Formulation and Comparison of Herbal Gels Containing Essential Oils and their Antimicrobial Evaluation.

Infectious disorders drug targets Pub Date : 2025-01-01 DOI:10.2174/0118715265293665240905043446

Karan Agrawal, Vibha, Yogesh Murti, Migul Agrawal, Mayank Kulshreshtha

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Abstract

Objective: The current study aimed to formulate and evaluate herbal gels containing essential oils for the treatment of infection caused by microbial species, i.e., S. aureus, E. coli, P. aeruginosa, and B. subtilis. These species are also responsible for acne directly and indirectly.

Material and methods: The gels were prepared using a gelling agent with 1% Carbopol-940, and they were further evaluated for physical appearance, drug content, in-vitro drug release, viscosity, extrudability, pH, and spreadability. Further, anti-microbial screening was done with various microbial species.

Results: Studies revealed that the gel was highly effective against the selected species except for the fungal strain. ZOI was observed ranging from 3.1 ± 0.01 mm to 13.4 ± 0.14 mm. The maximum ZOI was observed at 13.4 ± 0.14 mm against S. aureus. The physical properties of the gel satisfied the standard parameters.

Conclusion: The prepared herbal gel was found to have highly promising activity against bacterial species associated with bacterial infection but in a dose-dependent manner. However, more research is required.

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含有精油的草本凝胶的配制和比较及其抗菌评估

研究目的本研究旨在配制和评估含有精油的草药凝胶，用于治疗由微生物物种（即金黄色葡萄球菌、大肠杆菌、绿脓杆菌和枯草杆菌）引起的感染。这些微生物也是直接或间接导致痤疮的原因：使用含 1% Carbopol-940 的胶凝剂制备凝胶，并进一步对凝胶的物理外观、药物含量、体外药物释放、粘度、挤出性、pH 值和铺展性进行评估。此外，还对各种微生物进行了抗微生物筛选：研究表明，除真菌菌株外，凝胶对所选菌种都非常有效。观察到的 ZOI 从 3.1 ± 0.01 毫米到 13.4 ± 0.14 毫米不等。对金黄色葡萄球菌的最大 ZOI 值为 13.4 ± 0.14 mm。凝胶的物理性质符合标准参数：结论：研究发现，制备的草药凝胶对与细菌感染有关的细菌种类具有很好的活性，但其活性与剂量有关。不过，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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