A Clinical Multicenter Trial of Recombinant Human Interferon Gamma in Tuberculosis (GAM2022) Experience with the Use of Human Recombinant Interferon Gamma in TB Practice.
Veronika E Izosimova, Natal'ja A Barmina, Marija P Zharikova, Oleg Ye Alekseyev, Oxana A Ryzhkova, Marat H Sayfulin, Natal'ja A Popova, Mihail A Andreyev, Svetlana G Gagarina, Raisa M Rysdauletova, Natal'ja G Kamaeva, Anastasiya G Samoylova, Marija I Romanova
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Abstract
Background: In this article, we present the results of a multicenter clinical trial of IFN-γ in patients with drug-susceptible and drug-resistant pulmonary Tuberculosis (TB) in routine clinical practice.
Objective: This study aimed to confirm the efficacy and safety of IFN-γ administered to patients with TB.
Methods: All patients were diagnosed with TB after being tested by bacterioscopic and molecular genetic methods and had no contraindications to standard chemotherapy.
Results: Recombinant human IFN-γ proved high efficacy in multi-center clinical trials in routine TB practice.
Conclusion: The results show that IFN-γ is efficient and safe in the treatment of pulmonary tuberculosis.
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