Infectious disorders drug targets最新文献

{"title":"The Effect of Licorice Extract on Clinically Isolated Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis.","authors":"Mohammad Yousef Memar, Sepideh Bohlouli, Samira Mohammad Mirzapour, Islam Nasiri, Hadi Eslami, Solmaz Maleki Dizaj, Simin Sharifi","doi":"10.2174/0118715265433644251226073827","DOIUrl":"https://doi.org/10.2174/0118715265433644251226073827","url":null,"abstract":"<p><strong>Introduction: </strong>Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (P. gingivalis) are key pathogens in periodontitis. Considering the antibacterial properties of licorice, this study investigated the prevalence of Aa and P. gingivalis in patients with chronic periodontitis using PCR and evaluated the antimicrobial effects of licorice root extract.</p><p><strong>Materials and methods: </strong>Subgingival samples were obtained from 50 patients with chronic periodontitis at the Faculty of Dentistry, Tabriz University of Medical Sciences. DNA was extracted, and specific primers were used for PCR detection. All positive isolates (n=24) were cultured, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of licorice extract (Barij Esans Co., Iran) were determined in triplicate using the microbroth dilution method. Statistical analyses were performed using one-way ANOVA and chi-square tests with SPSS 24.</p><p><strong>Results: </strong>Aa and P. gingivalis were detected in 48% of samples (Aa: 18%, P. gingivalis: 26%, both: 4%). The MIC and MBC values of licorice extract were 7.81 ± 0.42 mg/mL and 20.53 ± 0.61 mg/mL for Aa, and 4.69 ± 0.37 mg/mL and 10.94 ± 0.54 mg/mL for P. gingivalis, respectively. Statistical analysis confirmed significant differences in bacterial prevalence between localized and generalized periodontitis (p < 0.05).</p><p><strong>Discussion: </strong>Due to the potential toxicity of licorice, such as hypertension and hypokalemia, careful dose standardization and toxicity evaluation must be performed before clinical use.</p><p><strong>Conclusion: </strong>Licorice extract demonstrated promising in vitro antibacterial activity against Aa and P. gingivalis. These findings suggest that licorice may serve as a potential adjunctive agent in the management of chronic periodontitis. However, further in vivo and clinical studies are required before clinical application.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Trends of Research on Meningococcal Disease in the 21st century.","authors":"Hongmei Chen, Jian Li","doi":"10.2174/0118715265397446251203112441","DOIUrl":"https://doi.org/10.2174/0118715265397446251203112441","url":null,"abstract":"<p><p>Meningococcal disease (MD) is an infectious disease caused by Neisseria meningitides (Nm) with high morbidity and mortality. The disease has been studied for more than two centuries and remains a serious concern in global public health. To assess the evolving research landscape of MD, an extensive analysis was conducted on multiple indicators retrieved from the Web of Science (WoS) database. These indicators comprised publication volume, country, author and affiliation, number of citations, journal, keyword cluster, and research impact bursts. The findings from the bibliometric evaluation and visualization tools revealed a volatile increase in publication volume on MD after 2000. The United States and European countries, such as the United Kingdom and France, have been conducting extensive research on MD. France, the United Kingdom, and the United States have emerged as the predominant research groups for MD in recent years. The application of keyword co-occurrence investigation and the identification of impactful citation bursts elucidated the primary research focus in MD research. Vaccine development, immunization practice, epidemic prevention, and MD control are fields that have attracted continuous attention in MD research. The research maps generated from our comprehensive analysis provide invaluable support to researchers exploring MD.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Antimicrobial and Antibiofilm Properties of a New Endodontic Sealer against Enterococcus faecalis with AH Plus Sealer.","authors":"Shahriar Shahi, Solmaz Maleki Dizaj, Naiemeh Motallebi, Simin Sharifi, Danial Haghighi, Majid Yaltaghiani","doi":"10.2174/0118715265387112251115065105","DOIUrl":"https://doi.org/10.2174/0118715265387112251115065105","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the antimicrobial and antibiofilm properties of a novel endodontic sealer against Enterococcus faecalis (E. faecalis). Long-lasting antimicrobial sealers can inhibit bacterial growth and reduce persistent infections following root canal treatment. The primary objective was to compare the new sealer with the AH Plus sealer in terms of antimicrobial and antibiofilm efficacy.</p><p><strong>Methods: </strong>Five experimental sealer formulations (Groups A-E) were prepared using the spatula mixing method. Disks (6 mm diameter) were fabricated and evaluated using colony-forming unit (CFU) counts and disk diffusion assays. Biofilm formation by E. faecalis was assessed prior to testing the antibiofilm activity, which was quantified using the minimum biofilm inhibitory concentration (MBIC).</p><p><strong>Results: </strong>Group D and AH Plus sealer demonstrated the lowest CFU counts among the new sealer formulations (P>0.05). Group D exhibited the largest inhibition zone compared to the other experimental groups (P>0.05). The mean MBIC against E. faecalis was 256 μg/mL for both Group D and AH Plus sealer.</p><p><strong>Discussion: </strong>The newly developed sealer (Group D) displayed antimicrobial and antibiofilm effects comparable to AH Plus sealer against E. faecalis.</p><p><strong>Conclusion: </strong>Group D shows promise as a candidate for further evaluation in clinical studies, demonstrating efficacy similar to the commercially available AH Plus sealer.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ribosome-targeted and Adjuvant Strategies to Combat Antibiotic Resistance.","authors":"Sejal Porwal, Rishabha Malviya, Sathvik Belagodu Srighar, Javedh Shareef","doi":"10.2174/0118715265396934250805055608","DOIUrl":"https://doi.org/10.2174/0118715265396934250805055608","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines ribosome-targeted and adjuvant strategies to combat the growing threat of antimicrobial resistance (AMR), with a focus on novel therapeutic approaches, including phage therapy, monoclonal antibodies, CRISPR systems, and AI-driven drug discovery. The objective is to review current challenges and evaluate innovative strategies targeting bacterial ribosomes, a primary site for antibiotic action.</p><p><strong>Methods: </strong>A systematic literature review was conducted using databases, such as PubMed, ScienceDirect, Scopus, and Google Scholar.</p><p><strong>Results: </strong>The study indicates that bacteria evade ribosome-targeting antibiotics through various mechanisms, including porin modification, efflux pumps, ribosomal mutations, and enzymatic degradation. Innovative strategies, including AI-enabled virtual screening, phage-antibiotic synergy, ribosomal protein-targeted monoclonal antibodies and vaccines, and CRISPR-Cas systems, have shown potential in overcoming these mechanisms and restoring antibiotic efficacy.</p><p><strong>Discussion: </strong>These advanced strategies represent a significant shift from traditional approaches, as they directly target ribosomal functions or resistance genes. While promising, limitations such as phage specificity, challenges in CRISPR delivery, and regulatory concerns must be addressed to ensure clinical translation. The integration of AI with molecular techniques enhances therapeutic precision and development speed.</p><p><strong>Conclusion: </strong>Ribosome-targeted therapies and adjunctive strategies, such as AI, phage therapy, monoclonal antibodies, and CRISPR, offer precise and innovative solutions to overcome antibiotic resistance.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Deceptive Signal: p16 Positivity Suggestive of Human Papilloma Virus Infection Masking a Second Primary Malignancy - A Case Report and Review on Literature.","authors":"Naina Kumar, Gunvanti Rathod, Annapurna Srirambhatla, Mishu Mangla, R Chandramouli, Aparna Setty, Pooja T Rathod","doi":"10.2174/0118715265413651251029062614","DOIUrl":"https://doi.org/10.2174/0118715265413651251029062614","url":null,"abstract":"<p><strong>Introduction: </strong>Synchronous primary malignancies of the female genital tract are rare, comprising a small subset of gynecologic cancers. The concurrent presence of endometrioid endometrial adenocarcinoma and Squamous Cell Carcinoma (SCC) of the cervix is exceptionally rare. It accounts for less than 1% of reported cases.</p><p><strong>Case presentation: </strong>A 75-year-old postmenopausal woman presented with intermittent vaginal bleeding. Imaging studies revealed a bulky uterus with an endometrial lesion suspicious for malignancy. An initial cervical biopsy identified high-grade papillary SCC of the ectocervix with diffuse p16 positivity. However, the MRI revealed a large endometrial mass that invaded more than 50% of the myometrium. The patient underwent a staging laparotomy with a radical hysterectomy. Histopathological evaluation confirmed two distinct malignancies: a moderately differentiated endometrioid endometrial adenocarcinoma (FIGO Stage IB) with squamous morules and a small, completely excised cervical SCC. No nodal or peritoneal metastases were identified. Postoperatively, the patient received adjuvant external beam radiotherapy and vaginal brachytherapy.</p><p><strong>Conclusion: </strong>This case underscores the importance of a multidisciplinary approach, including immunohistochemistry and imaging, in diagnosing synchronous gynecological malignancies. Recognizing the coexistence of distinct tumors is essential for accurate staging and tailored treatment planning to improve patient outcomes.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematocervix and Hematometra: A Rare Case Report of HPV-16 Induced Cervical Intraepithelial Neoplasia (CIN).","authors":"Mishu Mangla, Naina Kumar, Jitendra Singh Nigam, Anusha Devalla, Subhrajyoti Roy, Nireesha Bukke","doi":"10.2174/0118715265392020251020103352","DOIUrl":"https://doi.org/10.2174/0118715265392020251020103352","url":null,"abstract":"<p><strong>Introduction: </strong>Hematocervix and hematometra are uncommon manifestations of cervical intraepithelial neoplasia (CIN). While cervical stenosis is more commonly associated with senile at-rophy or post-procedural scarring, its occurrence in the context of CIN remains exceptionally rare.</p><p><strong>Case presentation: </strong>A 49-year-old female presented to the gynaecology outpatient department with complaints of diffuse pain in the lower abdomen for the last 3 months. On examination, the vagina appeared atrophic, and a reddish-blue swelling was noted at the location of the cervix. Cough impulse was positive. On bimanual examination, the uterus was approximately 10 weeks in size, and a glob-ular swelling was palpable in the cervical region, which was soft, cystic, and boggy to the touch. USG and MRI confirmed hematocervix likely due to stenosis of the external os. On dilatation of the exter-nal os, about 250 ml of dark brown chocolate-coloured thick fluid was drained. Cervical biopsy was suggestive of intra-epithelial dysplasia (CIN III). HPV testing was positive for HPV-16. The patient was counselled for LEEP, followed by close surveillance, but instead she opted for a hysterectomy. Histopathology confirmed CIN III with features suggestive of cervical thinning characterized by ep-ithelial atrophy, underlying stromal fibrosis, and chronic inflammatory infiltrates comprising lym-phocytes and plasma cells, indicative of a longstanding inflammatory process.</p><p><strong>Conclusion: </strong>Severe cervical thinning and hematocervix are uncommon but significant presentations of CIN. A high index of suspicion, timely histopathological evaluation, and appropriate management are essential in preventing adverse outcomes. This case highlights the importance of a comprehensive assessment in patients presenting with similar findings, particularly in those with risk factors or a history of cervical disease.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Cancer Complexity: Exploring the Coexistence of CIN3 and Glandular Lesions.","authors":"Leo Guidobaldi, Concetta Cafiero, Giuseppina Stillitano, Enzo Ricciardi, Luigi Coppola, Alessandra Perfetti, Maria Colacicco, Luigi Santacroce, Raffaele Palmirotta, Salvatore Pisconti","doi":"10.2174/0118715265414137251106123730","DOIUrl":"https://doi.org/10.2174/0118715265414137251106123730","url":null,"abstract":"<p><strong>Introduction: </strong>Although cases of squamous cell carcinoma of the cervix are declining, the increase in adenocarcinoma and in situ adenocarcinoma raises new concerns and requires improvements in diagnostic and therapeutic strategies. This study investigates the relationship between advanced CIN3 and concurrent cervical glandular diseases, emphasising the importance of high-risk HPV genotypes in the progression of these conditions.</p><p><strong>Methods: </strong>The clinical data of 104 patients who underwent conization for CIN3 at our centre in the last 10 years were reviewed. Cytological and histological diagnoses were performed according to the 2014 Bethesda system and WHO classification criteria, respectively. The analysis included patient age, HPV genotype of the surgical specimen, length of the cone, resection margin status, and follow-up details.</p><p><strong>Results: </strong>Of the 104 patients, 92 (88.46%) were diagnosed with single CIN3 lesions (group 1), while 12 patients (11.54%) had coexisting glandular CIN3 lesions (group 2). All women tested were found to be positive for high-risk HPV (HPV-HR). The HPV18 genotype was found to be statistically more prevalent in group 2 (41.7%) than in group 1 (13%) (p = 0.011). At the first follow-up, HPV persistence was observed in 14/92 (15.2%) patients in group 1 and 10/12 (83.3%) patients in group 2 (p= 0.00001). Finally, the recurrence rate was 6.5% (6/92) in group 1 vs 30% (3/10) in group 2 (p= 0.012).</p><p><strong>Discussion: </strong>In the management of cervical lesions, glandular pathology may go undetected at initial diagnosis, as it is often not visible on colposcopy or cytology. It is only through excisional treatment, which allows a more detailed analysis of the tissue, that these lesions can be identified. The presence of an associated glandular lesion radically changes the clinical picture and therapeutic management, requiring a more radical approach than that expected for an isolated CIN3 lesion.</p><p><strong>Conclusions: </strong>The results of the study not only highlight the complexity of CIN3 associated with AIS/AC lesions, but also the importance of an integrated strategy that includes early diagnosis, appropriate treatment, and rigorous follow-up. The ultimate goal is the improvement of clinical outcomes and quality of life for cervical cancer patients.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of Testing Serum C-reactive Protein and its Clinical Significance in COVID-19 Patients.","authors":"Yousef Rasmi, Johra Khan, Md Shariful Islam, Ashwin Kotnis","doi":"10.2174/0118715265373889251115060408","DOIUrl":"https://doi.org/10.2174/0118715265373889251115060408","url":null,"abstract":"<p><p>The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the current coronavirus disease 2019 (COVID-19) pandemic, which has disclosed alarming challenges to global health. The disease demonstrates several clinical issues, from mild symptoms to severe acute respiratory-related problems, including multi-organ failure. The virus is key in COVID-19's pathogenesis, triggering different inflammatory responses. A well-known inflammatory biomarker, C-reactive protein (CRP), has become a possible diagnostic and prognostic marker in COVID-19 patients. This review aims to explain CRP in COVID patients and disease progression. It also shows how it can have a predictive value for clinical outcomes and potential therapeutic purposes. Additionally, we address the limitations and offer recommendations for future CRP studies. Overall, this review underscores the potential of CRP as a promising biomarker for managing COVID-19 and highlights the necessity of further research to understand its clinical significance thoroughly.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Genotypic Characterization of ESBL- and Carbapenemase-producing Escherichia coli Isolates in Irritable Bowel Syndrome (IBS) Patients.","authors":"Anis Ramezani, Mohammad Yazdanmanesh, Hamid Heidari, Arezo Khadiv, Fateme Yazdani, Hamidreza Houri, Morteza Karami-Zarandi, Hossein Kazemian","doi":"10.2174/0118715265415259251104122457","DOIUrl":"https://doi.org/10.2174/0118715265415259251104122457","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of irritable bowel syndrome (IBS) is estimated to range from 10% to 20%. The symptoms of IBS have been associated with an increased presence of Escherichia coli bacteria in the bowel. Treatment is often complicated by the growing prevalence of antibioticresistant strains, particularly those producing extended-spectrum β-lactamases (ESBLs) and carbapenemases. Given the clinical significance of antibiotic resistance in E. coli among IBS patients, this study aimed to investigate the phenotypic and genotypic characteristics of ESBL- and carbapenemase-producing E. coli isolates.</p><p><strong>Methods: </strong>The isolates were obtained from stool samples of IBS patients and identified using conventional biochemical methods. Phenotypic tests were conducted to detect ESBL- and carbapenemaseproducing strains. Polymerase chain reaction (PCR) was employed to identify genes associated with ESBL and carbapenemase production. Additionally, biofilm formation was assessed using a microtiter plate assay.</p><p><strong>Results: </strong>A total of 67 E. coli isolates were recovered from patients. Of these, 37 (55.2%) were phenotypically positive for ESBL or carbapenemase production. PCR analysis revealed that 18 isolates (26.9%) harbored at least one ESBL gene, while 16 (23.9%) carried at least one carbapenemaserelated gene. The most prevalent ESBL gene was blaTEM (23.9%), while blaOXA-23 and blaKPC were the most common carbapenemase genes (each found in 10.4% of isolates). Notably, all isolates exhibited biofilm-forming ability, with nearly half (49.25%) forming strong biofilms.</p><p><strong>Conclusion: </strong>The notable prevalence of ESBL- and carbapenemase-producing E. coli among IBS patients may significantly affect patient outcomes, underscoring the need for targeted antibiotic stewardship and monitoring of biofilm-forming, drug-resistant strains.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and Microscopic Characterization of Fungal Pathogens from Onychomycosis-Infected Toe Nails: A Case Report.","authors":"Ritika Digra, Nitasha Chauhan, Amit Bhatia, Shruti Chopra","doi":"10.2174/0118715265424943251124113256","DOIUrl":"https://doi.org/10.2174/0118715265424943251124113256","url":null,"abstract":"<p><strong>Background: </strong>Onychomycosis is a chronic fungal nail infection caused by dermatophytes, yeasts, and non-dermatophyte molds. Confirming the causative organism is critical for guiding appropriate anti-fungal therapy.</p><p><strong>Case presentation: </strong>This study reports the case of a male patient with nail discoloration, thickening, and dystrophy that were clinically suggestive of onychomycosis. Nail clippings were collected, cultured on Sabouraud Dextrose Agar, and examined microscopically. Colonies were identified by lactophenol cotton blue staining and confirmed using scanning electron microscopy. Morphological features, including pseudohyphae, blastoconidia, and chlamydospores, confirmed Candida albicans as the causative agent. The study focused on the laboratory isolation and identification of the causative fungal pathogen from nail specimens, a critical step for accurate diagnosis.</p><p><strong>Conclusion: </strong>This case emphasizes the value of simple, economical microscopy-based methods for identifying Candida albicans in onychomycosis and underscores their role in supporting clinical management.</p>","PeriodicalId":101326,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}