Journal of Cartilage & Joint Preservation最新文献

{"title":"Patellofemoral stabilization with and without cartilage restoration","authors":"Joseph M. Rund ,&nbsp;John W. Welsh ,&nbsp;M. Benjamin Burch ,&nbsp;John R. Worley ,&nbsp;Lasun O. Oladeji ,&nbsp;Taylor Ray ,&nbsp;Aaron D. Gray ,&nbsp;Betina B. Hinckel ,&nbsp;Seth L. Sherman","doi":"10.1016/j.jcjp.2024.100190","DOIUrl":"10.1016/j.jcjp.2024.100190","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Cartilage restoration as an adjunct to patellofemoral (PF) soft tissue and/or bony stabilization in patients with symptomatic PF instability remains controversial. Our purpose was to evaluate patients undergoing surgical stabilization for PF instability with or without concomitant cartilage restoration.</div></div><div><h3>Methods</h3><div>Retrospective review of prospectively collected data identified patients undergoing surgical stabilization for recurrent patella instability, with or without concomitant cartilage restoration. Presurgical and postsurgical patient-reported outcomes were collected. Complications requiring reoperation were recorded. Statistically significant difference was set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>One hundred thirty patients (144 knees) were included. One hundred thirteen knees in the isolated stabilization (STAB) and 31 knees in the Stabilization-Cartilage Restoration (STAB-CART) group. The average age was 20.64 and 25.03 in the STAB and STAB-CART groups (<em>P</em> = .034), respectively. STAB-CART group had significantly lower preoperative Knee injury and Osteoarthritis Outcomes Score (57.24 ± 17.45 vs 46.11 ± 14.74, <em>P</em> = .019) and Single Assessment Numeric Evaluation scores (43.15 ± 19.05 vs 26.85 ± 13.74, <em>P</em> = .002). Both groups statistically improved in all Knee injury and Osteoarthritis Outcomes Score, International Knee Documentation Committee, and Single Assessment Numeric Evaluation domains with no statistically significant differences at final follow-up between groups. Thirteen knees (11.5%) in the STAB and 6 knees (19.4%) in the STAB-CART group had complications requiring reoperation, including 6 and 3 revision stabilizations, respectively. There were no statistically significant differences in total major complications (<em>P</em> = .246) or medial PF ligament revision (<em>P</em> = .405).</div></div><div><h3>Conclusions</h3><div>The addition of cartilage restoration in patients undergoing soft tissue and/or bony PF stabilization appears to be safe and effective. Despite lower baseline scores, patients undergoing PF stabilization with cartilage restoration had similar final subjective outcome scores compared to the group without.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe acute localized reactions after intra-articular hyaluronic acid injections: a narrative review and physician’s guide to incidence, prevention, and management of these adverse reactions","authors":"David Humphries ,&nbsp;Michael Baria ,&nbsp;Jane Fitzpatrick","doi":"10.1016/j.jcjp.2024.100187","DOIUrl":"10.1016/j.jcjp.2024.100187","url":null,"abstract":"<div><h3>Introduction</h3><div>Hyaluronic acids (HAs) are commonly used in osteoarthritis. Whilst adverse events are infrequent, the most common is pain and swelling of the joint.</div></div><div><h3>Objectives and Methods</h3><div>A narrative review of the incidence and causes of severe acute localized reactions (SALR) with insights into the prevention and management of SALR.</div></div><div><h3>Results</h3><div>SALR refers to the onset of acute arthralgia, associated swelling, erythema, and motion restriction, after the intra-articular injection of HA. The onset of symptoms is between 4 hours and several days. SALR appears to be immunological responses to the HA and related to poor injection techniques. This literature review identifies that the incidence of SALR following intra-articular injection of HA is relatively low but is not rare. Thus, clinicians using intra-articular HA injections can expect to see patients with SALR and should be prepared to diagnose and treat SALR. The risk of SALR appears to be independent of the source of HA (avian or bacterial fermentation) and the use of crosslinking of the HA product.</div></div><div><h3>Conclusions</h3><div>Intra-articular HA injections are relatively common treatments for the symptoms of osteoarthritis, where primary interventions have been ineffective. Whilst the risk of complications from such injections is low, both mild and more SALR do occur. The reactions can be mitigated by the careful selection of injection portal and the use of ultrasound guidance. Once the differential diagnosis of septic arthritis is excluded, the management of a SALR will generally consist of reassurance and simple analgesia, with more severe cases requiring nonsteroidal anti-inflammatory medication or intra-articular corticosteroids.</div></div><div><h3>What is known about this topic</h3><div>Hyaluronic acids have been used in the management of osteoarthritis for over 3 decades. Whilst adverse events are infrequent, the most common is pain and swelling of the joint, which when severe are termed severe acute localized reactions (SALR) or pseudo-sepsis.</div></div><div><h3>What this study adds</h3><div>This paper provides the injecting physician with a narrative review of the incidence and causes of SALR, insights into the prevention and a discussion of the management.</div></div><div><h3>How might this affect research practice or policy?</h3><div>This information will allow clinicians to mitigate the risks of triggering a SALR and provides a clear pathway for management if such an event occurs. Additionally, it informs the creation of specific policies around the use of HA injections.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biointegrative fiber-reinforced implants for fixation of subchondral insufficiency with avascular necrosis: a case report","authors":"Sarah A. Muth,&nbsp;Alexander C. Weissman,&nbsp;Allen A. Yazdi,&nbsp;Katie J. McMorrow,&nbsp;Richard M. Danilkowicz,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100171","DOIUrl":"10.1016/j.jcjp.2024.100171","url":null,"abstract":"<div><h3>Introduction</h3><div>Treating avascular necrosis (AVN) of the knee can be challenging, particularly at later stages of progression. After subchondral collapse occurs, the only existing surgical treatment is arthroplasty. In earlier stages of collapse, joint sparing procedures for the treatment of AVN include core decompression, osteotomy with metallic implant fixation, and osteochondral grafting. However, there are no reported cases of using biointegrative nails to directly treat subchondral insufficiency of the femoral condyle due to AVN.</div></div><div><h3>Case presentation</h3><div>In this case, the patient suffered from lateral-sided knee pain and swelling, which affected mobility and activities of daily living. At 6 months postoperatively, following subchondral cortex to cortex implantation of 2 biointegrative nails, the patient achieved full range of motion, and at 1 year, magnetic resonance imaging (MRI) showed improved resolution of edema and bone remodeling around the biointegrative nails.</div></div><div><h3>Conclusion</h3><div>In this case report, we demonstrate a new surgical approach to the treatment of subchondral insufficiency due to AVN. Although the outcomes are positive, a larger sample size should be evaluated for the efficacy of treatment of AVN with biointegrative nails.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large osteochondritis dissecans lesion of the knee treated with “snowman” osteochondral allograft transplantation: a case report","authors":"Katie J. McMorrow,&nbsp;Allen A. Yazdi,&nbsp;Alexander C. Weissman,&nbsp;Sarah A. Muth,&nbsp;Stephanie A. Boden,&nbsp;Ron Gilat,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100203","DOIUrl":"10.1016/j.jcjp.2024.100203","url":null,"abstract":"<div><h3>Introduction</h3><div>Symptomatic osteochondritis dissecans (OCD) is a relatively uncommon condition characterized by avascular subchondral bone, resulting in fragmentation and detachment of overlying articular cartilage. Osteochondral allograft transplantation (OCA) offers an effective solution for patients with multifocal, large, unstable, or complex OCD lesions. In certain cases, the “snowman” configuration, involving the use of multiple grafts, may be necessary due to lesion size or shape. This configuration ensures proper press-fit fixation of the grafts while restoring the topography of the articular surface. However, literature on using this technique for large OCD lesions of the lateral femoral condyle remains limited, making it difficult to draw conclusions about surgical outcomes.</div></div><div><h3>Case presentation</h3><div>Here, we present the case of a 17-year-old patient with a symptomatic, 30 mm × 20 mm OCD lesion of the lateral femoral condyle of the left knee. Initially, conservative treatment and physical therapy were pursued, but an injury during a football game resulted in exacerbation of his condition, necessitating 2 surgeries. The first procedure involved a diagnostic arthroscopy and loose body removal, while the second procedure included an OCA (using 2 plugs in a “snowman” configuration), a lateral meniscus repair, and bone marrow aspirate concentrate to saturate the graft.</div></div><div><h3>Conclusion</h3><div>The patient experienced favorable outcomes following surgery. Despite the “snowman” technique’s association with higher reoperation and failure rates compared to single or multicompartmental OCA plugs, it remains one of the few viable options for patients with large OCD lesions, enabling full defect restoration and accurate anatomical curvature of the femoral condyle.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial femoral condyle cartilage restoration using a single-stage combined autologous-allogenic technique: a case report","authors":"Brendan Swift,&nbsp;Brian Chilelli","doi":"10.1016/j.jcjp.2024.100208","DOIUrl":"10.1016/j.jcjp.2024.100208","url":null,"abstract":"<div><h3>Introduction</h3><div>Cartilage injjuries in the knee pose a significant treatment dilemma. Multiple cartilage restoration procedures currently exist, but often come with significant cost and multistage procedures.</div></div><div><h3>Case presentation</h3><div>We report a case of a young, active female who, due to insurance limitations, was unable to undergo matrix-associated autologous chondrocyte implantation. The patient was instead treated with a single-stage combined autogenous-allogenic cartilage restoration. In the follow-up period, the patient endorsed marked improvements in Knee injury and Osteoarthritis Outcome Score, International Knee Documentation Committee Subjective Knee Form, and Western Ontario and McMaster Universities Osteoarthritis Index scores as compared to preoperative scores.</div></div><div><h3>Conclusion</h3><div>Single-stage cartilage restoration with a combined autogenous-allogenic graft technique offers an acceptable alternative to currently available cartilage techniques, with excellent short-term patient-reported outcomes.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postinjection protocols following platelet rich plasma injection for knee osteoarthritis: a systematic review of randomized controlled trials","authors":"Anna L. Park ,&nbsp;Zachary P. Bailowitz ,&nbsp;Peter M. DeJong ,&nbsp;Zainab Shirazi ,&nbsp;Nicholas Tsitsilianos ,&nbsp;Kristian J. von Rickenbach ,&nbsp;Christine E. Townsend ,&nbsp;Drew A. Lansdown ,&nbsp;Alfred C. Gellhorn ,&nbsp;Anthony Luke","doi":"10.1016/j.jcjp.2024.100201","DOIUrl":"10.1016/j.jcjp.2024.100201","url":null,"abstract":"<div><h3>Background</h3><div>There are currently no established postinjection recommendations for the use of platelet-rich plasma (PRP) as a treatment for knee osteoarthritis (OA).</div></div><div><h3>Objectives</h3><div>This paper systematically reviews postinjection protocols for randomized controlled trials of PRP for knee OA, with a particular focus on nonsteroidal anti-inflammatory drugs (NSAIDs) restrictions, activity limitations, and rehabilitation protocols.</div></div><div><h3>Data sources</h3><div>We searched the PubMed and Embase databases through February 2024 for the terms “knee osteoarthritis,” and “PRP,” “platelet rich plasma,” or “autologous,” resulting in 1156 unique articles.</div></div><div><h3>Study eligibility criteria, participants, and interventions</h3><div>Studies were included if they were randomized controlled trials with more than 10 participants using PRP for knee OA. Seventy-one studies met the inclusion criteria.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Data on NSAID restrictions, activity limitations, and rehabilitation protocols were extracted and summarized. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool.</div></div><div><h3>Results</h3><div>Exactly 54.9% of the reviewed articles provided information about postinjection NSAID restriction, with the most common time frame being longer than 4 weeks. Exactly 33.8% provided information about weight-bearing restrictions. Two studies reported detailed rehabilitation protocols.</div></div><div><h3>Limitations</h3><div>Randomized controlled trials for PRP injections for knee OA have significant variability and deficits in the reporting of postinjection protocols.</div></div><div><h3>Conclusions and implications of key findings</h3><div>Lack of reporting and potential heterogeneity in postinjection protocols limits the ability to compare results between studies.</div></div><div><h3>Systematic review registraiton number</h3><div>CRD42024509022</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for response to viscosupplementation in patients with knee osteoarthritis: an analysis of clinical and imaging factors","authors":"Gustavo Rossanese Pinto ,&nbsp;Guilherme Conforto Gracitelli ,&nbsp;Fernando Cury Rezende ,&nbsp;Claudio Gattas ,&nbsp;Thais Cristina Pereira Vasques ,&nbsp;Flavio Duarte Silva ,&nbsp;Carlos Eduardo da Silveira Franciozi ,&nbsp;Marcus Vinicius Malheiros Luzo","doi":"10.1016/j.jcjp.2024.100181","DOIUrl":"10.1016/j.jcjp.2024.100181","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the widespread use of viscosupplementation (VS) in the treatment of knee arthritis, the factors that may influence its effectiveness or failure are still controversial and little explored in the literature.</div></div><div><h3>Objectives</h3><div>To identify clinical, radiographic, and magnetic resonance imaging predictive factors associated with VS failure in the treatment of knee osteoarthritis.</div></div><div><h3>Methods</h3><div>In this prospective study, patients with knee osteoarthritis were evaluated for predictive factors before the intervention, including radiographic images (Kellgren-Lawrence [KL] classification and femorotibial angle), magnetic resonance images Osteoarthritis Knee Score (MOAKS) and meniscal extrusion, joint effusion, body mass index, previous surgery, sex, and age. All patients received a single intra-articular dose of Synolis-VA 4 mL (80 mg hyaluronic acid<!--> <!-->+<!--> <!-->160 mg sorbitol). The WOMAC (Western Ontario Mcmaster Universities Arthritis Index), Visual Analog Scale, and SF-12v2 questionnaires were administered at baseline, 15<!--> <!-->days, 3<!--> <!-->months, and 6<!--> <!-->months of clinical follow-up.</div></div><div><h3>Results</h3><div>The results showed a significant reduction in WOMAC and Visual Analog Scale scores for all evaluated times after VS compared to baseline. Using the OMERACT-OARSI (Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International) criteria, 53 patients were classified as the \"success group\" and 55 patients as the \"failure group.\" The KL classification and MOAKS score showed a significant difference between these 2 groups, <em>P</em> = .042 and <em>P</em> = .009, respectively. Univariate logistic regression analysis revealed that a KL classification of 3 or 4 and MOAKS score predicted a higher risk of failure.</div></div><div><h3>Conclusions</h3><div>Patients with a KL classification of 3 or 4 or a high MOAKS score were more likely to fail VS, while the other analyzed factors showed no significant difference.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the final issue of JCJP 2024","authors":"Miranda Manfre,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100225","DOIUrl":"10.1016/j.jcjp.2024.100225","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis","authors":"Yusuf Mufti,&nbsp;Jared P. Sachs,&nbsp;Andrew S. Bi,&nbsp;Chloe Franzia,&nbsp;John Ebersole,&nbsp;Taylor Giordano,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100221","DOIUrl":"10.1016/j.jcjp.2024.100221","url":null,"abstract":"<div><h3>Introduction</h3><div>Chondroplasty is a surgical option for chondral defects, but its effect on larger cartilage defects in the setting of knee osteoarthritis remains unclear.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate patient-reported outcomes (PROs) following chondroplasty in patients with larger chondral defects (≥2 cm²) of the femur in the setting of osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Retrospective review of patients who underwent chondroplasty of the femur. All patients had Kellgren-Lawrence (KL) grades of 2 or 3 and a minimum of 1-year postoperative follow-up. Chondral loss was estimated by arthroscopic measurements and by Magnetic Resonance Imaging (MRI). PROs included the International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, and the Veterans Rand-12 Item. Statistical analysis was performed using paired <em>t</em> tests to compare baseline and follow-up data, as well as linear regressions to correlate lesion size with symptom improvement.</div></div><div><h3>Results</h3><div>39 patients with 20 KL grade 2 and 19 KL grade 3 knees were included. At both 1- and 2-year follow-ups, significant improvements were noted in International Knee Documentation Committee (34.9 ± 13.5 preoperative, 55.6 ± 18.8 at 2 years, <em>P</em> = .0025), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (56.3 ± 14.7 preoperative, 64.5 ± 17.0 at 2 years, <em>P</em> = .0243), and Veterans Rand-12 Item Physical Component Scores (38.0 ± 12.7 preoperative, 43.8 ± 8.6 at 2 years, <em>P</em> = .0044). Four (10.3%) conversions to arthroplasty were noted at most recent follow-up.</div></div><div><h3>Conclusions</h3><div>Articular cartilage debridement for large areas of cartilage loss of the femur in the setting of mild to moderate osteoarthritis results in significant improvements in physical function and knee-specific PROs at 1- and 2-year follow-ups.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical potential of meniscal progenitor cells","authors":"Wan-Ting Yan ,&nbsp;Jing-Song Wang ,&nbsp;Peng-Zhou Fan ,&nbsp;Sally Roberts ,&nbsp;Karina Wright ,&nbsp;Zheng-Zheng Zhang","doi":"10.1016/j.jcjp.2024.100166","DOIUrl":"10.1016/j.jcjp.2024.100166","url":null,"abstract":"<div><h3>Introduction</h3><div>The meniscus is an important cushioning structure of the knee joint, with the maintenance of its normal structure and function playing a crucial role in protecting the joint from early degeneration. Stem/progenitor cells could be the key to help researchers to have a deeper understanding of the biological process of meniscal injury repair and may be important in the meniscus tissue regeneration processes. To the best of our knowledge, there is currently a lack of comprehensive reviews on existing research about the meniscus progenitor cells (MPCs).</div></div><div><h3>Objectives</h3><div>By reviewing the existing MPC literature, we aim to provide insights for future research on meniscus regeneration.</div></div><div><h3>Methods</h3><div>The isolation methods, biological characteristics and the translational application of MPCs were summarized.</div></div><div><h3>Results</h3><div>MPCs could be isolated according to their colony-forming ability, marker expression, migration ability, and differential adhesion to fibronectin. Most existing studies on surface markers of MPCs have largely followed the paradigm of mesenchymal stromal/stem cell research. Based on the information provided by their surface markers and expression profile, researchers located MPCs in the peripheral surface area of the meniscus. Few researches have investigated the translation and application of MPCs, with most studies being limited to MPCs extraction and subsequent reimplantation in vivo.</div></div><div><h3>Conclusions</h3><div>MPCs are a group of meniscus-resident cells, which exhibit certain stem/progenitor cell characteristics, such as the ability to undergo multilineage differentiation in in vitro culture.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}