Journal of Cartilage & Joint Preservation最新文献

{"title":"Acellular scaffolds, cellular therapy and next generation approaches for knee cartilage repair","authors":"Pedro Debieux ,&nbsp;Enzo Salviato Mameri ,&nbsp;Giovanna Medina ,&nbsp;Keng Lin Wong ,&nbsp;Camila Cohen Keleka","doi":"10.1016/j.jcjp.2024.100180","DOIUrl":"10.1016/j.jcjp.2024.100180","url":null,"abstract":"<div><h3>Introduction</h3><p>Full-thickness knee cartilage defects are a potential source of significant morbidity for patients and incur an increased risk for early degenerative joint disease. Recent decades have seen several advancements in the field of cartilage repair, among which osteochondral allograft transplantation and autologous chondrocyte implantation stand out as the options with the most durable and effective results. There are several limitations, however, to the current generation of cartilage repair options, spanning from cost and availability-related issues to the inherent implications of 2-stage surgery, and potentially limited capacity for tissue regeneration.</p></div><div><h3>Objectives</h3><p>The present review aims to offer an overview of next-generation approaches for cartilage repair, providing the rationale and available evidence for novel acellular scaffolds, cell-based therapies, mesenchymal stem cells, extra-cellularextracellular vesicles (exosomes), allogenic therapies, and gene therapies.</p></div><div><h3>Methods</h3><p>This article reviews current literature regarding innovations in the repair of chondral and osteochondral injuries.</p></div><div><h3>Results</h3><p>Emerging approaches the so-called next generation of cartilage repair are numerous and aim to harness the optimal biological environment and structural support needed to potentially enhance clinical outcomes.</p></div><div><h3>Conclusion</h3><p>The next generation of care for cartilage injuries aims to enhance the quality of scaffolds, cell types, cell viability, and integration with the receptor; and to introduce new technologies such as three dimensional bioprinting scaffolds, acellular and gene therapies.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000167/pdfft?md5=204fa1e72c13991bae7ff3934ac164fb&pid=1-s2.0-S2667254524000167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapies for osteoarthritis: progress and prospects","authors":"Anais Defois ,&nbsp;Nina Bon ,&nbsp;Mathieu Mével ,&nbsp;David Deniaud ,&nbsp;Yves Maugars ,&nbsp;Jérôme Guicheux ,&nbsp;Oumeya Adjali ,&nbsp;Claire Vinatier","doi":"10.1016/j.jcjp.2024.100186","DOIUrl":"10.1016/j.jcjp.2024.100186","url":null,"abstract":"<div><h3>Introduction</h3><p>Osteoarthritis (OA), the most common form of joint disease, affects more than 500 million people worldwide. This painful and debilitating disease imposes a huge socioeconomic cost worldwide. Despite years of promising research, no etiological drug has been successfully introduced into daily clinical practice. In this context, gene therapy (GT) is emerging as a tool capable of meeting an increasingly specialized medical need. Five GT drugs for OA are currently under clinical evaluation, demonstrating the relevance of this tool. However, the widespread use of GT is still limited by considerations of safety, long-term efficacy, controlled and specific targeting, and the presence of neutralizing immune responses. Cartilage, a tissue of interest to target in OA, is a complex tissue to penetrates with the various GT vectors.</p></div><div><h3>Methods</h3><p>This manuscript reviews current clinical trials involving DNA-based GT for OA and suggests ways to improve recombinant adenoviral and adeno-associated viral vectors, including capsid engineering and transgene sequence optimization to achieve long-term expression of a given transgene exclusively in the target joint tissue, including cartilage.</p></div><div><h3>Results</h3><p>This review then highlights that the use of hybrid serotypes and/or chemical modifications of capsids are promising for improved tissue targeting. In addition, the choice of promoter and type of vectorized nucleic acid (single- or double-stranded DNA) appears to be critical for efficient transgene expression.</p></div><div><h3>Conclusion</h3><p>Finally, the combination of increasing knowledge about biocompatible materials and viral vectors should also be a way to improve transduction efficiency, increase the stability of transgene expression, and allow escape from neutralizing antibodies.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000222/pdfft?md5=ddc6a80ea4c466f5a8e0b03c1abd6dff&pid=1-s2.0-S2667254524000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index and sex and their effect on patient-reported outcomes following cartilage repair: an insight from the International Cartilage Regeneration and Joint Preservation Society Patient Registry","authors":"Gwenllian F. Tawy ,&nbsp;Reza Ojaghi ,&nbsp;Michael J. McNicholas","doi":"10.1016/j.jcjp.2024.100165","DOIUrl":"10.1016/j.jcjp.2024.100165","url":null,"abstract":"<div><h3>Introduction</h3><p>Chondral injuries in the knee, whether isolated or accompanying other injuries are found in as many as 60% of arthroscopic examinations. Although current research has identified negative outcomes for patients with a body mass index (BMI) &gt;30<!--> <!-->kg/m² undergoing chondral repair, our understanding of the relationship between presurgery BMI and postoperative patient-reported outcomes across all BMI categories remains lacking.</p></div><div><h3>Objectives</h3><p>Through the International Cartilage Regeneration and Joint Preservation Society (ICRS) Patient Registry, this study aimed to explore this relationship, taking into account sex variations.</p></div><div><h3>Methods</h3><p>The ICRS Patient Registry was used to extract the data for this study. The outcomes in focus were the Knee Osteoarthritis Outcome Score (KOOS) and EQ-5D scores. Pearson and Spearman correlation methods were applied and the level of significance was set as <span><math><mi>α</mi></math></span> <!-->= 0.05.</p></div><div><h3>Results</h3><p>Of 3194 Registry patients at the time of data extraction, 1757 had undergone a surgical procedure, and 336 of these had complete KOOS or EQ-5D scores available for 6-week, 6-month, and 1-year postoperation. Analyses revealed that neither male (average BMI – 28.2 kg/m²) nor female (average BMI – 25.3 kg/m²) data sets indicated a correlation between BMI and the patient-reported outcomes.</p></div><div><h3>Conclusions</h3><p>BMI, irrespective of sex, is not correlated with patient-reported outcomes in patients enrolled in the ICRS Registry with a BMI &lt;30 kg/m². Although BMIs in the overweight classification were not associated with poorer outcomes than BMIs in the normal classification, the current literature continues to support the notion that a BMI &gt;30 kg/m² is linked to poor cartilage repair and failure.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000015/pdfft?md5=bb700722f65c469f6a4413658742c995&pid=1-s2.0-S2667254524000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From past and current cartilage surgical techniques to NextGen approaches","authors":"Ignacio Dallo ,&nbsp;Cassandra A. Lee ,&nbsp;Luis Eduardo Passarelli Tirico ,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100188","DOIUrl":"10.1016/j.jcjp.2024.100188","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000246/pdfft?md5=e6e5add58ae9a40dd9b94b4dcc44d09e&pid=1-s2.0-S2667254524000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-free biomimetic scaffold for chondral and osteochondral lesions: surgical technique for custom and standardized implantation","authors":"Luca Andriolo ,&nbsp;Luca De Marziani ,&nbsp;Alessandro Di Martino ,&nbsp;Angelo Boffa ,&nbsp;Stefano Zaffagnini ,&nbsp;Giuseppe Filardo","doi":"10.1016/j.jcjp.2024.100173","DOIUrl":"10.1016/j.jcjp.2024.100173","url":null,"abstract":"<div><h3>Introduction</h3><p>Cell-free chondral and osteochondral scaffolds have been introduced to address lesions of the articular surface. A proper implantation technique is key to favor scaffold integration, regenerative processes, and positive clinical outcomes.</p></div><div><h3>Objectives</h3><p>The purpose of this article is to describe indications and surgical steps for both the custom traditional free-hand implantation approach and an innovative minimally invasive technique for the standardized implantation of this biomimetic cell-free scaffold (MaioRegen; Fin-Ceramica Faenza Spa).</p></div><div><h3>Methods</h3><p>Indications and contraindications for this scaffold implantation have been provided. The required steps for surgical preparation, implantation technique, and postoperative management have been described as well to address articular surface lesions of the knee.</p></div><div><h3>Results</h3><p>A dedicated instrumentation for circular implants of different sizes has been developed to allow more precise preparation of the depth and width of the defect, reducing the invasiveness and increasing implant stability. The custom free-hand technique with chisels and osteotomes remains useful when the lesion does not allow the use of the standardized instrumented technique. In case further stability of the implant is needed, fibrin glue addition should be considered.</p></div><div><h3>Conclusions</h3><p>By guiding the readers with the key perioperative and intraoperative steps, chondral and osteochondral defects can be addressed with the use of a cell-free scaffold, maximizing implant stability.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266725452400009X/pdfft?md5=88c34609da3d3d4d0570d11da9082792&pid=1-s2.0-S266725452400009X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of mesenchymal stem/stromal cell-derived extracellular vesicles as cell-free therapy for osteoarthritis: a narrative review","authors":"Kazunori Shimomura ,&nbsp;Keng Lin Wong ,&nbsp;Samundeeswari Saseendar ,&nbsp;Sathish Muthu ,&nbsp;Sebastian Concaro ,&nbsp;Tiago Lazzaretti Fernandes ,&nbsp;Ansar Mahmood","doi":"10.1016/j.jcjp.2024.100184","DOIUrl":"10.1016/j.jcjp.2024.100184","url":null,"abstract":"<div><h3>Introduction</h3><p>Mesenchymal stem/stromal cell (MSC)-based therapies in cartilage repair and osteoarthritis (OA) treatment have gained attention. Recently, there has been increasing evidence to suggest that MSCs secrete a wide range of trophic factors to modulate the injured tissue environment. Extracellular vesicles (EVs) have been suggested to explain the positive and sometimes curative effect, through the paracrine stimulation of the resident progenitor cells to aid in repair.</p></div><div><h3>Objectives</h3><p>To give a narrative review of the current evidence for MSC-derived EV’s potential therapeutic effects and future perspectives for the treatment of OA.</p></div><div><h3>Methods</h3><p>A literature search was conducted using the MEDLINE databases in November 2023. A total of 24 animal studies describing EV, including exosomes utilized in cartilage and OA treatments were identified and analyzed.</p></div><div><h3>Results</h3><p>Preclinical animal studies indicated that EVs could enhance the therapeutic effects for the treatment of OA, although the purification methods for EVs and their cell sources would be highly relevant to therapeutic efficacy. In contrast, there have been no published clinical studies regarding EVs for the treatment of OA, and thus, properly controlled clinical trials and regulations are essential steps in future clinical applications.</p></div><div><h3>Conclusions</h3><p>The current evidences suggest that the administration of MSC-derived EVs into damaged joints could effectively reduce cartilage loss and alleviate the progression of OA. In contrast, there are still several potential problems to be solved, including their classification, safety and toxicity in clinical use, as well as optimal dosage and frequency for human administration.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000209/pdfft?md5=7691bdef97dc2adbd01d0448c6558dae&pid=1-s2.0-S2667254524000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of techniques in cartilage imaging","authors":"Mary Elizabeth Buchanan ,&nbsp;Brian Keegan Markhardt","doi":"10.1016/j.jcjp.2023.100155","DOIUrl":"10.1016/j.jcjp.2023.100155","url":null,"abstract":"<div><h3>Introduction</h3><p>This narrative review provides a historical overview and updates on the current status of qualitative and quantitative magnetic resonance imaging (MRI) for the evaluation of articular cartilage. The review emphasizes the basic physics principles underlying common cartilage-specific imaging sequences, provides explanations of the magnetic resonance pulse sequences used in articular cartilage imaging, and highlights the advantages and limitations of different pulse sequences.</p></div><div><h3>Objectives</h3><p>To review current literature on qualitative and qualitative MRI for the evaluation of articular cartilage.</p></div><div><h3>Methods</h3><p>A computer-based search of the PubMed database was used to perform a comprehensive literature review on MRI for evaluation of articular cartilage. All journals were considered, and all relevant articles were retrieved. Relevant material was drawn from the years 1977 to 2023 and a total of 84 publications were ultimately included in the review.</p></div><div><h3>Results</h3><p>The literature review highlights the physics principles and rationale underlying the most commonly used cartilage-specific MRI sequences.</p></div><div><h3>Conclusions</h3><p>MRI is the optimal noninvasive method for the assessment of articular cartilage. Many factors affect the clinical utility of various cartilage-specific MRI sequences. It is important that radiologists and clinicians alike have a basic understanding of the optimal methods for cartilage imaging.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 1","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254523000616/pdfft?md5=54d24bd6a1f7538e2b0a32fd34b66741&pid=1-s2.0-S2667254523000616-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134016926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to imaging of cartilage","authors":"Alexander N. Merkle,&nbsp;Corey K. Ho","doi":"10.1016/j.jcjp.2023.100164","DOIUrl":"10.1016/j.jcjp.2023.100164","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 1","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254523000707/pdfft?md5=508359a47ed56ea4920a52544e4df039&pid=1-s2.0-S2667254523000707-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal variants, imaging artifacts, and other diagnostic pitfalls in articular cartilage imaging of the extremities","authors":"John H. Schilling,&nbsp;Paulo Miro,&nbsp;Brian Y. Chan","doi":"10.1016/j.jcjp.2023.100147","DOIUrl":"10.1016/j.jcjp.2023.100147","url":null,"abstract":"<div><h3>Introduction</h3><p>Imaging of the articular cartilage of the extremities is a complex topic that is continually refined through advancements in imaging, surgery, and conservative management of chondral pathology. However, there are many commonly encountered pitfalls in articular cartilage imaging, which are critical for both radiologists and surgeons to be aware of.</p></div><div><h3>Objectives</h3><p>This review will overview the basic concepts of imaging of the cartilage, with a focus on magnetic resonance imaging, including a discussion of magic angle, chemical shift, and susceptibility artifacts that can be mistaken for abnormal cartilage.</p></div><div><h3>Methods</h3><p>A review of described variant cartilage anatomy and imaging artifacts from the imaging and arthroscopic literature is undertaken with illustrative examples retrieved from the University of Utah picture archiving and communication system (PACS).</p></div><div><h3>Results</h3><p>Tools for distinguishing pathologic cartilage from the expected appearance of normal variant accessory ossicles, coalitions, partitions, and the normal labrum are introduced. Joint-specific considerations of commonly encountered cartilage-related entities in the shoulder, elbow, wrist, hip, knee, ankle, and foot are also reviewed.</p></div><div><h3>Conclusions</h3><p>Correlation of imaging, arthroscopic, and clinical findings is key to reducing diagnostic dilemmas, preventing inadvertent overestimation of disease, and ensuring appropriate intervention.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 1","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254523000537/pdfft?md5=0368bb127ea200d0c2c9f556d2210402&pid=1-s2.0-S2667254523000537-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128079614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow signal abnormalities in arthritis and trauma","authors":"David C. Gimarc ,&nbsp;Mary K. Jesse Lowry","doi":"10.1016/j.jcjp.2023.100157","DOIUrl":"10.1016/j.jcjp.2023.100157","url":null,"abstract":"<div><p>Joint pain and dysfunction are common presenting symptoms of both younger and older patients, resulting in significant cost and burden to the healthcare system. In both the acute and chronic setting, the advanced imaging evaluation for assessing joint dysfunction most commonly utilizes magnetic resonance imaging that allows for detailed evaluation of all components of a joint, including the cartilage, bone, fibrocartilage, and ligamentous components. Signal alterations of the subchondral bone and marrow have been recently recognized as an important component in both trauma and arthritis and modern treatment strategies focus on addressing both the cartilage and bone in an attempt to optimize joint preservation and restore function. The presence of bone marrow signal abnormalities is often associated with patient symptoms, cartilage loss, and risk of disease progression. A thorough understanding of the unique anatomy and biomechanics of the chondro-osseous junction can help to explain the many marrow signal abnormalities and clinical implications that are commonly encountered by imagers. In this review article, we will describe the anatomy and basic physiology of the subchondral bone, and discuss multiple pathologic appearances of the bone with an emphasis on edema-like signal changes seen in the setting of osteoarthritis and trauma.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 1","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266725452300063X/pdfft?md5=c1ca8eb91204583e25bc6120f9d47179&pid=1-s2.0-S266725452300063X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136128438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}