Formulation and Comparison of Herbal Gels Containing Essential oils and their Antimicrobial Evaluation.

Infectious disorders drug targets Pub Date : 2024-09-20 DOI:10.2174/0118715265293665240905043446

Karan Agrawal, Vibha, Yogesh Murti, Migul Agrawal, Mayank Kulshreshtha

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Abstract

Objective: The current study aimed to formulate and evaluate herbal gels con-taining essential oils for the treatment of infection caused by microbial species, i.e., S. au-reus, E. coli, P. aeruginosa, and B. subtilis. These species are also responsible for acne directly and indirectly.

Material and methods: The gels were prepared using a gelling agent with 1% Carbopol-940, and they were further evaluated for physical appearance, drug content, in-vitro drug release, viscosity, extrudability, pH, and spreadability. Further, anti-microbial screening was done with various microbial species.

Results: Studies revealed that the gel was highly effective against the selected species ex-cept for the fungal strain. ZOI was observed ranging from 3.1 ± 0.01 mm to 13.4 ± 0.14 mm. The maximum ZOI was observed at 13.4 ± 0.14 mm against S. aureus. The physical properties of the gel satisfied the standard parameters.

Conclusion: The prepared herbal gel was found to have highly promising activity against bacterial species associated with bacterial infection but in a dose-dependent manner. How-ever, more research is required.

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含有精油的草本凝胶的配制和比较及其抗菌评估

研究目的本研究旨在配制和评估含有精油的草药凝胶，用于治疗由微生物物种（即金黄色葡萄球菌、大肠杆菌、绿脓杆菌和枯草杆菌）引起的感染。这些微生物也是直接或间接导致痤疮的原因：使用含 1% Carbopol-940 的胶凝剂制备凝胶，并进一步对凝胶的物理外观、药物含量、体外药物释放、粘度、挤出性、pH 值和铺展性进行评估。此外，还对各种微生物进行了抗微生物筛选：研究表明，除真菌菌株外，凝胶对所选菌种都非常有效。观察到的 ZOI 从 3.1 ± 0.01 毫米到 13.4 ± 0.14 毫米不等。对金黄色葡萄球菌的最大 ZOI 值为 13.4 ± 0.14 mm。凝胶的物理性质符合标准参数：结论：研究发现，制备的草药凝胶对与细菌感染有关的细菌种类具有很好的活性，但其活性与剂量有关。不过，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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