly in populations resistant to conventional treatments. Furthermore, <i>in-vivo</i> and environmental impact studies are recommended to validate their practical application.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265355668"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Prolonged SARS-CoV-2 Shedding and HIV Co-infection: Clinical and Diagnostic Challenges.","authors":"Meenakshi Singh, Mandeep Kaur, Girish Dogra, Vandana Awasthi, Ajit Dua","doi":"10.2174/0118715265388132251014105118","DOIUrl":"10.2174/0118715265388132251014105118","url":null,"abstract":"<p><strong>Introduction: </strong>Co-infection of SARS-CoV-2 and HIV presents unique challenges for patients, including potential barriers to accessing care and social support. In the present case report, an unexpected revelation of HIV status was made in an asymptomatic individual who was concurrently infected with SARS-CoV-2. There is insufficient information on asymptomatic but SARS-CoV-2-positive carriers, who have been identified only because of contact tracing and surveillance. Asymptomatic individuals co-infected with SARS-CoV-2 and HIV pose a significant challenge, not only for the patients and their families, but also for the broader community, highlighting the need for enhanced awareness, testing, and contact tracing strategies.</p><p><strong>Case presentation: </strong>This study reports a case of a routine surveillance-based asymptomatic patient who was consistently SARS-CoV-2 positive from June to August 2021 by real-time PCR. Clinical investigations revealed that all vital parameters and laboratory tests were within normal limits, except for a notable elevation in D-dimer levels. The patient was vaccinated with two doses of Covishield, with the second dose administered during the quarantine period. The patient was followed up after six months, and we came to know that the patient's condition deteriorated in the month of November 2021, and he was tested HIV positive during his admission to a tertiary care hospital. Later on, he died in March 2022.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first study reporting accidental finding of HIV in a SARS-CoV-2 asymptomatic patient who was previously false negative. The persistence of SARS-CoV-2 in this case highlights the importance of comprehensive diagnostic workups and careful clinical management in patients with co-infections. This report also highlights the high risk of silent transmission of SARS-CoV-2 by asymptomatic individuals, emphasizing the need to include such cases in dynamic surveillance strategies to prevent further spread. Along with this, the study highlights the need for further investigation into the interplay between HIV co-infection, COVID-19 vaccination outcomes, and the dynamics of SARS-CoV-2 shedding.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265388132"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Assay for Detection and Quantification of Anti-Prostate Specific Antigen Antibodies Using Indirect ELISA.","authors":"Naina Kumar, Labanyamoy Kole, Amit Kant Singh","doi":"10.2174/0118715265342094250423103513","DOIUrl":"10.2174/0118715265342094250423103513","url":null,"abstract":"<p><p>Prostate-specific antigen (PSA) or gamma-selenoprotein or kallikrein-3 (KLK3) is a glycoprotein enzyme secreted by the epithelial cells of the prostate glands. It plays a crucial role in male fertility and is commonly used as a marker of prostate cancer. Antibodies to PSA antigen might play a role in male immune infertility. To date, the tests available in the market provide information only about the presence or absence of these antibodies in body fluids, which is further confirmed by the Western blot test. There are no tests available to quantify the amount of anti-PSA antibodies in human body fluid. Hence, the present patent relates to <i>in vitro</i> immunoassay for detecting and quantifying anti-prostate specific antigen (anti-PSA) antibodies in a human body fluid sample. In particular, the immunoassay is an indirect ELISA. The assay has demonstrated high sensitivity and specificity, capable of detecting anti-PSA antibodies in body fluids within a range of 4.61 ng/mL to 431.37 ng/mL. To further validate the assay's specificity, additional experiments have been conducted using various samples, including chicken seminal fluid, and the serum and semen of azoospermic individuals. These samples, standardized to the same volume, have been incubated with a fixed amount of human PSA-coated antigen. Similar experiments have been performed with anti-human, anti-rabbit, anti-mouse, anti-horse, and antigoat antibodies, further confirming the assay's specificity.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265342094"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Adrenal Tuberculosis Causing Addison's Disease: A Rare Case Report and A brief Update on Diagnosis and Treatment.","authors":"Anju Dinkar, Jitendra Singh, Nidhi Tejan, Munna Lal Patel, Ajay Kumar Patwa, Isha Atam","doi":"10.2174/0118715265391446250916054124","DOIUrl":"10.2174/0118715265391446250916054124","url":null,"abstract":"<p><strong>Introduction: </strong>Primary adrenal tuberculosis is a rare but significant cause of adrenal insufficiency (Addison's disease), particularly in regions where tuberculosis remains endemic. The destruction of the adrenal glands due to Mycobacterium tuberculosis leads to hormonal imbalances, which, if undiagnosed, can result in life-threatening adrenal crises.</p><p><strong>Case presentation: </strong>We report a rare case of a 54-year-old immunocompetent male who presented with progressive weight loss, generalized weakness, and hyperpigmentation over five months. Biochemical investigations revealed hyponatremia, hyperkalemia, low morning cortisol, and elevated adrenocorticotropic hormone (ACTH) levels, confirming primary adrenal insufficiency. Contrast-enhanced computed tomography (CECT) of the abdomen showed bilateral adrenal enlargement with central necrosis. A CT-guided adrenal biopsy revealed caseating granulomas, confirming adrenal TB. The patient was started on a standard anti-tuberculosis treatment (ATT) under the National Tuberculosis Elimination Programme (NTEP) guidelines, along with lifelong hormone replacement therapy.</p><p><strong>Conclusion: </strong>This case highlights the importance of early diagnosis and prompt intervention in adrenal TB to prevent complications. Adrenal TB remains a diagnostic challenge due to its nonspecific presentation. A multidisciplinary approach, integrating TB control programs with endocrinology, is vital for improving patient outcomes.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265391446"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Tuberculous Intramuscular Abscess in a Diabetic Elderly Male: An Unusual Case Report.","authors":"Anju Dinkar, Jitendra Singh, Ajay Kumar Patwa, Saurabh Kumar, Isha Atam","doi":"10.2174/0118715265384910250721042045","DOIUrl":"10.2174/0118715265384910250721042045","url":null,"abstract":"<p><strong>Introduction: </strong>Tuberculosis (TB) primarily affects the lungs, but extrapulmonary manifestations, such as musculoskeletal TB, account for 15-20% of cases. Isolated intramuscular TB abscesses are exceedingly rare cases of extrapulmonary TB. Predisposing factors, such as diabetes mellitus, immunosuppression, and advanced age, increase the risk of such atypical presentations. This report presents a rare case of a primary tuberculous intramuscular abscess in an elderly diabetic male, emphasizing diagnostic challenges and the importance of a multidisciplinary approach.</p><p><strong>Case presentation: </strong>A 63-year-old male with uncontrolled type 2 diabetes presented with a 2-month history of right thigh pain and progressive swelling. Examination revealed an 8×9 cm, nontender, firm lump in the right thigh with normal overlying skin. Imaging with 3T MRI showed a multilobulated fluid collection in the thigh's upper third region, predominantly in the adductor and anterior compartments, with surrounding muscle edema and multiple enlarged inguinal lymph nodes. Histopathological examination of drained material revealed caseating granulomas with Langhans giant cells, consistent with tuberculosis. CBNAAT confirmed rifampicin-sensitive <i>Mycobacterium tuberculosis</i>. The patient was diagnosed with a primary tuberculous abscess and initiated on a 6-month antituberculosis therapy. He showed significant clinical improvement at the 1-month follow-up and successfully completed his 6-month ATT without any intolerance.</p><p><strong>Conclusion: </strong>This case underscores the importance of considering TB in atypical presentations, particularly in endemic regions and high-risk populations. Prompt diagnosis through advanced imaging, histopathology, molecular testing, and appropriate surgical and pharmacological interventions is critical for optimal outcomes in such rare presentations.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":"e18715265384910"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}